Understanding development and prevention of chronic physical aggression: towards experimental epigenetic studies.
- Authors
- Tremblay, Richard E
- Year
- 2008
- Journal
- Philosophical transactions of the Royal Society of London. Series B, Biological sciences
- PMID
- 18467277
- DOI
- 10.1098/rstb.2008.0030
- PMCID
- PMC2606712
The aim of this paper was to highlight how developmental psychopathology, epigenetics and prevention experiments are starting to blend together to explain the developmental causes of chronic physical aggression (CPA) and, more importantly, to help prevent CPA and its associated physical, mental and social problems. After defining the keywords (prevention, chronic and physical aggression), a selected review of published studies is used to answer the following four questions: when should we attempt to prevent onset of CPA? What are the risk factors for CPA? Have early childhood interventions been shown to prevent CPA? Can early preventive interventions benefit from epigenetic studies? The last section of this paper gives two examples of experimental prevention designs that integrate present knowledge of CPA development, risk factors, early childhood preventive interventions and epigenetic programming of brain development during pregnancy and early childhood. I conclude that randomized control trials of preventive interventions during pregnancy and early childhood with a specific focus on epigenetic effects are the research design most likely to advance our understanding of the biopsychosocial mechanisms that lead to CPA, and the only research design that can identify effective interventions for preventing the development of CPA.
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| Epigenome-Wide Association Study of Aggressive Behavior. | van Dongen J et al. | — | 2015 | → |
| The protective role of school friendship ties for substance use and aggressive behaviors among middle school students. | Forster M et al. | — | 2015 | → |
| Associations between child disciplinary practices and bullying behavior in adolescents. | Zottis GA et al. | — | 2014 | → |
| Neurocriminology: implications for the punishment, prediction and prevention of criminal behaviour. | Glenn AL et al. | — | 2014 | → |
| Remote population-based intervention for disruptive behavior at age four: study protocol for a randomized trial of Internet-assisted parent training (Strongest Families Finland-Canada). | McGrath PJ et al. | — | 2013 | → |
| Cesare Lombroso: Methodological ambiguities and brilliant intuitions. | Gatti U et al. | — | 2012 | → |
| Neuroscience, neuroimaging and the law. | Markowitsch HJ et al. | — | 2011 | → |
| Opposition-Defiance in the Second Year of Life: A Population-Based Cohort Study. | Baillargeon RH et al. | — | 2011 | → |
| Addressing, understanding and treating conduct disorders in adolescents through psychoanalysis and neuroscience: towards a disappearance of sex-differences. | Bronsard G et al. | — | 2010 | → |
| Aggression in low functioning children and adolescents with autistic disorder. | Bronsard G et al. | — | 2010 | → |
| Brain serotonin synthesis in adult males characterized by physical aggression during childhood: a 21-year longitudinal study. | Booij L et al. | — | 2010 | → |
| Developmental origins of disruptive behaviour problems: the 'original sin' hypothesis, epigenetics and their consequences for prevention. | Tremblay RE | — | 2010 | → |
| Developmental trajectories of physical aggression: prediction of overt and covert antisocial behaviors from self- and mothers' reports. | Di Giunta L et al. | — | 2010 | → |
| Understanding relations among early family environment, cortisol response, and child aggression via a prevention experiment. | O'Neal CR et al. | — | 2010 | → |
| Childhood disruptive behaviour disorders: review of their origin, development, and prevention. | Petitclerc A et al. | — | 2009 | → |
| Differentiating early-onset persistent versus childhood-limited conduct problem youth. | Barker ED et al. | — | 2009 | → |
| Early life stress, the development of aggression and neuroendocrine and neurobiological correlates: what can we learn from animal models? | Veenema AH | — | 2009 | → |
| The neurobiology of violence: implications for prevention and treatment. Introduction. | Rutter M | — | 2008 | → |