Cellular therapy.
- Authors
- Flake, A W; Zanjani, E D
- Year
- 1997
- Journal
- Obstetrics and gynecology clinics of North America
- PMID
- 9086524
- DOI
- 10.1016/s0889-8545(05)70295-3
From a clinical perspective, prenatal transplantation has tremendous potential to broaden the current indications for reconstitution therapy and to offer a safe, efficacious, and cost-effective alternative to conventional postnatal BMT for many congenital hematopoietic diseases. Experimental work and limited clinical experience offer hope for the future. The primary experimental challenges will be to manipulate the biology of in utero HSC transplantation so that the approach will be safe and broadly applicable. This will require strategies to improve engraftment; use alternative sources of cells safely and effectively; and develop techniques for procurement, ex vivo expansion, and tissue banking of safe donor cells. The clinical challenges in the future will be to identify recipients most likely to benefit from the approach, and to define further the clinical and ethical guidelines for its application.
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In this knowledge base
| Title | Year | PMID |
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| Using human stem cells as a model system to understand the neural mechanisms of alcohol use disorders: Current status and outlook. | 2019 | 30087005 |
External
| Title | Authors | Journal | Year | Link |
|---|---|---|---|---|
| Using human stem cells as a model system to understand the neural mechanisms of alcohol use disorders: Current status and outlook. | Scarnati MS et al. | — | 2019 | → |
| In utero stem cell transplantation and gene therapy: rationale, history, and recent advances toward clinical application. | Almeida-Porada G et al. | — | 2016 | → |
| In utero hematopoietic cell transplantation for the treatment of congenital anomalies. | Nijagal A et al. | — | 2012 | → |
| Advances in reprogramming somatic cells to induced pluripotent stem cells. | Patel M et al. | — | 2010 | → |
| Prenatal tolerance induction: relationship between cell dose, marrow T-cells, chimerism, and tolerance. | Chen JC et al. | — | 2008 | → |
| In utero stem cell transplantation. | Flake AW | — | 2004 | → |
| In utero transplantation of wild-type fetal liver cells rescues factor X-deficient mice from fatal neonatal bleeding diatheses. | Rosen ED et al. | — | 2003 | → |
| Genetic therapies for the fetus. | Flake AW | — | 2002 | → |
| In utero transplantation of haemopoietic stem cells. | Flake AW | — | 2001 | → |
| Stem cell therapy in utero. | Pschera H | — | 2000 | → |
| Cotransplantation of stroma results in enhancement of engraftment and early expression of donor hematopoietic stem cells in utero. | Almeida-Porada G et al. | — | 1999 | → |
| In utero hematopoietic stem cell transfer: current status and future strategies. | Surbek DV et al. | — | 1999 | → |
| Current status in intrauterine fetal stem cell therapy. | Pschera H | — | 1998 | → |