Hepatic fibroblast growth factor 21 is regulated by PPARalpha and is a key mediator of hepatic lipid metabolism in ketotic states.
paper
Cited
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- Authors
- Badman, Michael K; Pissios, Pavlos; Kennedy, Adam R; Koukos, George; Flier, Jeffrey S; Maratos-Flier, Eleftheria
- Year
- 2007
- Journal
- Cell metabolism
- PMID
- 17550778
- DOI
- 10.1016/j.cmet.2007.05.002
Mice fed a high-fat, low-carbohydrate ketogenic diet (KD) exhibit marked changes in hepatic metabolism and energy homeostasis. Here, we identify liver-derived fibroblast growth factor 21 (FGF21) as an endocrine regulator of the ketotic state. Hepatic expression and circulating levels of FGF21 are induced by both KD and fasting, are rapidly suppressed by refeeding, and are in large part downstream of PPARalpha. Importantly, adenoviral knockdown of hepatic FGF21 in KD-fed mice causes fatty liver, lipemia, and reduced serum ketones, due at least in part to altered expression of key genes governing lipid and ketone metabolism. Hence, induction of FGF21 in liver is required for the normal activation of hepatic lipid oxidation, triglyceride clearance, and ketogenesis induced by KD. These findings identify hepatic FGF21 as a critical regulator of lipid homeostasis and identify a physiological role for this hepatic hormone.
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| Alcoholic fatty liver is blunted by rFGF21 administration in mice lacking adipose FGFR1: The role of FGF21 in PPARΞ±-mediated regulation of adipose tissue mass. | Xu Y et al. | β | 2022 | β |
| An fgf21-like gene from swamp eel (Monopterus albus): Recombinant expression and its potential roles in glucose and lipid homeostasis. | Zheng S et al. | β | 2022 | β |
| ATGL-dependent white adipose tissue lipolysis controls hepatocyte PPARΞ± activity. | Fougerat A et al. | β | 2022 | β |
| BDK inhibition acts as a catabolic switch to mimic fasting and improve metabolism in mice. | Bollinger E et al. | β | 2022 | β |
| Bibliometric analysis of fibroblast growth factor 21 research over the period 2000 to 2021. | She QY et al. | β | 2022 | β |
| Bile acid and receptors: biology and drug discovery for nonalcoholic fatty liver disease. | Jiao TY et al. | β | 2022 | β |
| Browning of the white adipose tissue regulation: new insights into nutritional and metabolic relevance in health and diseases. | Machado SA et al. | β | 2022 | β |
| Circadian clock controls rhythms in ketogenesis by interfering with PPARΞ± transcriptional network. | Mezhnina V et al. | β | 2022 | β |
| Close association between lifestyle and circulating FGF21 levels: A systematic review and meta-analysis. | Qian Z et al. | β | 2022 | β |
| CRISPR-Cas9-based genome-wide screening identified novel targets for treating sorafenib-resistant hepatocellular carcinoma: a cross-talk between FGF21 and the NRF2 pathway. | Chen J et al. | β | 2022 | β |
| Critical role of peroxisome proliferator-activated receptor Ξ± in promoting platelet hyperreactivity and thrombosis under hyperlipidemia. | Li L et al. | β | 2022 | β |
| Dietary induction of obesity and insulin resistance is associated with changes in Fgf21 DNA methylation in liver of mice. | GeiΓler C et al. | β | 2022 | β |
| Dietary Interventions in Autosomal Dominant Polycystic Kidney Disease. | Pickel L et al. | β | 2022 | β |
| Do Sugar-Sweetened Beverages Increase Fasting FGF21 Irrespective of the Type of Added Sugar? A Secondary Exploratory Analysis of a Randomized Controlled Trial. | Geidl-Flueck B et al. | β | 2022 | β |
| Efruxifermin, a long-acting Fc-fusion FGF21 analogue, reduces body weight gain but does not increase sympathetic tone or urine volume in Sprague Dawley rats. | Tillman EJ et al. | β | 2022 | β |
| Elimination of Vitamin D Signaling Causes Increased Mortality in a Model of Overactivation of the Insulin Receptor: Role of Lipid Metabolism. | Crespo-Masip M et al. | β | 2022 | β |
| Endocrine Fibroblast Growth Factors in Relation to Stress Signaling. | Shimizu M et al. | β | 2022 | β |
| Epigallocatechin-3-gallate ameliorates hepatic damages by relieve FGF21 resistance and promotion of FGF21-AMPK pathway in mice fed a high fat diet. | Zhang Y et al. | β | 2022 | β |
| Factors mediating exercise-induced organ crosstalk. | Sabaratnam R et al. | β | 2022 | β |
| Fasting or the short-term consumption of a ketogenic diet protects against antipsychotic-induced hyperglycaemia in mice. | Shamshoum H et al. | β | 2022 | β |
| FGF21: A Novel Regulator of Glucose and Lipid Metabolism and Whole-Body Energy Balance. | SzczepaΕska E et al. | β | 2022 | β |
| FGF21 contributes to metabolic improvements elicited by combination therapy with exenatide and pioglitazone in patients with type 2 diabetes. | Samms RJ et al. | β | 2022 | β |
| FGF21 controls hepatic lipid metabolism via sex-dependent interorgan crosstalk. | Chaffin AT et al. | β | 2022 | β |
| FGF21 (Fibroblast Growth Factor 21) Defines a Potential Cardiohepatic Signaling Circuit in End-Stage Heart Failure. | Sommakia S et al. | β | 2022 | β |
| FGF21 Is Released During Increased Lipogenesis State Following Rapid-Onset Radioiodine-Induced Hypothyroidism. | SzczepaΕska E et al. | β | 2022 | β |
| FGF4 protects the liver from nonalcoholic fatty liver disease by activating the AMP-activated protein kinase-Caspase 6 signal axis. | Song L et al. | β | 2022 | β |
| FGF9 Alleviates the Fatty Liver Phenotype by Regulating Hepatic Lipid Metabolism. | Zhao F et al. | β | 2022 | β |
| Fibroblast Growth Factor 21 Facilitates the Homeostatic Control of Feeding Behavior. | Wu CT et al. | β | 2022 | β |
| Fibroblast growth factor-21 (FGF21) analogs as possible treatment options for diabetes mellitus in veterinary patients. | Corbee RJ et al. | β | 2022 | β |
| Fibroblast growth factor 21 is associated with widening QRS complex and prolonged corrected QT interval in patients with stable angina. | Hung WC et al. | β | 2022 | β |
| Fibroblast Growth Factor 21 Predicts Short-Term Prognosis in Patients With Acute Heart Failure: A Prospective Cohort Study. | Wu G et al. | β | 2022 | β |
| Garcinia Biflavonoid 1 Improves Lipid Metabolism in HepG2 Cells via Regulating PPARΞ±. | Chen HX et al. | β | 2022 | β |
| Hepatic FGF21: Its Emerging Role in Inter-Organ Crosstalk and Cancers. | Sui Y et al. | β | 2022 | β |
| Hepatic hormone FGF21 and its analogues in clinical trials. | Shao W et al. | β | 2022 | β |
| Insights into the molecular targets and emerging pharmacotherapeutic interventions for nonalcoholic fatty liver disease. | Negi CK et al. | β | 2022 | β |
| Integrative study of diet-induced mouse models of NAFLD identifies PPARΞ± as a sexually dimorphic drug target. | Smati S et al. | β | 2022 | β |
| Ketogenic diets, physical activity and body composition: a review. | Ashtary-Larky D et al. | β | 2022 | β |
| Ketone body and FGF21 coordinately regulate fasting-induced oxidative stress response in the heart. | Kawakami R et al. | β | 2022 | β |
| Liver Brain Interactions: Focus on FGF21 a Systematic Review. | Prida E et al. | β | 2022 | β |
| LLF580, an FGF21 Analog, Reduces Triglycerides and Hepatic Fat in Obese Adults With Modest Hypertriglyceridemia. | Rader DJ et al. | β | 2022 | β |
| Long-Term Dietary Taurine Lowers Plasma Levels of Cholesterol and Bile Acids. | Tagawa R et al. | β | 2022 | β |
| Maternal Fibroblast Growth Factor 21 Levels Decrease during Early Pregnancy in Normotensive Pregnant Women but Are Higher in Preeclamptic Women-A Longitudinal Study. | Buell-Acosta JD et al. | β | 2022 | β |
| Mechanisms of autophagic responses to altered nutritional status. | Tao Z et al. | β | 2022 | β |
| Methionine adenosyltransferase 1a antisense oligonucleotides activate the liver-brown adipose tissue axis preventing obesity and associated hepatosteatosis. | SΓ‘enz de Urturi D et al. | β | 2022 | β |
| Mitochondria homeostasis: Biology and involvement in hepatic steatosis to NASH. | Li YF et al. | β | 2022 | β |
| Molecular Mechanisms for Ketone Body Metabolism, Signaling Functions, and Therapeutic Potential in Cancer. | Hwang CY et al. | β | 2022 | β |
| Multidimensional Biomarker Analysis Including Mitochondrial Stress Indicators for Nonalcoholic Fatty Liver Disease. | Chang E et al. | β | 2022 | β |
| Orosomucoid 2 maintains hepatic lipid homeostasis through suppression of de novo lipogenesis. | Zhou B et al. | β | 2022 | β |
| Pathophysiology and risk factors of peripartum cardiomyopathy. | Hoes MF et al. | β | 2022 | β |
| Performance and Metabolic, Inflammatory, and Oxidative Stress-Related Parameters in Early Lactating Dairy Cows with High and Low Hepatic FGF21 Expression. | Gessner DK et al. | β | 2022 | β |
| Perspectives in liver redox imbalance: Toxicological and pharmacological aspects underlying iron overloading, nonalcoholic fatty liver disease, and thyroid hormone action. | Videla LA et al. | β | 2022 | β |
| Pharmacological treatment with FGF21 strongly improves plasma cholesterol metabolism to reduce atherosclerosis. | Liu C et al. | β | 2022 | β |
| Phosphorylation of RXRΞ± mediates the effect of JNK to suppress hepatic FGF21 expression and promote metabolic syndrome. | Vernia S et al. | β | 2022 | β |
| Plasma FGF21 concentrations are regulated by glucose independently of insulin and GLP-1 in lean, healthy humans. | Solomon TPJ et al. | β | 2022 | β |
| PPAR Alpha as a Metabolic Modulator of the Liver: Role in the Pathogenesis of Nonalcoholic Steatohepatitis (NASH). | Todisco S et al. | β | 2022 | β |
| PTEN Deletion in Adult Mice Induces Hypoinsulinemia With Concomitant Low Glucose Levels. | Crespo-Masip M et al. | β | 2022 | β |
| Pyruvate Upregulates Hepatic FGF21 Expression by Activating PDE and Inhibiting cAMP-Epac-CREB Signaling Pathway. | Zhao YY et al. | β | 2022 | β |
| Review article: vascular effects of PPARs in the context of NASH. | GuixΓ©-Muntet S et al. | β | 2022 | β |
| Roles of the fibroblast growth factor signal transduction system in tissue injury repair. | Chen K et al. | β | 2022 | β |
| Seed- and leaf-based expression of FGF21-transferrin fusion proteins for oral delivery and treatment of non-alcoholic steatohepatitis. | Hou HW et al. | β | 2022 | β |
| Selective PPARΞ΄ agonist seladelpar suppresses bile acid synthesis by reducing hepatocyte CYP7A1 via the fibroblast growth factor 21 signaling pathway. | Kouno T et al. | β | 2022 | β |
| Serum Fibroblast Growth Factor 21 Level Is Associated with Aortic Stiffness in Patients on Maintenance Hemodialysis. | Chiu LT et al. | β | 2022 | β |
| Sex and genetic background define the metabolic, physiologic, and molecular response to protein restriction. | Green CL et al. | β | 2022 | β |
| Short Term Isocaloric Ketogenic Diet Modulates NLRP3 Inflammasome <i>Via</i> B-hydroxybutyrate and Fibroblast Growth Factor 21. | Kim ER et al. | β | 2022 | β |
| Spatial distribution of beta-klotho mRNA in the mouse hypothalamus, hippocampal region, subiculum, and amygdala. | Bono BS et al. | β | 2022 | β |
| Suppression of obesity by melatonin through increasing energy expenditure and accelerating lipolysis in mice fed a high-fat diet. | Xu L et al. | β | 2022 | β |
| Symposium review: Adipose tissue endocrinology in the periparturient period of dairy cows. | HΓ€ussler S et al. | β | 2022 | β |
| Targeted therapeutics and novel signaling pathways in non-alcohol-associated fatty liver/steatohepatitis (NAFL/NASH). | Xu X et al. | β | 2022 | β |
| The elevation of fibroblast growth factor 21 is associated with generalized periodontitis in patients with treated metabolic syndrome. | Sawangpanyangkura T et al. | β | 2022 | β |
| The ketogenic diet prevents steatosis and insulin resistance by reducing lipogenesis, diacylglycerol accumulation and protein kinase C activity in male rat liver. | Jani S et al. | β | 2022 | β |
| The Lipid Energy Model: Reimagining Lipoprotein Function in the Context of Carbohydrate-Restricted Diets. | Norwitz NG et al. | β | 2022 | β |
| The New Markers of Early Obesity-Related Organ and Metabolic Abnormalities. | Ziomber-Lisiak A et al. | β | 2022 | β |
| The potential function and clinical application of FGF21 in metabolic diseases. | Chen Z et al. | β | 2022 | β |
| Vanin 1 Gene Role in Modulation of iNOS/MCP-1/TGF-Ξ²1 Signaling Pathway in Obese Diabetic Patients. | Mosaad YO et al. | β | 2022 | β |
| Ξ²-Hydroxybutyrate upregulates FGF21 expression through inhibition of histone deacetylases in hepatocytes. | Yan A et al. | β | 2022 | β |
| Advances in Biological Functions and Clinical Studies of FGF21. | Lin W et al. | β | 2021 | β |
| A feed-forward regulatory loop in adipose tissue promotes signaling by the hepatokine FGF21. | Han MS et al. | β | 2021 | β |
| Ahnak deficiency attenuates high-fat diet-induced fatty liver in mice through FGF21 induction. | Kim YN et al. | β | 2021 | β |
| Antiaging diets: Separating fact from fiction. | Lee MB et al. | β | 2021 | β |
| Association between serum FGF21 level and sarcopenia in older adults. | Jung HW et al. | β | 2021 | β |
| Association of FGF-19 and FGF-21 levels with primary sarcopenia. | Bag Soytas R et al. | β | 2021 | β |
| Association of fibroblast growth factor 21 with metabolic syndrome and endothelial function in children: a prospective cross-sectional study on novel biomarkers. | Domouzoglou EM et al. | β | 2021 | β |
| Changes in hepatic triglyceride content with the activation of ER stress and increased FGF21 secretion during pregnancy. | Lu J et al. | β | 2021 | β |
| CREBH Systemically Regulates Lipid Metabolism by Modulating and Integrating Cellular Functions. | Nakagawa Y et al. | β | 2021 | β |
| (+)-Dehydrovomifoliol Alleviates Oleic Acid-Induced Lipid Accumulation in HepG2 Cells <i>via</i> the PPARΞ±-FGF21 Pathway. | Xi Y et al. | β | 2021 | β |
| Diet and exercise in NAFLD/NASH: Beyond the obvious. | Semmler G et al. | β | 2021 | β |
| Differential roles of GDF15 and FGF21 in systemic metabolic adaptation to the mitochondrial integrated stress response. | Kang SG et al. | β | 2021 | β |
| Discovery of novel, potent and orally efficacious inhibitor of neutral amino acid transporter B<sup>0</sup>AT1 (SLC6A19). | Desai J et al. | β | 2021 | β |
| Dynamic folding modulation generates FGF21 variant against diabetes. | Zhu L et al. | β | 2021 | β |
| Effective and safe delivery of GLP-1AR and FGF-21 plasmids using amino-functionalized dual-mesoporous silica nanoparticles in vitro and in vivo. | Geng S et al. | β | 2021 | β |
| Effects of dietary curcumin on growth, antioxidant capacity, fatty acid composition and expression of lipid metabolism-related genes of large yellow croaker fed a high-fat diet. | Ji R et al. | β | 2021 | β |
| Effects of dietary restriction on metabolic and cognitive health. | Souza Matos M et al. | β | 2021 | β |
| Effects of pemafibrate on glucose metabolism markers and liver function tests in patients with hypertriglyceridemia: a pooled analysis of six phase 2 and phase 3 randomized double-blind placebo-controlled clinical trials. | Yokote K et al. | β | 2021 | β |
| Elucidation of the mechanism of NEFA-induced PERK-eIF2Ξ± signaling pathway regulation of lipid metabolism in bovine hepatocytes. | Huang Y et al. | β | 2021 | β |
| Epigenetic Regulation of Processes Related to High Level of Fibroblast Growth Factor 21 in Obese Subjects. | PΕatek T et al. | β | 2021 | β |
| Fatty Acid Desaturase 1 Influences Hepatic Lipid Homeostasis by Modulating the PPARΞ±-FGF21 Axis. | Athinarayanan S et al. | β | 2021 | β |
| Fenofibrate Protects against Retinal Dysfunction in a Murine Model of Common Carotid Artery Occlusion-Induced Ocular Ischemia. | Lee D et al. | β | 2021 | β |
| FGF19 and FGF21: In NASH we trust. | Talukdar S et al. | β | 2021 | β |
| FGF21 in obesity and cancer: New insights. | Lu W et al. | β | 2021 | β |
| FGF21 Normalizes Plasma Glucose in Mouse Models of Type 1 Diabetes and Insulin Receptor Dysfunction. | Diener JL et al. | β | 2021 | β |
| FGF21 promotes thermogenic gene expression as an autocrine factor in adipocytes. | Abu-Odeh M et al. | β | 2021 | β |
| FGF2 disruption enhances thermogenesis in brown and beige fat to protect against adiposity and hepatic steatosis. | Li H et al. | β | 2021 | β |
| FGF/FGFR Signaling in Hepatocellular Carcinoma: From Carcinogenesis to Recent Therapeutic Intervention. | Wang Y et al. | β | 2021 | β |
| Fibroblast Growth Factor 21 Augments Autophagy and Reduces Apoptosis in Damaged Liver to Improve Tissue Regeneration in Zebrafish. | Qiang W et al. | β | 2021 | β |
| Fibroblast growth factor 21 in dairy cows: current knowledge and potential relevance. | Eder K et al. | β | 2021 | β |
| FoxO1 suppresses Fgf21 during hepatic insulin resistance to impair peripheral glucose utilization and acute cold tolerance. | StΓΆhr O et al. | β | 2021 | β |
| Glucagon's Metabolic Action in Health and Disease. | Zeigerer A et al. | β | 2021 | β |
| Gut microbiota mediate the FGF21 adaptive stress response to chronic dietary protein-restriction in mice. | Martin A et al. | β | 2021 | β |
| Hepatic FGF21 preserves thermoregulation and cardiovascular function during bacterial inflammation. | Huen SC et al. | β | 2021 | β |
| Hepatic Fibroblast Growth Factor 21 Is Involved in Mediating Functions of Liraglutide in Mice With Dietary Challenge. | Liu D et al. | β | 2021 | β |
| Hepatic metabolic regulation by nuclear factor E4BP4. | Zhao Z et al. | β | 2021 | β |
| Hepatic Small Ubiquitin-Related Modifier (SUMO)-Specific Protease 2 Controls Systemic Metabolism Through SUMOylation-Dependent Regulation of Liver-Adipose Tissue Crosstalk. | Liu Y et al. | β | 2021 | β |
| Hepatokines and metabolism: Deciphering communication from the liver. | Jensen-Cody SO et al. | β | 2021 | β |
| Hepatokines and Non-Alcoholic Fatty Liver Disease: Linking Liver Pathophysiology to Metabolism. | Kim TH et al. | β | 2021 | β |
| Impact of acute exercise on immediate and following early post-exercise FGF-21 concentration in adults: systematic review and meta-analysis. | Khalafi M et al. | β | 2021 | β |
| Increased Fibroblast Growth Factor 21 (FGF21) Concentration in Early Second Trimester Amniotic Fluid and Its Association with Fetal Growth. | Vrachnis N et al. | β | 2021 | β |
| Inducible hepatic expression of CREBH mitigates diet-induced obesity, insulin resistance, and hepatic steatosis in mice. | Krumm CS et al. | β | 2021 | β |
| Intestinal-derived FGF15 protects against deleterious effects of vertical sleeve gastrectomy in mice. | Bozadjieva-Kramer N et al. | β | 2021 | β |
| Ketogenic Diet Enhances the Cholesterol Accumulation in Liver and Augments the Severity of CCl<sub>4</sub> and TAA-Induced Liver Fibrosis in Mice. | Liao YJ et al. | β | 2021 | β |
| Ketone Bodies in the Brain Beyond Fuel Metabolism: From Excitability to Gene Expression and Cell Signaling. | GarcΓa-RodrΓguez D et al. | β | 2021 | β |
| Liraglutide regulates lipid metabolism via FGF21- LKB1- AMPK- ACC1 pathway in white adipose tissues and macrophage of type 2 diabetic mice. | Zhang N et al. | β | 2021 | β |
| Longitudinal changes in fatty acid metabolism and in the mitochondrial protein import system in overconditioned and normal conditioned cows: A transcriptional study using microfluidic quantitative PCR. | Ghaffari MH et al. | β | 2021 | β |
| Metabolic and Signaling Roles of Ketone Bodies in Health and Disease. | Puchalska P et al. | β | 2021 | β |
| Metabolic Messengers: FGF21. | Flippo KH et al. | β | 2021 | β |
| Mitochondrial Metabolic Signatures in Hepatocellular Carcinoma. | Lee HY et al. | β | 2021 | β |
| mTORC1 activation is not sufficient to suppress hepatic PPARΞ± signaling or ketogenesis. | Selen ES et al. | β | 2021 | β |
| Neuroprotective Effects of the FGF21 Analogue LY2405319. | RΓΌhlmann C et al. | β | 2021 | β |
| New targets for NAFLD. | Parlati L et al. | β | 2021 | β |
| Nuclear Receptor CoRepressors, NCOR1 and SMRT, are required for maintaining systemic metabolic homeostasis. | Ritter MJ et al. | β | 2021 | β |
| Nutritional Regulation of Hepatic FGF21 by Dietary Restriction of Methionine. | Fang H et al. | β | 2021 | β |
| Pegbelfermin, a PEGylated FGF21 analogue, has pharmacology without bone toxicity after 1-year dosing in skeletally-mature monkeys. | Thompson KE et al. | β | 2021 | β |
| Pemafibrate Prevents Retinal Dysfunction in a Mouse Model of Unilateral Common Carotid Artery Occlusion. | Lee D et al. | β | 2021 | β |
| Perspectives on Mitochondria-ER and Mitochondria-Lipid Droplet Contact in Hepatocytes and Hepatic Lipid Metabolism. | Ma X et al. | β | 2021 | β |
| Physical Exercise-Induced Myokines in Neurodegenerative Diseases. | Lee B et al. | β | 2021 | β |
| PPARΞ± agonist WY-14,643 induces adipose atrophy and fails to blunt chronic ethanol-induced hepatic fat accumulation in mice lacking adipose FGFR1. | Xu Y et al. | β | 2021 | β |
| Prognostic value of plasma fibroblast growth factor 21 among patients with acute ischemic stroke. | Zheng X et al. | β | 2021 | β |
| Protein Appetite at the Interface between Nutrient Sensing and Physiological Homeostasis. | Khan MS et al. | β | 2021 | β |
| Relationship between FGF21 and drug or nondrug therapy of type 2 diabetes mellitus. | Guo C et al. | β | 2021 | β |
| Severe protein deficiency induces hepatic expression and systemic level of FGF21 but inhibits its hypothalamic expression in growing rats. | Moro J et al. | β | 2021 | β |
| Skeletal Muscle and Bone - Emerging Targets of Fibroblast Growth Factor-21. | Sun H et al. | β | 2021 | β |
| Spinal Cord Injury Reduces Serum Levels of Fibroblast Growth Factor-21 and Impairs Its Signaling Pathways in Liver and Adipose Tissue in Mice. | Liu XH et al. | β | 2021 | β |
| Starvation-induced transcription factor CREBH negatively governs body growth by controlling GH signaling. | Nakagawa Y et al. | β | 2021 | β |
| Th2 Cytokines Increase the Expression of Fibroblast Growth Factor 21 in the Liver. | Kang SG et al. | β | 2021 | β |
| The dynamics of human bone marrow adipose tissue in response to feeding and fasting. | Fazeli PK et al. | β | 2021 | β |
| The FMRFamide Neuropeptide FLP-20 Acts as a Systemic Signal for Starvation Responses in <i>Caenorhabditis elegans</i>. | Kang C et al. | β | 2021 | β |
| The miR-182-5p/FGF21/acetylcholine axis mediates the crosstalk between adipocytes and macrophages to promote beige fat thermogenesis. | Meng W et al. | β | 2021 | β |
| The Nuanced Metabolic Functions of Endogenous FGF21 Depend on the Nature of the Stimulus, Tissue Source, and Experimental Model. | Spann RA et al. | β | 2021 | β |
| The Regulation of Circulating Hepatokines by Fructose Ingestion in Humans. | Richter MM et al. | β | 2021 | β |
| The Role and Mechanism of Oxidative Stress and Nuclear Receptors in the Development of NAFLD. | Hong T et al. | β | 2021 | β |
| The Role of Fibroblast Growth Factor 21 in Diabetic Cardiovascular Complications and Related Epigenetic Mechanisms. | Xiao M et al. | β | 2021 | β |
| The Saga of Endocrine FGFs. | Phan P et al. | β | 2021 | β |
| The transcription factors CREBH, PPARa, and FOXO1 as critical hepatic mediators of diet-induced metabolic dysregulation. | Yang Z et al. | β | 2021 | β |
| Transferrin receptor 1 ablation in satellite cells impedes skeletal muscle regeneration through activation of ferroptosis. | Ding H et al. | β | 2021 | β |
| Acute Hyperenergetic, High-Fat Feeding Increases Circulating FGF21, LECT2, and Fetuin-A in Healthy Men. | Willis SA et al. | β | 2020 | β |
| Altered nutrient status reprograms host inflammation and metabolic health via gut microbiota. | Golonka RM et al. | β | 2020 | β |
| ApolipoproteinΒ J is a hepatokine regulating muscle glucose metabolism and insulin sensitivity. | Seo JA et al. | β | 2020 | β |
| Astaxanthin attenuates hepatic damage and mitochondrial dysfunction in non-alcoholic fatty liver disease by up-regulating the FGF21/PGC-1Ξ± pathway. | Wu L et al. | β | 2020 | β |
| Baseline HOMA IR and Circulating FGF21 Levels Predict NAFLD Improvement in Patients Undergoing a Low Carbohydrate Dietary Intervention for Weight Loss: A Prospective Observational Pilot Study. | Watanabe M et al. | β | 2020 | β |
| Bile acid-based therapies for non-alcoholic steatohepatitis and alcoholic liver disease. | Li T et al. | β | 2020 | β |
| Cardiac ketone body metabolism. | Abdul Kadir A et al. | β | 2020 | β |
| Circulating Diabetic Candidate Neurotrophic Factors, Brain-Derived Neurotrophic Factor and Fibroblast Growth Factor 21, in Sleeve Gastrectomy. | Yen HH et al. | β | 2020 | β |
| CREBH Improves Diet-Induced Obesity, Insulin Resistance, and Metabolic Disturbances by FGF21-Dependent and FGF21-Independent Mechanisms. | Satoh A et al. | β | 2020 | β |
| CRISPR-mediated BMP9 ablation promotes liver steatosis via the down-regulation of PPARΞ± expression. | Yang Z et al. | β | 2020 | β |
| Dietary Cyanidin-3-Glucoside Attenuates High-Fat-Diet-Induced Body-Weight Gain and Impairment of Glucose Tolerance in Mice via Effects on the Hepatic Hormone FGF21. | Tian L et al. | β | 2020 | β |
| Discovery of a novel fibroblast activation protein (FAP) inhibitor, BR103354, with anti-diabetic and anti-steatotic effects. | Cho JM et al. | β | 2020 | β |
| Example of Adverse Outcome Pathway Concept Enabling Genome-to-Phenome Discovery in Toxicology. | Gust KA et al. | β | 2020 | β |
| FGF21 and its Relationship with Inflammatory and Metabolic Parameters in HIV Patients after Antiretroviral Treatment. | Ruiz-Padilla AJ et al. | β | 2020 | β |
| FGF21 and the Physiological Regulation of Macronutrient Preference. | Hill CM et al. | β | 2020 | β |
| FGF21: An Emerging Therapeutic Target for Non-Alcoholic Steatohepatitis and Related Metabolic Diseases. | Tillman EJ et al. | β | 2020 | β |
| FGF21 Mimics a Fasting-Induced Metabolic State and Increases Appetite in Zebrafish. | Blanco AM et al. | β | 2020 | β |
| FGF/FGFR signaling in health and disease. | Xie Y et al. | β | 2020 | β |
| Genome-wide association study for circulating fibroblast growth factor 21 and 23. | Chuang GT et al. | β | 2020 | β |
| GLP-1 Receptor Signaling in Astrocytes Regulates Fatty Acid Oxidation, Mitochondrial Integrity, and Function. | Timper K et al. | β | 2020 | β |
| Gomisin N from <i>Schisandra chinensis</i> Ameliorates Lipid Accumulation and Induces a Brown Fat-Like Phenotype through AMP-Activated Protein Kinase in 3T3-L1 Adipocytes. | Lee K et al. | β | 2020 | β |
| Hepatic exosome-derived miR-130a-3p attenuates glucose intolerance via suppressing PHLPP2 gene in adipocyte. | Wu J et al. | β | 2020 | β |
| Hepatocyte-specific deletion of PparΞ± promotes NAFLD in the context of obesity. | RΓ©gnier M et al. | β | 2020 | β |
| High-Intensity Interval Training Attenuates Ketogenic Diet-Induced Liver Fibrosis in Type 2 Diabetic Mice by Ameliorating TGF-Ξ²1/Smad Signaling. | Zhang Q et al. | β | 2020 | β |
| High-protein and low-calorie diets improved the anti-aging Klotho protein in the rats' brain: the toxic role of high-fat diet. | Shafie A et al. | β | 2020 | β |
| <i>miR-22</i> inhibition reduces hepatic steatosis via FGF21 and FGFR1 induction. | Hu Y et al. | β | 2020 | β |
| Impact of the Co-Administration of N-3 Fatty Acids and Olive Oil Components in Preclinical Nonalcoholic Fatty Liver Disease Models: A Mechanistic View. | Valenzuela R et al. | β | 2020 | β |
| Increased Expression of FGF-21 Negatively Affects Bone Homeostasis in Dystrophin/Utrophin Double Knockout Mice. | Li H et al. | β | 2020 | β |
| Ipragliflozin-induced improvement of liver steatosis in obese mice may involve sirtuin signaling. | Suga T et al. | β | 2020 | β |
| Ketogenesis activates metabolically protective Ξ³Ξ΄ T cells in visceral adipose tissue. | Goldberg EL et al. | β | 2020 | β |
| Liver-derived FGF21 is essential for full adaptation to ketogenic diet but does not regulate glucose homeostasis. | Watanabe M et al. | β | 2020 | β |
| Maintenance of liver glycogen during long-term fasting preserves energy state in mice. | LΓ³pez-Soldado I et al. | β | 2020 | β |
| Methionine restriction alleviates high-fat diet-induced obesity: Involvement of diurnal metabolism of lipids and bile acids. | Wang L et al. | β | 2020 | β |
| Novel Chemical Scaffolds to Inhibit the Neutral Amino Acid Transporter B<sup>0</sup>AT1 (SLC6A19), a Potential Target to Treat Metabolic Diseases. | Yadav A et al. | β | 2020 | β |
| Organokines in disease. | Chung HS et al. | β | 2020 | β |
| Peroxisome Proliferator-Activated Receptors and Caloric Restriction-Common Pathways Affecting Metabolism, Health, and Longevity. | Duszka K et al. | β | 2020 | β |
| Peroxisome Proliferator-Activated Receptors and Their Novel Ligands as Candidates for the Treatment of Non-Alcoholic Fatty Liver Disease. | Fougerat A et al. | β | 2020 | β |
| PPARΞ± and NCOR/SMRT corepressor network in liver metabolic regulation. | Kang Z et al. | β | 2020 | β |
| PPARΞ³ and PPARΞ± synergize to induce robust browning of white fat inΒ vivo. | Kroon T et al. | β | 2020 | β |
| Regulation of hepatokine gene expression in response to fasting and feeding: Influence of PPAR-Ξ± and insulin-dependent signalling in hepatocytes. | Smati S et al. | β | 2020 | β |
| Regulation of thermogenic adipocytes during fasting and cold. | Reinisch I et al. | β | 2020 | β |
| Role of GPRC6A in Regulating Hepatic Energy Metabolism in Mice. | Pi M et al. | β | 2020 | β |
| Sex-specific brain erythropoietin regulation of mouse metabolism and hypothalamic inflammation. | Dey S et al. | β | 2020 | β |
| Sweroside ameliorates NAFLD in high-fat diet induced obese mice through the regulation of lipid metabolism and inflammatory response. | Yang Q et al. | β | 2020 | β |
| Targeted DNA demethylation of the Fgf21 promoter by CRISPR/dCas9-mediated epigenome editing. | Hanzawa N et al. | β | 2020 | β |
| Targeting FGF21 for the Treatment of Nonalcoholic Steatohepatitis. | Zarei M et al. | β | 2020 | β |
| The Effects of B1344, a Novel Fibroblast Growth Factor 21 Analog, on Nonalcoholic Steatohepatitis in Nonhuman Primates. | Cui A et al. | β | 2020 | β |
| The Role of Exercise in the Interplay between Myokines, Hepatokines, Osteokines, Adipokines, and Modulation of Inflammation for Energy Substrate Redistribution and Fat Mass Loss: A Review. | Gonzalez-Gil AM et al. | β | 2020 | β |
| The Suitability of FGF21 and FGF23 as New Biomarkers in Endometrial Cancer Patients. | Cymbaluk-PΕoska A et al. | β | 2020 | β |
| The therapeutic potential of FGF21 in metabolic diseases: from bench to clinic. | Geng L et al. | β | 2020 | β |
| Transplantation of Mesenchymal Stem Cells Overexpressing Fibroblast Growth Factor 21 Facilitates Cognitive Recovery and Enhances Neurogenesis in a Mouse Model of Traumatic Brain Injury. | Shahror RA et al. | β | 2020 | β |
| Ultrasonic-microwave assisted extraction of total triterpenoid acids from Corni Fructus and hypoglycemic and hypolipidemic activities of the extract in mice. | Han B et al. | β | 2020 | β |
| Valine Supplementation Does Not Reduce Lipid Accumulation and Improve Insulin Sensitivity in Mice Fed High-Fat Diet. | Ma Q et al. | β | 2020 | β |
| 3-carboxy-4-methyl-5-propyl-2-furanpropanoic acid (CMPF) prevents high fat diet-induced insulin resistance via maintenance of hepatic lipid homeostasis. | Mohan H et al. | β | 2019 | β |
| Acromegaly is associated with high fibroblast growth factor-21 levels. | Yurekli BS et al. | β | 2019 | β |
| Activation of hepatic estrogen receptor-Ξ± increases energy expenditure by stimulating the production of fibroblast growth factor 21 in female mice. | Allard C et al. | β | 2019 | β |
| A Dozen Years of Discovery: Insights into the Physiology and Pharmacology of FGF21. | Kliewer SA et al. | β | 2019 | β |
| A Liver-Specific Thyromimetic, VK2809, Decreases Hepatosteatosis in Glycogen Storage Disease Type Ia. | Zhou J et al. | β | 2019 | β |
| A low-carbohydrate ketogenic diet promotes ganglioside synthesis via the transcriptional regulation of ganglioside metabolism-related genes. | Okuda T | β | 2019 | β |
| A review of the studies on food-derived factors which regulate energy metabolism via the modulation of lipid-sensing nuclear receptors. | Goto T | β | 2019 | β |
| Association between Circulating Fibroblast Growth Factor 21 and Aggressiveness in Thyroid Cancer. | Kang YE et al. | β | 2019 | β |
| Association of elevated circulating fibroblast growth factor 21 levels with prevalent and incident metabolic syndrome: The Multi-Ethnic Study of Atherosclerosis. | Ong KL et al. | β | 2019 | β |
| Association of moderately elevated trimethylamine N-oxide with cardiovascular risk: is TMAO serving as a marker for hepatic insulin resistance. | DiNicolantonio JJ et al. | β | 2019 | β |
| Astaxanthin plus berberine: a nutraceutical strategy for replicating the benefits of a metformin/fibrate regimen in metabolic syndrome. | DiNicolantonio JJ et al. | β | 2019 | β |
| BAT Exosomes: Metabolic Crosstalk with Other Organs and Biomarkers for BAT Activity. | Goody D et al. | β | 2019 | β |
| Can hepatokines be regarded as novel non-invasive serum biomarkers of intrahepatic lipid content in obese children? | Flisiak-Jackiewicz M et al. | β | 2019 | β |
| Carbohydrate Sensing Through the Transcription Factor ChREBP. | Ortega-Prieto P et al. | β | 2019 | β |
| Cardiac myocyte KLF5 regulates body weight via alteration of cardiac FGF21. | Pol CJ et al. | β | 2019 | β |
| Chronic Kidney Disease Is Associated with Increased Plasma Levels of Fibroblast Growth Factors 19 and 21. | Marchelek-MyΕliwiec M et al. | β | 2019 | β |
| Circadian blueprint of metabolic pathways in the brain. | Greco CM et al. | β | 2019 | β |
| CYP2A6 is associated with obesity: studies in human samples and a high fat diet mouse model. | Wang K et al. | β | 2019 | β |
| Dynamic repression by BCL6 controls the genome-wide liver response to fasting and steatosis. | Sommars MA et al. | β | 2019 | β |
| Effects of Moderate Chronic Food Restriction on the Development of Postprandial Dyslipidemia with Ageing. | FernΓ‘ndez A et al. | β | 2019 | β |
| Effects of Paramylon Extracted from <i>Euglena gracilis</i> EOD-1 on Parameters Related to Metabolic Syndrome in Diet-Induced Obese Mice. | Aoe S et al. | β | 2019 | β |
| Effects of Weight Loss on FGF-21 in Human Subjects: An Exploratory Study. | Headland ML et al. | β | 2019 | β |
| Elucidation of the Metabolic and Transcriptional Responses of an Oriental Herbal Medicine, Bangpungtongseong-san, to Nonalcoholic Fatty Liver Disease in Diet-Induced Obese Mice. | Choi JY et al. | β | 2019 | β |
| Emerging Pharmacological Targets for the Treatment of Nonalcoholic Fatty Liver Disease, Insulin Resistance, and Type 2 Diabetes. | Goedeke L et al. | β | 2019 | β |
| Emerging Structure-Function Paradigm of Endocrine FGFs in Metabolic Diseases. | Luo Y et al. | β | 2019 | β |
| Evaluation of a cell model expressing Ξ²Klotho for screening FGF21 analogues. | Guo X et al. | β | 2019 | β |
| Exercise ameliorates the FGF21-adiponectin axis impairment in diet-induced obese mice. | Yang W et al. | β | 2019 | β |
| FGF19 subfamily members: FGF19 and FGF21. | Dolegowska K et al. | β | 2019 | β |
| FGF21 as Modulator of Metabolism in Health and Disease. | Tezze C et al. | β | 2019 | β |
| Fibroblast activation protein is dispensable for control of glucose homeostasis and body weight in mice. | Panaro BL et al. | β | 2019 | β |
| Fibroblast growth factor 21 Ameliorates diabetes-induced endothelial dysfunction in mouse aorta via activation of the CaMKK2/AMPKΞ± signaling pathway. | Ying L et al. | β | 2019 | β |
| Fibroblast Growth Factor 21 and Browning of White Adipose Tissue. | Cuevas-Ramos D et al. | β | 2019 | β |
| Fibroblast Growth Factor 21 and the Adaptive Response to Nutritional Challenges. | MartΓnez-Garza Γ et al. | β | 2019 | β |
| Fibroblast growth factor 21: an endocrine inhibitor of sugar and alcohol appetite. | von Holstein-Rathlou S et al. | β | 2019 | β |
| Fibroblast Growth Factor-21 Controls Dietary Protein Intake in Male Mice. | Larson KR et al. | β | 2019 | β |
| Fibroblast growth factor 21 controls mitophagy and muscle mass. | Oost LJ et al. | β | 2019 | β |
| Fibroblast Growth Factor 21 Drives Dynamics of Local and Systemic Stress Responses in Mitochondrial Myopathy with mtDNA Deletions. | ForsstrΓΆm S et al. | β | 2019 | β |
| Fibroblast growth factor 21 is required for the therapeutic effects of Lactobacillus rhamnosus GG against fructose-induced fatty liver in mice. | Zhao C et al. | β | 2019 | β |
| Fibroblast growth factor-21 protects against fibrosis in hypertensive heart disease. | Ferrer-Curriu G et al. | β | 2019 | β |
| Fibroblast growth factor 21 protects against lipotoxicity-induced pancreatic Ξ²-cell dysfunction via regulation of AMPK signaling and lipid metabolism. | Xie T et al. | β | 2019 | β |
| Fibroblast growth factors in control of lipid metabolism: from biological function to clinical application. | Struik D et al. | β | 2019 | β |
| GDF15 Provides an Endocrine Signal of Nutritional Stress in Mice and Humans. | Patel S et al. | β | 2019 | β |
| Going Back to the Biology of FGF21: New Insights. | Lewis JE et al. | β | 2019 | β |
| Hepatic arginase 2 (Arg2) is sufficient to convey the therapeutic metabolic effects of fasting. | Zhang Y et al. | β | 2019 | β |
| Hepatic c-Jun regulates glucose metabolism via FGF21 and modulates body temperature through the neural signals. | Xiao F et al. | β | 2019 | β |
| Hepatic posttranscriptional network comprised of CCR4-NOT deadenylase and FGF21 maintains systemic metabolic homeostasis. | Morita M et al. | β | 2019 | β |
| Hepatocyte peroxisome proliferator-activated receptor Ξ± regulates bile acid synthesis and transport. | Xie C et al. | β | 2019 | β |
| Hepatocyte-specific loss of GPS2 in mice reduces non-alcoholic steatohepatitis via activation of PPARΞ±. | Liang N et al. | β | 2019 | β |
| Hepatokines-a novel group of exercise factors. | Weigert C et al. | β | 2019 | β |
| Higher serum levels of fibroblast growth factor 21 in old patients with cachexia. | Franz K et al. | β | 2019 | β |
| High-fat diet induces mouse liver steatosis with a concomitant decline in energy metabolism: attenuation by eicosapentaenoic acid (EPA) or hydroxytyrosol (HT) supplementation and the additive effects upon EPA and HT co-administration. | EcheverrΓa F et al. | β | 2019 | β |
| High plasma FGF21 levels predicts major cardiovascular events in patients treated with atorvastatin (from the Treating to New Targets [TNT] Study). | Ong KL et al. | β | 2019 | β |
| Identification and validation of common molecular targets of hydroxytyrosol. | LΓ³pez de Las Hazas MC et al. | β | 2019 | β |
| <i>Ishige okamurae</i> Extract Ameliorates the Hyperglycemia and Body Weight Gain of <i>db/db</i> Mice through Regulation of the PI3K/Akt Pathway and Thermogenic Factors by FGF21. | Seo YJ et al. | β | 2019 | β |
| Impact of Glucoraphanin-Mediated Activation of Nrf2 on Non-Alcoholic Fatty Liver Disease with a Focus on Mitochondrial Dysfunction. | Xu L et al. | β | 2019 | β |
| Implications of Mitochondrial Unfolded Protein Response and Mitokines: A Perspective on Fatty Liver Diseases. | Yi HS | β | 2019 | β |
| Improved FGF21 Sensitivity and Restored FGF21 Signaling Pathway in High-Fat Diet/Streptozotocin-Induced Diabetic Rats After Duodenal-Jejunal Bypass and Sleeve Gastrectomy. | Liu Q et al. | β | 2019 | β |
| Inter-organ communication: a gatekeeper for metabolic health. | Castillo-Armengol J et al. | β | 2019 | β |
| Ketogenic Diet: A New Light Shining on Old but Gold Biochemistry. | Longo R et al. | β | 2019 | β |
| Loss of hepatic PPARΞ± promotes inflammation and serum hyperlipidemia in diet-induced obesity. | Stec DE et al. | β | 2019 | β |
| Low bone mineral density in anorexia nervosa: Treatments and challenges. | Fazeli PK | β | 2019 | β |
| Maresin 1 Regulates Hepatic FGF21 in Diet-Induced Obese Mice and in Cultured Hepatocytes. | MartΓnez-FernΓ‘ndez L et al. | β | 2019 | β |
| Metabolic Targets in Nonalcoholic Fatty Liver Disease. | Esler WP et al. | β | 2019 | β |
| Methionine Restriction and Life-Span Extension. | Hoffman RM | β | 2019 | β |
| MiR-15b can target insulin receptor to regulate hepatic insulin signaling in mice. | Li WD et al. | β | 2019 | β |
| MS-275 induces hepatic FGF21 expression via H3K18ac-mediated CREBH signal. | Zhang Q et al. | β | 2019 | β |
| New Insights into Adipokines as Potential Biomarkers for Type-2 Diabetes Mellitus. | Catalina MO et al. | β | 2019 | β |
| Oncogenic KRAS Reduces Expression of FGF21 in Acinar Cells to Promote Pancreatic Tumorigenesis in Mice on a High-Fat Diet. | Luo Y et al. | β | 2019 | β |
| Pancreatic fibroblast growth factor 21 protects against type 2 diabetes in mice by promoting insulin expression and secretion in a PI3K/Akt signaling-dependent manner. | Pan Y et al. | β | 2019 | β |
| PAR2 controls cholesterol homeostasis and lipid metabolism in nonalcoholic fatty liver disease. | Rana R et al. | β | 2019 | β |
| Paracrine-endocrine FGF chimeras as potent therapeutics for metabolic diseases. | Zhao L et al. | β | 2019 | β |
| Peroxisome proliferator-activated receptor Ξ± attenuates high-cholesterol diet-induced toxicity and pro-thrombotic effects in mice. | Lu Y et al. | β | 2019 | β |
| Pharmacologic Modulation of Bile Acid-FXR-FGF15/FGF19 Pathway for the Treatment of Nonalcoholic Steatohepatitis. | Schumacher JD et al. | β | 2019 | β |
| Plasma fibroblast growth factor 21 levels increase with ectopic fat accumulation and its receptor levels are decreased in the visceral fat of patients with type 2 diabetes. | Hong ES et al. | β | 2019 | β |
| Regulation of metabolic health by essential dietary amino acids. | Green CL et al. | β | 2019 | β |
| Relationship of fibroblast growth factor 21 with subclinical atherosclerosis and cardiovascular events: Multi-Ethnic Study of Atherosclerosis. | Ong KL et al. | β | 2019 | β |
| RNA sequencing in human HepG2 hepatocytes reveals PPAR-Ξ± mediates transcriptome responsiveness of bilirubin. | Gordon DM et al. | β | 2019 | β |
| Role of Hepatokines in Non-alcoholic Fatty Liver Disease. | Ke Y et al. | β | 2019 | β |
| Role of Peptide Hormones in the Adaptation to Altered Dietary Protein Intake. | Rose AJ | β | 2019 | β |
| Sex Differences in Liver, Adipose Tissue, and Muscle Transcriptional Response to Fasting and Refeeding in Mice. | Bazhan N et al. | β | 2019 | β |
| SGLT2 inhibition reprograms systemic metabolism via FGF21-dependent and -independent mechanisms. | Osataphan S et al. | β | 2019 | β |
| Spontaneous ketonuria and risk of incident diabetes: a 12Β year prospective study. | Kim G et al. | β | 2019 | β |
| Tanycytes Regulate Lipid Homeostasis by Sensing Free Fatty Acids and Signaling to Key Hypothalamic Neuronal Populations via FGF21 Secretion. | Geller S et al. | β | 2019 | β |
| The contribution of collecting duct NOS1 to the concentrating mechanisms in male and female mice. | Mendoza LD et al. | β | 2019 | β |
| The Enterokine Fibroblast Growth Factor 15/19 in Bile Acid Metabolism. | Cariello M et al. | β | 2019 | β |
| The FGF metabolic axis. | Li X | β | 2019 | β |
| The hepatokine Tsukushi is released in response to NAFLD and impacts cholesterol homeostasis. | Mouchiroud M et al. | β | 2019 | β |
| The impact of keto-adaptation on exercise performance and the role of metabolic-regulating cytokines. | Sherrier M et al. | β | 2019 | β |
| The influence of skeletal muscle on appetite regulation. | Grannell A et al. | β | 2019 | β |
| The Klotho proteins in health and disease. | Kuro-O M | β | 2019 | β |
| The Liver as an Endocrine Organ-Linking NAFLD and Insulin Resistance. | Watt MJ et al. | β | 2019 | β |
| The paradox of marrow adipose tissue in anorexia nervosa. | Fazeli PK et al. | β | 2019 | β |
| Therapeutic Approaches to Alzheimer's Type of Dementia: A Focus on FGF21 Mediated Neuroprotection. | Taliyan R et al. | β | 2019 | β |
| The Role of Kupffer Cells as Mediators of Adipose Tissue Lipolysis. | Ma W et al. | β | 2019 | β |
| Timing of food intake is more potent than habitual voluntary exercise to prevent diet-induced obesity in mice. | Okauchi H et al. | β | 2019 | β |
| Understanding Peroxisome Proliferator-Activated Receptors: From the Structure to the Regulatory Actions on Metabolism. | Lamas Bervejillo M et al. | β | 2019 | β |
| An 8-Week Ketogenic Low Carbohydrate, High Fat Diet Enhanced Exhaustive Exercise Capacity in Mice. | Ma S et al. | β | 2018 | β |
| An Insulin-Responsive Sensor in the SIRT1 Disordered Region Binds DBC1 and PACS-2 to Control Enzyme Activity. | Krzysiak TC et al. | β | 2018 | β |
| An Integrated Understanding of the Rapid Metabolic Benefits of a Carbohydrate-Restricted Diet on Hepatic Steatosis in Humans. | Mardinoglu A et al. | β | 2018 | β |
| Apolipoprotein E is a pancreatic extracellular factor that maintains mature Ξ²-cell gene expression. | Mahmoud AI et al. | β | 2018 | β |
| Association between fibroblast growth factor 21 and bone mineral density in adults. | Hao RH et al. | β | 2018 | β |
| A systematic dissection of sequence elements determining Ξ²-Klotho and FGF interaction and signaling. | Shi SY et al. | β | 2018 | β |
| Autophagic control of cardiac steatosis through FGF21 in obesity-associated cardiomyopathy. | RupΓ©rez C et al. | β | 2018 | β |
| Berberine attenuates hepatic steatosis and enhances energy expenditure in mice by inducing autophagy and fibroblast growth factor 21. | Sun Y et al. | β | 2018 | β |
| Berberine-induced activation of AMPK increases hepatic FGF21 expression via NUR77. | Zhou F et al. | β | 2018 | β |
| Cardiomyokines from the heart. | Chiba A et al. | β | 2018 | β |
| Changes in Liver Gene Expression and Plasma Concentration of Rbp4, Fetuin-A, and Fgf21 in Sprague-Dawley Rats Subjected to Different Dietary Interventions and Bariatric Surgery. | Stygar D et al. | β | 2018 | β |
| Changes in plasma concentrations and mRNA expression of hepatokines fetuin A, fetuin B and FGF21 in physiological pregnancy and gestational diabetes mellitus. | Ε imjΓ‘k P et al. | β | 2018 | β |
| Circulating fibroblast growth factor 21 is reduced, whereas its production is increased in a fat depot-specific manner in cold-acclimated rats. | Sepa-Kishi DM et al. | β | 2018 | β |
| Comparative transcriptome analysis of rumen papillae in suckling and weaned Japanese Black calves using RNA sequencing. | Nishihara K et al. | β | 2018 | β |
| CREBH Regulates Systemic Glucose and Lipid Metabolism. | Nakagawa Y et al. | β | 2018 | β |
| Curcumin and dietary polyphenol research: beyond drug discovery. | Jin TR | β | 2018 | β |
| Cytochrome P450s and Alcoholic Liver Disease. | Lu Y et al. | β | 2018 | β |
| Deficiency in interleukin-18 promotes differentiation of brown adipose tissue resulting in fat accumulation despite dyslipidemia. | Yamanishi K et al. | β | 2018 | β |
| Deficiency of fibroblast growth factor 21 (FGF21) promotes hepatocellular carcinoma (HCC) in mice on a long term obesogenic diet. | Singhal G et al. | β | 2018 | β |
| DEPP/DEPP1/C10ORF10 regulates hepatic glucose and fat metabolism partly via ROS-induced FGF21. | Li W et al. | β | 2018 | β |
| Dietary Manipulations That Induce Ketosis Activate the HPA Axis in Male Rats and Mice: A Potential Role for Fibroblast Growth Factor-21. | Ryan KK et al. | β | 2018 | β |
| Divergent Role of Estrogen-Related Receptor Ξ± in Lipid- and Fasting-Induced Hepatic Steatosis in Mice. | B'chir W et al. | β | 2018 | β |
| Effects of Anorexia Nervosa on Bone Metabolism. | Fazeli PK et al. | β | 2018 | β |
| Effects of supplementing rumen-protected niacin on fiber composition and metabolism of skeletal muscle in dairy cows during early lactation. | Zeitz JO et al. | β | 2018 | β |
| Emerging roles of SGLT2 inhibitors in obesity and insulin resistance: Focus on fat browning and macrophage polarization. | Xu L et al. | β | 2018 | β |
| Enhanced Hepatic PPARΞ± Activity Links GLUT8 Deficiency to Augmented Peripheral Fasting Responses in Male Mice. | Mayer AL et al. | β | 2018 | β |
| Enteric Microbiotaβ»Gutβ»Brain Axis from the Perspective of Nuclear Receptors. | Duszka K et al. | β | 2018 | β |
| Epigenetic modulation of Fgf21 in the perinatal mouse liver ameliorates diet-induced obesity in adulthood. | Yuan X et al. | β | 2018 | β |
| Exploration of serum sensitive biomarkers of fatty liver in dairy cows. | Shen Y et al. | β | 2018 | β |
| Fasting decreases plasma FGF21 in obese subjects and the expression of FGF21 receptors in adipose tissue in both lean and obese subjects | Nygaard EB et al. | β | 2018 | β |
| Fasting exacerbates hepatic growth differentiation factor 15 to promote fatty acid Ξ²-oxidation and ketogenesis via activating XBP1 signaling in liver. | Zhang M et al. | β | 2018 | β |
| FGF21 Alleviates Hepatic Endoplasmic Reticulum Stress under Physiological Conditions. | Maruyama R et al. | β | 2018 | β |
| FGF21 Is Associated with Metabolic Effects and Treatment Response in Depressed Bipolar II Disorder Patients Treated with Valproate. | Chang HH et al. | β | 2018 | β |
| FGF21 mediates the protective effect of fenofibrate against acetaminophen -induced hepatotoxicity via activating autophagy in mice. | Zhang Y et al. | β | 2018 | β |
| FGF21 Prevents Angiotensin II-Induced Hypertension and Vascular Dysfunction by Activation of ACE2/Angiotensin-(1-7) Axis in Mice. | Pan X et al. | β | 2018 | β |
| FGF21 underlies a hormetic response to metabolic stress in methylmalonic acidemia. | Manoli I et al. | β | 2018 | β |
| Fibroblast growth factor 21 attenuates inflammation and oxidative stress in atherosclerotic rat via enhancing the Nrf1-ARE signaling pathway. | Jia H et al. | β | 2018 | β |
| Fibroblast Growth Factor 21: A Versatile Regulator of Metabolic Homeostasis. | BonDurant LD et al. | β | 2018 | β |
| Fibroblast growth factor 21 in cardio-metabolic disorders: a systematic review and meta-analysis. | Lakhani I et al. | β | 2018 | β |
| Fibroblast growth factor 21 increases hepatic oxidative capacity but not physical activity or energy expenditure in hepatic peroxisome proliferator-activated receptor Ξ³ coactivator-1Ξ±-deficient mice. | Fletcher JA et al. | β | 2018 | β |
| Fibroblast growth factor 21 inhibition aggravates cardiac dysfunction in diabetic cardiomyopathy by improving lipid accumulation. | Chen C et al. | β | 2018 | β |
| Fructose metabolism and metabolic disease. | Hannou SA et al. | β | 2018 | β |
| Gene expression profiling during hibernation in the European hamster. | Gautier C et al. | β | 2018 | β |
| Hepatic PPARΞ± function is controlled by polyubiquitination and proteasome-mediated degradation through the coordinated actions of PAQR3 and HUWE1. | Zhao Z et al. | β | 2018 | β |
| Hepatic Sel1L-Hrd1 ER-associated degradation (ERAD) manages FGF21 levels and systemic metabolism via CREBH. | Bhattacharya A et al. | β | 2018 | β |
| Hepatic tristetraprolin promotes insulin resistance through RNA destabilization of FGF21. | Sawicki KT et al. | β | 2018 | β |
| High non-esterified fatty acid concentrations promote expression and secretion of fibroblast growth factor 21 in calf hepatocytes cultured in vitro. | Wang JG et al. | β | 2018 | β |
| Homeostatic sensing of dietary protein restriction: A case for FGF21. | Hill CM et al. | β | 2018 | β |
| Identification of IQ motif-containing GTPase-activating protein 1 as a regulator of long-term ketosis. | Erickson HL et al. | β | 2018 | β |
| Impaired Fasting-Induced Adaptive Lipid Droplet Biogenesis in Liver-Specific Atg5-Deficient Mouse Liver Is Mediated by Persistent Nuclear Factor-Like 2 Activation. | Li Y et al. | β | 2018 | β |
| Increased butyrate priming in the gut stalls microbiome associated-gastrointestinal inflammation and hepatic metabolic reprogramming in a mouse model of Gulf War Illness. | Seth RK et al. | β | 2018 | β |
| Insights into the role of hepatocyte PPARΞ± activity in response to fasting. | RΓ©gnier M et al. | β | 2018 | β |
| Intestinal de novo phosphatidylcholine synthesis is required for dietary lipid absorption and metabolic homeostasis. | Kennelly JP et al. | β | 2018 | β |
| Intracellular lipids are an independent cause of liver injury and chronic kidney disease in non alcoholic fatty liver disease-like context. | Monteillet L et al. | β | 2018 | β |
| Low-fat diet, and medium-fat diets containing coconut oil and soybean oil exert different metabolic effects in untrained and treadmill-trained mice. | Manio MC et al. | β | 2018 | β |
| Mitochondrial diseases: the contribution of organelle stress responses to pathology. | Suomalainen A et al. | β | 2018 | β |
| Molecular Actions of PPARΞ± in Lipid Metabolism and Inflammation. | Bougarne N et al. | β | 2018 | β |
| Molecular elements in FGF19 and FGF21 defining KLB/FGFR activity and specificity. | Agrawal A et al. | β | 2018 | β |
| Neuroanatomical Framework of the Metabolic Control of Reproduction. | Hill JW et al. | β | 2018 | β |
| Nonalcoholic Fatty Liver Disease as a Nexus of Metabolic and Hepatic Diseases. | Samuel VT et al. | β | 2018 | β |
| Parsing the Potential Neuroendocrine Actions of FGF21 in Primates. | Gillum MP | β | 2018 | β |
| Pathogenesis of Nonalcoholic Steatohepatitis and Hormone-Based Therapeutic Approaches. | Kim KH et al. | β | 2018 | β |
| Physiological mechanisms of sustained fumagillin-induced weight loss. | An J et al. | β | 2018 | β |
| Preconditioning lessens high fat induced metabolic syndrome along with markers of increased metabolic capacity in muscle and adipose tissue. | Li S et al. | β | 2018 | β |
| Preemptive Activation of the Integrated Stress Response Protects Mice From Diet-Induced Obesity and Insulin Resistance by Fibroblast Growth Factor 21 Induction. | Xu X et al. | β | 2018 | β |
| Retracted: Transplantation of brown adipose tissue inhibits atherosclerosis in apoE-/- mice: contribution of the activated FGF-21-adiponectin axis. | Kikai M et al. | β | 2018 | β |
| Rho-kinase/AMPK axis regulates hepatic lipogenesis during overnutrition. | Huang H et al. | β | 2018 | β |
| Serum Fibroblast Growth Factor 21 and New-Onset Metabolic Syndrome: KoGES-ARIRANG Study. | Choi JR et al. | β | 2018 | β |
| Serum hepatokines in dairy cows: periparturient variation and changes in energy-related metabolic disorders. | Wang J et al. | β | 2018 | β |
| Sex differences in the development of hepatic steatosis in cafeteria diet-induced obesity in young mice. | Gasparin FRS et al. | β | 2018 | β |
| Team Players or Opponents: Coadministration of Selective Glucagon and GLP-1 Receptor Agonists in Obese Diabetic Monkeys. | Elvert R et al. | β | 2018 | β |
| The Biological Role of Klotho Protein in the Development of Cardiovascular Diseases. | Olejnik A et al. | β | 2018 | β |
| The Hormone FGF21 Stimulates Water Drinking in Response to Ketogenic Diet and Alcohol. | Song P et al. | β | 2018 | β |
| The influence of adiposity and acute exercise on circulating hepatokines in normal-weight and overweight/obese men. | Sargeant JA et al. | β | 2018 | β |
| The Peroxisome Proliferator-Activated Receptor Ξ± (PPARΞ±) Agonist Pemafibrate Protects against Diet-Induced Obesity in Mice. | Araki M et al. | β | 2018 | β |
| The relationship of circulating fibroblast growth factor 21 levels with incident atrial fibrillation: The Multi-Ethnic Study of Atherosclerosis. | Hui TH et al. | β | 2018 | β |
| The role of adipokines in skeletal muscle inflammation and insulin sensitivity. | Nicholson T et al. | β | 2018 | β |
| The role of FGF21 in type 1 diabetes and its complications. | Zhang J et al. | β | 2018 | β |
| Wide-range screening of anti-inflammatory compounds in tomato using LC-MS and elucidating the mechanism of their functions. | Mohri S et al. | β | 2018 | β |
| A combined docosahexaenoic acid-thyroid hormone protocol upregulates rat liver Ξ²-Klotho expression and downstream components of FGF21 signaling as a potential novel approach to metabolic stress conditions. | Vargas R et al. | β | 2017 | β |
| A critical role for ChREBP-mediated FGF21 secretion in hepatic fructose metabolism. | Fisher FM et al. | β | 2017 | β |
| Adipocyte Glucocorticoid Receptor Deficiency Attenuates Aging- and HFD-Induced Obesity and Impairs the Feeding-Fasting Transition. | Mueller KM et al. | β | 2017 | β |
| Adipose-derived circulating miRNAs regulate gene expression in other tissues. | Thomou T et al. | β | 2017 | β |
| A High-Concentrate Diet Induced Milk Fat Decline via Glucagon-Mediated Activation of AMP-Activated Protein Kinase in Dairy Cows. | Li L et al. | β | 2017 | β |
| Alcoholic fatty liver is enhanced in CYP2A5 knockout mice: The role of the PPARΞ±-FGF21 axis. | Chen X et al. | β | 2017 | β |
| A low-protein diet induces body weight loss and browning of subcutaneous white adipose tissue through enhanced expression of hepatic fibroblast growth factor 21 (FGF21). | PΓ©rez-MartΓ A et al. | β | 2017 | β |
| A low-protein, high-carbohydrate diet increases browning in perirenal adipose tissue but not in inguinal adipose tissue. | Pereira MP et al. | β | 2017 | β |
| Amelioration of late-onset hepatic steatosis in IDH2-deficient mice. | Lee SJ et al. | β | 2017 | β |
| Angiopoietin-like 4 directs uptake of dietary fat away from adipose during fasting. | Cushing EM et al. | β | 2017 | β |
| ANGPTL6 expression is coupled with mitochondrial OXPHOS function to regulate adipose FGF21. | Kang SG et al. | β | 2017 | β |
| A Specific ChREBP and PPARΞ± Cross-Talk Is Required for the Glucose-Mediated FGF21 Response. | Iroz A et al. | β | 2017 | β |
| Association between circulating fibroblast growth factor 21 and mortality in end-stage renal disease. | Kohara M et al. | β | 2017 | β |
| Beraprost sodium, a prostacyclin analogue, reduces fructose-induced hepatocellular steatosis in mice and in vitro via the microRNA-200a and SIRT1 signaling pathway. | Zhang P et al. | β | 2017 | β |
| Beyond obesity - thermogenic adipocytes and cardiometabolic health. | Aldiss P et al. | β | 2017 | β |
| Bile acid receptors link nutrient sensing to metabolic regulation. | Li J et al. | β | 2017 | β |
| Brown and Beige Adipose Tissues in Health and Disease. | Rui L | β | 2017 | β |
| Chronic activation of PPARΞ± with fenofibrate reduces autophagic proteins in the liver of mice independent of FGF21. | Jo E et al. | β | 2017 | β |
| Circulating FGF21 in humans is potently induced by short term overfeeding of carbohydrates. | Lundsgaard AM et al. | β | 2017 | β |
| Crosstalk between adipokines and myokines in fat browning. | RodrΓguez A et al. | β | 2017 | β |
| Decreased levels of Fibroblast Growth Factor 21 are correlated with improved hypoglycemia in patients with insulinoma. | Li X et al. | β | 2017 | β |
| Direct comparison of methionine restriction with leucine restriction on the metabolic health of C57BL/6J mice. | Lees EK et al. | β | 2017 | β |
| Distinct Circadian Signatures in Liver and Gut Clocks Revealed by Ketogenic Diet. | Tognini P et al. | β | 2017 | β |
| Effect of circulating glucagon and free fatty acids on hepatic FGF21 production in dairy cows. | Caixeta LS et al. | β | 2017 | β |
| Effects of body condition, monensin, and essential oils on ruminal lipopolysaccharide concentration, inflammatory markers, and endoplasmatic reticulum stress of transition dairy cows. | Drong C et al. | β | 2017 | β |
| Effects of insulin and exercise training on FGF21, its receptors and target genes in obesity and type 2 diabetes. | Kruse R et al. | β | 2017 | β |
| Effects of K-877, a novel selective PPARΞ± modulator, on small intestine contribute to the amelioration of hyperlipidemia in low-density lipoprotein receptor knockout mice. | Takei K et al. | β | 2017 | β |
| Effects of Ketogenic Diets on Cardiovascular Risk Factors: Evidence from Animal and Human Studies. | Kosinski C et al. | β | 2017 | β |
| Elevated FGF 21 in myotonic dystrophy type 1 and mitochondrial diseases. | Lovadi E et al. | β | 2017 | β |
| Elevated Fibroblast growth factor 21 (FGF21) in obese, insulin resistant states is normalised by the synthetic retinoid Fenretinide in mice. | Morrice N et al. | β | 2017 | β |
| Fasting-induced hormonal regulation of lysosomal function. | Chen L et al. | β | 2017 | β |
| Fasting the Microbiota to Improve Metabolism? | Haas JT et al. | β | 2017 | β |
| Fatty liver and FGF21 physiology. | Maratos-Flier E | β | 2017 | β |
| Feedback Activation of Basic Fibroblast Growth Factor Signaling via the Wnt/Ξ²-Catenin Pathway in Skin Fibroblasts. | Wang X et al. | β | 2017 | β |
| FGF21 inhibitor suppresses the proliferation and migration of human umbilical vein endothelial cells through the eNOS/PI3K/AKT pathway. | Li Y et al. | β | 2017 | β |
| FGF21 Is an Exocrine Pancreas Secretagogue. | Coate KC et al. | β | 2017 | β |
| FGF21 Is a Sugar-Induced Hormone Associated with Sweet Intake and Preference in Humans. | SΓΈberg S et al. | β | 2017 | β |
| Fgf21 is required for cardiac remodeling in pregnancy. | Redondo-Angulo I et al. | β | 2017 | β |
| FGF21-receptor agonists: an emerging therapeutic class for obesity-related diseases. | Sonoda J et al. | β | 2017 | β |
| Fgf21 regulates T-cell development in the neonatal and juvenile thymus. | Nakayama Y et al. | β | 2017 | β |
| FGF21 resistance is not mediated by downregulation of beta-klotho expression in white adipose tissue. | Markan KR et al. | β | 2017 | β |
| FGF23-Ξ±Klotho as a paradigm for a kidney-bone network. | Kuro-O M et al. | β | 2017 | β |
| Fibroblast growth factor 21: a regulator of metabolic disease and health span. | Xie T et al. | β | 2017 | β |
| Fibroblast growth factor 21, assisted by elevated glucose, activates paraventricular nucleus NUCB2/Nesfatin-1 neurons to produce satiety under fed states. | Santoso P et al. | β | 2017 | β |
| Fibroblast growth factor 21 (FGF21) is robustly induced by ethanol and has a protective role in ethanol associated liver injury. | Desai BN et al. | β | 2017 | β |
| Fibroblast Growth Factor 21-Metabolic Role in Mice and Men. | Staiger H et al. | β | 2017 | β |
| Fibroblast Growth Factor 21 Mimetics for Treating Atherosclerosis. | Kwok KHM et al. | β | 2017 | β |
| Fibroblast growth factor 21 night watch: advances and uncertainties in the field. | Kharitonenkov A et al. | β | 2017 | β |
| Fibroblast Growth Factor 21 Promotes C2C12 Cells Myogenic Differentiation by Enhancing Cell Cycle Exit. | Liu X et al. | β | 2017 | β |
| Glucagon and Insulin Cooperatively Stimulate Fibroblast Growth Factor 21 Gene Transcription by Increasing the Expression of Activating Transcription Factor 4. | Alonge KM et al. | β | 2017 | β |
| Hepatic Crtc2 controls whole body energy metabolism via a miR-34a-Fgf21 axis. | Han HS et al. | β | 2017 | β |
| Hepatic lipid accumulation: cause and consequence of dysregulated glucoregulatory hormones. | Geisler CE et al. | β | 2017 | β |
| Host-microbiome interactions: the aryl hydrocarbon receptor and the central nervous system. | Lee HU et al. | β | 2017 | β |
| Identification of Sp1 as a Transcription Activator to Regulate Fibroblast Growth Factor 21 Gene Expression. | Chen S et al. | β | 2017 | β |
| Impact of FGF21 on glycemic control. | Strowski MZ | β | 2017 | β |
| Impact of Fibroblast Growth Factors 19 and 21 in Bariatric Metabolism. | Patton A et al. | β | 2017 | β |
| Increased glucose-stimulated FGF21 response to oral glucose in obese nondiabetic subjects after Roux-en-Y gastric bypass. | Vienberg SG et al. | β | 2017 | β |
| Induction of fibroblast growth factor 21 does not require activation of the hepatic X-box binding protein 1 in mice. | Olivares S et al. | β | 2017 | β |
| Influence of IL13 on Periostin Secretion by Synoviocytes in Osteoarthritis. | Moue T et al. | β | 2017 | β |
| Inter-organ regulation of adipose tissue browning. | Wang S et al. | β | 2017 | β |
| Ketogenic Diet Reduces Midlife Mortality and Improves Memory in Aging Mice. | Newman JC et al. | β | 2017 | β |
| Lipolysis and thermogenesis in adipose tissues as new potential mechanisms for metabolic benefits of dietary fiber. | Han SF et al. | β | 2017 | β |
| Liver-adipose tissue crosstalk: A key player in the pathogenesis of glucolipid metabolic disease. | Ye DW et al. | β | 2017 | β |
| Long Distance Metabolic Regulation through Adipose-Derived Circulating Exosomal miRNAs: A Trail for RNA-Based Therapies? | Fatima F et al. | β | 2017 | β |
| Loss of hepatic AMP-activated protein kinase impedes the rate of glycogenolysis but not gluconeogenic fluxes in exercising mice. | Hughey CC et al. | β | 2017 | β |
| LPS infusion suppresses serum FGF21 levels in healthy adult volunteers. | Lauritzen ES et al. | β | 2017 | β |
| Mechanistic Investigations of the Mitochondrial Complex I Inhibitor Rotenone in the Context of Pharmacological and Safety Evaluation. | Heinz S et al. | β | 2017 | β |
| Metabolic role of fibroblast growth factor 21 in liver, adipose and nervous system tissues. | Lin X et al. | β | 2017 | β |
| miRNA-32 Drives Brown Fat Thermogenesis and Trans-activates Subcutaneous White Fat Browning in Mice. | Ng R et al. | β | 2017 | β |
| Multi-dimensional Roles of Ketone Bodies in Fuel Metabolism, Signaling, and Therapeutics. | Puchalska P et al. | β | 2017 | β |
| N-3 polyunsaturated fatty acids increase hepatic fibroblast growth factor 21 sensitivity via a PPAR-Ξ³-Ξ²-klotho pathway. | Yang W et al. | β | 2017 | β |
| Neohesperidin Exerts Lipid-Regulating Effects in vitro and in vivo via Fibroblast Growth Factor 21 and AMP-Activated Protein Kinase/Sirtuin Type 1/Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1Ξ± Signaling Axis. | Wu H et al. | β | 2017 | β |
| Nuclear factor E2-related factor 2 knockdown enhances glucose uptake and alters glucose metabolism in AML12 hepatocytes. | Yuan X et al. | β | 2017 | β |
| Potent long-acting rhFGF21 analog for treatment of diabetic nephropathy in db/db and DIO mice. | Zhao L et al. | β | 2017 | β |
| Regulation of longevity by FGF21: Interaction between energy metabolism and stress responses. | Salminen A et al. | β | 2017 | β |
| Relationship between FGF21 and UCP1 levels under time-restricted feeding and high-fat diet. | Chapnik N et al. | β | 2017 | β |
| Repletion of branched chain amino acids reverses mTORC1 signaling but not improved metabolism during dietary protein dilution. | Maida A et al. | β | 2017 | β |
| Rush to the fire: FGF21 extinguishes metabolic stress, metaflammation and tissue damage. | Luo Y et al. | β | 2017 | β |
| Selective peroxisome proliferator-activated receptor-Ξ± modulator K-877 efficiently activates the peroxisome proliferator-activated receptor-Ξ± pathway and improves lipid metabolism in mice. | Takei K et al. | β | 2017 | β |
| Sex-specific association between fibroblast growth factor 21 and type 2 diabetes: a nested case-control study in Singapore Chinese men and women. | Wang Y et al. | β | 2017 | β |
| SGLT2 Inhibition by Empagliflozin Promotes Fat Utilization and Browning and Attenuates Inflammation and Insulin Resistance by Polarizing M2 Macrophages in Diet-induced Obese Mice. | Xu L et al. | β | 2017 | β |
| System-wide Benefits of Intermeal Fasting by Autophagy. | Martinez-Lopez N et al. | β | 2017 | β |
| The effect of selective estrogen receptor modulators on type 2 diabetes onset in women: Basic and clinical insights. | Xu B et al. | β | 2017 | β |
| The effects of graded levels of calorie restriction: XI. Evaluation of the main hypotheses underpinning the life extension effects of CR using the hepatic transcriptome. | Derous D et al. | β | 2017 | β |
| The FGF21 response to fructose predicts metabolic health and persists after bariatric surgery in obese humans. | Ter Horst KW et al. | β | 2017 | β |
| The hepatokine FGF21 is crucial for peroxisome proliferator-activated receptor-Ξ± agonist-induced amelioration of metabolic disorders in obese mice. | Goto T et al. | β | 2017 | β |
| The New Biology and Pharmacology of Glucagon. | MΓΌller TD et al. | β | 2017 | β |
| The Role and Potential Therapeutic Implications of the Fibroblast Growth Factors in Energy Balance and Type 2 Diabetes. | Izaguirre M et al. | β | 2017 | β |
| The role of fibroblast growth factor 21 in atherosclerosis. | Kokkinos J et al. | β | 2017 | β |
| Use of FGF-21 as a Biomarker of Mitochondrial Disease in Clinical Practice. | Morovat A et al. | β | 2017 | β |
| Ξ±1-Adrenergic receptor downregulates hepatic FGF21 production and circulating FGF21 levels in mice. | Nonogaki K et al. | β | 2017 | β |
| Ξ²-Hydroxybutyrate: A Signaling Metabolite. | Newman JC et al. | β | 2017 | β |
| Ξ²-Klotho deficiency protects against obesity through a crosstalk between liver, microbiota, and brown adipose tissue. | Somm E et al. | β | 2017 | β |
| Acute endurance exercise lowers serum fibroblast growth factor 21 levels in Japanese men. | Taniguchi H et al. | β | 2016 | β |
| Acute exercise increases fibroblast growth factor 21 in metabolic organs and circulation. | Tanimura Y et al. | β | 2016 | β |
| Acyl CoA synthetase 5 (ACSL5) ablation in mice increases energy expenditure and insulin sensitivity and delays fat absorption. | Bowman TA et al. | β | 2016 | β |
| A High Phosphorus Diet Affects Lipid Metabolism in Rat Liver: A DNA Microarray Analysis. | Chun S et al. | β | 2016 | β |
| Anti-human fibroblast growth factor-21 monoclonal antibody preparation, characterization and analysis of <i>in vitro</i> bioactivity. | Ding L et al. | β | 2016 | β |
| Assessment of growth and metabolism characteristics in offspring of dehydroepiandrosterone-induced polycystic ovary syndrome adults. | Huang Y et al. | β | 2016 | β |
| Association between insulin resistance and impairment of FGF21 signal transduction in skeletal muscles. | Jeon JY et al. | β | 2016 | β |
| A weight of evidence assessment approach for adverse outcome pathways. | Collier ZA et al. | β | 2016 | β |
| Bilirubin Binding to PPARΞ± Inhibits Lipid Accumulation. | Stec DE et al. | β | 2016 | β |
| Biliverdin Reductase A Attenuates Hepatic Steatosis by Inhibition of Glycogen Synthase Kinase (GSK) 3Ξ² Phosphorylation of Serine 73 of Peroxisome Proliferator-activated Receptor (PPAR) Ξ±. | Hinds TD et al. | β | 2016 | β |
| Circulating Fibroblast Growth Factor 21 Is A Sensitive Biomarker for Severe Ischemia/reperfusion Injury in Patients with Liver Transplantation. | Ye D et al. | β | 2016 | β |
| Circulating Fibroblast Growth Factor 21 is Associated with Diastolic Dysfunction in Heart Failure Patients with Preserved Ejection Fraction. | Chou RH et al. | β | 2016 | β |
| Circulating periostin in relation to insulin resistance and nonalcoholic fatty liver disease among overweight and obese subjects. | Yang Z et al. | β | 2016 | β |
| CREB3L3 controls fatty acid oxidation and ketogenesis in synergy with PPARΞ±. | Nakagawa Y et al. | β | 2016 | β |
| CREBH-FGF21 axis improves hepatic steatosis by suppressing adipose tissue lipolysis. | Park JG et al. | β | 2016 | β |
| Defining the Nutritional and Metabolic Context of FGF21Β Using the Geometric Framework. | Solon-Biet SM et al. | β | 2016 | β |
| Dietary and pharmacological modification of the insulin/IGF-1 system: exploiting the full repertoire against cancer. | Klement RJ et al. | β | 2016 | β |
| Dietary Betaine Supplementation Increases Fgf21 Levels to Improve Glucose Homeostasis and Reduce Hepatic Lipid Accumulation in Mice. | Ejaz A et al. | β | 2016 | β |
| Effect of selective estrogen receptor modulators on metabolic homeostasis. | Xu B et al. | β | 2016 | β |
| Effects of a ketogenic diet on adipose tissue, liver, and serum biomarkers in sedentary rats and rats that exercised via resisted voluntary wheel running. | Holland AM et al. | β | 2016 | β |
| Elevated Serum Fibroblast Growth Factor 21 in Humans with Acute Pancreatitis. | Shenoy VK et al. | β | 2016 | β |
| Expansion of Bone Marrow Adipose Tissue During Caloric Restriction Is Associated With Increased Circulating Glucocorticoids and Not With Hypoleptinemia. | Cawthorn WP et al. | β | 2016 | β |
| Expression of fibroblast growth factor 21 in patients with biliary atresia. | Li D et al. | β | 2016 | β |
| FAP finds FGF21 easy to digest. | Gillum MP et al. | β | 2016 | β |
| Fenofibrate increases cardiac autophagy via FGF21/SIRT1 and prevents fibrosis and inflammation in the hearts of Type 1 diabetic mice. | Zhang J et al. | β | 2016 | β |
| Fenofibrate Induces Ketone Body Production in Melanoma and Glioblastoma Cells. | Grabacka MM et al. | β | 2016 | β |
| FGF21 Improves the Adipocyte Dysfunction Related to Seipin Deficiency. | Dollet L et al. | β | 2016 | β |
| FGF21 Is Associated with Acanthosis Nigricans in Obese Patients. | Huang Y et al. | β | 2016 | β |
| FGF21 Lowers Plasma Triglycerides by Accelerating Lipoprotein Catabolism in White and Brown Adipose Tissues. | Schlein C et al. | β | 2016 | β |
| FGF-21: promising biomarker for detecting ketosis in dairy cows. | Xu C et al. | β | 2016 | β |
| FGF21 Regulates Sweet and Alcohol Preference. | Talukdar S et al. | β | 2016 | β |
| Fibroblast activation protein (FAP) as a novel metabolic target. | SΓ‘nchez-Garrido MA et al. | β | 2016 | β |
| Fibroblast growth factor 21 and exercise-induced hepatic mitochondrial adaptations. | Fletcher JA et al. | β | 2016 | β |
| Fibroblast Growth Factor 21 As an Emerging Therapeutic Target for Type 2 Diabetes Mellitus. | So WY et al. | β | 2016 | β |
| Fibroblast Growth Factor 21 (Fgf21) Gene Expression Is Elevated in the Liver of Mice Fed a High-Carbohydrate Liquid Diet and Attenuated by a Lipid Emulsion but Is Not Upregulated in the Liver of Mice Fed a High-Fat Obesogenic Diet. | Hao L et al. | β | 2016 | β |
| Fibroblast growth factor 21 (FGF-21) in obese children: no relationship to growth, IGF-1, and IGFBP-3. | Reinehr T et al. | β | 2016 | β |
| Fibroblast Growth Factor 21 (FGF21) Protects against High Fat Diet Induced Inflammation and Islet Hyperplasia in Pancreas. | Singhal G et al. | β | 2016 | β |
| Fibroblast growth factor 21 has no direct role in regulating fertility in female mice. | Singhal G et al. | β | 2016 | β |
| Fibroblast growth factor 21 improves hepatic insulin sensitivity by inhibiting mammalian target of rapamycin complex 1 in mice. | Gong Q et al. | β | 2016 | β |
| Fibroblast growth factor 21 induction by activating transcription factor 4 is regulated through three amino acid response elements in its promoter region. | Maruyama R et al. | β | 2016 | β |
| Fibroblast Growth Factor 21 Mediates Glycemic Regulation by Hepatic JNK. | Vernia S et al. | β | 2016 | β |
| Fibroblast Growth Factor 21-Null Mice Do Not Exhibit an Impaired Response to Fasting. | Antonellis PJ et al. | β | 2016 | β |
| Fibroblast Growth Factor 21 Protects against Atherosclerosis via Fine-Tuning the Multiorgan Crosstalk. | Jin L et al. | β | 2016 | β |
| Fibroblast growth factor 21 reflects liver fat accumulation and dysregulation of signalling pathways in the liver of C57BL/6J mice. | Rusli F et al. | β | 2016 | β |
| Glucocorticoid receptor-PPARΞ± axis in fetal mouse liver prepares neonates for milk lipid catabolism. | Rando G et al. | β | 2016 | β |
| Glucocorticoid Receptor Ξ² Induces Hepatic Steatosis by Augmenting Inflammation and Inhibition of the Peroxisome Proliferator-activated Receptor (PPAR) Ξ±. | Marino JS et al. | β | 2016 | β |
| Hepatic Fatty Acid Oxidation Restrains Systemic Catabolism during Starvation. | Lee J et al. | β | 2016 | β |
| Hepatic Fgf21 Expression Is Repressed after Simvastatin Treatment in Mice. | Ziros P et al. | β | 2016 | β |
| Hepatic-specific PPARΞ±-FGF21 action in NAFLD. | Piccinin E et al. | β | 2016 | β |
| Hydroxytyrosol prevents metabolic impairment reducing hepatic inflammation and restoring duodenal integrity in a rat model of NAFLD. | Pirozzi C et al. | β | 2016 | β |
| Impact of high-fat diet on liver genes expression profiles in mice model of nonalcoholic fatty liver disease. | Wang C et al. | β | 2016 | β |
| Impaired Mitochondrial Fat Oxidation Induces FGF21 in Muscle. | Vandanmagsar B et al. | β | 2016 | β |
| iTRAQ-based proteomic analysis reveals alterations in the liver induced by restricted meal frequency in a pig model. | Liu J et al. | β | 2016 | β |
| Lack of fibroblast growth factor 21 accelerates metabolic liver injury characterized by steatohepatities in mice. | Liu X et al. | β | 2016 | β |
| Lactate induces FGF21 expression in adipocytes through a p38-MAPK pathway. | Jeanson Y et al. | β | 2016 | β |
| Lipodystrophy Due to Adipose Tissue-Specific Insulin Receptor Knockout Results in Progressive NAFLD. | Softic S et al. | β | 2016 | β |
| Lipodystrophy HIV-related and FGF21: A new marker to follow the progression of lipodystrophy? | Benedini S et al. | β | 2016 | β |
| Liver PPARΞ± is crucial for whole-body fatty acid homeostasis and is protective against NAFLD. | Montagner A et al. | β | 2016 | β |
| Long-term caloric restriction in <i>ApoE</i>-deficient mice results in neuroprotection via Fgf21-induced AMPK/mTOR pathway. | RΓΌhlmann C et al. | β | 2016 | β |
| Loss of CTRP1 disrupts glucose and lipid homeostasis. | Rodriguez S et al. | β | 2016 | β |
| Low-protein diet induces, whereas high-protein diet reduces hepatic FGF21 production in mice, but glucose and not amino acids up-regulate FGF21 in cultured hepatocytes. | Chalvon-Demersay T et al. | β | 2016 | β |
| Metabolic Adaptation in Obesity and Type II Diabetes: Myokines, Adipokines and Hepatokines. | Oh KJ et al. | β | 2016 | β |
| Metabolic fibroblast growth factors (FGFs): Mediators of energy homeostasis. | Markan KR et al. | β | 2016 | β |
| Metabolic interplay between white, beige, brown adipocytes and the liver. | Scheja L et al. | β | 2016 | β |
| Metabolic Responses to Dietary Protein Restriction Require an Increase in FGF21 that Is Delayed by the Absence of GCN2. | Laeger T et al. | β | 2016 | β |
| Microbiota and bile acid profiles in retinoic acid-primed mice that exhibit accelerated liver regeneration. | Liu HX et al. | β | 2016 | β |
| MicroRNA-34a and Impaired FGF19/21 Signaling in Obesity. | Fu T et al. | β | 2016 | β |
| Modulation of energy balance by fibroblast growth factor 21. | Cuevas-Ramos D et al. | β | 2016 | β |
| Muscle mitochondrial stress adaptation operates independently of endogenous FGF21 action. | Ost M et al. | β | 2016 | β |
| Nutritional regulation of fibroblast growth factor 21: from macronutrients to bioactive dietary compounds. | PΓ©rez-MartΓ A et al. | β | 2016 | β |
| Overexpression of Ξ²-Klotho in Adipose Tissue Sensitizes Male Mice to Endogenous FGF21 and Provides Protection From Diet-Induced Obesity. | Samms RJ et al. | β | 2016 | β |
| Pharmacology of bile acid receptors: Evolution of bile acids from simple detergents to complex signaling molecules. | Copple BL et al. | β | 2016 | β |
| Plasma Periostin Levels Are Increased in Chinese Subjects with Obesity and Type 2 Diabetes and Are Positively Correlated with Glucose and Lipid Parameters. | Luo Y et al. | β | 2016 | β |
| Potential roles of fibroblast growth factor 21 in the brain. | Sa-Nguanmoo P et al. | β | 2016 | β |
| Prolongevity hormone FGF21 protects against immune senescence by delaying age-related thymic involution. | Youm YH et al. | β | 2016 | β |
| Regulation of fibroblast growth factor 15/19 and 21 on metabolism: in the fed or fasted state. | Guan D et al. | β | 2016 | β |
| Regulation of Ketone Body Metabolism and the Role of PPARΞ±. | Grabacka M et al. | β | 2016 | β |
| Regulation of myokine expression: Role of exercise and cellular stress. | Ost M et al. | β | 2016 | β |
| Rice Koji Extract Enhances Lipid Metabolism through Proliferator-Activated Receptor Alpha (PPARΞ±) Activation in Mouse Liver. | Takahashi H et al. | β | 2016 | β |
| Role of BAF60a/BAF60c in chromatin remodeling and hepatic lipid metabolism. | Zhang P et al. | β | 2016 | β |
| Roux-en-Y gastric bypass surgery is effective in fibroblast growth factor-21 deficient mice. | Morrison CD et al. | β | 2016 | β |
| Single ingestion of soy Ξ²-conglycinin induces increased postprandial circulating FGF21 levels exerting beneficial health effects. | Hashidume T et al. | β | 2016 | β |
| The effects on weight loss and gene expression in adipose and hepatic tissues of very-low carbohydrate and low-fat isoenergetic diets in diet-induced obese mice. | Yamazaki T et al. | β | 2016 | β |
| The FGF21-adiponectin axis in controlling energy and vascular homeostasis. | Hui X et al. | β | 2016 | β |
| The FGF21 Receptor Signaling Complex: KlothoΞ², FGFR1c, and Other Regulatory Interactions. | Kilkenny DM et al. | β | 2016 | β |
| The Impact of Organokines on Insulin Resistance, Inflammation, and Atherosclerosis. | Choi KM | β | 2016 | β |
| The lipid sensor GPR120 promotes brown fat activation and FGF21 release from adipocytes. | Quesada-LΓ³pez T et al. | β | 2016 | β |
| Therapeutic potential of the endocrine fibroblast growth factors FGF19, FGF21 and FGF23. | Degirolamo C et al. | β | 2016 | β |
| The regulation of FGF21 gene expression by metabolic factors and nutrients. | Erickson A et al. | β | 2016 | β |
| The Sweet Path to Metabolic Demise: Fructose and Lipid Synthesis. | Herman MA et al. | β | 2016 | β |
| Thymus Maintenance and Regeneration by Specific Molecular Factors. | Mendelsohn AR et al. | β | 2016 | β |
| Understanding the Physiology of FGF21. | Fisher FM et al. | β | 2016 | β |
| Up-regulation of Nrf2 is involved in FGF21-mediated fenofibrate protection against type 1 diabetic nephropathy. | Cheng Y et al. | β | 2016 | β |
| Upregulation of rat liver PPARΞ±-FGF21 signaling by a docosahexaenoic acid and thyroid hormone combined protocol. | Videla LA et al. | β | 2016 | β |
| Very Low Density Lipoprotein Assembly Is Required for cAMP-responsive Element-binding Protein H Processing and Hepatic Apolipoprotein A-IV Expression. | Cheng D et al. | β | 2016 | β |
| 1,8-Cineole Ameliorates Steatosis of Pten Liver Specific KO Mice via Akt Inactivation. | Murata S et al. | β | 2015 | β |
| Activation of aryl hydrocarbon receptor dissociates fatty liver from insulin resistance by inducing fibroblast growth factor 21. | Lu P et al. | β | 2015 | β |
| Activation of mTORC1 in skeletal muscle regulates whole-body metabolism through FGF21. | Guridi M et al. | β | 2015 | β |
| Adaptive changes in amino acid metabolism permit normal longevity in mice consuming a low-carbohydrate ketogenic diet. | Douris N et al. | β | 2015 | β |
| Administration of Danhong Injection to diabetic db/db mice inhibits the development of diabetic retinopathy and nephropathy. | Liu M et al. | β | 2015 | β |
| A Grape Seed Procyanidin Extract Ameliorates Fructose-Induced Hypertriglyceridemia in Rats via Enhanced Fecal Bile Acid and Cholesterol Excretion and Inhibition of Hepatic Lipogenesis. | Downing LE et al. | β | 2015 | β |
| Alterations in Hepatic FGF21, Co-Regulated Genes, and Upstream Metabolic Genes in Response to Nutrition, Ketosis and Inflammation in Peripartal Holstein Cows. | Akbar H et al. | β | 2015 | β |
| A muscle-liver-fat signalling axis is essential for central control of adaptive adipose remodelling. | Shimizu N et al. | β | 2015 | β |
| Association between Serum Fibroblast Growth Factor 21 and Coronary Artery Disease in Patients with Type 2 Diabetes. | Kim WJ et al. | β | 2015 | β |
| Betaine alleviates hepatic lipid accumulation via enhancing hepatic lipid export and fatty acid oxidation in rats fed with a high-fat diet. | Xu L et al. | β | 2015 | β |
| Central Fibroblast Growth Factor 21 Browns White Fat via Sympathetic Action in Male Mice. | Douris N et al. | β | 2015 | β |
| Circulating FGF19 and FGF21 surge in early infancy from infra- to supra-adult concentrations. | SΓ‘nchez-Infantes D et al. | β | 2015 | β |
| Circulating levels of fibroblast growth factor-21 increase with age independently of body composition indices among healthy individuals. | Hanks LJ et al. | β | 2015 | β |
| Cord blood FGF21 in gestational diabetes and its relationship with postnatal growth. | Megia A et al. | β | 2015 | β |
| Cytochrome P450 1B1: An unexpected modulator of liver fatty acid homeostasis. | Larsen MC et al. | β | 2015 | β |
| Dual effects of fibroblast growth factor 21 on hepatic energy metabolism. | Samms RJ et al. | β | 2015 | β |
| Effect of low carbohydrate high protein (LCHP) diet on lipid metabolism, liver and kidney function in rats. | Kostogrys RB et al. | β | 2015 | β |
| Effects of a plant product consisting of green tea and curcuma extract on milk production and the expression of hepatic genes involved in endoplasmic stress response and inflammation in dairy cows. | Winkler A et al. | β | 2015 | β |
| Endocrine FGFs: Evolution, Physiology, Pathophysiology, and Pharmacotherapy. | Itoh N et al. | β | 2015 | β |
| Endoplasmic reticulum stress induces up-regulation of hepatic Ξ²-Klotho expression through ATF4 signaling pathway. | Dong K et al. | β | 2015 | β |
| FGF21 and Cardiac Physiopathology. | Planavila A et al. | β | 2015 | β |
| FGF21 and the late adaptive response to starvation in humans. | Fazeli PK et al. | β | 2015 | β |
| FGF-21, a novel metabolic regulator, has a robust neuroprotective role and is markedly elevated in neurons by mood stabilizers. | Leng Y et al. | β | 2015 | β |
| FGF21 as a mediator of adaptive responses to stress and metabolic benefits of anti-diabetic drugs. | Kim KH et al. | β | 2015 | β |
| FGF21 attenuates pathological myocardial remodeling following myocardial infarction through the adiponectin-dependent mechanism. | Joki Y et al. | β | 2015 | β |
| FGF21 deletion exacerbates diabetic cardiomyopathy by aggravating cardiac lipid accumulation. | Yan X et al. | β | 2015 | β |
| FGF21 is not required for glucose homeostasis, ketosis or tumour suppression associated with ketogenic diets in mice. | Stemmer K et al. | β | 2015 | β |
| FGF21 mediates alcohol-induced adipose tissue lipolysis by activation of systemic release of catecholamine in mice. | Zhao C et al. | β | 2015 | β |
| FGF21 Revolutions: Recent Advances Illuminating FGF21 Biology and Medicinal Properties. | Kharitonenkov A et al. | β | 2015 | β |
| Fibroblast Growth Factor 21 Analogs for Treating Metabolic Disorders. | Zhang J et al. | β | 2015 | β |
| Fibroblast growth factor-21, body composition, and insulin resistance in pre-pubertal and early pubertal males and females. | Hanks LJ et al. | β | 2015 | β |
| Fibroblast growth factor-21, energy balance and obesity. | Giralt M et al. | β | 2015 | β |
| Fibroblast growth factor 21 prevents atherosclerosis by suppression of hepatic sterol regulatory element-binding protein-2 and induction of adiponectin in mice. | Lin Z et al. | β | 2015 | β |
| Fibroblast growth factor 21 protects the heart from oxidative stress. | Planavila A et al. | β | 2015 | β |
| Fibroblast growth factors in cardiovascular disease: The emerging role of FGF21. | Domouzoglou EM et al. | β | 2015 | β |
| Forced expression of fibroblast growth factor 21 reverses the sustained impairment of liver regeneration in hPPARΞ±(PAC) mice due to dysregulated bile acid synthesis. | Liu HX et al. | β | 2015 | β |
| Fructose ingestion acutely stimulates circulating FGF21 levels in humans. | Dushay JR et al. | β | 2015 | β |
| Glucagon-to-insulin ratio is pivotal for splanchnic regulation of FGF-21 in humans. | Hansen JS et al. | β | 2015 | β |
| Glucocorticoids regulate the metabolic hormone FGF21 in a feed-forward loop. | Patel R et al. | β | 2015 | β |
| Hepatic insulin resistance and increased hepatic glucose production in mice lacking Fgf21. | Camporez JP et al. | β | 2015 | β |
| Hepatokines: unlocking the multi-organ network in metabolic diseases. | Iroz A et al. | β | 2015 | β |
| Homeostasis, inflammation, and disease susceptibility. | Kotas ME et al. | β | 2015 | β |
| Induction of peroxisomes by butyrate-producing probiotics. | Weng H et al. | β | 2015 | β |
| Initial Molecular-Level Response to Artificial Selection for Increased Aerobic Metabolism Occurs Primarily through Changes in Gene Expression. | Konczal M et al. | β | 2015 | β |
| Ketogenic Diet Impairs FGF21 Signaling and Promotes Differential Inflammatory Responses in the Liver and White Adipose Tissue. | Asrih M et al. | β | 2015 | β |
| Mice lacking neutral amino acid transporter B(0)AT1 (Slc6a19) have elevated levels of FGF21 and GLP-1 and improved glycaemic control. | Jiang Y et al. | β | 2015 | β |
| Minireview: Roles of Fibroblast Growth Factors 19 and 21 in Metabolic Regulation and Chronic Diseases. | Zhang F et al. | β | 2015 | β |
| Mitochondrial Respiratory Disorders: A Perspective on their Metabolite Biomarkers and Implications for Clinical Diagnosis and Therapeutic Intervention. | Uittenbogaard M et al. | β | 2015 | β |
| Molecular basis of Klotho: from gene to function in aging. | Xu Y et al. | β | 2015 | β |
| Molecular insights into the mechanisms of liver-associated diseases in early-lactating dairy cows: hypothetical role of endoplasmic reticulum stress. | Ringseis R et al. | β | 2015 | β |
| Molecular mechanism of PPARΞ± action and its impact on lipid metabolism, inflammation and fibrosis in non-alcoholic fatty liver disease. | Pawlak M et al. | β | 2015 | β |
| Naringenin prevents obesity, hepatic steatosis, and glucose intolerance in male mice independent of fibroblast growth factor 21. | Assini JM et al. | β | 2015 | β |
| Neuroendocrine causes of amenorrhea--an update. | Fourman LT et al. | β | 2015 | β |
| New paradigms in the treatment of hepatic cholestasis: from UDCA to FXR, PXR and beyond. | Beuers U et al. | β | 2015 | β |
| Nutritionally-induced catch-up growth. | Gat-Yablonski G et al. | β | 2015 | β |
| Perilipin 5-Driven Lipid Droplet Accumulation in Skeletal Muscle Stimulates the Expression of Fibroblast Growth Factor 21. | Harris LA et al. | β | 2015 | β |
| Plasma FGF21 concentrations, adipose fibroblast growth factor receptor-1 and Ξ²-klotho expression decrease with fasting in northern elephant seals. | Suzuki M et al. | β | 2015 | β |
| Protein-dependent regulation of feeding and metabolism. | Morrison CD et al. | β | 2015 | β |
| Rapid increase in fibroblast growth factor 21 in protein malnutrition and its impact on growth and lipid metabolism. | Ozaki Y et al. | β | 2015 | β |
| Research Perspectives on the Regulation and Physiological Functions of FGF21 and its Association with NAFLD. | Inagaki T | β | 2015 | β |
| Resistance to the Beneficial Metabolic Effects and Hepatic Antioxidant Defense Actions of Fibroblast Growth Factor 21 Treatment in Growth Hormone-Overexpressing Transgenic Mice. | Boparai RK et al. | β | 2015 | β |
| Response of fibroblast growth factor 21 to meal intake and insulin infusion in patients on maintenance haemodialysis. | Reinhard M et al. | β | 2015 | β |
| Role of fibroblast growth factor 21 in the early stage of NASH induced by methionine- and choline-deficient diet. | Tanaka N et al. | β | 2015 | β |
| Serum FGF21 levels are associated with brown adipose tissue activity in humans. | Hanssen MJ et al. | β | 2015 | β |
| Serum FGF-21 levels are associated with worsened radial trabecular bone microarchitecture and decreased radial bone strength in women with anorexia nervosa. | Fazeli PK et al. | β | 2015 | β |
| Serum fibroblast growth factor 21 in overweight and obese Thai children and adolescents: its relation to glucose metabolism and its change after glucose loading. | Korwutthikulrangsri M et al. | β | 2015 | β |
| Skeletal muscle as an endocrine organ: PGC-1Ξ±, myokines and exercise. | Schnyder S et al. | β | 2015 | β |
| Skeletal muscle increases FGF21 expression in mitochondrial disorders to compensate for energy metabolic insufficiency by activating the mTOR-YY1-PGC1Ξ± pathway. | Ji K et al. | β | 2015 | β |
| The brain and brown fat. | Contreras C et al. | β | 2015 | β |
| The brown fat secretome: metabolic functions beyond thermogenesis. | Wang GX et al. | β | 2015 | β |
| The Fibroblast Growth Factor signaling pathway. | Ornitz DM et al. | β | 2015 | β |
| The impact of diabetes and diabetes medications on bone health. | Gilbert MP et al. | β | 2015 | β |
| The impact of LDLR function on fibroblast growth factor 21 levels. | Besseling J et al. | β | 2015 | β |
| The protective effect of FGF21 on diabetes-induced male germ cell apoptosis is associated with up-regulated testicular AKT and AMPK/Sirt1/PGC-1Ξ± signaling. | Jiang X et al. | β | 2015 | β |
| The relationship of fibroblast growth factor 21 with cardiovascular outcome events in the Fenofibrate Intervention and Event Lowering in Diabetes study. | Ong KL et al. | β | 2015 | β |
| Thyroid hormone receptor regulates most genes independently of fibroblast growth factor 21 in liver. | Zhang A et al. | β | 2015 | β |
| Tissue-specific actions of the metabolic hormones FGF15/19 and FGF21. | Owen BM et al. | β | 2015 | β |
| TM-25659-Induced Activation of FGF21 Level Decreases Insulin Resistance and Inflammation in Skeletal Muscle via GCN2 Pathways. | Jung JG et al. | β | 2015 | β |
| Transcriptional and Chromatin Regulation during Fasting - The Genomic Era. | Goldstein I et al. | β | 2015 | β |
| Trans-system mechanisms against ischemic myocardial injury. | Liu SQ et al. | β | 2015 | β |
| Ξ±-Lipoic acid as a triglyceride-lowering nutraceutical. | Pashaj A et al. | β | 2015 | β |
| Acetylcholinesterase (AChE) inhibition aggravates fasting-induced triglyceride accumulation in the mouse liver. | Yokota S et al. | β | 2014 | β |
| A link between hepatic glucose production and peripheral energy metabolism via hepatokines. | Abdul-Wahed A et al. | β | 2014 | β |
| Alpha lipoic acid induces hepatic fibroblast growth factor 21 expression via up-regulation of CREBH. | Bae KH et al. | β | 2014 | β |
| Apolipoprotein A-IV reduces hepatic gluconeogenesis through nuclear receptor NR1D1. | Li X et al. | β | 2014 | β |
| A single daily meal at the beginning of the active or inactive period inhibits food deprivation-induced fatty liver in mice. | Aoki N et al. | β | 2014 | β |
| A solid-phase PEGylation strategy for protein therapeutics using a potent FGF21 analog. | Song L et al. | β | 2014 | β |
| ATF4- and CHOP-dependent induction of FGF21 through endoplasmic reticulum stress. | Wan XS et al. | β | 2014 | β |
| Autophagy as a crosstalk mediator of metabolic organs in regulation of energy metabolism. | Kim KH et al. | β | 2014 | β |
| Bile acid signaling in metabolic disease and drug therapy. | Li T et al. | β | 2014 | β |
| Calorie restriction and Roux-en-Y gastric bypass have opposing effects on circulating FGF21 in morbidly obese subjects. | Lips MA et al. | β | 2014 | β |
| Common single nucleotide polymorphisms in the FNDC5 gene are associated with glucose metabolism but do not affect serum irisin levels in Japanese men with low fitness levels. | Tanisawa K et al. | β | 2014 | β |
| Deficiency of the transcriptional repressor B cell lymphoma 6 (Bcl6) is accompanied by dysregulated lipid metabolism. | LaPensee CR et al. | β | 2014 | β |
| Effect of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) on hormones of energy balance in a TCDD-sensitive and a TCDD-resistant rat strain. | LindΓ©n J et al. | β | 2014 | β |
| Effects of a Lactobacillus paracasei B21060 based synbiotic on steatosis, insulin signaling and toll-like receptor expression in rats fed a high-fat diet. | Raso GM et al. | β | 2014 | β |
| Effects of fibroblast growth factor 21 on cell damage in vitro and atherosclerosis in vivo. | Zhu W et al. | β | 2014 | β |
| Elevated FGF21 secretion, PGC-1Ξ± and ketogenic enzyme expression are hallmarks of iron-sulfur cluster depletion in human skeletal muscle. | Crooks DR et al. | β | 2014 | β |
| Energy metabolism in the liver. | Rui L | β | 2014 | β |
| Exercise-induced myokines in health and metabolic diseases. | So B et al. | β | 2014 | β |
| FGF21 as a Stress Hormone: The Roles of FGF21 in Stress Adaptation and the Treatment of Metabolic Diseases. | Kim KH et al. | β | 2014 | β |
| FGF21-based pharmacotherapy--potential utility for metabolic disorders. | Gimeno RE et al. | β | 2014 | β |
| FGF21 expression and release in muscle cells: involvement of MyoD and regulation by mitochondria-driven signalling. | Ribas F et al. | β | 2014 | β |
| FGF21 is an endocrine signal of protein restriction. | Laeger T et al. | β | 2014 | β |
| FGF21 maintains glucose homeostasis by mediating the cross talk between liver and brain during prolonged fasting. | Liang Q et al. | β | 2014 | β |
| Fibroblast growth factor 21 and its relation to metabolic parameters in women with polycystic ovary syndrome. | Sahin SB et al. | β | 2014 | β |
| Fibroblast growth factor-21 and the beneficial effects of long-chain n-3 polyunsaturated fatty acids. | Villarroya J et al. | β | 2014 | β |
| Fibroblast growth factor 21 and thyroid hormone show mutual regulatory dependency but have independent actions in vivo. | Domouzoglou EM et al. | β | 2014 | β |
| Fibroblast growth factor 21: a promising therapeutic target in obesity-related diseases. | Cheung BM et al. | β | 2014 | β |
| Fibroblast growth factor 21 (FGF21) and glucagon-like peptide 1 contribute to diabetes resistance in glucagon receptor-deficient mice. | Omar BA et al. | β | 2014 | β |
| Fibroblast growth factor 21 is induced upon cardiac stress and alters cardiac lipid homeostasis. | Brahma MK et al. | β | 2014 | β |
| Fibroblast growth factor 21 is not required for the reductions in circulating insulin-like growth factor-1 or global cell proliferation rates in response to moderate calorie restriction in adult mice. | Thompson AC et al. | β | 2014 | β |
| Fibroblast growth factor 21 is regulated by the IRE1Ξ±-XBP1 branch of the unfolded protein response and counteracts endoplasmic reticulum stress-induced hepatic steatosis. | Jiang S et al. | β | 2014 | β |
| Fibroblast growth factor 21 limits lipotoxicity by promoting hepatic fatty acid activation in mice on methionine and choline-deficient diets. | Fisher FM et al. | β | 2014 | β |
| Fibroblast growth factor 21 protects against acetaminophen-induced hepatotoxicity by potentiating peroxisome proliferator-activated receptor coactivator protein-1Ξ±-mediated antioxidant capacity in mice. | Ye D et al. | β | 2014 | β |
| Fibroblast growth factor 21, the endocrine FGF pathway and novel treatments for metabolic syndrome. | Zhang J et al. | β | 2014 | β |
| Fibroblast growth factor (Fgf) 21 is a novel target gene of the aryl hydrocarbon receptor (AhR). | Cheng X et al. | β | 2014 | β |
| Glucagon is essential for adaptive thermogenesis in brown adipose tissue. | Kinoshita K et al. | β | 2014 | β |
| Glucagon stimulates hepatic FGF21 secretion through a PKA- and EPAC-dependent posttranscriptional mechanism. | Cyphert HA et al. | β | 2014 | β |
| Head over hepatocytes for FGF21. | Potthoff MJ et al. | β | 2014 | β |
| Hepatic CREB3L3 controls whole-body energy homeostasis and improves obesity and diabetes. | Nakagawa Y et al. | β | 2014 | β |
| Hepatic FGF21 production is increased in late pregnancy in the mouse. | Cui Y et al. | β | 2014 | β |
| Hepatic IRE1Ξ± regulates fasting-induced metabolic adaptive programs through the XBP1s-PPARΞ± axis signalling. | Shao M et al. | β | 2014 | β |
| Hepatic mTORC1 controls locomotor activity, body temperature, and lipid metabolism through FGF21. | Cornu M et al. | β | 2014 | β |
| Hepatic SIRT1 attenuates hepatic steatosis and controls energy balance in mice by inducing fibroblast growth factor 21. | Li Y et al. | β | 2014 | β |
| Hydrodynamic delivery of FGF21 gene alleviates obesity and fatty liver in mice fed a high-fat diet. | Gao M et al. | β | 2014 | β |
| Identification of the first potent, selective and bioavailable PPARΞ± antagonist. | Bravo Y et al. | β | 2014 | β |
| Impairments of hepatic gluconeogenesis and ketogenesis in PPARΞ±-deficient neonatal mice. | Cotter DG et al. | β | 2014 | β |
| Increased fibroblast growth factor 21 expression in high-fat diet-sensitive non-human primates (Macaca mulatta). | Nygaard EB et al. | β | 2014 | β |
| Integrated physiology and systems biology of PPARΞ±. | Kersten S | β | 2014 | β |
| Interplay between FGF21 and insulin action in the liver regulates metabolism. | Emanuelli B et al. | β | 2014 | β |
| Ketone bodies as signaling metabolites. | Newman JC et al. | β | 2014 | β |
| Lifelong caloric restriction reprograms hepatic fat metabolism in mice. | Kuhla A et al. | β | 2014 | β |
| Lipid profiling and transcriptomic analysis reveals a functional interplay between estradiol and growth hormone in liver. | FernΓ‘ndez-PΓ©rez L et al. | β | 2014 | β |
| Liver but not adipose tissue is responsive to the pattern of enteral feeding. | Otero YF et al. | β | 2014 | β |
| Liver-enriched transcription factor CREBH interacts with peroxisome proliferator-activated receptor Ξ± to regulate metabolic hormone FGF21. | Kim H et al. | β | 2014 | β |
| Liver functional genomics in beef cows on grazing systems: novel genes and pathways revealed. | Laporta J et al. | β | 2014 | β |
| Long-term low carbohydrate diet leads to deleterious metabolic manifestations in diabetic mice. | Handa K et al. | β | 2014 | β |
| LT175 is a novel PPARΞ±/Ξ³ ligand with potent insulin-sensitizing effects and reduced adipogenic properties. | Gilardi F et al. | β | 2014 | β |
| Mechanisms of increased in vivo insulin sensitivity by dietary methionine restriction in mice. | Stone KP et al. | β | 2014 | β |
| Methionine restriction restores a younger metabolic phenotype in adult mice with alterations in fibroblast growth factor 21. | Lees EK et al. | β | 2014 | β |
| MicroRNA 34a inhibits beige and brown fat formation in obesity in part by suppressing adipocyte fibroblast growth factor 21 signaling and SIRT1 function. | Fu T et al. | β | 2014 | β |
| Molecular characterization and mapping of Fgf21 gene in a foodfish species asian seabass. | Wang L et al. | β | 2014 | β |
| Myokines in insulin resistance and type 2 diabetes. | Eckardt K et al. | β | 2014 | β |
| Nonalcoholic fatty liver disease and the heart in children and adolescents. | Pacifico L et al. | β | 2014 | β |
| Nonalcoholic fatty liver disease/nonalcoholic steatohepatitis in obese adolescents: a looming marker of cardiac dysfunction. | Santoro N et al. | β | 2014 | β |
| Novel sandwich immunoassays for the measurement of total and active FGF21. | Umberger TS et al. | β | 2014 | β |
| Nrf2 induces fibroblast growth factor 21 in diabetic mice. | Furusawa Y et al. | β | 2014 | β |
| Nuclear receptors and metabolism: from feast to famine. | Hong SH et al. | β | 2014 | β |
| Oleoylethanolamide enhances Ξ²-adrenergic-mediated thermogenesis and white-to-brown adipocyte phenotype in epididymal white adipose tissue in rat. | SuΓ‘rez J et al. | β | 2014 | β |
| Periostin promotes liver steatosis and hypertriglyceridemia through downregulation of PPARΞ±. | Lu Y et al. | β | 2014 | β |
| Photoperiodic regulation of FGF21 production in the Siberian hamster. | Samms RJ et al. | β | 2014 | β |
| Play down protein to play up metabolism? | MΓΌller TD et al. | β | 2014 | β |
| Role of adipose triglyceride lipase (PNPLA2) in protection from hepatic inflammation in mouse models of steatohepatitis and endotoxemia. | Jha P et al. | β | 2014 | β |
| Serum FGF21 concentration is associated with hypertriglyceridaemia, hyperinsulinaemia and pericardial fat accumulation, independently of obesity, but not with current coronary artery status. | Lee Y et al. | β | 2014 | β |
| Significant gender difference in serum levels of fibroblast growth factor 21 in Danish children and adolescents. | Bisgaard A et al. | β | 2014 | β |
| Silencing of the Fibroblast growth factor 21 gene is an underlying cause of acinar cell injury in mice lacking MIST1. | Johnson CL et al. | β | 2014 | β |
| Skeletal muscle mitochondrial uncoupling drives endocrine cross-talk through the induction of FGF21 as a myokine. | Keipert S et al. | β | 2014 | β |
| SUMO wars. | Fisher FM et al. | β | 2014 | β |
| The PPARΞ±-FGF21 hormone axis contributes to metabolic regulation by the hepatic JNK signaling pathway. | Vernia S et al. | β | 2014 | β |
| The role of fibroblast growth factor 21 in the pathogenesis of liver disease: a novel predictor and therapeutic target. | Liu WY et al. | β | 2014 | β |
| The single nucleotide polymorphism rs499765 is associated with fibroblast growth factor 21 and nonalcoholic fatty liver disease in a Chinese population with normal glucose tolerance. | Jiang S et al. | β | 2014 | β |
| Thioesterase superfamily member 2 (Them2) and phosphatidylcholine transfer protein (PC-TP) interact to promote fatty acid oxidation and control glucose utilization. | Kawano Y et al. | β | 2014 | β |
| Thyroid hormone regulation of metabolism. | Mullur R et al. | β | 2014 | β |
| Transcriptional regulation of fibroblast growth factor 21 expression. | Bae KH et al. | β | 2014 | β |
| Up-regulation of endoplasmic reticulum stress induced genes of the unfolded protein response in the liver of periparturient dairy cows. | Gessner DK et al. | β | 2014 | β |
| Ξ²-hydroxybutyrate: much more than a metabolite. | Newman JC et al. | β | 2014 | β |
| Activation of Liver FGF21 in hepatocarcinogenesis and during hepatic stress. | Yang C et al. | β | 2013 | β |
| Acute exercise induces FGF21 expression in mice and in healthy humans. | Kim KH et al. | β | 2013 | β |
| Adaptive thermogenesis in adipocytes: is beige the new brown? | Wu J et al. | β | 2013 | β |
| Adiponectin mediates the metabolic effects of FGF21 on glucose homeostasis and insulin sensitivity in mice. | Lin Z et al. | β | 2013 | β |
| An FGF21-adiponectin-ceramide axis controls energy expenditure and insulin action in mice. | Holland WL et al. | β | 2013 | β |
| A novel approach to improve the function of FGF21. | Smith R et al. | β | 2013 | β |
| Association of fibroblast growth factor (FGF-21) as a biomarker with primary mitochondrial disorders, but not with secondary mitochondrial disorders (Friedreich Ataxia). | Salehi MH et al. | β | 2013 | β |
| Clinical implications of adipocytokines and newly emerging metabolic factors with relation to insulin resistance and cardiovascular health. | Choi SH et al. | β | 2013 | β |
| Deficiency of metabolic regulator FGFR4 delays breast cancer progression through systemic and microenvironmental metabolic alterations. | Luo Y et al. | β | 2013 | β |
| Development of a novel long-acting antidiabetic FGF21 mimetic by targeted conjugation to a scaffold antibody. | Huang J et al. | β | 2013 | β |
| Dichotomous roles of leptin and adiponectin as enforcers against lipotoxicity during feast and famine. | Unger RH et al. | β | 2013 | β |
| Dietary Lipid During Late-Pregnancy and Early-Lactation to Manipulate Metabolic and Inflammatory Gene Network Expression in Dairy Cattle Liver with a Focus on PPARs. | Akbar H et al. | β | 2013 | β |
| Downstream signaling pathways in mouse adipose tissues following acute in vivo administration of fibroblast growth factor 21. | Muise ES et al. | β | 2013 | β |
| Endocrine protection of ischemic myocardium by FGF21 from the liver and adipose tissue. | Liu SQ et al. | β | 2013 | β |
| Expression of fibroblast growth factor-21 in muscle is associated with lipodystrophy, insulin resistance and lipid disturbances in patients with HIV. | Lindegaard B et al. | β | 2013 | β |
| FGF19 (fibroblast growth factor 19) as a novel target gene for activating transcription factor 4 in response to endoplasmic reticulum stress. | Shimizu M et al. | β | 2013 | β |
| Fgf21 impairs adipocyte insulin sensitivity in mice fed a low-carbohydrate, high-fat ketogenic diet. | Murata Y et al. | β | 2013 | β |
| FGF21 mediates the lipid metabolism response to amino acid starvation. | De Sousa-Coelho AL et al. | β | 2013 | β |
| Fibroblast growth factor 21: a novel biomarker for human muscle-manifesting mitochondrial disorders. | Suomalainen A | β | 2013 | β |
| Fibroblast growth factor 21: a novel metabolic regulator from pharmacology to physiology. | Li H et al. | β | 2013 | β |
| Fibroblast growth factor 21 as an emerging metabolic regulator: clinical perspectives. | Woo YC et al. | β | 2013 | β |
| Fibroblast growth factor 21 improves insulin resistance and ameliorates renal injury in db/db mice. | Kim HW et al. | β | 2013 | β |
| Fibroblast growth factor 21 is not required for the antidiabetic actions of the thiazoladinediones. | Adams AC et al. | β | 2013 | β |
| Fibroblast growth factor 21 mediates specific glucagon actions. | Habegger KM et al. | β | 2013 | β |
| Fibroblast growth factor 21 protects against cardiac hypertrophy in mice. | Planavila A et al. | β | 2013 | β |
| Fibroblast growth factor-21 serum concentrations are associated with metabolic and hepatic markers in humans. | Kralisch S et al. | β | 2013 | β |
| Fibroblast growth factor 23 and Klotho: physiology and pathophysiology of an endocrine network of mineral metabolism. | Hu MC et al. | β | 2013 | β |
| Forever (FGF) 21. | Bass J | β | 2013 | β |
| Genome-wide meta-analysis of observational studies shows common genetic variants associated with macronutrient intake. | Tanaka T et al. | β | 2013 | β |
| Gestational ingestion of oxidized frying oil by C57BL/6J mice differentially affects the susceptibility of the male and female offspring to diet-induced obesity in adulthood. | Chuang HC et al. | β | 2013 | β |
| Glucagon increases circulating fibroblast growth factor 21 independently of endogenous insulin levels: a novel mechanism of glucagon-stimulated lipolysis? | Arafat AM et al. | β | 2013 | β |
| High sugar intake and development of skeletal muscle insulin resistance and inflammation in mice: a protective role for PPAR- Ξ΄ agonism. | Benetti E et al. | β | 2013 | β |
| Increased FGF21 plasma levels in humans with sepsis and SIRS. | Gariani K et al. | β | 2013 | β |
| Increased responses to the actions of fibroblast growth factor 21 on energy balance and body weight in a seasonal model of adiposity. | Murphy M et al. | β | 2013 | β |
| Influence of growth hormone on circulating fibroblast growth factor 21 levels in humans. | Lundberg J et al. | β | 2013 | β |
| Involvement of heparan sulfate 6-O-sulfation in the regulation of energy metabolism and the alteration of thyroid hormone levels in male mice. | Nagai N et al. | β | 2013 | β |
| Irisin is inversely associated with intrahepatic triglyceride contents in obese adults. | Zhang HJ et al. | β | 2013 | β |
| Ketone body metabolism and cardiovascular disease. | Cotter DG et al. | β | 2013 | β |
| Klotho, phosphate and FGF-23 in ageing and disturbed mineral metabolism. | Kuro-o M | β | 2013 | β |
| Lipocalin 13 regulation of glucose and lipid metabolism in obesity. | Zhou Y et al. | β | 2013 | β |
| Metabolically protective cytokines adiponectin and fibroblast growth factor-21 are increased by acute overfeeding in healthy humans. | Heilbronn LK et al. | β | 2013 | β |
| Metabolic hormone FGF21 is induced in ground squirrels during hibernation but its overexpression is not sufficient to cause torpor. | Nelson BT et al. | β | 2013 | β |
| Metabolite and transcriptome analysis during fasting suggest a role for the p53-Ddit4 axis in major metabolic tissues. | Schupp M et al. | β | 2013 | β |
| Metformin-induced inhibition of the mitochondrial respiratory chain increases FGF21 expression via ATF4 activation. | Kim KH et al. | β | 2013 | β |
| Methionine and choline regulate the metabolic phenotype of a ketogenic diet. | Pissios P et al. | β | 2013 | β |
| Obesity as the common soil of non-alcoholic fatty liver disease and diabetes: Role of adipokines. | Hui E et al. | β | 2013 | β |
| Pegylated Fgf21 rapidly normalizes insulin-stimulated glucose utilization in diet-induced insulin resistant mice. | Camacho RC et al. | β | 2013 | β |
| Plasma FGF21 levels are increased in patients with hypothyroidism independently of lipid profile. | Lee Y et al. | β | 2013 | β |
| Protective effect of FGF21 on type 1 diabetes-induced testicular apoptotic cell death probably via both mitochondrial- and endoplasmic reticulum stress-dependent pathways in the mouse model. | Jiang X et al. | β | 2013 | β |
| Recruitment of histone methyltransferase G9a mediates transcriptional repression of Fgf21 gene by E4BP4 protein. | Tong X et al. | β | 2013 | β |
| Regulation of glucose homoeostasis by brown adipose tissue. | Peirce V et al. | β | 2013 | β |
| Retinoic acid receptor Ξ² stimulates hepatic induction of fibroblast growth factor 21 to promote fatty acid oxidation and control whole-body energy homeostasis in mice. | Li Y et al. | β | 2013 | β |
| Reversal of obesity-induced hypertriglyceridemia by (R)-Ξ±-lipoic acid in ZDF (fa/fa) rats. | Yi X et al. | β | 2013 | β |
| Role of choline deficiency in the Fatty liverΒ phenotype of mice fed a low protein, very low carbohydrate ketogenic diet. | Schugar RC et al. | β | 2013 | β |
| Roux-en-Y gastric bypass surgery but not vertical sleeve gastrectomy decreases bone mass in male rats. | Stemmer K et al. | β | 2013 | β |
| Serum fibroblast growth factor 21 in human obesity: regulation by insulin infusion and relationship with glucose and lipid oxidation. | StrΔ czkowski M et al. | β | 2013 | β |
| Serum levels of the adipokine fibroblast growth factor-21 are increased in preeclampsia. | Stepan H et al. | β | 2013 | β |
| Stressed Liver and Muscle Call on Adipocytes with FGF21. | Luo Y et al. | β | 2013 | β |
| Stress heats up the adipocyte. | Fisher FM et al. | β | 2013 | β |
| Successful adaptation to ketosis by mice with tissue-specific deficiency of ketone body oxidation. | Cotter DG et al. | β | 2013 | β |
| TFEB controls cellular lipid metabolism through a starvation-induced autoregulatory loop. | Settembre C et al. | β | 2013 | β |
| The cell adhesion molecule L1 regulates the expression of FGF21 and enhances neurite outgrowth. | Huang X et al. | β | 2013 | β |
| The role of mitochondrial DNA mutations and free radicals in disease and ageing. | Lagouge M et al. | β | 2013 | β |
| Transcript profiling identifies iqgap2(-/-) mouse as a model for advanced human hepatocellular carcinoma. | Gnatenko DV et al. | β | 2013 | β |
| Autofluorescence imaging of living pancreatic islets reveals fibroblast growth factor-21 (FGF21)-induced metabolism. | Sun MY et al. | β | 2012 | β |
| Circulating fibroblast growth factors as metabolic regulators--a critical appraisal. | Angelin B et al. | β | 2012 | β |
| Emerging role of fibroblast growth factors 15/19 and 21 as metabolic integrators in the liver. | Cicione C et al. | β | 2012 | β |
| Fibroblast growth factor-21 is a promising dietary restriction mimetic. | Mendelsohn AR et al. | β | 2012 | β |
| Peripheral signalling involved in energy homeostasis control. | Lancha A et al. | β | 2012 | β |