Induced pluripotent stem cells (iPSCs) and neurological disease modeling: progress and promises.
paper
Cited
Public
Unavailable
- Authors
- Marchetto, Maria C; Brennand, Kristen J; Boyer, Leah F; Gage, Fred H
- Year
- 2011
- Journal
- Human molecular genetics
- PMID
- 21828073
- DOI
- 10.1093/hmg/ddr336
- PMCID
- PMC4447776
The systematic generation of neurons from patients with neurological disorders can provide important insights into disease pathology, progression and mechanism. This review will discuss recent progress in modeling neurodegenerative and neurodevelopmental diseases using induced pluripotent stem cells (iPSCs) and highlight some of the current challenges in the field. Combined with other technologies previously used to study brain disease, iPSC modeling has the promise to influence modern medicine on several fronts: early diagnosis, drug development and effective treatment.
No figures extracted from this document.
No chunks β full text not yet ingested.
No entities extracted from this document yet.
No uploaded files.
Not in any collection.
No citations found.
In this knowledge base
External
| Title | Authors | Journal | Year | Link |
|---|---|---|---|---|
| Cell death detection in iPSC-derived cortical neurons as model of neurodegeneration. | Colasuonno F et al. | β | 2026 | β |
| Chimeric brain models: Unlocking insights into human neural development, aging, diseases, and cell therapies. | Papetti AV et al. | β | 2025 | β |
| Current Applications of Human Pluripotent Stem Cells in Neuroscience Research and Cell Transplantation Therapy for Neurological Disorders. | Verma I et al. | β | 2025 | β |
| From Serendipity to Precision: Integrating AI, Multi-Omics, and Human-Specific Models for Personalized Neuropsychiatric Care. | Tanaka M | β | 2025 | β |
| Potential of olfactory neuroepithelial cells as a model toΒ study schizophrenia: A focus on GPCRs (Review). | SΓ‘nchez-Florentino ZA et al. | β | 2024 | β |
| Conflicting theories on addiction aetiology and the strengths and limitations of substance use disorder disease modelling. | Greener MR et al. | β | 2023 | β |
| Developing a human iPSC-derived three-dimensional myelin spheroid platform for modeling myelin diseases. | Feng L et al. | β | 2023 | β |
| Differentiation of peripheral sensory neurons from iPSCs derived from stem cells from human exfoliated deciduous teeth (SHED). | Oliveira NC et al. | β | 2023 | β |
| IPSC-Derived Astrocytes to Model Neuroinflammatory and Metabolic Responses in X-linked Adrenoleukodystrophy. | Parasar P et al. | β | 2023 | β |
| Mitochondrial, cell cycle control and neuritogenesis alterations in an iPSC-based neurodevelopmental model for schizophrenia. | Zuccoli GS et al. | β | 2023 | β |
| On the utilization of the induced pluripotent stem cell (iPSC) model to study substance use disorders: A scoping review protocol. | Niemis W et al. | β | 2023 | β |
| Visualization of accessible cholesterol using a GRAM domain-based biosensor. | Koh DHZ et al. | β | 2023 | β |
| Bilirubin-Induced Neurological Damage: Current and Emerging iPSC-Derived Brain Organoid Models. | Pranty AI et al. | β | 2022 | β |
| Cell models for Down syndrome-Alzheimer's disease research. | Wu Y et al. | β | 2022 | β |
| Modeling Schizophrenia In Vitro: Challenges and Insights on Studying Brain Cells. | BrandΓ£o-Teles C et al. | β | 2022 | β |
| P97/VCP ATPase inhibitors can rescue p97 mutation-linked motor neuron degeneration. | Wang F et al. | β | 2022 | β |
| Reduced <i>LYNX1</i> expression in transcriptome of human iPSC-derived neural progenitors modeling fragile X syndrome. | Talvio K et al. | β | 2022 | β |
| Reversibility and therapeutic development for neurodevelopmental disorders, insights from genetic animal models. | Megagiannis P et al. | β | 2022 | β |
| Stem Cell Transplantation Therapy and Neurological Disorders: Current Status and Future Perspectives. | Rahman MM et al. | β | 2022 | β |
| Advances in microfluidic in vitro systems for neurological disease modeling. | Holloway PM et al. | β | 2021 | β |
| Altered neuronal physiology, development, and function associated with a common chromosome 15 duplication involving CHRNA7. | Meganathan K et al. | β | 2021 | β |
| ApoE-Isoform-Dependent SARS-CoV-2 Neurotropism and Cellular Response. | Wang C et al. | β | 2021 | β |
| A simplified approach for derivation of induced pluripotent stem cells from Epstein-Barr virus immortalized B-lymphoblastoid cell lines. | Walker SJ et al. | β | 2021 | β |
| Human Keratinocytes Adopt Neuronal Fates After <i>In Utero</i> Transplantation in the Developing Rat Brain. | Tenorio-Mina A et al. | β | 2021 | β |
| Pluripotent Stem Cell Derived Neurons as In Vitro Models for Studying Autosomal Recessive Parkinson's Disease (ARPD): PLA2G6 and Other Gene Loci. | Gopurappilly R | β | 2021 | β |
| SETBP1 accumulation induces P53 inhibition and genotoxic stress in neural progenitors underlying neurodegeneration in Schinzel-Giedion syndrome. | Banfi F et al. | β | 2021 | β |
| The right tools for the job: the central role for next generation chemical probes and chemistry-based target deconvolution methods in phenotypic drug discovery. | JΓΆrg M et al. | β | 2021 | β |
| An iPSC-Derived Neuron Model of CLN3 Disease Facilitates Small Molecule Phenotypic Screening. | Kinarivala N et al. | β | 2020 | β |
| Cell Reprogramming Preserving Epigenetic Age: Advantages and Limitations. | Samoylova EM et al. | β | 2020 | β |
| Disease-specific phenotypes in iPSC-derived neural stem cells with POLG mutations. | Liang KX et al. | β | 2020 | β |
| Examining the Characteristics and Applications of Mesenchymal, Induced Pluripotent, and Embryonic Stem Cells for Tissue Engineering Approaches across the Germ Layers. | Priester C et al. | β | 2020 | β |
| Genetic predispositions of Parkinson's disease revealed in patient-derived brain cells. | Tran J et al. | β | 2020 | β |
| Mitochondrial Dysfunction: a Potential Therapeutic Target to Treat Alzheimer's Disease. | Rai SN et al. | β | 2020 | β |
| Modeling genetic epilepsies in a dish. | Niu W et al. | β | 2020 | β |
| Negative Symptoms of Schizophrenia and Dopaminergic Transmission: Translational Models and Perspectives Opened by iPSC Techniques. | Collo G et al. | β | 2020 | β |
| Probing the therapeutic potential of TRPC6 for Alzheimer's disease in live neurons from patient-specific iPSCs. | Tao R et al. | β | 2020 | β |
| Advances in the Differentiation of Retinal Ganglion Cells from Human Pluripotent Stem Cells. | Ohlemacher SK et al. | β | 2019 | β |
| Astrocytes Regulate the Development and Maturation of Retinal Ganglion Cells Derived from Human Pluripotent Stem Cells. | VanderWall KB et al. | β | 2019 | β |
| Differentiation of Human Induced Pluripotent Stem Cells (iPSCs) into an Effective Model of Forebrain Neural Progenitor Cells and Mature Neurons. | Bell S et al. | β | 2019 | β |
| Important advances in Alzheimer's disease from the use of induced pluripotent stem cells. | Majolo F et al. | β | 2019 | β |
| Pluripotent Stem Cell-Derived Cerebral Organoids Reveal Human Oligodendrogenesis with Dorsal and Ventral Origins. | Kim H et al. | β | 2019 | β |
| Recent advances of induced pluripotent stem cells application in neurodegenerative diseases. | Amin N et al. | β | 2019 | β |
| Using human stem cells as a model system to understand the neural mechanisms of alcohol use disorders: Current status and outlook. | Scarnati MS et al. | β | 2019 | β |
| Astrocyte-enriched feeder layers from cryopreserved cells support differentiation of spontaneously active networks of human iPSC-derived neurons. | Schutte RJ et al. | β | 2018 | β |
| Astrocytes Regulate the Development and Maturation of Retinal Ganglion Cells Derived from Human Pluripotent Stem Cells | Langer KB et al. | β | 2018 | β |
| Concise Review: The Use of Stem Cells for Understanding and Treating Huntington's Disease. | Connor B | β | 2018 | β |
| GFAP Mutations in Astrocytes Impair Oligodendrocyte Progenitor Proliferation and Myelination in an hiPSC Model of Alexander Disease. | Li L et al. | β | 2018 | β |
| hiPSC-derived neural stem cells from patients with schizophrenia induce an impaired angiogenesis. | Casas BS et al. | β | 2018 | β |
| Neural progenitors derived from Tuberous Sclerosis Complex patients exhibit attenuated PI3K/AKT signaling and delayed neuronal differentiation. | Zucco AJ et al. | β | 2018 | β |
| Neural Stem Cell Dysfunction in Human Brain Disorders. | Liszewska E et al. | β | 2018 | β |
| Patient-Derived iPSCs and iNs-Shedding New Light on the Cellular Etiology of Neurodegenerative Diseases. | Tang BL | β | 2018 | β |
| Strategies to Advance Drug Discovery in Rare Monogenic Intellectual Disability Syndromes. | Hettige NC et al. | β | 2018 | β |
| Survival of syngeneic and allogeneic iPSC-derived neural precursors after spinal grafting in minipigs. | Strnadel J et al. | β | 2018 | β |
| Transdifferentiation: a new promise for neurodegenerative diseases. | Mollinari C et al. | β | 2018 | β |
| A Rapid Pipeline to Model Rare Neurodevelopmental Disorders with Simultaneous CRISPR/Cas9 Gene Editing. | Bell S et al. | β | 2017 | β |
| Efficient neural differentiation of mouse pluripotent stem cells in a serum-free medium and development of a novel strategy for enrichment of neural cells. | Verma I et al. | β | 2017 | β |
| Glia-neuron interactions in neurological diseases: Testing non-cell autonomy in a dish. | Meyer K et al. | β | 2017 | β |
| Hypoxia Epigenetically Confers Astrocytic Differentiation Potential on Human Pluripotent Cell-Derived Neural Precursor Cells. | Yasui T et al. | β | 2017 | β |
| Modeling autism spectrum disorders with human neurons. | BeltrΓ£o-Braga PC et al. | β | 2017 | β |
| Modeling HuntingtonΧ³s disease with patient-derived neurons. | Mattis VB et al. | β | 2017 | β |
| Personalized genome sequencing coupled with iPSC technology identifies GTDC1 as a gene involved in neurodevelopmental disorders. | Aksoy I et al. | β | 2017 | β |
| Proteasome inhibitors to alleviate aberrant IKBKAP mRNA splicing and low IKAP/hELP1 synthesis in familial dysautonomia. | HervΓ© M et al. | β | 2017 | β |
| The Importance of Non-neuronal Cell Types in hiPSC-Based Disease Modeling and Drug Screening. | Gonzalez DM et al. | β | 2017 | β |
| Advances in Stem Cell Research- A Ray of Hope in Better Diagnosis and Prognosis in Neurodegenerative Diseases. | Singh S et al. | β | 2016 | β |
| Coenzyme A corrects pathological defects in human neurons of PANK2-associated neurodegeneration. | Orellana DI et al. | β | 2016 | β |
| Functional Evaluations of Genes Disrupted in Patients with Tourette's Disorder. | Sun N et al. | β | 2016 | β |
| Generation of functional human serotonergic neurons from fibroblasts. | Vadodaria KC et al. | β | 2016 | β |
| Glycosylation and stem cells: Regulatory roles and application of iPSCs in the study of glycosylation-related disorders. | Berger RP et al. | β | 2016 | β |
| High-Throughput Phenotypic Screening of Human Astrocytes to Identify Compounds That Protect Against Oxidative Stress. | Thorne N et al. | β | 2016 | β |
| Humanized neuronal chimeric mouse brain generated by neonatally engrafted human iPSC-derived primitive neural progenitor cells. | Chen C et al. | β | 2016 | β |
| Induced pluripotent stem cells for modeling and cell therapy of Parkinson's disease. | CsΓΆbΓΆnyeiovΓ‘ M et al. | β | 2016 | β |
| Integrative analysis of genes and miRNA alterations in human embryonic stem cells-derived neural cells after exposure to silver nanoparticles. | Oh JH et al. | β | 2016 | β |
| iPSC-based drug screening for Huntington's disease. | Zhang N et al. | β | 2016 | β |
| Modeling psychiatric disorders: from genomic findings to cellular phenotypes. | Falk A et al. | β | 2016 | β |
| Predicting the functional states of human iPSC-derived neurons with single-cell RNA-seq and electrophysiology. | Bardy C et al. | β | 2016 | β |
| Proteomics and molecular tools for unveiling missing links in the biochemical understanding of schizophrenia. | Nascimento JM et al. | β | 2016 | β |
| Rapid and efficient CRISPR/Cas9 gene inactivation in human neurons during human pluripotent stem cell differentiation and direct reprogramming. | Rubio A et al. | β | 2016 | β |
| Stem and Progenitor Cell-Based Therapy of the Central Nervous System: Hopes, Hype, and Wishful Thinking. | Goldman SA | β | 2016 | β |
| Stepwise Differentiation of Retinal Ganglion Cells from Human Pluripotent Stem Cells Enables Analysis of Glaucomatous Neurodegeneration. | Ohlemacher SK et al. | β | 2016 | β |
| The Human Model: Changing Focus on Autism Research. | Muotri AR | β | 2016 | β |
| A transposon-mediated system for flexible control of transgene expression in stem and progenitor-derived lineages. | Akhtar AA et al. | β | 2015 | β |
| Directly Reprogrammed Human Neurons Retain Aging-Associated Transcriptomic Signatures and Reveal Age-Related Nucleocytoplasmic Defects. | Mertens J et al. | β | 2015 | β |
| GluD1 is a common altered player in neuronal differentiation from both MECP2-mutated and CDKL5-mutated iPS cells. | Livide G et al. | β | 2015 | β |
| Human Pluripotent Stem Cell-Derived Retinal Ganglion Cells: Applications for the Study and Treatment of Optic Neuropathies. | Cooke JA et al. | β | 2015 | β |
| Importance of being Nernst: Synaptic activity and functional relevance in stem cell-derived neurons. | Bradford AB et al. | β | 2015 | β |
| Induced pluripotent stem cells and their use in cardiac and neural regenerative medicine. | Skalova S et al. | β | 2015 | β |
| Modeling non-syndromic autism and the impact of TRPC6 disruption in human neurons. | Griesi-Oliveira K et al. | β | 2015 | β |
| Neural Differentiation of Human Pluripotent Stem Cells for Nontherapeutic Applications: Toxicology, Pharmacology, and In Vitro Disease Modeling. | Yap MS et al. | β | 2015 | β |
| Neuronal medium that supports basic synaptic functions and activity of human neurons in vitro. | Bardy C et al. | β | 2015 | β |
| Reprogramming patient-derived cells to study the epilepsies. | Parent JM et al. | β | 2015 | β |
| Stem cell-based approach for the treatment of Parkinson's disease. | Goodarzi P et al. | β | 2015 | β |
| The Use of Induced Pluripotent Stem Cell Technology to Advance Autism Research and Treatment. | Acab A et al. | β | 2015 | β |
| Translational potential of olfactory mucosa for the study of neuropsychiatric illness. | Borgmann-Winter K et al. | β | 2015 | β |
| Using Patient-Derived Induced Pluripotent Stem Cells to Model and Treat Epilepsies. | Du X et al. | β | 2015 | β |
| ZNF804A Transcriptional Networks in Differentiating Neurons Derived from Induced Pluripotent Stem Cells of Human Origin. | Chen J et al. | β | 2015 | β |
| A time course analysis of the electrophysiological properties of neurons differentiated from human induced pluripotent stem cells (iPSCs). | PrΓ¨ D et al. | β | 2014 | β |
| Biomarkers for combat-related PTSD: focus on molecular networks from high-dimensional data. | Neylan TC et al. | β | 2014 | β |
| Directing human induced pluripotent stem cells into a neurosensory lineage for auditory neuron replacement. | Gunewardene N et al. | β | 2014 | β |
| Epigenetic therapy for Friedreich ataxia. | Soragni E et al. | β | 2014 | β |
| Fresh approaches to antidepressant drug discovery. | Anacker C | β | 2014 | β |
| Great expectations: autism spectrum disorder and induced pluripotent stem cell technologies. | Liu EY et al. | β | 2014 | β |
| Induced pluripotent stem cells for modeling of pediatric neurological disorders. | Jang J et al. | β | 2014 | β |
| iPSC-derived neurons as a higher-throughput readout for autism: promises and pitfalls. | Prilutsky D et al. | β | 2014 | β |
| Passage number is a major contributor to genomic structural variations in mouse iPSCs. | Liu P et al. | β | 2014 | β |
| Polyglutamine-expanded androgen receptor interferes with TFEB to elicit autophagy defects in SBMA. | Cortes CJ et al. | β | 2014 | β |
| Recent developments in cell-based assays and stem cell technologies for botulinum neurotoxin research and drug discovery. | Kiris E et al. | β | 2014 | β |
| Stem cells and modeling of autism spectrum disorders. | Freitas BC et al. | β | 2014 | β |
| The need for a comprehensive molecular characterization of autism spectrum disorders. | Broek JA et al. | β | 2014 | β |
| Connexin 43 is involved in the generation of human-induced pluripotent stem cells. | Ke Q et al. | β | 2013 | β |
| Disease modeling and drug screening for neurological diseases using human induced pluripotent stem cells. | Xu XH et al. | β | 2013 | β |
| Generation and characterization of human cryptorchid-specific induced pluripotent stem cells from urine. | Zhou J et al. | β | 2013 | β |
| Joubert syndrome: congenital cerebellar ataxia with the molar tooth. | Romani M et al. | β | 2013 | β |
| Neurons generated by direct conversion of fibroblasts reproduce synaptic phenotype caused by autism-associated neuroligin-3 mutation. | Chanda S et al. | β | 2013 | β |
| Pharmacogenomics of selective serotonin reuptake inhibitor treatment for major depressive disorder: genome-wide associations and functional genomics. | Ji Y et al. | β | 2013 | β |
| Pluripotent stem cells as a model to study oxygen metabolism in neurogenesis and neurodevelopmental disorders. | Paulsen Bda S et al. | β | 2013 | β |
| Progress and prospects for genetic modification of nonhuman primate models in biomedical research. | Chan AW | β | 2013 | β |
| Systematic review of induced pluripotent stem cell technology as a potential clinical therapy for spinal cord injury. | Kramer AS et al. | β | 2013 | β |
| The potential of stem cell research for the treatment of neuronal damage in glaucoma. | Karl MO | β | 2013 | β |
| Alzheimer's disease in a dish: promises and challenges of human stem cell models. | Young JE et al. | β | 2012 | β |
| Amyloid precursor proteins, neural differentiation of pluripotent stem cells and its relevance to Alzheimer's disease. | Khandekar N et al. | β | 2012 | β |
| Amyotrophic lateral sclerosis: new insights into underlying molecular mechanisms and opportunities for therapeutic intervention. | Cozzolino M et al. | β | 2012 | β |
| Gene-expression studies in understanding the mechanism of action of lithium. | Toker L et al. | β | 2012 | β |
| Induced pluripotent stem cells to model and treat neurogenetic disorders. | Wang H et al. | β | 2012 | β |
| Loci nominally associated with autism from genome-wide analysis show enrichment of brain expression quantitative trait loci but not lymphoblastoid cell line expression quantitative trait loci. | Davis LK et al. | β | 2012 | β |
| Marked hyperglycemia attenuates anesthetic preconditioning in human-induced pluripotent stem cell-derived cardiomyocytes. | Canfield SG et al. | β | 2012 | β |
| Modeling brain disease in a dish: really? | Marchetto MC et al. | β | 2012 | β |
| Modeling neurodevelopmental disorders using human neurons. | Chailangkarn T et al. | β | 2012 | β |
| Pluripotent stem cells models for Huntington's disease: prospects and challenges. | Carter RL et al. | β | 2012 | β |
| Programming and reprogramming neuronal subtypes in the central nervous system. | Rouaux C et al. | β | 2012 | β |
| Rett syndrome: genes, synapses, circuits, and therapeutics. | Banerjee A et al. | β | 2012 | β |
| The potential of induced pluripotent stem cells as a translational model for neurotoxicological risk. | Kumar KK et al. | β | 2012 | β |
| Using induced pluripotent stem cells (iPSC) to model human neuromuscular connectivity: promise or reality? | Thomson SR et al. | β | 2012 | β |
| X-chromosome inactivation in rett syndrome human induced pluripotent stem cells. | Cheung AY et al. | β | 2012 | β |