Cloning of the gamma-aminobutyric acid (GABA) rho 1 cDNA: a GABA receptor subunit highly expressed in the retina.
paper
Cited
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- Authors
- Cutting, G R; Lu, L; O'Hara, B F; Kasch, L M; Montrose-Rafizadeh, C; Donovan, D M; Shimada, S; Antonarakis, S E; Guggino, W B; Uhl, G R
- Year
- 1991
- Journal
- Proceedings of the National Academy of Sciences of the United States of America
- PMID
- 1849271
- DOI
- 10.1073/pnas.88.7.2673
- PMCID
- PMC51300
Type A gamma-aminobutyric acid (GABAA) receptors are a family of ligand-gated chloride channels that are the major inhibitory neurotransmitter receptors in the nervous system. Molecular cloning has revealed diversity in the subunits that compose this heterooligomeric receptor, but each previously elucidated subunit displays amino acid similarity in conserved structural elements. We have used these highly conserved regions to identify additional members of this family by using the polymerase chain reaction (PCR). One PCR product was used to isolate a full-length cDNA from a human retina cDNA library. The mature protein predicted from this cDNA sequence in 458 amino acids long and displays between 30 and 38% amino acid similarity to the previously identified GABAA subunits. This gene is expressed primarily in the retina but transcripts are also detected in the brain, lung, and thymus. Injection of Xenopus oocytes with RNA transcribed in vitro produces a GABA-responsive chloride conductance and expression of the cDNA in COS cells yields GABA-displaceable muscimol binding. These features are consistent with our identification of a GABA subunit, GABA rho 1, with prominent retinal expression that increases the diversity and tissue specificity of this ligand-gated ion-channel receptor family.
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| GABRR1 and GABRR2, encoding the GABA-A receptor subunits rho1 and rho2, are associated with alcohol dependence. | 2010 | 19536785 |
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| Benzodiazepine receptors in focal epilepsy with cortical dysgenesis: an 11C-flumazenil PET study. | Richardson MP et al. | β | 1996 | β |
| Brain GABAA receptors studied with subunit-specific antibodies. | De Blas AL | β | 1996 | β |
| Correlation between a bicuculline-resistant response to GABA and GABAA receptor rho 1 subunit expression in single rat retinal bipolar cells. | Yeh HH et al. | β | 1996 | β |
| Effects of ethanol on ion channels. | Crews FT et al. | β | 1996 | β |
| GABAC receptors in the vertebrate retina. | Lukasiewicz PD | β | 1996 | β |
| Glutamate responses of bipolar cells in a slice preparation of the rat retina. | Euler T et al. | β | 1996 | β |
| Immunocytochemical localization of the GABAc receptor rho subunits in the mammalian retina. | Enz R et al. | β | 1996 | β |
| Insights into the activation mechanism of rho1 GABA receptors obtained by coexpression of wild type and activation-impaired subunits. | Amin J et al. | β | 1996 | β |
| Modulation of amino acid-gated ion channels by protein phosphorylation. | Moss SJ et al. | β | 1996 | β |
| Molecular genetic analysis of the role of GABAergic systems in the behavioral and cellular actions of alcohol. | Buck KJ | β | 1996 | β |
| Synaptic organization of an organotypic slice culture of the mammalian retina. | SassoΓ¨-Pognetto M et al. | β | 1996 | β |
| The cerebellum: a model system for studying GABAA receptor diversity. | Wisden W et al. | β | 1996 | β |
| Zinc modulation of bicuculline-sensitive and -insensitive GABA receptors in the developing rat hippocampus. | Martina M et al. | β | 1996 | β |
| Antiepileptic drug mechanisms of action. | Macdonald RL et al. | β | 1995 | β |
| A single amino acid in gamma-aminobutyric acid rho 1 receptors affects competitive and noncompetitive components of picrotoxin inhibition. | Wang TL et al. | β | 1995 | β |
| Cerebral GABAA and GABAB receptors. Structure and function. | Nakayasu H et al. | β | 1995 | β |
| Cloning of a gamma-aminobutyric acid type C receptor subunit in rat retina with a methionine residue critical for picrotoxinin channel block. | Zhang D et al. | β | 1995 | β |
| Deciphering the native GABAA receptor: is there hope? | Yeh HH et al. | β | 1995 | β |
| Ethanol, gamma-aminobutyrate type A receptors, and protein kinase C phosphorylation. | Macdonald RL | β | 1995 | β |
| Expression of GABA receptor rho 1 and rho 2 subunits in the retina and brain of the rat. | Enz R et al. | β | 1995 | β |
| From ion currents to genomic analysis: recent advances in GABAA receptor research. | Rabow LE et al. | β | 1995 | β |
| Functional role of GABA in cat retina: II. Effects of GABAA antagonists. | Frumkes TE et al. | β | 1995 | β |
| GABAA receptor subunits have differential distributions in the rat retina: in situ hybridization and immunohistochemistry. | Greferath U et al. | β | 1995 | β |
| Modulatory actions of gamma aminobutyric acid (GABA) on GABA type A receptor subunit expression and function. | Schousboe A et al. | β | 1995 | β |
| Molecular cloning and chromosomal localization of a pseudogene related to the human acyl-CoA binding protein/diazepam binding inhibitor. | Gersuk VH et al. | β | 1995 | β |
| Presynaptic excitability. | Jackson MB | β | 1995 | β |
| Regulation of GABAA receptor function and gene expression in the central nervous system. | Morrow AL | β | 1995 | β |
| Structure and pharmacology of vertebrate GABAA receptor subtypes. | Whiting PJ et al. | β | 1995 | β |
| The GABAA receptors. | Stephenson FA | β | 1995 | β |
| The gamma-aminobutyric acid receptor gamma 3 subunit gene (GABRG3) is tightly linked to the alpha 5 subunit gene (GABRA5) on human chromosome 15q11-q13 and is transcribed in the same orientation. | Greger V et al. | β | 1995 | β |
| A single amino acid of the human gamma-aminobutyric acid type A receptor gamma 2 subunit determines benzodiazepine efficacy. | Mihic SJ et al. | β | 1994 | β |
| Cationic modulation of rho 1-type gamma-aminobutyrate receptors expressed in Xenopus oocytes. | Calvo DJ et al. | β | 1994 | β |
| Desensitization and noncompetitive blockade of GABAA receptors in ventral midbrain neurons by a neurosteroid dehydroepiandrosterone sulfate. | Spivak CE | β | 1994 | β |
| Evidence for a multigenic system controlling methyl-beta-carboline-3-carboxylate (beta-CCM)-induced seizures. | Martin B et al. | β | 1994 | β |
| Expression profiling of GABAA receptor beta-subunits in the rat retina. | Grigorenko EV et al. | β | 1994 | β |
| GABA-activated chloride currents of postnatal mouse retinal ganglion cells are blocked by acetylcholine and acetylcarnitine: how specific are ion channels in immature neurons? | BΓ€hring R et al. | β | 1994 | β |
| GABAA receptor alpha 1 subunit, an early marker for area specification in developing rat cerebral cortex. | Paysan J et al. | β | 1994 | β |
| Identification of a [3H]muscimol photoaffinity substrate in the bovine gamma-aminobutyric acidA receptor alpha subunit. | Smith GB et al. | β | 1994 | β |
| Localization of GABAA receptors in the rabbit retina. | Greferath U et al. | β | 1994 | β |
| Mechanisms of action of currently prescribed and newly developed antiepileptic drugs. | Macdonald RL et al. | β | 1994 | β |
| Modulation of GABAC receptors in rat retinal bipolar cells by protein kinase C. | Feigenspan A et al. | β | 1994 | β |
| Molecular neurobiology of the GABAA receptor. | Dunn SM et al. | β | 1994 | β |
| Rand Lecture, ASCEPT. GABA receptors: as complex as ABC? Australaisian Society for Clinical and Experimental Pharmacologists and Toxicologists. | Johnston GA | β | 1994 | β |
| Regulation of endogenous dopamine release in amphibian retina by gamma-aminobutyric acid and glycine. | Boatright JH et al. | β | 1994 | β |
| Transient expression of a novel type of GABA response in rat CA3 hippocampal neurones during development. | Strata F et al. | β | 1994 | β |
| Analysis of gamma-aminobutyric acidA receptor subunits in the mouse cochlea by means of the polymerase chain reaction. | Drescher DG et al. | β | 1993 | β |
| Antibodies specific for alpha-subunit subtypes of GABAA receptors reveal brain regional heterogeneity. | Endo S et al. | β | 1993 | β |
| Antibodies to the human gamma 2 subunit of the gamma-aminobutyric acidA/benzodiazepine receptor. | Khan ZU et al. | β | 1993 | β |
| Antiepileptic drug mechanisms of action. | Macdonald RL et al. | β | 1993 | β |
| A point mutation in a Drosophila GABA receptor confers insecticide resistance. | Ffrench-Constant RH et al. | β | 1993 | β |
| Developmental changes in human gamma-aminobutyric acidA receptor subunit composition. | Brooks-Kayal AR et al. | β | 1993 | β |
| GABAA receptor populations with novel subunit combinations and drug binding profiles identified in brain by alpha 5- and delta-subunit-specific immunopurification. | Mertens S et al. | β | 1993 | β |
| Identification of the GABAA receptor alpha 3 subunit in the IMR-32 neuroblastoma cell line. | Noble PJ et al. | β | 1993 | β |
| Immunochemical characterization of the beta 2 subunit of the GABAA receptor. | Machu TK et al. | β | 1993 | β |
| Immunocytochemical localization of glycine receptors in the mammalian retina. | GrΓΌnert U et al. | β | 1993 | β |
| Immunohistochemical localization of GABAA receptors in the scotopic pathway of the cat retina. | GrΓΌnert U et al. | β | 1993 | β |
| Localization of GABAA receptors in the rat retina. | Greferath U et al. | β | 1993 | β |
| Molecular pharmacology. The binding issue. | Colquhoun D et al. | β | 1993 | β |
| Multiplicity, structure, and function in GABAA receptors. | Barnard EA et al. | β | 1993 | β |
| Novel GABA responses from rod-driven retinal horizontal cells. | Qian H et al. | β | 1993 | β |
| Organotypic slice culture of the mammalian retina. | Feigenspan A et al. | β | 1993 | β |
| Pharmacology of GABA receptor Cl- channels in rat retinal bipolar cells. | Feigenspan A et al. | β | 1993 | β |
| Pharmacology of GABA rho 1 and GABA alpha/beta receptors expressed in Xenopus oocytes and COS cells. | Kusama T et al. | β | 1993 | β |
| Phosphorylation of the GABAA receptor by cAMP-dependent protein kinase and by protein kinase C: analysis of the substrate domain. | Browning MD et al. | β | 1993 | β |
| Rapid decline of GABAA receptor subunit mRNA expression in hippocampus following transient cerebral ischemia in the gerbil. | Li H et al. | β | 1993 | β |
| Appearance of water channels in Xenopus oocytes expressing red cell CHIP28 protein. | Preston GM et al. | β | 1992 | β |
| Bicuculline- and baclofen-insensitive gamma-aminobutyric acid binding to rat cerebellar membranes. | Drew CA et al. | β | 1992 | β |
| Comparative molecular neuroanatomy of cloned GABAA receptor subunits in the rat CNS. | Persohn E et al. | β | 1992 | β |
| Drosophila cyclodiene resistance gene shows conserved genomic organization with vertebrate gamma-aminobutyric acidA receptors. | ffrench-Constant RH et al. | β | 1992 | β |
| Ethanol potentiation of GABAA receptors requires phosphorylation of the alternatively spliced variant of the gamma 2 subunit. | Wafford KA et al. | β | 1992 | β |
| Five subtypes of type A gamma-aminobutyric acid receptors identified in neurons by double and triple immunofluorescence staining with subunit-specific antibodies. | Fritschy JM et al. | β | 1992 | β |
| Gamma-aminobutyric acidA receptor structure and function. | DeLorey TM et al. | β | 1992 | β |
| Immunoreactivity to GABAA receptor in the outer plexiform layer of the cat retina. | Vardi N et al. | β | 1992 | β |
| Kinetic properties and regulation of GABAA receptor channels. | MacDonald RL et al. | β | 1992 | β |
| Molecular mechanisms of the partial allosteric modulatory effects of bretazenil at gamma-aminobutyric acid type A receptor. | Puia G et al. | β | 1992 | β |
| Point mutations affecting antagonist affinity and agonist dependent gating of GABAA receptor channels. | Sigel E et al. | β | 1992 | β |
| Preparation of antibodies to beta subunits of gamma-aminobutyric acidA receptors. | Endo S et al. | β | 1992 | β |
| The third gamma subunit of the gamma-aminobutyric acid type A receptor family. | Herb A et al. | β | 1992 | β |
| Cloning, pharmacological characteristics and expression pattern of the rat GABAA receptor alpha 4 subunit. | Wisden W et al. | β | 1991 | β |
| Localization of the gene encoding the GABAA receptor beta 3 subunit to the Angelman/Prader-Willi region of human chromosome 15. | Wagstaff J et al. | β | 1991 | β |
| New nucleotide sequence data on the EMBL File Server. | β | β | 1991 | β |
| Sequence of a functional invertebrate GABAA receptor subunit which can form a chimeric receptor with a vertebrate alpha subunit. | Harvey RJ et al. | β | 1991 | β |
| The gamma 3-subunit of the GABAA-receptor confers sensitivity to benzodiazepine receptor ligands. | Knoflach F et al. | β | 1991 | β |