Genetic and environmental contributions to smoking.
paper
Cited
Public
Unavailable
- Authors
- True, W R; Heath, A C; Scherrer, J F; Waterman, B; Goldberg, J; Lin, N; Eisen, S A; Lyons, M J; Tsuang, M T
- Year
- 1997
- Journal
- Addiction (Abingdon, England)
- PMID
- 9489045
We estimate the magnitude of genetic and shared environmental contributions to risk of initiation and maintenance of smoking. Genetic models were fitted to data from 2,204 male-male monozygotic and 1,793 male-male dizygotic twin pairs from the Vietnam Era Twin Registry who responded to smoking questions on a 1987 mail and telephone survey. The best fitting model allowed for both genetic and shared environmental effects on smoking initiation, accounting for 50% and 30% of the variance in risk, but allowed for only genetic effects, (accounting for 70% of the variance in risk), on persistence in smoking among those who had become regular smokers. This finding of a major genetic influence on smoking persistence confirms similar results from studies in Scandinavia and Australia. The role of heritable traits such as nicotine sensitivity should be addressed in smoking prevention and cessation efforts.
No figures extracted from this document.
No chunks — full text not yet ingested.
No entities extracted from this document yet.
No uploaded files.
Not in any collection.
No citations found.
In this knowledge base
External
| Title | Authors | Journal | Year | Link |
|---|---|---|---|---|
| Clinical, laboratory and genetic factors associated with smoking in a Brazilian Sickle Cell Disease (SCD) cohort. | Cruz T et al. | — | 2025 | → |
| Can Treatment Support Mitigate Nicotine Metabolism-Based Disparities in Smoking Abstinence? Secondary Analysis of the Helping HAND 4 Trial. | Lee SS et al. | — | 2023 | → |
| Intergenerational transmission of parental smoking: when are offspring most vulnerable? | Alves J et al. | — | 2022 | → |
| Shared genetic risk between eating disorder- and substance-use-related phenotypes: Evidence from genome-wide association studies. | Munn-Chernoff MA et al. | — | 2021 | → |
| Meta-analytic method reveal a significant association of theBDNF Val66Met variant with smoking persistence based on a large samples. | Zhao H et al. | — | 2020 | → |
| Association Study of OPRM1 Gene in a Sample of Schizophrenia Patients With Alcohol Dependence or Abuse. | Gendy MNS et al. | — | 2019 | → |
| Dopamine D4 Receptor Gene Exon III VNTR Variant Influences Smoking Status in Turkish Population. | Uysal MA et al. | — | 2019 | → |
| Neurogenetic determinants and mechanisms of addiction to nicotine and smoked tobacco. | Sharp BM et al. | — | 2019 | → |
| Shared Genetic Risk between Eating Disorder- and Substance-Use-Related Phenotypes: Evidence from Genome-Wide Association Studies | Munn-Chernoff MA et al. | — | 2019 | — |
| A Human Polymorphism in CHRNA5 Is Linked to Relapse to Nicotine Seeking in Transgenic Rats. | Forget B et al. | — | 2018 | → |
| Nicotinic acetylcholine receptor gene polymorphism is not associated with tobacco-related oral squamous cell carcinoma. | Rajesh D et al. | — | 2018 | → |
| The dopamine transporter role in psychiatric phenotypes. | Salatino-Oliveira A et al. | — | 2018 | → |
| CYP2A6 Genetic Variation Alters Striatal-Cingulate Circuits, Network Hubs, and Executive Processing in Smokers. | Li S et al. | — | 2017 | → |
| Pharmacotherapy for smoking cessation: effects by subgroup defined by genetically informed biomarkers. | Schuit E et al. | — | 2017 | → |
| Prevalence and patterns of tobacco use and nicotine dependence among males industrial workers. | Divinakumar KJ et al. | — | 2017 | → |
| The genetic epidemiology of substance use disorder: A review. | Prom-Wormley EC et al. | — | 2017 | → |
| Association Between CHRNA3 and CHRNA5 Nicotine Receptor Subunit Gene Variants and Nicotine Dependence in an Isolated Populationof Kashubians in Poland. | Kita-Milczarska K et al. | — | 2016 | → |
| Meta-analysis reveals significant association of 3'-UTR VNTR in SLC6A3 with smoking cessation in Caucasian populations. | Ma Y et al. | — | 2016 | → |
| The association of dopamine pathway gene score, nicotine dependence and smoking cessation in a rural male population of Shandong, China. | Li S et al. | — | 2016 | → |
| Adolescent alcohol exposure: Are there separable vulnerable periods within adolescence? | Spear LP | — | 2015 | → |
| Genetic and environmental contributions to initiation of cigarette smoking in young African-American and European-American women. | Sartor CE et al. | — | 2015 | → |
| Genetic and Environmental Influences on Smoking Behavior across Adolescence and Young Adulthood in the Virginia Twin Study of Adolescent Behavioral Development and the Transitions to Substance Abuse Follow-Up. | Do EK et al. | — | 2015 | → |
| Intergenerational Patterns of Smoking and Nicotine Dependence Among US Adolescents. | Kandel DB et al. | — | 2015 | → |
| Nicotine dependence in an isolated population of Kashubians from North Poland: a population survey. | Sieminska A et al. | — | 2015 | → |
| Pharmacogenetics of nicotine and associated smoking behaviors. | Tanner JA et al. | — | 2015 | → |
| The significant association of Taq1A genotypes in DRD2/ANKK1 with smoking cessation in a large-scale meta-analysis of Caucasian populations. | Ma Y et al. | — | 2015 | → |
| Updated findings of the association and functional studies of DRD2/ANKK1 variants with addictions. | Ma Y et al. | — | 2015 | → |
| What predicts early smoking milestones? | Roberts ME et al. | — | 2015 | → |
| Pharmacogenetics of smoking: how far to the clinic? | Quaak M et al. | — | 2014 | → |
| Dual growth of adolescent smoking and drinking: evidence for an interaction between the mu-opioid receptor (OPRM1) A118G polymorphism and sex. | Kleinjan M et al. | — | 2013 | → |
| Early smoking onset and risk for subsequent nicotine dependence: a monozygotic co-twin control study. | Kendler KS et al. | — | 2013 | → |
| Genetic background influences the effects of withdrawal from chronic nicotine on learning and high-affinity nicotinic acetylcholine receptor binding in the dorsal and ventral hippocampus. | Wilkinson DS et al. | — | 2013 | → |
| Influence of a dopamine pathway additive genetic efficacy score on smoking cessation: results from two randomized clinical trials of bupropion. | David SP et al. | — | 2013 | → |
| Nicotine exposure caused significant transgenerational heritable behavioral changes in Caenorhabditis elegans. | Taki FA et al. | — | 2013 | → |
| Alpha-5 and -3 nicotinic receptor gene variants predict nicotine dependence but not cessation: findings from the COMMIT cohort. | Bousman CA et al. | — | 2012 | → |
| Associations between substance use disorders and major depression in parents and late adolescent-emerging adult offspring: an adoption study. | Marmorstein NR et al. | — | 2012 | → |
| Attention deficit/hyperactivity disorder symptoms and depression symptoms as mediators in the intergenerational transmission of smoking. | Zoloto A et al. | — | 2012 | → |
| Epidemiology of substance use disorders. | Merikangas KR et al. | — | 2012 | → |
| Genetics of smoking and depression. | Tsuang MT et al. | — | 2012 | → |
| Genome-wide meta-analyses of smoking behaviors in African Americans. | David SP et al. | — | 2012 | → |
| Parent, sibling and peer influences on smoking initiation, regular smoking and nicotine dependence. Results from a genetically informative design. | Scherrer JF et al. | — | 2012 | → |
| Suicidal behavior, smoking, and familial vulnerability. | Scherrer JF et al. | — | 2012 | → |
| The genetic correlation between cigarette smoking and alcohol drinking among Chinese adult male twins: an ordinal bivariate genetic analysis. | Zhang T et al. | — | 2012 | → |
| The role of ANKK1 and TTC12 genes on drinking behaviour in tobacco dependent subjects. | Lobo DS et al. | — | 2012 | → |
| Are smokers interested in genetic testing for smoking addiction? A socio-cognitive approach. | Smerecnik C et al. | — | 2011 | → |
| The galanin receptor 1 gene associates with tobacco craving in smokers seeking cessation treatment. | Lori A et al. | — | 2011 | → |
| The German multi-centre study on smoking-related behavior-description of a population-based case-control study. | Lindenberg A et al. | — | 2011 | → |
| Treatment for tobacco dependence: a potential application for stratified medicine? | Brock AJ et al. | — | 2011 | → |
| Association study of a functional catechol-O-methyltransferase polymorphism and smoking in healthy Caucasian subjects. | Nedic G et al. | — | 2010 | → |
| Genetic variation in three candidate genes and nicotine dependence, withdrawal and smoking cessation in hospitalized patients. | De Ruyck K et al. | — | 2010 | → |
| Initial response to cigarettes predicts rate of progression to regular smoking: findings from an offspring-of-twins design. | Sartor CE et al. | — | 2010 | → |
| Characterization of pharmacological and behavioral differences to nicotine in C57Bl/6 and DBA/2 mice. | Jackson KJ et al. | — | 2009 | → |
| Constitutional mechanisms of vulnerability and resilience to nicotine dependence. | Hiroi N et al. | — | 2009 | → |
| From the American Academy of Pediatrics: Technical report--Tobacco as a substance of abuse. | Sims TH et al. | — | 2009 | → |
| Genetic variation as a predictor of smoking cessation success. A promising preventive and intervention tool for chronic respiratory diseases? | Quaak M et al. | — | 2009 | → |
| Genetic variation in the CHRNA5 gene affects mRNA levels and is associated with risk for alcohol dependence. | Wang JC et al. | — | 2009 | → |
| Implications of gene-drug interactions in smoking cessation for improving the prevention of chronic degenerative diseases. | Quaak M et al. | — | 2009 | → |
| Smoking as a product of gene-environment interaction. | Nilsson KW et al. | — | 2009 | → |
| Variants in nicotinic acetylcholine receptors alpha5 and alpha3 increase risks to nicotine dependence. | Chen X et al. | — | 2009 | → |
| An examination of the relationship between adolescents' initial smoking experience and their exposure to peer and family member smoking. | Okoli CT et al. | — | 2008 | → |
| Are there genetic influences on addiction: evidence from family, adoption and twin studies. | Agrawal A et al. | — | 2008 | → |
| Cannabinoid receptor 1 gene association with nicotine dependence. | Chen X et al. | — | 2008 | → |
| CYP2A6 polymorphisms and risk for tobacco-related cancers. | Rossini A et al. | — | 2008 | → |
| Do the same genetic and environmental effects underlie the covariation of alcohol dependence, smoking, and aggressive behaviour? | von der Pahlen B et al. | — | 2008 | → |
| Gamma-aminobutyric acid receptor genes and nicotine dependence: evidence for association from a case-control study. | Agrawal A et al. | — | 2008 | → |
| Genes and cigarette smoking. | Munafò MR et al. | — | 2008 | → |
| Genetic variability in nicotinic acetylcholine receptors and nicotine addiction: converging evidence from human and animal research. | Portugal GS et al. | — | 2008 | → |
| Genetic variation in the dopamine D4 receptor (DRD4) gene and smoking cessation: follow-up of a randomised clinical trial of transdermal nicotine patch. | David SP et al. | — | 2008 | → |
| Psychiatric and familial predictors of transition times between smoking stages: results from an offspring-of-twins study. | Sartor CE et al. | — | 2008 | → |
| Review. Genetics of addictions: strategies for addressing heterogeneity and polygenicity of substance use disorders. | Wong CC et al. | — | 2008 | → |
| Secondhand tobacco smoke exposure, nicotine dependence, and smoking cessation. | Okoli CT et al. | — | 2008 | → |
| The CHRNA5/A3/B4 gene cluster variability as an important determinant of early alcohol and tobacco initiation in young adults. | Schlaepfer IR et al. | — | 2008 | → |
| A research agenda for assessing the potential contribution of genomic medicine to tobacco control. | Hall WD | — | 2007 | → |
| Association between dopamine transporter genotypes and smoking cessation: a meta-analysis. | Stapleton JA et al. | — | 2007 | → |
| Association of functional catechol O-methyl transferase (COMT) Val108Met polymorphism with smoking severity and age of smoking initiation in Chinese male smokers. | Guo S et al. | — | 2007 | → |
| Can comparison of MZ- and DZ-twin concordance rates be used invariably to estimate heritability? | Tishler PV et al. | — | 2007 | → |
| Dopamine receptor genes (DRD2, DRD3 and DRD4) and gene-gene interactions associated with smoking-related behaviors. | Vandenbergh DJ et al. | — | 2007 | → |
| Dopamine transporter polymorphisms are associated with short-term response to smoking cessation treatment. | O'Gara C et al. | — | 2007 | → |
| Exploring the inter-relationship of smoking age-at-onset, cigarette consumption and smoking persistence: genes or environment? | Morley KI et al. | — | 2007 | → |
| Genetic linkage to chromosome 22q12 for a heavy-smoking quantitative trait in two independent samples. | Saccone SF et al. | — | 2007 | → |
| Genetics and smoking cessation improving outcomes in smokers at risk. | Lerman CE et al. | — | 2007 | → |
| Genetic variation in catechol-O-methyltransferase (COMT) and obesity in the prostate, lung, colorectal, and ovarian (PLCO) cancer screening trial. | Wang SS et al. | — | 2007 | → |
| Heavy nicotine and alcohol use in alcohol dependence is associated with D2 dopamine receptor (DRD2) polymorphism. | Connor JP et al. | — | 2007 | → |
| Overview of the pharmacogenomics of cigarette smoking. | Ho MK et al. | — | 2007 | → |
| RhoA, encoding a Rho GTPase, is associated with smoking initiation. | Chen X et al. | — | 2007 | → |
| Alcohol, tobacco and caffeine use: spouse similarity processes. | Reynolds CA et al. | — | 2006 | → |
| Association of the phosphatase and tensin homolog gene (PTEN) with smoking initiation and nicotine dependence. | Zhang L et al. | — | 2006 | → |
| Assortative mating for cigarette smoking and for alcohol consumption in female Australian twins and their spouses. | Agrawal A et al. | — | 2006 | → |
| Extensions to the modeling of initiation and progression: applications to substance use and abuse. | Neale MC et al. | — | 2006 | → |
| Genetic architecture of smoking behavior: a study of Finnish adult twins. | Broms U et al. | — | 2006 | → |
| Genetic correlations between smoking initiation and smoking behaviors in a twin sample. | Hardie TL et al. | — | 2006 | → |
| [Heritability and candidate genes in tobacco use]. | Hamdani N et al. | — | 2006 | → |
| Heritability of cigarette smoking and alcohol use in Chinese male twins: the Qingdao twin registry. | Lessov-Schlaggar CN et al. | — | 2006 | → |
| The genetics of nicotine dependence: relationship to pancreatic cancer. | MacLeod SL et al. | — | 2006 | → |
| The influence of genetics on nicotine dependence and the role of pharmacogenetics in treating the smoking habit. | Chatkin JM | — | 2006 | → |
| The serotonin transporter gene polymorphism is not associated with smoking behavior. | Trummer O et al. | — | 2006 | → |
| CYP2A6 genetic polymorphisms and correlation with smoking status in Brazilians. | Vasconcelos GM et al. | — | 2005 | → |
| Genetic basis for the psychostimulant effects of nicotine: a quantitative trait locus analysis in AcB/BcA recombinant congenic mice. | Gill KJ et al. | — | 2005 | → |
| Mapping and verification of susceptibility loci for smoking quantity using permutation linkage analysis. | Wang D et al. | — | 2005 | → |
| Nicotine addiction through a neurogenomic prism: ethics, public health, and smoking. | Caron L et al. | — | 2005 | → |
| Nicotine dependence, depression, and gender: characterizing phenotypes based on withdrawal discomfort, response to smoking, and ability to abstain. | Pomerleau OF et al. | — | 2005 | → |
| Reliability of self-reported smoking history and age at initial tobacco use. | Huerta M et al. | — | 2005 | → |
| Sibling effects on smoking in adolescence: evidence for social influence from a genetically informative design. | Slomkowski C et al. | — | 2005 | → |
| Will nicotine genetics and a nicotine vaccine prevent cigarette smoking and smoking-related diseases? | Hall WD | — | 2005 | → |
| A genomic scan for habitual smoking in families of alcoholics: common and specific genetic factors in substance dependence. | Bierut LJ et al. | — | 2004 | → |
| Association study of the Epac gene and tobacco smoking and nicotine dependence. | Chen X et al. | — | 2004 | → |
| Ethnic variation in CYP2A6 and association of genetically slow nicotine metabolism and smoking in adult Caucasians. | Schoedel KA et al. | — | 2004 | → |
| Genetics and drug use as a complex phenotype. | Lessov CN et al. | — | 2004 | → |
| Genetic variation in dopaminergic pathways and short-term effectiveness of the nicotine patch. | Johnstone EC et al. | — | 2004 | → |
| Identifying shared environmental contributions to early substance use: the respective roles of peers and parents. | Walden B et al. | — | 2004 | → |
| Nicotine dependence. | Berrettini WH | — | 2004 | → |
| Progress in searching for susceptibility loci and genes for smoking-related behaviour. | Li MD et al. | — | 2004 | → |
| Psychiatric disorders and stages of smoking. | Breslau N et al. | — | 2004 | → |
| The dopamine D2 receptor C32806T polymorphism (DRD2 Taq1A RFLP) exhibits no association with smoking behaviour in a healthy UK population. | Johnstone EC et al. | — | 2004 | → |
| A genome-wide search for quantitative trait loci influencing substance dependence vulnerability in adolescence. | Stallings MC et al. | — | 2003 | → |
| A meta-analysis of estimated genetic and environmental effects on smoking behavior in male and female adult twins. | Li MD et al. | — | 2003 | → |
| Decreasing smoking behaviour and risk through CYP2A6 inhibition. | Sellers EM et al. | — | 2003 | → |
| Diagnosed diabetes and ethnic disparities in adverse health behaviors of American women. | Okosun IS et al. | — | 2003 | → |
| Finding order in the DSM-IV nicotine dependence syndrome: a Rasch analysis. | Strong DR et al. | — | 2003 | → |
| Genetic influence on cigarette-induced cardiovascular disease. | Wang XL et al. | — | 2003 | → |
| Nicotine dependence: development, mechanisms, individual differences and links to possible neurophysiological correlates. | Groman E et al. | — | 2003 | → |
| Substance use disorders, externalizing psychopathology, and P300 event-related potential amplitude. | Iacono WG et al. | — | 2003 | → |
| The genetic determinants of smoking. | Batra V et al. | — | 2003 | → |
| Tobacco smoking: current concepts in etiology and treatment. | Patkar AA et al. | — | 2003 | → |
| Twenty-first century tobacco use: it is not just a risk factor anymore. | Khurana S et al. | — | 2003 | → |
| Why do so many drug users smoke? | McCool RM et al. | — | 2003 | → |
| Adolescent alcohol and tobacco use: onset, persistence and trajectories of use across two samples. | Jackson KM et al. | — | 2002 | → |
| A functional polymorphism within the mu-opioid receptor gene and risk for abuse of alcohol and other substances. | Schinka JA et al. | — | 2002 | → |
| CYP2A6 genetic variation and potential consequences. | Xu C et al. | — | 2002 | → |
| Genetic variation in CYP2A6-mediated nicotine metabolism alters smoking behavior. | Tyndale RF et al. | — | 2002 | → |
| No association between functional catechol O-methyl transferase 1947A>G polymorphism and smoking initiation, persistent smoking or smoking cessation. | David SP et al. | — | 2002 | → |
| Persistence of cigarette smoking: familial liability and the role of nicotine dependence. | Johnson EO et al. | — | 2002 | → |
| Psychosocial antecedents of tobacco chipping. | Presson CC et al. | — | 2002 | → |
| Smoking and Parkinson's disease in twins. | Tanner CM et al. | — | 2002 | → |
| Smoking and quitting: a qualitative study with community-living psychiatric clients. | Lawn SJ et al. | — | 2002 | → |
| The genetics of tobacco use: methods, findings and policy implications. | Hall W et al. | — | 2002 | → |
| The role of pharmacogenetically-variable cytochrome P450 enzymes in drug abuse and dependence. | Howard LA et al. | — | 2002 | → |
| The selectively bred high alcohol sensitivity (HAS) and low alcohol sensitivity (LAS) rats differ in sensitivity to nicotine. | de Fiebre NC et al. | — | 2002 | → |
| Tobacco smoking as a chronic disease: notes on prevention and treatment. | Batra V et al. | — | 2002 | → |
| Cholecystokinin (CCK) gene as a possible risk factor for smoking: a replication in two independent samples. | Comings DE et al. | — | 2001 | → |
| Knowing the risk: relationships between risk behaviour and health knowledge. | Cook PA et al. | — | 2001 | → |
| New directions in the genetic mechanisms underlying nicotine addiction. | Munafò M et al. | — | 2001 | → |
| Reduced dopamine D1 receptor binding in the ventral striatum of cigarette smokers. | Dagher A et al. | — | 2001 | → |
| Smoking cessation in cancer prevention. | Vainio H et al. | — | 2001 | → |
| Adolescent occasional smokers, a target group for smoking cessation? the Nord-Trøndelag Health Study, Norway, 1995-1997. | Holmen TL et al. | — | 2000 | → |
| Association between polymorphisms in dopamine metabolic enzymes and tobacco consumption in smokers. | McKinney EF et al. | — | 2000 | → |
| Co-occurring risk factors for alcohol dependence and habitual smoking. | Bierut LJ et al. | — | 2000 | → |
| Current models of nicotine dependence: what is known and what is needed to advance understanding of tobacco etiology among youth. | Shadel WG et al. | — | 2000 | → |
| Genetic studies of substance abuse. | Vanyukov MM et al. | — | 2000 | → |
| Mimicking gene defects to treat drug dependence. | Sellers EM et al. | — | 2000 | → |
| Polymorphisms in genes involved in neurotransmission in relation to smoking. | Arinami T et al. | — | 2000 | → |
| Schizophrenia and smoking: evidence for a common neurobiological basis? | Stassen HH et al. | — | 2000 | → |
| The dopamine D2 receptor (DRD2) gene-a genetic risk factor in heavy smoking? | Batra A et al. | — | 2000 | → |
| The natural history of cigarette smoking from adolescence to adulthood in a midwestern community sample: multiple trajectories and their psychosocial correlates. | Chassin L et al. | — | 2000 | → |
| A common genetic defect in nicotine metabolism decreases risk for dependence and lowers cigarette consumption. | Tyndale RF et al. | — | 1999 | → |
| A twin study of drinking and smoking onset and latencies from first use to regular use. | Stallings MC et al. | — | 1999 | → |
| Cigarette smoking. | Bergen AW et al. | — | 1999 | → |
| Genetic and environmental risk factors in the aetiology of illicit drug initiation and subsequent misuse in women. | Kendler KS et al. | — | 1999 | → |
| Genetic and social determinants of initiation and age at onset of smoking in Australian twins. | Heath AC et al. | — | 1999 | → |
| Genetics of alcoholism and substance abuse. | Enoch MA et al. | — | 1999 | → |
| Genetic studies of alcoholism and substance dependence. | Reich T et al. | — | 1999 | → |
| Myocardial stunning and dopamine receptor polymorphism. | Poullis M | — | 1999 | → |
| Smoking behavior is under the influence of a major quantitative trait locus on human chromosome 5q. | Duggirala R et al. | — | 1999 | → |
| The genetic epidemiology of smoking. | Sullivan PF et al. | — | 1999 | → |
| The genetics of smoking initiation and quantity smoked in Dutch adolescent and young adult twins. | Koopmans JR et al. | — | 1999 | → |
| Statistical methods in genetic research on smoking. | Heath AC et al. | — | 1998 | → |
| Tobacco smoking, genes, and dopamine. | Clarke PB | — | 1998 | → |