Autism spectrum disorders associated with X chromosome markers in French-Canadian males.
- Authors
- Gauthier, J; Joober, R; Dubé, M-P; St-Onge, J; Bonnel, A; Gariépy, D; Laurent, S; Najafee, R; Lacasse, H; St-Charles, L; Fombonne, E; Mottron, L; Rouleau, G A
- Year
- 2006
- Journal
- Molecular psychiatry
- PMID
- 16261168
- DOI
- 10.1038/sj.mp.4001756
It is now well established that genetic factors play an important role in the pathogenesis of autism disorder and converging lines of evidence suggest the implication of the X chromosome. Using a sample of subjects diagnosed with autism spectrum disorders, exclusively composed of males from French-Canadian (FC) origin, we tested markers covering the entire X chromosome using a family-based association study. Our initial analysis revealed the presence of association at two loci: DXS6789 (P=0.026) and DXS8043 (P=0.0101). In a second step, we added support to the association at DXS8043 using additional markers, additional subjects and a haplotype-based analysis (best obtained P-value=0.00001). These results provide support for the existence of a locus on the X chromosome that predisposes the FC to autism spectrum disorders.
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