Fetal alcohol syndrome: neuropsychiatric phenomics.
paper
Cited
Public
Unavailable
- Authors
- Burd, Larry; Klug, Marilyn G; Martsolf, John T; Kerbeshian, Jacob
- Year
- 2003
- Journal
- Neurotoxicology and teratology
- PMID
- 14624969
- DOI
- 10.1016/j.ntt.2003.07.014
Fetal alcohol syndrome (FAS) is a common developmental disorder with impairments in multiple neuropsychiatric spheres of varying severity. Few population-derived studies of the behavioral phenotype are available. The purpose of this study was to estimate the prevalence of neuropsychiatric disorders in three groups: subjects who met criteria for FAS (n=152); subjects who met criteria for partial FAS/ARND (n=150); and referred subjects who did not meet criteria for either FAS or partial FAS/ARND (n=86). Each subject had a standardized evaluation by a medical geneticist. All subjects were from North Dakota. We found increases in the prevalence rates of neuropsychiatric disorders in subjects with FAS compared to subjects with partial FAS/ARND and the lowest rates in the group that did not meet criteria for either FAS or partial FAS/ARND. Comorbid attention deficit hyperactivity disorder occurred in 73% of cases with FAS, in 72% cases with partial FAS/ARND, and in 36% subjects who did not meet criteria for either. For other neuropsychiatric disorders, a similar distribution of comorbidity was found. This study supports the concept of a continuum of impairment resulting from prenatal alcohol exposure. The presence of complex cognitive, behavioral, and physical symptomatology in the affected subjects with prenatal alcohol exposure would seem to fit well under the diagnostic rubric of fetal alcohol spectrum disorder (FASD). Diagnosis and long-term management will require increasing access to multidisciplinary child development teams including mental health professionals who treat children and adolescents. Adults will require care primarily from teams with expertise in mental health and developmental disabilities.
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| Title | Authors | Journal | Year | Link |
|---|---|---|---|---|
| Adolescent Vitamin D Supplementation Reverses Neuroplasticity and Motivational Deficits Induced by Developmental Alcohol Exposure and Early-Life Stress. | Alves AP et al. | β | 2026 | β |
| Comorbidities associated with fetal alcohol spectrum disorders in the United States. | Attell BK et al. | β | 2025 | β |
| Role of Drinking Attitudes and Trait Impulsivity in Prenatal Alcohol Craving and Consumption in Mothers of Reproductive Age. | Hayashi Y et al. | β | 2025 | β |
| Prevalence of co-occurring diagnoses in people exposed to alcohol prenatally: Findings from a meta-analysis. | Clark CA et al. | β | 2024 | β |
| Fetal alcohol spectrum disorders prevention and clinical guidelines research-workshop report. | Koehlmoos TP et al. | β | 2023 | β |
| Postnatal ethanol exposure impairs social behavior and operant extinction in the adult female mouse offspring. | Bariselli S et al. | β | 2023 | β |
| Autism Spectrum Disorder and Fetal Alcohol Spectrum Disorder: A Literature Review. | Carpita B et al. | β | 2022 | β |
| Influence of <i>COMT</i> (rs4680) and <i>DRD2</i> (rs1076560, rs1800497) Gene Polymorphisms on Safety and Efficacy of Methylphenidate Treatment in Children with Fetal Alcohol Spectrum Disorders. | Εmiarowska M et al. | β | 2022 | β |
| Psychotropic Medication Utilization Among Children Diagnosed With Fetal Alcohol Spectrum Disorder. | Senturias Y et al. | β | 2022 | β |
| Maternal choline supplementation mitigates alcohol exposure effects on neonatal brain volumes. | Warton FL et al. | β | 2021 | β |
| Role of phosphodiesterase 1 in the pathophysiology of diseases and potential therapeutic opportunities. | Samidurai A et al. | β | 2021 | β |
| Sex- and age-dependent differences in nicotine susceptibility evoked by developmental exposure to tobacco smoke and/or ethanol in mice. | Nunes-Freitas AL et al. | β | 2021 | β |
| Multivariate models of brain volume for identification of children and adolescents with fetal alcohol spectrum disorder. | Little G et al. | β | 2020 | β |
| Association of adverse childhood experiences and neurodevelopmental disorders in people with fetal alcohol spectrum disorders (FASD) and non-FASD controls. | Kambeitz C et al. | β | 2019 | β |
| Comparing Executive Functioning in Children and Adolescents With Fetal Alcohol Spectrum Disorders and ADHD: A Meta-Analysis. | Khoury JE et al. | β | 2019 | β |
| Parenting and prenatal risk as moderators of genetic influences on conduct problems during middle childhood. | Marceau K et al. | β | 2019 | β |
| Relation between adaptive function and IQ among youth with histories of heavy prenatal alcohol exposure. | Doyle LR et al. | β | 2019 | β |
| Relation Between Oppositional/Conduct Behaviors and Executive Function Among Youth with Histories of Heavy Prenatal Alcohol Exposure. | Doyle LR et al. | β | 2019 | β |
| Applying a Developmental Framework to the Self-Regulatory Difficulties of Young Children with Prenatal Alcohol Exposure: A Review. | Reid N et al. | β | 2018 | β |
| Comparison of Alcohol-Related Neurodevelopmental Disorders and Neurodevelopmental Disorders Associated with Prenatal Alcohol Exposure Diagnostic Criteria. | Johnson S et al. | β | 2018 | β |
| Executive Functioning Correlates With Communication Ability in Youth With Histories of Heavy Prenatal Alcohol Exposure. | Doyle LR et al. | β | 2018 | β |
| Meta-Analyses of Externalizing Disorders: Genetics or Prenatal Alcohol Exposure? | Wetherill L et al. | β | 2018 | β |
| Nicotinamide Inhibits Ethanol-Induced Caspase-3 and PARP-1 Over-activation and Subsequent Neurodegeneration in the Developing Mouse Cerebellum. | Ieraci A et al. | β | 2018 | β |
| Plasminogen activator system homeostasis and its dysregulation by ethanol in astrocyte cultures and the developing brain. | Wilhelm CJ et al. | β | 2018 | β |
| Prenatal Alcohol Exposure Is Associated With Adverse Cognitive Effects and Distinct Whole-Genome DNA Methylation Patterns in Primary School Children. | Frey S et al. | β | 2018 | β |
| Prevalence of externalizing disorders and Autism Spectrum Disorders among children with Fetal Alcohol Spectrum Disorder: systematic review and meta-analysis. | Lange S et al. | β | 2018 | β |
| Academic Difficulties in Children with Prenatal Alcohol Exposure: Presence, Profile, and Neural Correlates. | Glass L et al. | β | 2017 | β |
| Comorbid Mental Disorders in Fetal Alcohol Spectrum Disorders: A Systematic Review. | Weyrauch D et al. | β | 2017 | β |
| Deficits in spatial learning and memory in adult mice following acute, low or moderate levels of prenatal ethanol exposure during gastrulation or neurulation. | Schambra UB et al. | β | 2017 | β |
| Fetal Alcohol Spectrum Disorders: A Case Study. | Glass L et al. | β | 2017 | β |
| Interventions in fetal alcohol spectrum disorders: An international perspective. | Petrenko CL et al. | β | 2017 | β |
| Neurodevelopmental profile of Fetal Alcohol Spectrum Disorder: A systematic review. | Lange S et al. | β | 2017 | β |
| Prenatal alcohol exposure is a risk factor for adult neuropathic pain via aberrant neuroimmune function. | Sanchez JJ et al. | β | 2017 | β |
| Sexual dimorphism of volume reduction but not cognitive deficit in fetal alcohol spectrum disorders: A combined diffusion tensor imaging, cortical thickness and brain volume study. | Treit S et al. | β | 2017 | β |
| Animal Models for Medication Development and Application to Treat Fetal Alcohol Effects. | Barron S et al. | β | 2016 | β |
| Clinical improvements in adopted children with fetal alcohol spectrum disorders through neurodevelopmentally informed clinical intervention: A pilot study. | Zarnegar Z et al. | β | 2016 | β |
| Comorbidity of fetal alcohol spectrum disorder: a systematic review and meta-analysis. | Popova S et al. | β | 2016 | β |
| Epigenetic Mechanisms in Developmental Alcohol-Induced Neurobehavioral Deficits. | Basavarajappa BS et al. | β | 2016 | β |
| FASD and ADHD: Are they related and How? | Burd L | β | 2016 | β |
| Fetal alcohol spectrum disorder: complexity from comorbidity. | Burd L | β | 2016 | β |
| Special Education of Children with Fetal Alcohol Spectrum Disorder. | Popova S et al. | β | 2016 | β |
| The Influence of Extrinsic Reinforcement on Children with Heavy Prenatal Alcohol Exposure. | Graham DM et al. | β | 2016 | β |
| Aberrant NMDA-dependent LTD after perinatal ethanol exposure in young adult rat hippocampus. | Kervern M et al. | β | 2015 | β |
| Epigenetic mechanisms: A possible link between autism spectrum disorders and fetal alcohol spectrum disorders. | Varadinova M et al. | β | 2015 | β |
| Fetal Alcohol Spectrum Disorder: Potential Role of Endocannabinoids Signaling. | Basavarajappa BS | β | 2015 | β |
| GABAA overactivation potentiates the effects of NMDA blockade during the brain growth spurt in eliciting locomotor hyperactivity in juvenile mice. | Oliveira-Pinto J et al. | β | 2015 | β |
| Impaired ILK Function Is Associated with Deficits in Hippocampal Based Memory and Synaptic Plasticity in a FASD Rat Model. | Bhattacharya D et al. | β | 2015 | β |
| Neurobehavioral Disorder Associated with Prenatal Alcohol Exposure (ND-PAE): Review of Evidence and Guidelines for Assessment. | Doyle LR et al. | β | 2015 | β |
| Objective assessment of ADHD core symptoms in children with heavy prenatal alcohol exposure. | Infante MA et al. | β | 2015 | β |
| Environmental alterations of epigenetics prior to the birth. | Lo CL et al. | β | 2014 | β |
| Exposure to neurotoxicants and the development of attention deficit hyperactivity disorder and its related behaviors in childhood. | Yolton K et al. | β | 2014 | β |
| Hippocampal abnormalities in youth with alcohol-related neurodevelopmental disorder. | Dudek J et al. | β | 2014 | β |
| Longitudinal MRI reveals impaired cortical thinning in children and adolescents prenatally exposed to alcohol. | Treit S et al. | β | 2014 | β |
| Neurobehavioral, neurologic, and neuroimaging characteristics of fetal alcohol spectrum disorders. | Glass L et al. | β | 2014 | β |
| Performance measurement: a proposal to increase use of SBIRT and decrease alcohol consumption during pregnancy. | O'Brien PL | β | 2014 | β |
| Validation of a novel method to identify in utero ethanol exposure: simultaneous meconium extraction of fatty acid ethyl esters, ethyl glucuronide, and ethyl sulfate followed by LC-MS/MS quantification. | Himes SK et al. | β | 2014 | β |
| Cognitive aspects of fetal alcohol spectrum disorder. | Davis KM et al. | β | 2013 | β |
| Cost of specialized addiction treatment of clients with fetal alcohol spectrum disorder in Canada. | Popova S et al. | β | 2013 | β |
| Diffusion tensor imaging correlates of saccadic reaction time in children with fetal alcohol spectrum disorder. | Green CR et al. | β | 2013 | β |
| Epigenetic medicine and fetal alcohol spectrum disorders. | Resendiz M et al. | β | 2013 | β |
| Neuropsychological deficits associated with heavy prenatal alcohol exposure are not exacerbated by ADHD. | Glass L et al. | β | 2013 | β |
| Phenomics of cardiac chloride channels. | Duan DD | β | 2013 | β |
| Prenatal alcohol exposure, attention-deficit/hyperactivity disorder, and sluggish cognitive tempo. | Graham DM et al. | β | 2013 | β |
| The impact of prenatal alcohol exposure on addiction treatment. | Grant TM et al. | β | 2013 | β |
| Ego-dystonic pregnancy and prenatal consumption of alcohol among first-time mothers. | O'Brien PL et al. | β | 2012 | β |
| [Validity of a maternal alcohol consumption questionnaire in detecting prenatal exposure]. | Manich A et al. | β | 2012 | β |
| Acute administration of vinpocetine, a phosphodiesterase type 1 inhibitor, ameliorates hyperactivity in a mice model of fetal alcohol spectrum disorder. | Nunes F et al. | β | 2011 | β |
| Behavioral interventions for children and adolescents with fetal alcohol spectrum disorders. | Paley B et al. | β | 2011 | β |
| Cortical thickness in fetal alcohol syndrome and attention deficit disorder. | FernΓ‘ndez-JaΓ©n A et al. | β | 2011 | β |
| Discriminating the effects of prenatal alcohol exposure from other behavioral and learning disorders. | Coles CD | β | 2011 | β |
| Fetal alcohol spectrum disorders: neuropsychological and behavioral features. | Mattson SN et al. | β | 2011 | β |
| From research to practice: an integrative framework for the development of interventions for children with fetal alcohol spectrum disorders. | Kodituwakku PW et al. | β | 2011 | β |
| Imaging the impact of prenatal alcohol exposure on the structure of the developing human brain. | Lebel C et al. | β | 2011 | β |
| Protective effect of pyruvate against ethanol-induced apoptotic neurodegeneration in the developing rat brain. | Ullah N et al. | β | 2011 | β |
| Fetal alcohol syndrome, Tourette syndrome, and hyperactivity in nine adopted children. | FernΓ‘ndez-Mayoralas DM et al. | β | 2010 | β |
| Prenatal alcohol exposure: fetal programming and later life vulnerability to stress, depression and anxiety disorders. | Hellemans KG et al. | β | 2010 | β |
| Role of central nervous system insulin resistance in fetal alcohol spectrum disorders. | de la Monte SM et al. | β | 2010 | β |
| [Alcohol and pregnancy]. | Seror E et al. | β | 2009 | β |
| Characteristics of children whose siblings have fetal alcohol syndrome or incomplete fetal alcohol syndrome. | Kvigne VL et al. | β | 2009 | β |
| Early exposure to ethanol but not red wine at the same alcohol concentration induces behavioral and brain neurotrophin alterations in young and adult mice. | Fiore M et al. | β | 2009 | β |
| Estimated Risk of Developing Selected DSM-IV Disorders Among 5-Year-Old Children with Prenatal Cocaine Exposure. | Morrow CE et al. | β | 2009 | β |
| Infant irritability: The impact of fetal alcohol exposure, maternal depressive symptoms, and low emotional support from the husband. | Lemola S et al. | β | 2009 | β |
| Intervention for individuals with fetal alcohol spectrum disorders: treatment approaches and case management. | Paley B et al. | β | 2009 | β |
| Psychiatric conditions associated with prenatal alcohol exposure. | O'Connor MJ et al. | β | 2009 | β |
| Review of published studies of kidney, liver, and gastrointestinal birth defects in fetal alcohol spectrum disorders. | Hofer R et al. | β | 2009 | β |
| Social cognitive and emotion processing abilities of children with fetal alcohol spectrum disorders: a comparison with attention deficit hyperactivity disorder. | Greenbaum RL et al. | β | 2009 | β |
| Treatment of fetal alcohol spectrum disorders: are we ready yet? | Burd L et al. | β | 2009 | β |
| Alarming prevalence of fetal alcohol exposure in a Mediterranean city. | Garcia-Algar O et al. | β | 2008 | β |
| Computational models of ethanol-induced neurodevelopmental toxicity across species: Implications for risk assessment. | Gohlke JM et al. | β | 2008 | β |
| Ethanol-BDNF interactions: still more questions than answers. | Davis MI | β | 2008 | β |
| Medication effects on symptoms of attention-deficit/hyperactivity disorder in children with fetal alcohol spectrum disorder. | Doig J et al. | β | 2008 | β |
| Use of psychotropic medications in children with developmental disabilities. | Calles JL | β | 2008 | β |
| Chronic ethanol exposure causes mitochondrial dysfunction and oxidative stress in immature central nervous system neurons. | Chu J et al. | β | 2007 | β |
| Fetal Alcohol Spectrum Disorders: understanding the effects of prenatal alcohol exposure and supporting students. | Green JH | β | 2007 | β |
| Re-examining the core features of autism: a comparison of autism spectrum disorder and fetal alcohol spectrum disorder. | Bishop S et al. | β | 2007 | β |
| Relationship between dysmorphic features and general cognitive function in children with fetal alcohol spectrum disorders. | Ervalahti N et al. | β | 2007 | β |
| Risperidone treatment of preschool children with thermal burns and acute stress disorder. | Meighen KG et al. | β | 2007 | β |
| Association of attention deficit hyperactivity disorder and gestational alcohol exposure: an exploratory study. | Bhatara V et al. | β | 2006 | β |
| Early chronic ethanol exposure in rats disturbs respiratory network activity and increases sensitivity to ethanol. | Dubois C et al. | β | 2006 | β |
| Fetal alcohol spectrum disorders in Finland: clinical delineation of 77 older children and adolescents. | Autti-RΓ€mΓΆ I et al. | β | 2006 | β |
| Nicotinamide protects against ethanol-induced apoptotic neurodegeneration in the developing mouse brain. | Ieraci A et al. | β | 2006 | β |
| Pediatric bipolar disorder: emerging diagnostic and treatment approaches. | Kowatch RA et al. | β | 2006 | β |
| Disorders of attention or learning in neurodevelopmental disorders. | Ewen JB et al. | β | 2005 | β |
| Neuropathological examination of fetal rat brain in the 5-bromo-2'-deoxyuridine-induced neurodevelopmental disorder model. | Ogawa T et al. | β | 2005 | β |
| Treatment guidelines for children and adolescents with bipolar disorder. | Kowatch RA et al. | β | 2005 | β |
| Characteristics of children who have full or incomplete fetal alcohol syndrome. | Kvigne VL et al. | β | 2004 | β |
| Cost of fetal alcohol spectrum disorders. | Lupton C et al. | β | 2004 | β |
| Fetal alcohol syndrome in the United States corrections system. | Burd L et al. | β | 2004 | β |
| Fetal, infant, and child mortality in a context of alcohol use. | Burd L et al. | β | 2004 | β |