Metabolomics for laboratory diagnostics.
paper
Cited
Public
Unavailable
- Authors
- Bujak, Renata; Struck-Lewicka, Wiktoria; Markuszewski, MichaΕ J; Kaliszan, Roman
- Year
- 2015
- Journal
- Journal of pharmaceutical and biomedical analysis
- PMID
- 25577715
- DOI
- 10.1016/j.jpba.2014.12.017
Metabolomics is an emerging approach in a systems biology field. Due to continuous development in advanced analytical techniques and in bioinformatics, metabolomics has been extensively applied as a novel, holistic diagnostic tool in clinical and biomedical studies. Metabolome's measurement, as a chemical reflection of a current phenotype of a particular biological system, is nowadays frequently implemented to understand pathophysiological processes involved in disease progression as well as to search for new diagnostic or prognostic biomarkers of various organism's disorders. In this review, we discussed the research strategies and analytical platforms commonly applied in the metabolomics studies. The applications of the metabolomics in laboratory diagnostics in the last 5 years were also reviewed according to the type of biological sample used in the metabolome's analysis. We also discussed some limitations and further improvements which should be considered taking in mind potential applications of metabolomic research and practice.
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| Challenges in Translating Clinical Metabolomics Data SetsΒ from the Bench to the Bedside. | Ulmer CZ et al. | β | 2021 | β |
| Comparing Metabolomics Profiles in Various Types of Liquid Biopsies among Screening Participants with and without Advanced Colorectal Neoplasms. | Erben V et al. | β | 2021 | β |
| Comparison of bacteria disintegration methods and their influence on data analysis in metabolomics. | Mielko KA et al. | β | 2021 | β |
| Comprehensive Metabolomic Analysis Reveals Dynamic Metabolic Reprogramming in Hep3B Cells with Aflatoxin B1 Exposure. | Wang S et al. | β | 2021 | β |
| Contribution of Metabolomics to Multiple Sclerosis Diagnosis, Prognosis and Treatment. | Rispoli MG et al. | β | 2021 | β |
| Correlation of Metabolic Profiles of Plasma and Cerebrospinal Fluid of High-Grade Glioma Patients. | Rogachev AD et al. | β | 2021 | β |
| Development of computational models using omics data for the identification of effective cancer metabolic biomarkers. | Lee SM et al. | β | 2021 | β |
| Differential modulation of polyunsaturated fatty acids in patients with myocardial infarction treated with ticagrelor or clopidogrel. | Samman KN et al. | β | 2021 | β |
| Epigenomic and Metabolomic Integration Reveals Dynamic Metabolic Regulation in Bladder Cancer. | Loras A et al. | β | 2021 | β |
| Hepatic lipid metabolomics in response to heat stress in local broiler chickens breed (Huaixiang chickens). | Guo Y et al. | β | 2021 | β |
| Lipid Metabolism in the Development and Progression of Vascular Cognitive Impairment: A Systematic Review. | Qin Q et al. | β | 2021 | β |
| Mass spectrometry with derivatization method for concurrent measurement of amino acids and acylcarnitines in plasma of diabetic type 2 patients with diabetic nephropathy. | Esmati P et al. | β | 2021 | β |
| Metabolic Alterations Associated with Ξ³-Hydroxybutyric Acid and the Potential of Metabolites as Biomarkers of Its Exposure. | Jung S et al. | β | 2021 | β |
| Metabolic Phenotypes in Asthmatic Adults: Relationship with Inflammatory and Clinical Phenotypes and Prognostic Implications. | Santos A et al. | β | 2021 | β |
| Metabolic profiling of liver and faeces in mice infected with echinococcosis. | Zhu M et al. | β | 2021 | β |
| Metabolic Signature of Arrhythmogenic Cardiomyopathy. | Volani C et al. | β | 2021 | β |
| Metabolomic Profiling for Diagnosis and Prognostication in Surgery: A Scoping Review. | Khan TA et al. | β | 2021 | β |
| Metabolomic Profiling Reveals That 5-Hydroxylysine and 1-Methylnicotinamide Are Metabolic Indicators of Keloid Severity. | Shan M et al. | β | 2021 | β |
| Metabolomics analysis of serum in pediatric nephrotic syndrome based on targeted and non-targeted platforms. | Guo J et al. | β | 2021 | β |
| Metabolomics Analysis of the Development of Sepsis and Potential Biomarkers of Sepsis-Induced Acute Kidney Injury. | Ping F et al. | β | 2021 | β |
| Metabolomics and microbiome profiling as biomarkers in obstructive sleep apnoea: a comprehensive review. | Zhang X et al. | β | 2021 | β |
| Metabolomics as an Important Tool for Determining the Mechanisms of Human Skeletal Muscle Deconditioning. | Alldritt I et al. | β | 2021 | β |
| Metabolomic Signature Between Metabolically Healthy Overweight/Obese and Metabolically Unhealthy Overweight/Obese: A Systematic Review. | Cheng D et al. | β | 2021 | β |
| Metabolomic Signatures of Autoimmune Hepatitis in the Development of Cirrhosis. | Li SS et al. | β | 2021 | β |
| Narrative review of metabolomics in cardiovascular disease. | MΓΌller J et al. | β | 2021 | β |
| Personal Metabolomics: A Global Challenge. | Lokhov PG et al. | β | 2021 | β |
| Plasma Metabolomics Reveals Metabolic Profiling For Diabetic Retinopathy and Disease Progression. | Sun Y et al. | β | 2021 | β |
| Pre- and Post-treatment Levels of Plasma Metabolites in Patients With Bipolar Depression. | Guo XJ et al. | β | 2021 | β |
| Pursuing Multiple Biomarkers for Early Idiopathic Parkinson's Disease Diagnosis. | Gopar-Cuevas Y et al. | β | 2021 | β |
| Serum metabolic profile of postoperative acute kidney injury following infant cardiac surgery with cardiopulmonary bypass. | Davidson JA et al. | β | 2021 | β |
| Serum metabolomics in chickens infected with Cryptosporidium baileyi. | Wu XM et al. | β | 2021 | β |
| Sex-Specific Relationship between the Cardiorespiratory Fitness and Plasma Metabolite Patterns in Healthy Humans-Results of the KarMeN Study. | Kistner S et al. | β | 2021 | β |
| Slit2-Mediated Metabolic Reprogramming in Bone Marrow-Derived Macrophages Enhances Antitumor Immunity. | Kaul K et al. | β | 2021 | β |
| Understanding the pathophysiological changes via untargeted metabolomics in COVID-19 patients. | DoΔan HO et al. | β | 2021 | β |
| A contemporary insight of metabolomics approach for COVID-19: Potential for novel therapeutic and diagnostic targets. | Asim M et al. | β | 2020 | β |
| Alterations in Metabolites Associated with Hypoxemia in Neonates and Infants with Congenital Heart Disease. | Pagano E et al. | β | 2020 | β |
| Analysis of biomarkers and metabolic pathways in patients with unstable angina based on ultraβhighβperformance liquid chromatographyβquadrupole timeβofβflight mass spectrometry. | Liu Y et al. | β | 2020 | β |
| An NMR-Based Approach to Identify Urinary Metabolites Associated with Acute Physical Exercise and Cardiorespiratory Fitness in Healthy Humans-Results of the KarMeN Study. | Kistner S et al. | β | 2020 | β |
| A novel serum metabolome score for breast cancer diagnosis. | Rashed R et al. | β | 2020 | β |
| An Overview of the Application of Systems Biology in an Understanding of Chronic Rhinosinusitis (CRS) Development. | Michalik M et al. | β | 2020 | β |
| Changes in Amino Acid and Acylcarnitine Plasma Profiles for Distinguishing Patients with Multiple Sclerosis from Healthy Controls. | Kasakin MF et al. | β | 2020 | β |
| Circulating Metabolites as Potential Biomarkers for Neurological Disorders-Metabolites in Neurological Disorders. | Donatti A et al. | β | 2020 | β |
| Estrogen Deprivation and Myocardial Infarction: Role of Aerobic Exercise Training, Inflammation and Metabolomics. | Ruberti OM et al. | β | 2020 | β |
| Identification of Metabonomics Changes in Longissimus Dorsi Muscle of Finishing Pigs Following Heat Stress through LC-MS/MS-Based Metabonomics Method. | Gao J et al. | β | 2020 | β |
| Metabolomics Profiling of Critically Ill Coronavirus Disease 2019 Patients: Identification of Diagnostic and Prognostic Biomarkers. | Fraser DD et al. | β | 2020 | β |
| Metabolomics profiling to investigate nanomaterial toxicity <i>inΒ vitro</i> and <i>inΒ vivo</i>. | Bannuscher A et al. | β | 2020 | β |
| Metabolomics to Improve the Diagnostic Efficiency of Inborn Errors of Metabolism. | Mordaunt D et al. | β | 2020 | β |
| Metabonomic Insights into the Sperm Activation Mechanisms in Ricefield Eel (<i>Monopterus albus</i>). | Zhang H et al. | β | 2020 | β |
| Mouse Age Matters: How Age Affects the Murine Plasma Metabolome. | Pann P et al. | β | 2020 | β |
| New Diagnostic Approaches for Undiagnosed Rare Genetic Diseases. | Hartley T et al. | β | 2020 | β |
| Recommendations and Best Practices for Standardizing the Pre-Analytical Processing of Blood and Urine Samples in Metabolomics. | GonzΓ‘lez-DomΓnguez R et al. | β | 2020 | β |
| Research progress and perspective in metabolism and metabolomics of psoriasis. | Lian N et al. | β | 2020 | β |
| Saliva NMR-Based Metabolomics in the War Against COVID-19. | Costa Dos Santos Junior G et al. | β | 2020 | β |
| Synergistic therapeutic effects of Duzhong Jiangya Tablets and amlodipine besylate combination in spontaneously hypertensive rats using <sup>1</sup> H-NMR- and MS-based metabolomics. | Li J et al. | β | 2020 | β |
| Zika Virus Infection Results in Biochemical Changes Associated With RNA Editing, Inflammatory and Antiviral Responses in <i>Aedes albopictus</i>. | Onyango MG et al. | β | 2020 | β |
| 5,7,3',4'-flavan-on-ol (taxifolin) protects against acetaminophen-induced liver injury by regulating the glutathione pathway. | Hu C et al. | β | 2019 | β |
| A Preliminary Study of Uric Metabolomic Alteration for Postpartum Depression Based on Liquid Chromatography Coupled to Quadrupole Time-of-Flight Mass Spectrometry. | Zhang L et al. | β | 2019 | β |
| Changes in the Human Metabolome Associated With Alcohol Use: A Review. | Voutilainen T et al. | β | 2019 | β |
| Contribution of skeletal muscular glycine to rapid antidepressant effects of ketamine in an inflammation-induced mouse model of depression. | Huang N et al. | β | 2019 | β |
| Gas chromatography-mass spectrometry based serum metabolic analysis for premature infants and the relationship with necrotizing enterocolitis: a cross-sectional study. | Wang F et al. | β | 2019 | β |
| Hair Metabolomics in Animal Studies and Clinical Settings. | Jang WJ et al. | β | 2019 | β |
| High-Intensity Interval Training Decreases Resting Urinary Hypoxanthine Concentration in Young Active Men-A Metabolomic Approach. | Kistner S et al. | β | 2019 | β |
| Messenger RNA Delivery for Tissue Engineering and Regenerative Medicine Applications. | Patel S et al. | β | 2019 | β |
| Metabolomics Characterizes the Effects and Mechanisms of Quercetin in Nonalcoholic Fatty Liver Disease Development. | Xu Y et al. | β | 2019 | β |
| Metabolomics of the amniotic fluid: Is it a feasible approach to evaluate the safety of Chinese medicine during pregnancy? | Shan J et al. | β | 2019 | β |
| Protective effect of 7,3',4'-flavon-3-ol (fisetin) on acetaminophen-induced hepatotoxicity in vitro and in vivo. | Zhao L et al. | β | 2019 | β |
| Proteomic and metabolomic insights into the functions of the male reproductive system in fishes. | Dietrich MA et al. | β | 2019 | β |
| Serum Metabolic Profiling Identified a Distinct Metabolic Signature in Bladder Cancer Smokers: A Key Metabolic Enzyme Associated with Patient Survival. | Amara CS et al. | β | 2019 | β |
| Serum polyamine metabolic profile in autoimmune thyroid disease patients. | Song J et al. | β | 2019 | β |
| The application of metabolomics toward pulmonary tuberculosis research. | du Preez I et al. | β | 2019 | β |
| The applications of metabolomics in the molecular diagnostics of cancer. | Cheung PK et al. | β | 2019 | β |
| Urinary Metabolic Signatures Detect Recurrences in Non-Muscle Invasive Bladder Cancer. | Loras A et al. | β | 2019 | β |
| Commentary for Special Issue of Prevention Science "Using Genetics in Prevention: Science Fiction or Science Fact?" | Dick DM | β | 2018 | β |
| Discrimination of patients with different serological evolution of HIV and co-infection with HCV using metabolic fingerprinting based on Fourier transform infrared. | Pizarro C et al. | β | 2018 | β |
| Effects of cold exposure on metabolites in brown adipose tissue of rats. | Hiroshima Y et al. | β | 2018 | β |
| Elemental metabolomics. | Zhang P et al. | β | 2018 | β |
| GC-MS based metabolomics used for the identification of cancer volatile organic compounds as biomarkers. | Lubes G et al. | β | 2018 | β |
| Maternal plasma metabolic fingerprint indicative for fetal Down syndrome. | Parfieniuk E et al. | β | 2018 | β |
| Metabolomic Fingerprinting of Infants Undergoing Cardiopulmonary Bypass: Changes in Metabolic Pathways and Association With Mortality and Cardiac Intensive Care Unit Length of Stay. | Davidson JA et al. | β | 2018 | β |
| Metabolomics analysis of alloxan-induced diabetes in mice using UPLC-Q-TOF-MS after Crassostrea gigas polysaccharide treatment. | Zhao G et al. | β | 2018 | β |
| Metabolomics and Biomarker Discovery in Traumatic Brain Injury. | Banoei MM et al. | β | 2018 | β |
| Metabolomic Signature of Endometrial Cancer. | Troisi J et al. | β | 2018 | β |
| Prediction of Clinical Endpoints in Breast Cancer Using NMR Metabolic Profiles. | Euceda LR et al. | β | 2018 | β |
| Serum metabolic profiling identified a distinct metabolic signature in patients with idiopathic pulmonary fibrosis - a potential biomarker role for LysoPC. | Rindlisbacher B et al. | β | 2018 | β |
| Serum metabolomics study of nutrient metabolic variations in chronic heat-stressed broilers. | Lu Z et al. | β | 2018 | β |
| Untargeted search and identification of metabolites of antiviral agent camphecene in rat urine by liquid chromatography and mass spectrometry and studying their distribution in organs following peroral administration of the compound. | Rogachev AD et al. | β | 2018 | β |
| Applications of Metabolomics in Cancer Studies. | Armitage EG et al. | β | 2017 | β |
| Designing and interpreting 'multi-omic' experiments that may change our understanding of biology. | Haas R et al. | β | 2017 | β |
| Development of LC-QTOF-MS method for human lung tissue fingerprinting. A preliminary application to nonsmall cell lung cancer. | Ciborowski M et al. | β | 2017 | β |
| Direct Analysis of Samples of Various Origin and Composition Using Specific Types of Mass Spectrometry. | ByliΕski H et al. | β | 2017 | β |
| Discovery and identification of potential biomarkers for alcohol-induced oxidative stress based on cellular metabolomics. | Hu Q et al. | β | 2017 | β |
| Earwax: A neglected body secretion or a step ahead in clinical diagnosis? A pilot study. | Shokry E et al. | β | 2017 | β |
| LC-MS-Based Metabolic Fingerprinting of Aqueous Humor. | Pietrowska K et al. | β | 2017 | β |
| Metabolomic-guided discovery of Alzheimer's disease biomarkers from body fluid. | Enche Ady CNA et al. | β | 2017 | β |
| Urine metabolomics of high-fat diet induced obesity using UHPLC-Q-TOF-MS. | Men L et al. | β | 2017 | β |
| An LC-MS based untargeted metabolomics study identified novel biomarkers for coronary heart disease. | Li R et al. | β | 2016 | β |
| A Review of Analytical Techniques and Their Application in Disease Diagnosis in Breathomics and Salivaomics Research. | Beale DJ et al. | β | 2016 | β |
| Metabolomics - A wide-open door to personalized treatment in chronic heart failure? | Marcinkiewicz-Siemion M et al. | β | 2016 | β |
| Biomarkers of An Autoimmune Skin Disease--Psoriasis. | Jiang S et al. | β | 2015 | β |
| Gas-Sensing Performance of M-Doped CuO-Based Thin Films Working at Different Temperatures upon Exposure to Propane. | Rydosz A et al. | β | 2015 | β |