Liability to substance use disorders: 1. Common mechanisms and manifestations.
paper
Cited
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- Authors
- Vanyukov, Michael M; Tarter, Ralph E; Kirisci, Levent; Kirillova, Galina P; Maher, Brion S; Clark, Duncan B
- Year
- 2003
- Journal
- Neuroscience and biobehavioral reviews
- PMID
- 14599432
- DOI
- 10.1016/j.neubiorev.2003.08.002
Variation in the risk for and severity of substance use disorders (SUD) in the population is caused by multiple organismic (genetic, biochemical, psychological) and environmental factors. Whereas drug- or drug-class-specific liability mechanisms exist, a substantial proportion of variance in the risk is shared between specific liabilities, reflecting mechanisms that determine common liability to SUD. Data from epidemiologic, clinical, psychological, physiological, biochemical, and family and genetic studies reviewed in this paper indicate the existence of mechanisms and characteristics shared in common by liabilities to SUD related to different drugs. These mechanisms can be conceptualized as common liability to SUD, a latent trait accounting for a substantial portion of variation in SUD risk and severity and determined by all factors influencing the probability of SUD development. An accompanying paper describes an approach to the quantitative estimation of this trait.
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| Title | Authors | Journal | Year | Link |
|---|---|---|---|---|
| Mental health matters? An examination of how anxiety and depression influence the alcohol-e-cigarette use relationship. | Richards VL et al. | β | 2026 | β |
| Behavioral, personality, and temperamental characteristics predict escalating alcohol and cannabis use and problems during the first-year of college | Benca-Bachman CE et al. | β | 2025 | β |
| Interplay of cultural beliefs, psychological disposition, and social milieu during childhood on development of substance use disorder by early adulthood. | Kirisci L et al. | β | 2025 | β |
| The Impact of Substance Use Disorder and Drug Transfer into Breast Milk: Implications for Maternal and Infant Health. | Yang Y et al. | β | 2025 | β |
| The Youth Risk Index: psychometrics, predicting the initiation of early adolescent substance use, and the breadth of liability detected. | Ridenour TA et al. | β | 2025 | β |
| Problematic alcohol use among gay, bisexual, and other men who have sex with men in Canada: the role of proximal stressors and anxiety. | Zahran A et al. | β | 2024 | β |
| Stigmata that are desired: Contradictions in addiction. | Vanyukov MM | β | 2024 | β |
| First use of cannabis compared to first use of alcohol and tobacco: Associations with single and poly-substance use behavior. | Cohn AM et al. | β | 2023 | β |
| Multilevel Risk and Protective Factors for Frequent and Nonfrequent Past-30-Day Marijuana Use: Findings From a Representative Sample of High School Youth. | Lensch T et al. | β | 2023 | β |
| Repeated Cocaine Intake Differentially Impacts Striatal D<sub>2/3</sub> Receptor Availability, Psychostimulant-Induced Dopamine Release, and Trait Behavioral Markers of Drug Abuse. | UrueΓ±a-MΓ©ndez G et al. | β | 2023 | β |
| THC and CBD: Villain versus Hero? Insights into Adolescent Exposure. | Pintori N et al. | β | 2023 | β |
| The Concept of Resistance to Substance Use and a Research Approach: The Resist! Project. | Vanyukov MM et al. | β | 2023 | β |
| The Genetically Informed Neurobiology of Addiction (GINA) model. | Bogdan R et al. | β | 2023 | β |
| Positive associations between cannabis and alcohol use polygenic risk scores and phenotypic opioid misuse among African-Americans. | Rabinowitz JA et al. | β | 2022 | β |
| Alcohol substitution during one month of cannabis abstinence among non-treatment seeking youth. | Schuster RM et al. | β | 2021 | β |
| A systematic review of gene-by-intervention studies of alcohol and other substance use. | Neale ZE et al. | β | 2021 | β |
| Do the Transmissible Liability Index (TLI) and Adolescent Cannabis Use Predict Paranoid and Schizotypal Symptoms at Young Adulthood? | Sharma P et al. | β | 2021 | β |
| Identification of novel risk loci with shared effects on alcoholism, heroin, and methamphetamine dependence. | Sun Y et al. | β | 2021 | β |
| Mental health and music engagement: review, framework, and guidelines for future studies. | Gustavson DE et al. | β | 2021 | β |
| Nonmedical Cannabis Use: Patterns and Correlates of Use, Exposure, and Harm, and Cancer Risk. | Cohn AM et al. | β | 2021 | β |
| The Etiologic, Theory-Based, Ontogenetic Hierarchical Framework of Alcohol Use Disorder: A Translational Systematic Review of Reviews. | Boness CL et al. | β | 2021 | β |
| Analysis of substance use and its outcomes by machine learning: II. Derivation and prediction of the trajectory of substance use severity. | Hu Z et al. | β | 2020 | β |
| Derivation and assessment of the opioid use disorder severity scale: prediction of health, psychological and social adjustment problems. | Kirisci L et al. | β | 2020 | β |
| Forecasting Opioid Use Disorder at 25Β Years of Age in 16-Year-Old Adolescents. | Tarter RE et al. | β | 2020 | β |
| Measuring the temporal association between cannabis and tobacco use among Co-using young adults using ecological momentary assessment. | Wilhelm J et al. | β | 2020 | β |
| Role of genetic background in the effects of adolescent nicotine exposure on mesolimbic dopamine transmission. | Cadoni C et al. | β | 2020 | β |
| The risk for drug abuse, alcohol use disorder, and psychosocial dysfunction in offspring from high-density pedigrees: its moderation by personal, family, and community factors. | Kendler KS et al. | β | 2020 | β |
| Total Recall: Lateral Habenula and Psychedelics in the Study of Depression and Comorbid Brain Disorders. | Vitkauskas M et al. | β | 2020 | β |
| Dysregulation as a correlate of cannabis use and problem use. | Lopez-Vergara HI et al. | β | 2019 | β |
| Explaining Excessive Weight Gain during Early Recovery from Addiction. | Gottfredson NC et al. | β | 2019 | β |
| Identifying trajectories of alcohol use in a sample of secondary school students in Ontario and Alberta: longitudinal evidence from the COMPASS study. | Gohari MR et al. | β | 2019 | β |
| Onset, Comorbidity, and Predictors of Nicotine, Alcohol, and Marijuana Use Disorders Among North American Indigenous Adolescents. | Hautala D et al. | β | 2019 | β |
| The Effects of Marijuana Use on Transitions through Stages of Alcohol Involvement for Men and Women in the NESARC I and II. | Green KM et al. | β | 2019 | β |
| The Relationship Between Tobacco and Cannabis Use: A Review. | Lemyre A et al. | β | 2019 | β |
| A brief validated screen to identify boys and girls at risk for early marijuana use. | Loeber R et al. | β | 2018 | β |
| Global white matter microstructural abnormalities associated with addiction liability score in drug naΓ―ve youth. | Hulvershorn L et al. | β | 2018 | β |
| Informing Prevention and Intervention Policy Using Genetic Studies of Resistance. | Maher BS et al. | β | 2018 | β |
| Population-level patterns and mental health and substance use correlates of alcohol, marijuana, and tobacco use and co-use in US young adults and adults: Results from the population assessment for tobacco and health. | Cohn AM et al. | β | 2018 | β |
| Smoking Cessation for Those Pursuing Recovery from Substance Use Disorders. | Derefinko KJ et al. | β | 2018 | β |
| Determining non-cigarette tobacco, alcohol, and substance use typologies across menthol and non-menthol smokers using latent class analysis. | Cohn A et al. | β | 2017 | β |
| Preadolescent sensation seeking and early adolescent stress relate to at-risk adolescents' substance use by age 15. | Charles NE et al. | β | 2017 | β |
| Rural and urban comparisons of polysubstance use profiles and associated injection behaviors among people who inject drugs in Puerto Rico. | Hautala D et al. | β | 2017 | β |
| Association of the OPRM1 Variant rs1799971 (A118G) with Non-Specific Liability to Substance Dependence in a Collaborative de novo Meta-Analysis of European-Ancestry Cohorts. | Schwantes-An TH et al. | β | 2016 | β |
| Characterizing substance use and mental health profiles of cigar, blunt, and non-blunt marijuana users from the National Survey of Drug Use and Health. | Cohn A et al. | β | 2016 | β |
| Family Functioning as a Mediator of Relations between Family History of Substance Use Disorder and Impulsivity. | Ryan SR et al. | β | 2016 | β |
| Introduction to Metrics in Person Centered Medicine Research. | Kirisci L et al. | β | 2016 | β |
| Item Response Theory Analysis to Assess Dimensionality of Substance Use Disorder Abuse and Dependence Symptoms. | Kirisci L et al. | β | 2016 | β |
| Menthol tobacco use is correlated with mental health symptoms in a national sample of young adults: implications for future health risks and policy recommendations. | Cohn AM et al. | β | 2016 | β |
| Nicotinic acetylcholine receptors: upregulation, age-related effects and associations with drug use. | Melroy-Greif WE et al. | β | 2016 | β |
| Patterns of the co-use of alcohol, marijuana, and emerging tobacco products in a national sample of young adults. | Cohn AM et al. | β | 2016 | β |
| Racial and ethnic trends and correlates of non-medical use of prescription opioids among adolescents in the United States 2004-2013. | Vaughn MG et al. | β | 2016 | β |
| Restless Sleep and Variable Sleep Timing During Late Childhood Accelerate the Onset of Alcohol and Other Drug Involvement. | Hasler BP et al. | β | 2016 | β |
| Risk and resistance perspectives in translation-oriented etiology research. | Vanyukov MM et al. | β | 2016 | β |
| Visited a vape shop? Prevalence and correlates from a national sample of U.S. young adults. | Rose SW et al. | β | 2016 | β |
| Was it the drink? The conditioned association of alcohol and desire to quit smoking on the dual use of little cigars/cigarillos and cigarettes among men and women. | Ehlke SJ et al. | β | 2016 | β |
| Aggression as a Predictor of Early Substance Use Initiation among Youth with Family Histories of Substance Use Disorders. | Mathias CW et al. | β | 2015 | β |
| Comorbidity and temporal relations of alcohol and cannabis use disorders from youth through adulthood. | Duncan SC et al. | β | 2015 | β |
| Does the Transmissible Liability Index (TLI) assessed in late childhood predict suicidal symptoms at young adulthood? | Cornelius JR et al. | β | 2015 | β |
| Externalizing behavior and emotion dysregulation are indicators of transmissible risk for substance use disorder. | Kirisci L et al. | β | 2015 | β |
| Genetic relationship between the addiction diagnosis in adults and their childhood measure of addiction liability. | Vanyukov M et al. | β | 2015 | β |
| Longitudinal Modeling of the Association Between Transmissible Risk, Affect During Drug Use and Development of Substance Use Disorder. | Tarter RE et al. | β | 2015 | β |
| Progression to regular heroin use: examination of patterns, predictors, and consequences. | Woodcock EA et al. | β | 2015 | β |
| Risky behaviors, e-cigarette use and susceptibility of use among college students. | Saddleson ML et al. | β | 2015 | β |
| Sex differences in self-report and behavioral measures of disinhibition predicting marijuana use across adolescence. | Felton JW et al. | β | 2015 | β |
| Sleep and circadian contributions to adolescent alcohol use disorder. | Hasler BP et al. | β | 2015 | β |
| Temperament disturbances measured in infancy progress to substance use disorder 20 years later. | Horner MS et al. | β | 2015 | β |
| A new approach to researching the etiology of cannabis use disorder: integrating transmissible and nontransmissible risk within a developmental framework. | Tarter R et al. | β | 2014 | β |
| Comparative gene expression profiling analysis of lymphoblastoid cells reveals neuron-specific enolase gene (ENO2) as a susceptibility gene of heroin dependence. | Liao DL et al. | β | 2014 | β |
| Delay discounting differentiates pre-adolescents at high and low risk for substance use disorders based on family history. | Dougherty DM et al. | β | 2014 | β |
| Does stress mediate the development of substance use disorders among youth transitioning to young adulthood? | Cornelius J et al. | β | 2014 | β |
| Drug addiction and stress-response genetic variability: association study in African Americans. | Levran O et al. | β | 2014 | β |
| Drug Use among Residents of Juvenile Correctional Center in Kerman, Iran, and its Relationship with Personality Dimensions and Self-concept. | Gousheh A et al. | β | 2014 | β |
| Early adolescent patterns of alcohol, cigarettes, and marijuana polysubstance use and young adult substance use outcomes in a nationally representative sample. | Moss HB et al. | β | 2014 | β |
| Identifying childhood characteristics that underlie premorbid risk for substance use disorders: socialization and boldness. | Hicks BM et al. | β | 2014 | β |
| Longitudinal trajectories of sensation seeking, risk taking propensity, and impulsivity across early to middle adolescence. | Collado A et al. | β | 2014 | β |
| Moving beyond misuse and diversion: the urgent need to consider the role of iatrogenic addiction in the current opioid epidemic. | Beauchamp GA et al. | β | 2014 | β |
| Predictors of onset of cannabis and other drug use in male young adults: results from a longitudinal study. | Haug S et al. | β | 2014 | β |
| Age of alcohol and cannabis use onset mediates the association of transmissible risk in childhood and development of alcohol and cannabis disorders: evidence for common liability. | Kirisci L et al. | β | 2013 | β |
| Assessing TLI as a Predictor of Treatment Seeking for SUD among Youth Transitioning to Young Adulthood. | Cornelius JR et al. | β | 2013 | β |
| Circadian misalignment, reward-related brain function, and adolescent alcohol involvement. | Hasler BP et al. | β | 2013 | β |
| Estimation of BDNF gene polymorphism and predisposition to dependence development for selected psychoactive compounds: genetic aspects of addiction with the selected drugs, amphetamine, tetrahydrocannabinol and opiates. | Biskupska J et al. | β | 2013 | β |
| Gender differences in prevalence of substance use disorders among individuals with lifetime exposure to substances: results from a large representative sample. | Lev-Ran S et al. | β | 2013 | β |
| Impulsivity-related personality traits and adolescent alcohol use: a meta-analytic review. | Stautz K et al. | β | 2013 | β |
| Longitudinal modeling of transmissible risk in boys who subsequently develop cannabis use disorder. | Kirisci L et al. | β | 2013 | β |
| Modeling the association between sexual maturation, transmissible risk, and peer relationships during childhood and adolescence on development of substance use disorder in young adulthood. | Horner MS et al. | β | 2013 | β |
| Quick screen to detect current substance use disorder in adolescents and the likelihood of future disorder. | Kirisci L et al. | β | 2013 | β |
| Relation among HPA and HPG neuroendocrine systems, transmissible risk and neighborhood quality on development of substance use disorder: results of a 10-year prospective study. | Tarter RE et al. | β | 2013 | β |
| Transitioning from DSM-IV abuse to dependence: the essence of harmful compulsive substance use is ontogenetic and dynamic. | Ridenour TA | β | 2013 | β |
| Adolescent non-suicidal self-injury: a cross-national study of community samples from Italy, the Netherlands and the United States. | Giletta M et al. | β | 2012 | β |
| A longitudinal examination of the relationships between childhood maltreatment and patterns of adolescent substance use among high-risk adolescents. | Hyucksun Shin S | β | 2012 | β |
| Application of person-centered medicine in addiction. | Tarter RE et al. | β | 2012 | β |
| Common liability to addiction and "gateway hypothesis": theoretical, empirical and evolutionary perspective. | Vanyukov MM et al. | β | 2012 | β |
| Common liability to drug addictions: theory, research, practice. | Vanyukov MM et al. | β | 2012 | β |
| Computer adaptive testing of liability to addiction: identifying individuals at risk. | Kirisci L et al. | β | 2012 | β |
| Decline in genetic influence on the co-occurrence of alcohol, marijuana, and nicotine dependence symptoms from age 14 to 29. | Vrieze SI et al. | β | 2012 | β |
| Developmental momentum toward substance dependence: natural histories and pliability of risk factors in youth experiencing chronic stress. | Ridenour TA et al. | β | 2012 | β |
| Does the "gateway" sequence increase prediction of cannabis use disorder development beyond deviant socialization? Implications for prevention practice and policy. | Tarter RE et al. | β | 2012 | β |
| Genetic etiology of the common liability to drug dependence: evidence of common and specific mechanisms for DSM-IV dependence symptoms. | Palmer RH et al. | β | 2012 | β |
| Impulsivity differences in recreational cannabis users and binge drinkers in a university population. | Moreno M et al. | β | 2012 | β |
| Index of the transmissible common liability to addiction: heritability and prospective associations with substance abuse and related outcomes. | Hicks BM et al. | β | 2012 | β |
| Revisiting the concepts of risk and protective factors for understanding the etiology and development of substance use and substance use disorders: implications for prevention. | Sloboda Z et al. | β | 2012 | β |
| Separate and combined effects of the GABA reuptake inhibitor tiagabine and Ξ9-THC in humans discriminating Ξ9-THC. | Lile JA et al. | β | 2012 | β |
| Subjective effects for alcohol, tobacco, and marijuana association with cross-drug outcomes. | Zeiger JS et al. | β | 2012 | β |
| The genetics of the opioid system and specific drug addictions. | Levran O et al. | β | 2012 | β |
| The P300 event-related brain potential as a neurobiological endophenotype for substance use disorders: a meta-analytic investigation. | Euser AS et al. | β | 2012 | β |
| Common and drug-specific genetic influences on subjective effects to alcohol, tobacco and marijuana use. | Haberstick BC et al. | β | 2011 | β |
| Could a continuous measure of individual transmissible risk be useful in clinical assessment of substance use disorder? Findings from the National Epidemiological Survey on Alcohol and Related Conditions. | Ridenour TA et al. | β | 2011 | β |
| Deviant socialization mediates transmissible and contextual risk on cannabis use disorder development: a prospective study. | Tarter RE et al. | β | 2011 | β |
| Failure to sustain prepulse inhibition in adolescent marijuana users. | Mathias CW et al. | β | 2011 | β |
| The AVPR1A gene and substance use disorders: association, replication, and functional evidence. | Maher BS et al. | β | 2011 | β |
| Measuring addiction propensity and severity: the need for a new instrument. | Conway KP et al. | β | 2010 | β |
| PTSD contributes to teen and young adult cannabis use disorders. | Cornelius JR et al. | β | 2010 | β |
| The reinforcing, self-reported performance and physiological effects of Delta9-tetrahydrocannabinol, triazolam, hydromorphone, and methylphenidate in cannabis users. | Lile JA et al. | β | 2010 | β |
| Developmental epidemiology of drug use and abuse in adolescence and young adulthood: Evidence of generalized risk. | Palmer RH et al. | β | 2009 | β |
| Does report of craving opioid medication predict aberrant drug behavior among chronic pain patients? | Wasan AD et al. | β | 2009 | β |
| Do pain patients at high risk for substance misuse experience more pain? A longitudinal outcomes study. | Jamison RN et al. | β | 2009 | β |
| Genetic variation in components of dopamine neurotransmission impacts ventral striatal reactivity associated with impulsivity. | Forbes EE et al. | β | 2009 | β |
| Infusing neuroscience into the study and prevention of drug misuse and co-occurring aggressive behavior. | Fishbein D et al. | β | 2009 | β |
| Introduction and rationale for individualized substance abuse prevention from an ontogenetic perspective. | Ridenour TA et al. | β | 2009 | β |
| Measurement of the risk for substance use disorders: phenotypic and genetic analysis of an index of common liability. | Vanyukov MM et al. | β | 2009 | β |
| Prediction of cannabis use disorder between boyhood and young adulthood: clarifying the phenotype and environtype. | Kirisci L et al. | β | 2009 | β |
| Underage alcohol use: summary of developmental processes and mechanisms: ages 16-20. | Brown SA et al. | β | 2009 | β |
| A developmental perspective on alcohol and youths 16 to 20 years of age. | Brown SA et al. | β | 2008 | β |
| Adolescent cannabis users at 24 years: trajectories to regular weekly use and dependence in young adulthood. | Swift W et al. | β | 2008 | β |
| Adolescents' self-defined tobacco use status, marijuana use, and tobacco dependence. | Okoli CTC et al. | β | 2008 | β |
| Alcohol, psychological dysregulation, and adolescent brain development. | Clark DB et al. | β | 2008 | β |
| Behavioral disinhibition and the development of early-onset addiction: common and specific influences. | Iacono WG et al. | β | 2008 | β |
| Meta-analysis of depression and substance use and impairment among cocaine users. | Conner KR et al. | β | 2008 | β |
| Neurobiological processes in adolescent addictive disorders. | Schepis TS et al. | β | 2008 | β |
| Neurobiology of addiction. An integrative review. | Goodman A | β | 2008 | β |
| Physical maturation, peer environment, and the ontogenesis of substance use disorders. | Kirillova GP et al. | β | 2008 | β |
| Acute and non-acute effects of cannabis on brain functioning and neuropsychological performance. | Gonzalez R | β | 2007 | β |
| Cognitive impulsivity in cocaine and heroin polysubstance abusers. | Verdejo-GarcΓa AJ et al. | β | 2007 | β |
| Testosterone levels and sexual maturation predict substance use disorders in adolescent boys: a prospective study. | Reynolds MD et al. | β | 2007 | β |
| The MAOA promoter polymorphism, disruptive behavior disorders, and early onset substance use disorder: gene-environment interaction. | Vanyukov MM et al. | β | 2007 | β |
| Application of item response theory to quantify substance use disorder severity. | Kirisci L et al. | β | 2006 | β |
| Different lengths of times for progressions in adolescent substance involvement. | Ridenour TA et al. | β | 2006 | β |
| Heritability of P300 amplitude development from adolescence to adulthood. | Carlson SR et al. | β | 2006 | β |
| Predictors of marijuana use in adolescents before and after licit drug use: examination of the gateway hypothesis. | Tarter RE et al. | β | 2006 | β |
| Psychiatric comorbidity and progression in drug use in adult male twins: implications for the design of genetic association studies. | Todorov AA et al. | β | 2006 | β |
| Translating genetics, cognitive science, and other basic science research findings into applications for prevention. | Ames SL et al. | β | 2006 | β |
| Brain-derived neurotrophic factor (Val66Met) genetic polymorphism is associated with substance abuse in males. | Cheng CY et al. | β | 2005 | β |
| Detection of youth at high risk for substance use disorders: a longitudinal study. | Kirisci L et al. | β | 2005 | β |
| The impact of emotional stress early in life on adult voluntary ethanol intake-results of maternal separation in rats. | Roman E et al. | β | 2005 | β |
| Relation between cognitive distortions and neurobehavior disinhibition on the development of substance use during adolescence and substance use disorder by young adulthood: a prospective study. | Kirisci L et al. | β | 2004 | β |
| The natural history of adolescent alcohol use disorders. | Clark DB | β | 2004 | β |
| Trajectories of alcohol and drug use and dependence from adolescence to adulthood: the effects of familial alcoholism and personality. | Chassin L et al. | β | 2004 | β |
| Liability to substance use disorders: 2. A measurement approach. | Vanyukov MM et al. | β | 2003 | β |