Effort-related functions of nucleus accumbens dopamine and associated forebrain circuits.
paper
Cited
Public
Unavailable
- Authors
- Salamone, J D; Correa, M; Farrar, A; Mingote, S M
- Year
- 2007
- Journal
- Psychopharmacology
- PMID
- 17225164
- DOI
- 10.1007/s00213-006-0668-9
BACKGROUND: Over the last several years, it has become apparent that there are critical problems with the hypothesis that brain dopamine (DA) systems, particularly in the nucleus accumbens, directly mediate the rewarding or primary motivational characteristics of natural stimuli such as food. Hypotheses related to DA function are undergoing a substantial restructuring, such that the classic emphasis on hedonia and primary reward is giving way to diverse lines of research that focus on aspects of instrumental learning, reward prediction, incentive motivation, and behavioral activation. OBJECTIVE: The present review discusses dopaminergic involvement in behavioral activation and, in particular, emphasizes the effort-related functions of nucleus accumbens DA and associated forebrain circuitry. RESULTS: The effects of accumbens DA depletions on food-seeking behavior are critically dependent upon the work requirements of the task. Lever pressing schedules that have minimal work requirements are largely unaffected by accumbens DA depletions, whereas reinforcement schedules that have high work (e.g., ratio) requirements are substantially impaired by accumbens DA depletions. Moreover, interference with accumbens DA transmission exerts a powerful influence over effort-related decision making. Rats with accumbens DA depletions reallocate their instrumental behavior away from food-reinforced tasks that have high response requirements, and instead, these rats select a less-effortful type of food-seeking behavior. CONCLUSIONS: Along with prefrontal cortex and the amygdala, nucleus accumbens is a component of the brain circuitry regulating effort-related functions. Studies of the brain systems regulating effort-based processes may have implications for understanding drug abuse, as well as energy-related disorders such as psychomotor slowing, fatigue, or anergia in depression.
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| Restoration of dopamine signaling to the dorsal striatum is sufficient for aspects of active maternal behavior in female mice. | Henschen CW et al. | β | 2013 | β |
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| A high-fat meal, or intraperitoneal administration of a fat emulsion, increases extracellular dopamine in the nucleus accumbens. | Rada P et al. | β | 2012 | β |
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| GABA(A) and dopamine receptors in the nucleus accumbens shell differentially influence performance of a water-reinforced progressive ratio task. | Covelo IR et al. | β | 2012 | β |
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| Interaction between age of irradiation and age of testing in the disruption of operant performance using a ground-based model for exposure to cosmic rays. | Rabin BM et al. | β | 2012 | β |
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| Phasic mesolimbic dopamine signaling precedes and predicts performance of a self-initiated action sequence task. | Wassum KM et al. | β | 2012 | β |
| Possible role of dopamine D1-like and D2-like receptors in behavioural activation and evaluation of response efficacy in the forced swimming test. | D'Aquila PS et al. | β | 2012 | β |
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| Clomipramine, but not haloperidol or aripiprazole, inhibits quinpirole-induced water contrafreeloading, a putative animal model of compulsive behavior. | De Carolis L et al. | β | 2011 | β |
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| How addiction happens, how change happens, and what social workers need to know to be effective facilitators of change. | Littrell J | β | 2011 | β |
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| Dipeptide Tyr-Leu (YL) exhibits anxiolytic-like activity after oral administration via activating serotonin 5-HT1A, dopamine D1 and GABAA receptors in mice. | Kanegawa N et al. | β | 2010 | β |
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| Dissociable roles of the medial prefrontal cortex and nucleus accumbens core in goal-directed actions for differential reward magnitude. | Gill TM et al. | β | 2010 | β |
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| Metabolic hormones, dopamine circuits, and feeding. | Narayanan NS et al. | β | 2010 | β |
| Methamphetamine facilitates female sexual behavior and enhances neuronal activation in the medial amygdala and ventromedial nucleus of the hypothalamus. | Holder MK et al. | β | 2010 | β |
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