Overlapping neuronal circuits in addiction and obesity: evidence of systems pathology.
paper
Cited
Public
Unavailable
- Authors
- Volkow, Nora D; Wang, Gene-Jack; Fowler, Joanna S; Telang, Frank
- Year
- 2008
- Journal
- Philosophical transactions of the Royal Society of London. Series B, Biological sciences
- PMID
- 18640912
- DOI
- 10.1098/rstb.2008.0107
- PMCID
- PMC2607335
Drugs and food exert their reinforcing effects in part by increasing dopamine (DA) in limbic regions, which has generated interest in understanding how drug abuse/addiction relates to obesity. Here, we integrate findings from positron emission tomography imaging studies on DA's role in drug abuse/addiction and in obesity and propose a common model for these two conditions. Both in abuse/addiction and in obesity, there is an enhanced value of one type of reinforcer (drugs and food, respectively) at the expense of other reinforcers, which is a consequence of conditioned learning and resetting of reward thresholds secondary to repeated stimulation by drugs (abuse/addiction) and by large quantities of palatable food (obesity) in vulnerable individuals (i.e. genetic factors). In this model, during exposure to the reinforcer or to conditioned cues, the expected reward (processed by memory circuits) overactivates the reward and motivation circuits while inhibiting the cognitive control circuit, resulting in an inability to inhibit the drive to consume the drug or food despite attempts to do so. These neuronal circuits, which are modulated by DA, interact with one another so that disruption in one circuit can be buffered by another, which highlights the need of multiprong approaches in the treatment of addiction and obesity.
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| Expanding applications of deep brain stimulation: a potential therapeutic role in obesity and addiction management. | Halpern CH et al. | β | 2011 | β |
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| Ghrelin and food reward: the story of potential underlying substrates. | Skibicka KP et al. | β | 2011 | β |
| How Prevalent is "Food Addiction"? | Meule A | β | 2011 | β |
| Impulse control disorders in Parkinson's disease: seeking a roadmap toward a better understanding. | Cilia R et al. | β | 2011 | β |
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| Pilot study examining the frequency of several gene polymorphisms involved in morphine pharmacodynamics and pharmacokinetics in a morbidly obese population. | Lloret Linares C et al. | β | 2011 | β |
| Pornography addiction: A neuroscience perspective. | Hilton DL et al. | β | 2011 | β |
| Reduced nucleus accumbens and caudate nucleus activation to a pleasant taste is associated with obesity in older adults. | Green E et al. | β | 2011 | β |
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| What have positron emission tomography and 'Zippy' told us about the neuropharmacology of drug addiction? | Cumming P et al. | β | 2011 | β |
| What virtual reality research in addictions can tell us about the future of obesity assessment and treatment. | Bordnick PS et al. | β | 2011 | β |
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| Body mass index is associated with brain metabolite levels in alcohol dependence--a multimodal magnetic resonance study. | Gazdzinski S et al. | β | 2010 | β |
| Brain imaging studies of appetite in the context of obesity and the menstrual cycle. | Van Vugt DA | β | 2010 | β |
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| Chronic cigarette smoking: implications for neurocognition and brain neurobiology. | Durazzo TC et al. | β | 2010 | β |
| Chronic suppression of ΞΌ-opioid receptor signaling in the nucleus accumbens attenuates development of diet-induced obesity in rats. | Lenard NR et al. | β | 2010 | β |
| Cortical perfusion in alcohol-dependent individuals during short-term abstinence: relationships to resumption of hazardous drinking after treatment. | Durazzo TC et al. | β | 2010 | β |
| Decreased dopamine type 2 receptor availability after bariatric surgery: preliminary findings. | Dunn JP et al. | β | 2010 | β |
| Dietary restriction mitigates cocaine-induced alterations of olfactory bulb cellular plasticity and gene expression, and behavior. | Xu X et al. | β | 2010 | β |
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| Genetically determined differences in brain response to a primary food reward. | Felsted JA et al. | β | 2010 | β |
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| Individual differences in nucleus accumbens dopamine receptors predict development of addiction-like behavior: a computational approach. | Piray P et al. | β | 2010 | β |
| Insulin, leptin and reward. | Davis JF et al. | β | 2010 | β |
| Metabolite levels in the brain reward pathway discriminate those who remain abstinent from those who resume hazardous alcohol consumption after treatment for alcohol dependence. | Durazzo TC et al. | β | 2010 | β |
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| Neurobiology of hyperactivity and reward: agreeable restlessness in anorexia nervosa. | Scheurink AJ et al. | β | 2010 | β |
| Obesity-resistant S5B rats showed greater cocaine conditioned place preference than the obesity-prone OM rats. | Thanos PK et al. | β | 2010 | β |
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| Pavlovian to instrumental transfer: a neurobehavioural perspective. | Holmes NM et al. | β | 2010 | β |
| Progressive and lasting amplification of accumbal nicotine-seeking neural signals. | Guillem K et al. | β | 2010 | β |
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| Special issue in honor of professor Armen Galoyan. Preface. | Lajtha A | β | 2010 | β |
| Stress-induced obesity and the emotional nervous system. | Dallman MF | β | 2010 | β |
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| The emerging link between alcoholism risk and obesity in the United States. | Grucza RA et al. | β | 2010 | β |
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| The plausibility of sugar addiction and its role in obesity and eating disorders. | Benton D | β | 2010 | β |
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| The Treatment of Obesity and Its Co-occurrence with Substance Use Disorders. | Vanbuskirk KA et al. | β | 2010 | β |
| An expanded view of energy homeostasis: neural integration of metabolic, cognitive, and emotional drives to eat. | Shin AC et al. | β | 2009 | β |
| Effective connectivity of a reward network in obese women. | Stoeckel LE et al. | β | 2009 | β |
| Evidence of gender differences in the ability to inhibit brain activation elicited by food stimulation. | Wang GJ et al. | β | 2009 | β |
| Feeding signals to the hungry mind. | Balthasar N | β | 2009 | β |
| Imaging of brain dopamine pathways: implications for understanding obesity. | Wang GJ et al. | β | 2009 | β |
| Influence of conditioned reinforcement on the response-maintaining effects of quinpirole in rats. | Collins GT et al. | β | 2009 | β |
| Motivation for sucrose in sated rats is predicted by low anxiety-like behavior. | AlsiΓΆ J et al. | β | 2009 | β |
| Neurosystems linking corticolimbic and hypothalamic pathways in energy balance: view from the Chair. | Fulton S | β | 2009 | β |
| Reanalysis of the obesity-related attenuation in the left dorsolateral prefrontal cortex response to a satiating meal using gyral regions-of-interest. | Le DS et al. | β | 2009 | β |
| Reward networks in the brain as captured by connectivity measures. | Camara E et al. | β | 2009 | β |
| Sugar and fat bingeing have notable differences in addictive-like behavior. | Avena NM et al. | β | 2009 | β |
| Understanding and treating alcohol craving and dependence: recent pharmacological and neuroendocrinological findings. | Leggio L | β | 2009 | β |
| Introduction. The neurobiology of drug addiction: new vistas. | Robbins TW et al. | β | 2008 | β |