Role of C-reactive protein in schizophrenia: an overview.
paper
Cited
Public
Unavailable
- Authors
- Singh, Bisu; Chaudhuri, Tapas Kumar
- Year
- 2014
- Journal
- Psychiatry research
- PMID
- 24565000
- DOI
- 10.1016/j.psychres.2014.02.004
Over the years, schizophrenia is speculated to be associated with immune or inflammatory reactions mediated by cytokines. It is proposed that chronic inflammation might damage the micro-vascular system of brain and hamper cerebral blood flow. Scientific evidence suggests that an increase of stress hormone like norepinephrine may activate the inflammatory arm of the immune system and trigger the expression of genes that cause chronic, low-grade inflammation. Thus, studies were conducted to decipher the potentiality of CRP as a marker for inflammation in schizophrenia. This article reviews the findings of CRP in schizophrenia, and the limitations of the previous studies have been discussed. The importance of simultaneous study of CRP modulating cytokines and CRP gene polymorphism in the study of serum or plasma level of CRP has been emphasized.
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External
| Title | Authors | Journal | Year | Link |
|---|---|---|---|---|
| Can Non-specific Blood Inflammatory Biomarkers Predict Recovery in Acute Transient Psychotic Disorder? A Prospective Observational Study. | Prakash J et al. | β | 2025 | β |
| Cardiovascular Changes due to Antipsychotic Agents among First Episode Patients with Schizophrenia. | Iyidobi TO et al. | β | 2025 | β |
| Cell-free DNA in extracellular vesicles: A candidate biomarker of schizophrenia. | Bai YL et al. | β | 2025 | β |
| Changes in psychopathology and peripheral inflammation in schizophrenia patients initiating treatment with second-generation antipsychotics: a post-hoc analysis. | Heil M et al. | β | 2025 | β |
| Childhood trauma and inflammatory biomarker effects on cortical thinning in schizophrenia spectrum disorders. | Narvaez S et al. | β | 2025 | β |
| Integrative evidence for causal links between gut microbiota and Schizophrenia: A Mendelian randomization and 16S rRNA study. | Zeng J et al. | β | 2025 | β |
| Targeting endoplasmic reticulum stress and protein misfolding in schizophrenia: the emerging promise of sigma-1 receptor agonists. | Ahmed MK et al. | β | 2025 | β |
| The clinical utility of the immune status questionnaire as a marker of immune function among persons with schizophrenia. | Lee JY et al. | β | 2025 | β |
| The effects of dance intervention on clinical symptoms and cognitive deficits in hospitalized patients with chronic schizophrenia: a randomized controlled trial. | Li G et al. | β | 2025 | β |
| Anxiety caused by chronic exposure to methylisothiazolinone in zebrafish: Behavioral analysis, brain histology and gene responses. | Li R et al. | β | 2024 | β |
| The relationship between inflammatory markers, clinical characteristics, and cognitive performance in drug-naΓ―ve patients with schizophrenia. | Sun X et al. | β | 2024 | β |
| Cortisol and cytokines in schizophrenia: A scoping review. | Farcas A et al. | β | 2023 | β |
| Evaluating the association of vitamin D3, parathyroid hormone, and C-reactive protein serum levels in patients with an acute psychotic episode: a cross-sectional study in tertiary centre in Iran. | Arya S et al. | β | 2023 | β |
| Inflammation and cognitive performance in first-episode schizophrenia spectrum disorders: The moderating effects of childhood trauma. | KeΕkovΓ‘ B et al. | β | 2023 | β |
| Association of TLR-4 896A/G, TLR-4 1196C/T, and TLR-9 C/T polymorphism with schizophrenia in Indian Bengalee patient. | Gurung J et al. | β | 2022 | β |
| Could CRP be a differential biomarker of illness stages in schizophrenia? A systematic review and meta-analysis. | Lestra V et al. | β | 2022 | β |
| Persistent Childhood and Adolescent Anxiety and Risk for Psychosis: A Longitudinal Birth Cohort Study. | Morales-MuΓ±oz I et al. | β | 2022 | β |
| Association of a Novel <i>KIF26B</i> Gene Polymorphism with Susceptibility to Schizophrenia and Breast Cancer: A Case-Control Study. | Sargazi S et al. | β | 2021 | β |
| Neuropsychiatric disorders: An immunological perspective. | Aw E et al. | β | 2021 | β |
| Serum level of high sensitive C-reactive protein and IL -β6 markers in patients with treatment-resistant schizophrenia in Ethiopia: a comparative study. | Challa F et al. | β | 2021 | β |
| Association of C-reactive protein and metabolic risk with cognitive effects of lurasidone in patients with schizophrenia. | Miller BJ et al. | β | 2020 | β |
| Association of high-sensitivity C-reactive protein with susceptibility to Schizophrenia in Tunisian population. | Ayari F et al. | β | 2020 | β |
| Galectin-1 and Galectin-3 Levels in Patients with Schizophrenia and their Unaffected Siblings. | YΓΌksel RN et al. | β | 2020 | β |
| Higher Serum C-Reactive Protein Levels in Catatonic Patients: A Comparison to Non-catatonic Patients and Healthy Controls. | Zhou FC et al. | β | 2020 | β |
| Serum C-Reactive Protein in Patients with Deficit Schizophrenia and the Relationship with Cognitive Function. | Pan LH et al. | β | 2020 | β |
| Increased Dietary Inflammatory Index Is Associated with Schizophrenia: Results of a Case-Control Study from Bahrain. | Jahrami H et al. | β | 2019 | β |
| Increased serum levels of leptin and insulin in both schizophrenia and major depressive disorder: A cross-disorder proteomics analysis. | Γakici N et al. | β | 2019 | β |
| Serum Levels of High Sensitivity C-reactive Protein in Drug-naΓve First-episode Psychosis and Acute Exacerbation of Schizophrenia. | Bolu A et al. | β | 2019 | β |
| The Effects of Exercise on IL-6 Levels and Cognitive Performance in Patients with Schizophrenia. | GΓ³mez-Rubio P et al. | β | 2019 | β |
| Validation of oxidative stress assay for schizophrenia. | Kim E et al. | β | 2019 | β |
| Commentary: Physical Functional Capacity and C-Reactive Protein in Schizophrenia. | Elliesen R et al. | β | 2018 | β |
| C-Reactive Protein: Higher During Acute Psychotic Episodes and Related to Cortical Thickness in Schizophrenia and Healthy Controls. | Jacomb I et al. | β | 2018 | β |
| Elevated C-reactive protein as a predictor of a random one-year clinical course in the first ten years of schizophrenia. | Gonzalez-Blanco L et al. | β | 2018 | β |
| Elevated levels of C-reactive protein and IL-6 among the antipsychotic medicating schizophrenia patients of Siliguri, West Bengal, India. | Gurung J et al. | β | 2018 | β |
| Inflammatory biomarkers in individuals at clinical high risk for psychosis (CHR-P): State or trait? | Khoury R et al. | β | 2018 | β |
| Procalcitonin and C - reactive protein as peripheral inflammatory markers in antipsychotic drug-free schizophrenia patients. | Varun CN et al. | β | 2018 | β |
| Protein-C Reactive as Biomarker Predictor of Schizophrenia Phases of Illness? A Systematic Review. | Orsolini L et al. | β | 2018 | β |
| Psychosocial factors at work and inflammatory markers: protocol for a systematic review and meta-analysis. | Eguchi H et al. | β | 2018 | β |
| Regulation of inflammatory pathways in schizophrenia: A comparative study with bipolar disorder and healthy controls. | GarcΓa-Γlvarez L et al. | β | 2018 | β |
| Relation of inflammatory markers with symptoms of psychotic disorders: a large cohort study. | Liemburg EJ et al. | β | 2018 | β |
| Antipsychotics influence Toll-like receptor (TLR) expression and its relationship with cognitive functions in schizophrenia. | KΓ©ri S et al. | β | 2017 | β |
| Association between C-reactive protein and risk of schizophrenia: An updated meta-analysis. | Wang Z et al. | β | 2017 | β |
| Is Toxoplasma gondii a Trigger of Bipolar Disorder? | Del Grande C et al. | β | 2017 | β |
| Theranostic Biomarkers for Schizophrenia. | Perkovic MN et al. | β | 2017 | β |
| Uniting the neurodevelopmental and immunological hypotheses: Neuregulin 1 receptor ErbB and Toll-like receptor activation in first-episode schizophrenia. | KΓ©ri S et al. | β | 2017 | β |
| A significant causal association between C-reactive protein levels and schizophrenia. | Inoshita M et al. | β | 2016 | β |
| Cardiometabolic risk factors in young people at ultra-high risk for psychosis: A systematic review and meta-analysis. | Carney R et al. | β | 2016 | β |
| Differential blood-based biomarkers of psychopathological dimensions of schizophrenia. | Garcia-Alvarez L et al. | β | 2016 | β |
| Elevated copper, hs C-reactive protein and dyslipidemia in drug free schizophrenia: Relation with psychopathology score. | Devanarayanan S et al. | β | 2016 | β |
| Genome-wide Association Study of Cannabis Dependence Severity, Novel Risk Variants, and Shared Genetic Risks. | Sherva R et al. | β | 2016 | β |
| Inflammatory Markers in Recent Onset Psychosis and Chronic Schizophrenia. | Dickerson F et al. | β | 2016 | β |
| Investigating the Causal Relationship of C-Reactive Protein with 32 Complex Somatic and Psychiatric Outcomes: A Large-Scale Cross-Consortium Mendelian Randomization Study. | Prins BP et al. | β | 2016 | β |
| Physical Functional Capacity and C-Reactive Protein in Schizophrenia. | Szortyka MF et al. | β | 2016 | β |
| Serum high-sensitivity C-reactive protein: A delicate sentinel elevated in drug-free acutely agitated patients with schizophrenia. | Pan S et al. | β | 2016 | β |
| Shared Immune and Repair Markers During Experimental Toxoplasma Chronic Brain Infection and Schizophrenia. | Tomasik J et al. | β | 2016 | β |
| The serum level of C-reactive protein (CRP) is associated with cognitive performance in acute phase psychosis. | Johnsen E et al. | β | 2016 | β |
| Elevated serum immunoinflammation-related protein complexes are associated with psychosis. | Liu Y et al. | β | 2015 | β |
| Infection and inflammation in schizophrenia and bipolar disorder: a genome wide study for interactions with genetic variation. | Avramopoulos D et al. | β | 2015 | β |
| Quality of life is associated with chronic inflammation in schizophrenia: a cross-sectional study. | Faugere M et al. | β | 2015 | β |