Role of serotonin in memory impairment.
paper
Cited
Public
Unavailable
- Authors
- Buhot, M C; Martin, S; Segu, L
- Year
- 2000
- Journal
- Annals of medicine
- PMID
- 10821328
- DOI
- 10.3109/07853890008998828
As a result of its presence in various structures of the central nervous system serotonin (5-HT) plays a role in a great variety of behaviours such as food intake, activity rythms, sexual behaviour and emotional states. Despite this lack of functional specialization, the serotonergic system plays a significant role in learning and memory, in particular by interacting with the cholinergic, glutamatergic, dopaminergic or GABAergic systems. Its action is mediated via specific receptors located in crucial brain structures involved in these functions, primarily the septo-hippocampal complex and the nucleus basalis magnocellularis (NBM)-frontal cortex. Converging evidence suggests that the administration of 5-HT2A/2C or 5-HT4 receptor agonists or 5-HT1A or 5-HT3 and 5-HT1B receptor antagonists prevents memory impairment and facilitates learning in situations involving a high cognitive demand. In contrast, antagonists for 5-HT2A/2C and 5-HT4, or agonists for 5-HT1A or 5-HT3 and 5-HT1B generally have opposite effects. A better understanding of the role played by these and other serotonin receptor subtypes in learning and memory is likely to result from the recent availability of highly specific ligands, such as 5-HT1A, 5-HT1B, 5-HT2A receptor antagonists, and new molecular tools, such as gene knock-out mice, especially inducible mice in which a specific genetic alteration can be restricted both temporally and anatomically.
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| Title | Year | PMID |
|---|---|---|
| Genome-wide association study of theta band event-related oscillations identifies serotonin receptor gene HTR7 influencing risk of alcohol dependence. | 2011 | 21184583 |
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| Impaired pre-attentive auditory processing in opioid dependence with and without benzodiazepine co-dependence revealed by combined magnetoencephalography and electroencephalography. | Kivisaari R et al. | β | 2007 | β |
| Memory performance in abstinent 3,4-methylenedioxymethamphetamine (MDMA, "ecstasy") users. | Groth-Marnat G et al. | β | 2007 | β |
| Neotic preferences in laboratory rodents: issues, assessment and substrates. | Hughes RN | β | 2007 | β |
| Presynaptic modulation of 5-HT release in the rat septal region. | Rutz S et al. | β | 2007 | β |
| Quetiapine for mania due to traumatic brain injury. | Oster TJ et al. | β | 2007 | β |
| Selective verbal and spatial memory impairment after 5-HT1A and 5-HT2A receptor blockade in healthy volunteers pre-treated with an SSRI. | Wingen M et al. | β | 2007 | β |
| Serotonin catabolism in the central and enteric nervous systems of rats upon induction of serotonin syndrome. | Squires LN et al. | β | 2007 | β |
| Serotonin transporter polymorphism, memory and hippocampal volume in the elderly: association and interaction with cortisol. | O'Hara R et al. | β | 2007 | β |
| Sex differences in the effect of acute tryptophan depletion on declarative episodic memory: a pooled analysis of nine studies. | Sambeth A et al. | β | 2007 | β |
| The 5-HT3 receptor as a therapeutic target. | Thompson AJ et al. | β | 2007 | β |
| 5,7-DHT lesion of the dorsal raphe nuclei impairs object recognition but not affective behavior and corticosterone response to stressor in the rat. | Lieben CK et al. | β | 2006 | β |
| 5-Hydroxytryptamine 1A receptor blockade facilitates aversive learning in mice: interactions with cholinergic and glutamatergic mechanisms. | Madjid N et al. | β | 2006 | β |
| A sleep-promoting role for the Drosophila serotonin receptor 1A. | Yuan Q et al. | β | 2006 | β |
| Challenging the serotonergic system in Parkinson disease patients: effects on cognition, mood, and motor performance. | Scholtissen B et al. | β | 2006 | β |
| Cognitive effects of SL65.0155, a serotonin 5-HT4 receptor partial agonist, in animal models of amnesia. | Micale V et al. | β | 2006 | β |
| Cognitive function and social abilities in patients with schizophrenia: relationship with atypical antipsychotics. | Tyson PJ et al. | β | 2006 | β |
| Dopaminergic modulation of the persistence of one-trial hippocampus-dependent memory. | O'Carroll CM et al. | β | 2006 | β |
| Effect of selective cholinergic denervation on the serotonergic system: implications for learning and memory. | Garcia-Alloza M et al. | β | 2006 | β |
| Effects of 5-HT on memory and the hippocampus: model and data. | Meeter M et al. | β | 2006 | β |
| Effects of acute tryptophan depletion on cognition, memory and motor performance in Parkinson's disease. | Scholtissen B et al. | β | 2006 | β |
| Influence of serotonin receptor 2A His452Tyr polymorphism on brain temporal structures: a volumetric MR study. | Filippini N et al. | β | 2006 | β |
| Long-term tryptophan administration enhances cognitive performance and increases 5HT metabolism in the hippocampus of female rats. | Haider S et al. | β | 2006 | β |
| Multi-target strategies for the improved treatment of depressive states: Conceptual foundations and neuronal substrates, drug discovery and therapeutic application. | Millan MJ | β | 2006 | β |
| Neuroactive steroid effects on cognitive functions with a focus on the serotonin and GABA systems. | Birzniece V et al. | β | 2006 | β |
| Neurotoxicity of methylenedioxyamphetamines (MDMA; ecstasy) in humans: how strong is the evidence for persistent brain damage? | Gouzoulis-Mayfrank E et al. | β | 2006 | β |
| Of minds and embryos: left-right asymmetry and the serotonergic controls of pre-neural morphogenesis. | Levin M et al. | β | 2006 | β |
| Opposing effects of AMPA and 5-HT1A receptor blockade on passive avoidance and object recognition performance: correlation with AMPA receptor subunit expression in rat hippocampus. | Schiapparelli L et al. | β | 2006 | β |
| Presynaptic serotonergic modulation of 5-HT and acetylcholine release in the hippocampus and the cortex of 5-HT1B-receptor knockout mice. | Rutz S et al. | β | 2006 | β |
| Serotonin catabolism and the formation and fate of 5-hydroxyindole thiazolidine carboxylic acid. | Squires LN et al. | β | 2006 | β |
| Unexpected inhibitory regulation of glutamate release from rat cerebrocortical nerve terminals by presynaptic 5-hydroxytryptamine-2A receptors. | Wang SJ et al. | β | 2006 | β |
| Verbal memory performance during subchronic challenge with a selective serotonergic and a mixed action antidepressant. | Wingen M et al. | β | 2006 | β |
| Analysis of the role of 5-HT1A receptors in spatial and aversive learning in the rat. | LΓΌttgen M et al. | β | 2005 | β |
| Cholinergic-serotonergic imbalance contributes to cognitive and behavioral symptoms in Alzheimer's disease. | Garcia-Alloza M et al. | β | 2005 | β |
| Decrease in brain serotonin level and short term memory loss in mice: a preliminary study. | Banik S et al. | β | 2005 | β |
| Effects of a novel method of acute tryptophan depletion on plasma tryptophan and cognitive performance in healthy volunteers. | Evers EA et al. | β | 2005 | β |
| Loss of serotonin 5-HT2A receptors in the postmortem temporal cortex correlates with rate of cognitive decline in Alzheimer's disease. | Lai MK et al. | β | 2005 | β |
| Memory-related hippocampal dysfunction in poly-drug ecstasy (3,4-methylenedioxymethamphetamine) users. | Daumann J et al. | β | 2005 | β |
| Metabolism and receptor binding of serotonin in brain structures during performance of a conditioned passive avoidance response. | Molodtsova GF | β | 2005 | β |
| Neuro-modulation, aminergic neuro-disinhibition and neuro-degeneration. Draft of a comprehensive theory for Alzheimer disease. | Schmitt HP | β | 2005 | β |
| REM sleep deprivation affects extinction of cued but not contextual fear conditioning. | Silvestri AJ | β | 2005 | β |
| Selective cholinergic denervation, independent from oxidative stress, in a mouse model of Alzheimer's disease. | Aucoin JS et al. | β | 2005 | β |
| Selective serotonin 5-HT2A receptor antagonist EMD 281014 improves delayed matching performance in young and aged rhesus monkeys. | Terry AV et al. | β | 2005 | β |
| Serotonergic modulation of mismatch negativity. | KΓ€hkΓΆnen S et al. | β | 2005 | β |
| Serotonin modulates circadian entrainment in Drosophila. | Yuan Q et al. | β | 2005 | β |
| Serotonin transporter function is an early step in left-right patterning in chick and frog embryos. | Fukumoto T et al. | β | 2005 | β |
| The effect of citalopram adjunctive treatment added to atypical antipsychotic medications for cognitive performance in patients with schizophrenia. | Friedman JI et al. | β | 2005 | β |
| The effects of SB 224289 on anxiety and cocaine-related behaviors in a novel object task. | Hoplight BJ et al. | β | 2005 | β |
| The influence of sertraline on attention and verbal memory in children and adolescents with anxiety disorders. | GΓΌnther T et al. | β | 2005 | β |
| The selective 5-HT6 receptor antagonist Ro4368554 restores memory performance in cholinergic and serotonergic models of memory deficiency in the rat. | Lieben CK et al. | β | 2005 | β |
| Acute psychological and physiological effects of psilocybin in healthy humans: a double-blind, placebo-controlled dose-effect study. | Hasler F et al. | β | 2004 | β |
| A novel immunohistochemical method for evaluation of antibody specificity and detection of labile targets in biological tissue. | Levin M | β | 2004 | β |
| Are the cognitive effects of atypical antipsychotics influenced by their affinity to 5HT-2A receptors? | Tyson PJ et al. | β | 2004 | β |
| BDNF and 5-HT: a dynamic duo in age-related neuronal plasticity and neurodegenerative disorders. | Mattson MP et al. | β | 2004 | β |
| Cellular mechanisms of serotonin 5-HT2A receptor-mediated cGMP formation: the essential role of glutamate. | Regina MJ et al. | β | 2004 | β |
| Differential involvement of 5-HT(1B/1D) and 5-HT6 receptors in cognitive and non-cognitive symptoms in Alzheimer's disease. | Garcia-Alloza M et al. | β | 2004 | β |
| Enhanced cognitive performance and cheerful mood by standardized extracts of Piper methysticum (Kava-kava). | Thompson R et al. | β | 2004 | β |
| Facilitation of cholinergic transmission by combined treatment of ondansetron with flumazenil after cortical cholinergic deafferentation. | Gil-Bea FJ et al. | β | 2004 | β |
| Fluoxetine-induced memory impairment in four family members. | Huang SC et al. | β | 2004 | β |
| Intraseptal injection of the 5-HT1A/5-HT7 agonist 8-OH-DPAT and working memory in rats. | Jeltsch H et al. | β | 2004 | β |
| Is there a timing synergy during multi-finger production of quick force pulses? | Latash ML et al. | β | 2004 | β |
| Nelumbinis Semen reverses a decrease in 5-HT1A receptor binding induced by chronic mild stress, a depression-like symptom. | Jang CG et al. | β | 2004 | β |
| Nelumbinis Semen reverses a decrease in 5-HT1A receptor binding induced by chronic mild stress, a depression-like symptom. | Jang CG et al. | β | 2004 | β |
| Selective effects of acute serotonin and catecholamine depletion on memory in healthy women. | Harrison BJ et al. | β | 2004 | β |
| Sensitization and dishabituation of swim induction in the leech Hirudo medicinalis: role of serotonin and cyclic AMP. | Zaccardi ML et al. | β | 2004 | β |
| Serotonin reuptake inhibitors in auditory processing disorders in elderly patients: preliminary results. | Cruz OL et al. | β | 2004 | β |
| Sibutramine may be associated with memory impairment. | Clark DW et al. | β | 2004 | β |
| The AMPA receptor potentiator LY404187 increases cerebral glucose utilization and c-fos expression in the rat. | Fowler JH et al. | β | 2004 | β |
| The cognitive paradox in posttraumatic stress disorder: a hypothesis. | van Praag HM | β | 2004 | β |
| Very low doses of delta 8-THC increase food consumption and alter neurotransmitter levels following weight loss. | Avraham Y et al. | β | 2004 | β |
| Analysis of the role of the 5-HT1B receptor in spatial and aversive learning in the rat. | Ahlander-LΓΌttgen M et al. | β | 2003 | β |
| A pharmacological analysis of an associative learning task: 5-HT(1) to 5-HT(7) receptor subtypes function on a pavlovian/instrumental autoshaped memory. | Meneses A | β | 2003 | β |
| Association of a haplotype in the serotonin 5-HT4 receptor gene (HTR4) with Japanese schizophrenia. | Suzuki T et al. | β | 2003 | β |
| Baseline and 8-OH-DPAT-induced release of acetylcholine in the hippocampus of aged rats with different levels of cognitive dysfunction. | Lazaris A et al. | β | 2003 | β |
| BIMU 1 and RS 67333, two 5-HT4 receptor agonists, modulate spontaneous alternation deficits induced by scopolamine in the mouse. | Lelong V et al. | β | 2003 | β |
| Blockade of striatal 5-HT2 receptors produces retrograde amnesia in rats. | Prado-AlcalΓ‘ RA et al. | β | 2003 | β |
| Delay-dependent working memory impairment in young-adult and aged 5-HT1BKO mice as assessed in a radial-arm water maze. | Wolff M et al. | β | 2003 | β |
| Dose-response effects of chronic lithium regimens on spatial memory in the black molly fish. | Creson TK et al. | β | 2003 | β |
| Effect of L-tryptophan on memory in patients with schizophrenia. | Levkovitz Y et al. | β | 2003 | β |
| Effects of acute tryptophan depletion on executive function in healthy male volunteers. | Gallagher P et al. | β | 2003 | β |
| Flumazenil and tacrine increase the effectiveness of ondansetron on scopolamine-induced impairment of spatial learning in rats. | Diez-Ariza M et al. | β | 2003 | β |
| Imaging of the 5-HT2A system: age-, gender-, and Alzheimer's disease-related findings. | Versijpt J et al. | β | 2003 | β |
| Inhibitory effect of hippocampal 5-HT1A receptors on human explicit memory. | Yasuno F et al. | β | 2003 | β |
| Memory impairment suggests hippocampal dysfunction in abstinent ecstasy users. | Gouzoulis-Mayfrank E et al. | β | 2003 | β |
| New benzimidazole derivatives: selective and orally active 5-HT3 receptor antagonists. | Pascual D et al. | β | 2003 | β |
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| Positron emission tomography imaging of the aging brain. | Meltzer CC et al. | β | 2003 | β |
| Protective effect of 5-HT1B receptor gene deletion on the age-related decline in spatial learning abilities in mice. | Buhot MC et al. | β | 2003 | β |
| Serotonin catabolism depends upon location of release: characterization of sulfated and gamma-glutamylated serotonin metabolites in Aplysia californica. | Stuart JN et al. | β | 2003 | β |
| Serotonin depletion in rat hippocampus attenuates L-NAME-induced spatial learning deficits. | Majlessi N et al. | β | 2003 | β |
| Spatial learning in the 5-HT1B receptor knockout mouse: selective facilitation/impairment depending on the cognitive demand. | Buhot MC et al. | β | 2003 | β |
| Three cases of zolpidem dependence treated with fluoxetine: the serotonin hypothesis. | Liappas IA et al. | β | 2003 | β |
| Treatment of dementia with neurotransmission modulation. | Doggrell SA et al. | β | 2003 | β |
| Ultrafast capillary electrophoresis and bioanalytical applications. | Stuart JN et al. | β | 2003 | β |
| Impaired spatial learning in the Morris water maze induced by serotonin reuptake inhibitors in rats. | Majlessi N et al. | β | 2002 | β |
| Prednisone induces cognitive dysfunction, neuronal degeneration, and reactive gliosis in rats. | Ramos-Remus C et al. | β | 2002 | β |
| Serotonin agents in the treatment of acquired brain injury. | Zafonte RD et al. | β | 2002 | β |
| The medical benefit of 5-HT research. | Jones BJ et al. | β | 2002 | β |
| Tianeptine: 5-HT uptake sites and 5-HT(1-7) receptors modulate memory formation in an autoshaping Pavlovian/instrumental task. | Meneses A | β | 2002 | β |
| Adenosine preferentially suppresses serotonin2A receptor-enhanced excitatory postsynaptic currents in layer V neurons of the rat medial prefrontal cortex. | Stutzmann GE et al. | β | 2001 | β |
| Age-associated changes in the serotonergic system in rat superior colliculus and pretectum. | Parsons MJ et al. | β | 2001 | β |
| Could the 5-HT1B receptor inverse agonism affect learning consolidation? | Meneses A | β | 2001 | β |
| Histochemical study of acute and chronic intraperitoneal nicotine effects on several glycolytic and Krebs cycle dehydrogenase activities in the frontoparietal cortex and subcortical nuclei of the rat brain. | TurΓ©gano L et al. | β | 2001 | β |
| Region-specific decrease in 5-HT1A and 5-HT1B binding sites after intra-hippocampal ibotenic acid injections in the rat. | AΓ―t Amara D et al. | β | 2001 | β |
| RS 67333 and D-cycloserine accelerate learning acquisition in the rat. | Lelong V et al. | β | 2001 | β |