Linkage of an alcoholism-related severity phenotype to chromosome 16.
- Authors
- Foroud, T; Bucholz, K K; Edenberg, H J; Goate, A; Neuman, R J; Porjesz, B; Koller, D L; Rice, J; Reich, T; Bierut, L J; Cloninger, C R; Nurnberger, J I; Li, T K; Conneally, P M; Tischfield, J A; Crowe, R; Hesselbrock, V; Schuckit, M; Begleiter, H
- Year
- 1998
- Journal
- Alcoholism, clinical and experimental research
- PMID
- 9884148
There is substantial evidence for a significant genetic component to the risk for alcoholism. In searching for genes that contribute to this risk, the diagnostic criteria for alcohol dependence may not be the optimal phenotype; rather, creation of a more homogeneous phenotype will lead to a more homogeneous genetic etiology. Items from the Semi-Structured Assessment for the Genetics of Alcoholism collected from 830 individuals in 105 alcoholic families were used in a latent class analysis to identify a more homogeneous alcoholism-related phenotype. A four-class solution was chosen: class 1, unaffected group; class 2, mildly problematic group; class 3, moderately affected group; and class 4, severely affected group. Classes 3 and 4 had higher symptom endorsement probabilities than classes 1 and 2 for items reflecting severe alcohol dependence, and were combined to provide enough sibling pairs for genetic linkage analysis. A total of 291 markers distributed throughout the genome, with an average intermarker distance of 14 cM, were genotyped. Linkage analysis was performed to detect loci underlying classes 3 and 4, the moderately and severely affected alcoholics, of whom 88% met the Collaborative Study of the Genetics of Alcoholism, and >99% met ICD-10 criteria for alcohol dependence. Evidence for a locus on chromosome 16, near the marker D16S675, was found with a maximum multipoint lod score of 4.0. Analysis of additional markers on chromosome 16 yielded a lod score of 3.2, narrowed the critical region, and placed the gene between D16S475 and D16S675 in a 15 cM interval.
No figures extracted from this document.
No chunks β full text not yet ingested.
No entities extracted from this document yet.
No uploaded files.
No citations found.
In this knowledge base
External
| Title | Authors | Journal | Year | Link |
|---|---|---|---|---|
| Association Study of Gene Polymorphisms in GABA, Serotonin, Dopamine, and Alcohol Metabolism Pathways with Alcohol Dependence in Taiwanese Han Men. | Wu LS et al. | β | 2016 | β |
| Gene expression signatures affected by alcohol-induced DNA methylomic deregulation in human embryonic stem cells. | Khalid O et al. | β | 2014 | β |
| Genetic influences on craving for alcohol. | Agrawal A et al. | β | 2013 | β |
| The genetics of alcohol dependence. | Rietschel M et al. | β | 2013 | β |
| ANKRD7 and CYTL1 are novel risk genes for alcohol drinking behavior. | Chen XD et al. | β | 2012 | β |
| Comparison of Methods for Identifying Phenotype Subgroups Using Categorical Features Data With Application to Autism Spectrum Disorder. | Gebregziabher M et al. | β | 2012 | β |
| Genome-wide association study of copy number variants suggests LTBP1 and FGD4 are important for alcohol drinking. | Pei YF et al. | β | 2012 | β |
| The genetics of alcohol dependence: advancing towards systems-based approaches. | Palmer RH et al. | β | 2012 | β |
| Convergent functional genomic studies of Ο-3 fatty acids in stress reactivity, bipolar disorder and alcoholism. | Le-Niculescu H et al. | β | 2011 | β |
| A comparison of selected quantitative trait loci associated with alcohol use phenotypes in humans and mouse models. | Ehlers CL et al. | β | 2010 | β |
| Alcohol consumption indices of genetic risk for alcohol dependence. | Grant JD et al. | β | 2009 | β |
| [Genetic factors of alcohol-dependence]. | Pinto E et al. | β | 2009 | β |
| Heritability and a genome-wide linkage analysis of a Type II/B cluster construct for cannabis dependence in an American Indian community. | Ehlers CL et al. | β | 2009 | β |
| A novel non-parametric regression reveals linkage on chromosome 4 for the number of externalizing symptoms in sib-pairs. | Ghosh S et al. | β | 2008 | β |
| DSM-IV criteria endorsement patterns in alcohol dependence: relationship to severity. | Moss HB et al. | β | 2008 | β |
| HPA-axis activity in alcoholism: examples for a gene-environment interaction. | Clarke TK et al. | β | 2008 | β |
| Phenomic, convergent functional genomic, and biomarker studies in a stress-reactive genetic animal model of bipolar disorder and co-morbid alcoholism. | Le-Niculescu H et al. | β | 2008 | β |
| Review. Genetics of addictions: strategies for addressing heterogeneity and polygenicity of substance use disorders. | Wong CC et al. | β | 2008 | β |
| Candidate genes, pathways and mechanisms for alcoholism: an expanded convergent functional genomics approach. | Rodd ZA et al. | β | 2007 | β |
| Genomic screen for substance dependence and body mass index in southwest California Indians. | Ehlers CL et al. | β | 2007 | β |
| Are there empirically supported and clinically useful subtypes of alcohol dependence? | Hesselbrock VM et al. | β | 2006 | β |
| Endophenotypes successfully lead to gene identification: results from the collaborative study on the genetics of alcoholism. | Dick DM et al. | β | 2006 | β |
| [Factors influencing juvenile alcohol consumption: the role of gene-environment interactions]. | Hinckers AS et al. | β | 2006 | β |
| New findings on the genetic influences on alcohol use and dependence. | Higuchi S et al. | β | 2006 | β |
| The genetics of alcoholism: identifying specific genes through family studies. | Edenberg HJ et al. | β | 2006 | β |
| Alcohol and gene interactions. | Whitfield JB | β | 2005 | β |
| Combining research approaches to advance our understanding of drug addiction. | van den Bree MB | β | 2005 | β |
| EEG spectral changes in treatment-naive, actively drinking alcoholics. | Fein G et al. | β | 2005 | β |
| Heritability of substance dependence in a native American population. | Wilhelmsen KC et al. | β | 2005 | β |
| Use of susceptibility scoring in conjunction with the genotypic transmission disequilibrium test. | Benke KS et al. | β | 2005 | β |
| Genomic screen for loci associated with alcohol dependence in Mission Indians. | Ehlers CL et al. | β | 2004 | β |
| The University of California, San Francisco Family Alcoholism Study. I. Design, methods, and demographics. | Vieten C et al. | β | 2004 | β |
| Analyses of quantitative trait loci contributing to alcohol preference in HAD1/LAD1 and HAD2/LAD2 rats. | Carr LG et al. | β | 2003 | β |
| Association of GABA(A) receptors and alcohol dependence and the effects of genetic imprinting. | Song J et al. | β | 2003 | β |
| Autism families with a high incidence of alcoholism. | Miles JH et al. | β | 2003 | β |
| Genetic contributions to addiction. | Crabbe JC | β | 2002 | β |
| Platelet adenylyl cyclase activity as a state or trait marker in alcohol dependence: results of the WHO/ISBRA Study on State and Trait Markers of Alcohol Use and Dependence. | Hoffman PL et al. | β | 2002 | β |
| Suggestive linkage on chromosome 1 for a quantitative alcohol-related phenotype. | Dick DM et al. | β | 2002 | β |
| The collaborative study on the genetics of alcoholism: an update. | Edenberg HJ | β | 2002 | β |
| A genome-wide search for genes that relate to a low level of response to alcohol. | Schuckit MA et al. | β | 2001 | β |
| Classification and course of alcohol problems among adolescents in addictions treatment programs. | Chung T et al. | β | 2001 | β |
| P300 event-related potential amplitude as an endophenotype of alcoholism--evidence from the collaborative study on the genetics of alcoholism. | Hesselbrock V et al. | β | 2001 | β |
| WHP/ISBRA study on state and trait markers in alcoholism. | Tabakoff B et al. | β | 2001 | β |
| Alcoholism susceptibility loci: confirmation studies in a replicate sample and further mapping. | Foroud T et al. | β | 2000 | β |
| Identifying a series of candidate genes for mania and psychosis: a convergent functional genomics approach. | Niculescu AB et al. | β | 2000 | β |
| Neuropsychological deficits in sober alcoholics: influences of chronicity and recent alcohol consumption. | Beatty WW et al. | β | 2000 | β |
| Platelet adenylyl cyclase activity as a trait marker of alcohol dependence. WHO/ISBRA Collaborative Study Investigators. International Society for Biomedical Research on Alcoholism. | Menninger JA et al. | β | 2000 | β |
| Genetic studies of alcoholism and substance dependence. | Reich T et al. | β | 1999 | β |
| Nosology and epidemiology of addictive disorders and their comorbidity. | Bucholz KK | β | 1999 | β |
| Phenotyping alcoholism. | McGue M | β | 1999 | β |