The level of response to alcohol in daughters of alcoholics and controls.
paper
Primary
Public
Unavailable
- Authors
- Eng, Mimy Y; Schuckit, Marc A; Smith, Tom L
- Year
- 2005
- Journal
- Drug and alcohol dependence
- PMID
- 15943947
- DOI
- 10.1016/j.drugalcdep.2005.01.002
BACKGROUND: The low level of response (LR) to alcohol is a genetically influenced characteristic related to the development of alcohol use disorders (AUDs). This phenotype is found in men with a family history (FH) of alcoholism, predicts future AUDs, and has heritabilities as high as 60%. However, despite evidence of genetic influences for AUDs in both sexes, the majority of studies evaluating differences in LR across high- and low-risk groups have been conducted on males, and it is unclear how generalizable these results are to women. METHODS: Twenty-five women who are family history positive (FHP) for alcohol dependence were matched with 25 women with no FH of alcoholism (FHN) on factors that may impact LR. Using an alcohol challenge paradigm, data on the reaction to a moderate dose of alcohol were gathered over a period of 3.5 h. Assessments included breath alcohol concentrations (BrACs), the Subjective High Assessment Scale (SHAS), as well as body sway or static ataxia. RESULTS: Family history positives reported lower subjective intoxication than FHNs. In addition, when body sway scores were corrected for skewness, FHPs had significantly lower scores on alcohol-related changes in lateral sway. These differences remained after considering the effects of drinking history and BrAC values. CONCLUSIONS: This study evaluated the LR to alcohol in the largest sample of alcohol challenges in matched FHP and FHN women to date. Overall, the findings are consistent with most data from earlier investigations of smaller sized samples of FHP women. The results suggest that, similar to sons of alcoholics, a low LR to alcohol might also be characteristic of daughters of alcoholics.
No figures extracted from this document.
No chunks β full text not yet ingested.
No entities extracted from this document yet.
No uploaded files.
Not in any collection.
No citations found.
In this knowledge base
External
| Title | Authors | Journal | Year | Link |
|---|---|---|---|---|
| The 10-year stability of three subscale scores of the Self-Report of the Effects of Alcohol measure and their relationship to changes in drinking quantities over the same period. | Schuckit MA et al. | β | 2026 | β |
| Comparing subjective effects and intoxication on simultaneous alcohol and cannabis use occasions relative to alcohol- or cannabis-only occasions. | Linden-Carmichael AN et al. | β | 2025 | β |
| Evaluations of potential sex differences in alcohol use and problems in 454 offspring from the San Diego Prospective Study. | Schuckit MA et al. | β | 2025 | β |
| High prevalence of alcohol use disorders in 454 young adult offspring from the San Diego prospective study. | Schuckit MA et al. | β | 2025 | β |
| Inhibitory control in the sober state as a function of alcohol sensitivity: a pilot functional magnetic resonance imaging (fMRI) study. | CofresΓ RU et al. | β | 2025 | β |
| Assessment of simultaneous alcohol and cannabis use and its related consequences and cognitions in college students: AΒ narrative review. | Shipley JL et al. | β | 2024 | β |
| Interpretations and experiences of subjective effects for alcohol alone and when combined with cannabis: A mixed-methods approach. | Boness CL et al. | β | 2024 | β |
| Subjective intoxication predicts alcohol-related consequences at equivalent alcohol concentrations in young adults using ecological momentary assessment and alcohol sensors. | Richards VL et al. | β | 2024 | β |
| The effects of simultaneous alcohol and cannabis use on subjective drug effects: A narrative review across methodologies. | Bedillion MF et al. | β | 2024 | β |
| Changes over time in endorsement of 11 DSM-IV alcohol use disorder (AUD) criteria in young adults with persistent or recurrent AUD in The Collaborative Study on the Genetics of Alcoholism. | Schuckit MA et al. | β | 2023 | β |
| Paternal alcohol exposure attenuates maintenance and reinstated operant responding for alcohol in the offspring ofΒ rats. | Nieto SJ et al. | β | 2023 | β |
| Subjective response to alcohol: Interactive effects of early life stress, parental risk for mood and substance use disorders, and drinking context. | Kosted R et al. | β | 2023 | β |
| The life and times of endogenous opioid peptides: Updated understanding of synthesis, spatiotemporal dynamics, and the clinical impact in alcohol use disorder. | Margolis EB et al. | β | 2023 | β |
| Paternal alcohol exposure has task- and sex-dependent behavioral effect in offspring. | Nieto SJ et al. | β | 2022 | β |
| Cross-sectional and prospective associations of drinking characteristics with scores from the Self-Report of the Effects of Alcohol questionnaire and findings from alcohol challenges. | Schuckit MA et al. | β | 2021 | β |
| Relationship between level of response to alcohol and acute tolerance. | Anthenelli RM et al. | β | 2021 | β |
| Transfer of incentive salience from a first-order alcohol cue to a novel second-order alcohol cue among individuals at risk for alcohol use disorder: electrophysiological evidence. | Fleming KA et al. | β | 2021 | β |
| The Search for Contributors to Low Rates of Recognition of Paternal Alcohol Use Disorders in Offspring From the San Diego Prospective Study. | Schuckit MA et al. | β | 2020 | β |
| Acute ethanol exposure reduces serotonin receptor 1A internalization by increasing ubiquitination and degradation of Ξ²-arrestin2. | Luessen DJ et al. | β | 2019 | β |
| Comparison of Subjective Responses to Oral and Intravenous Alcohol Administration Under Similar Systemic Exposures. | Plawecki MH et al. | β | 2019 | β |
| Performance of the Self-Report of the Effects of Alcohol Questionnaire Across Sexes and Generations. | Schuckit MA et al. | β | 2019 | β |
| Predictors of Increases in Alcohol Problems and Alcohol Use Disorders in Offspring in the San Diego Prospective Study. | Schuckit MA et al. | β | 2019 | β |
| The Relationship Between Regional Cerebral Blood Flow Estimates and Alcohol Problems at 5-Year Follow-Up: The Role of Level of Response. | Courtney KE et al. | β | 2019 | β |
| Sex differences in the association of alcohol with cognitive decline and brain pathology in a cohort of octogenarians. | Wardzala C et al. | β | 2018 | β |
| A Prospective Comparison of How the Level of Response to Alcohol and Impulsivity Relate to Future DSM-IV Alcohol Problems in the COGA Youth Panel. | Schuckit MA et al. | β | 2017 | β |
| Chronic Alcohol Exposure Differentially Alters One-Carbon Metabolism in Rat Liver and Brain. | Auta J et al. | β | 2017 | β |
| Differences in reporting of perceived acute effects of alcohol use, marijuana use, and simultaneous alcohol and marijuana use. | Lee CM et al. | β | 2017 | β |
| Women's Alcohol Sensitivity Predicts Alcohol-Related Regretted Sex. | Hone LSE et al. | β | 2017 | β |
| A Genetic Animal Model of Alcoholism for Screening Medications to Treat Addiction. | Bell RL et al. | β | 2016 | β |
| Alcohol-related blackouts across 55 weeks of college: Effects of European-American ethnicity, female sex, and low level of response to alcohol. | Schuckit MA et al. | β | 2016 | β |
| Alcohol Suppresses Tonic GABAA Receptor Currents in Cerebellar Granule Cells in the Prairie Vole: A Neural Signature of High-Alcohol-Consuming Genotypes. | Kaplan JS et al. | β | 2016 | β |
| Nicotine Enhances the Hypnotic and Hypothermic Effects of Alcohol in the Mouse. | Slater CA et al. | β | 2016 | β |
| The Ability of Functional Magnetic Resonance Imaging to Predict Heavy Drinking and Alcohol Problems 5 Years Later. | Schuckit MA et al. | β | 2016 | β |
| Gender, history of alcohol use and number of drinks consumed predict craving among drinkers in a field setting. | Day AM et al. | β | 2014 | β |
| Genetic influences on response to alcohol and response to pharmacotherapies for alcoholism. | Enoch MA | β | 2014 | β |
| How do we 'learn' addiction? Risk factors and mechanisms getting addicted to alcohol. | HΓ€gele C et al. | β | 2014 | β |
| The patterns of drug and alcohol use and associated problems over 30 years in 397 men. | Schuckit MA et al. | β | 2014 | β |
| A family history of substance dependence obscures the group differences in brain function associated with HIV-1 and ART. | Bauer LO | β | 2013 | β |
| Acute tolerance to alcohol in at-risk binge drinkers. | Fillmore MT et al. | β | 2012 | β |
| Animal models for medications development targeting alcohol abuse using selectively bred rat lines: neurobiological and pharmacological validity. | Bell RL et al. | β | 2012 | β |
| Do initial responses to drugs predict future use or abuse? | de Wit H et al. | β | 2012 | β |
| fMRI differences between subjects with low and high responses to alcohol during a stop signal task. | Schuckit MA et al. | β | 2012 | β |
| Heritability of level of response and association with recent drinking history in nonalcohol-dependent drinkers. | Kalu N et al. | β | 2012 | β |
| High versus low level of response to alcohol: evidence of differential reactivity to emotional stimuli. | Paulus MP et al. | β | 2012 | β |
| Lack of tolerance to the disinhibiting effects of alcohol in heavy drinkers. | Miller MA et al. | β | 2012 | β |
| Sex differences in how a low sensitivity to alcohol relates to later heavy drinking. | Schuckit MA et al. | β | 2012 | β |
| Structuring a college alcohol prevention program on the low level of response to alcohol model: a pilot study. | Schuckit MA et al. | β | 2012 | β |
| Alcohol effects on cerebral blood flow in subjects with low and high responses to alcohol. | Tolentino NJ et al. | β | 2011 | β |
| Comment on the paper by Quinn and Fromme entitled subjective response to alcohol challenge: a quantitative review. | Schuckit MA | β | 2011 | β |
| Response to alcohol in women: role of the menstrual cycle and a family history of alcoholism. | Evans SM et al. | β | 2011 | β |
| Subjective response to alcohol challenge: a quantitative review. | Quinn PD et al. | β | 2011 | β |
| A cognitive model for the intergenerational transference of alcohol use behavior. | Campbell JM et al. | β | 2010 | β |
| Comparing structural equation models that use different measures of the level of response to alcohol. | Schuckit MA et al. | β | 2010 | β |
| fMRI BOLD response in high-risk college students (Part 1): during exposure to alcohol, marijuana, polydrug and emotional picture cues. | Ray S et al. | β | 2010 | β |
| High risk groups often have higher levels of alcohol response than low risk: the other side of the coin. | Newlin DB et al. | β | 2010 | β |
| Human and laboratory rodent low response to alcohol: is better consilience possible? | Crabbe JC et al. | β | 2010 | β |
| Subjective response to alcohol: a critical review of the literature. | Morean ME et al. | β | 2010 | β |
| An evaluation of the full level of response to alcohol model of heavy drinking and problems in COGA offspring. | Schuckit MA et al. | β | 2009 | β |
| The overlap in predicting alcohol outcome for two measures of the level of response to alcohol. | Schuckit MA et al. | β | 2009 | β |
| The relationships of the level of response to alcohol and additional characteristics to alcohol use disorders across adulthood: a discrete-time survival analysis. | Trim RS et al. | β | 2009 | β |
| Variability in initial nicotine sensitivity due to sex, history of other drug use, and parental smoking. | Perkins KA et al. | β | 2009 | β |
| Ethnic differences in level of response to alcohol between Chinese Americans and Korean Americans. | Duranceaux NC et al. | β | 2008 | β |
| Increased mortality among women who drank alcohol during pregnancy. | Berg JP et al. | β | 2008 | β |
| Level of response to alcohol within the context of alcohol-related domains: an examination of longitudinal approaches assessing changes over time. | Trim RS et al. | β | 2008 | β |
| Relationship between ethanol's acute locomotor effects and ethanol self-administration in male Long-Evans rats. | Chappell AM et al. | β | 2008 | β |
| Subjective alcohol effects and drinking behavior: the relative influence of early response and acquired tolerance. | Morean ME et al. | β | 2008 | β |
| The self-rating of the effects of alcohol questionnaire as a predictor of alcohol-related outcomes in 12-year-old subjects. | Schuckit MA et al. | β | 2008 | β |
| Effects of a moderate evening alcohol dose. II: performance. | Rupp TL et al. | β | 2007 | β |
| Alcohol attenuates load-related activation during a working memory task: relation to level of response to alcohol. | Paulus MP et al. | β | 2006 | β |
| Genetics and alcoholism: how close are we to potential clinical applications? | Quickfall J et al. | β | 2006 | β |
| Low level of response to alcohol as associated with serotonin transporter genotype and high alcohol intake in adolescents. | Hinckers AS et al. | β | 2006 | β |
| QTL mapping for low-dose ethanol activation in the LXS recombinant inbred strains. | Downing C et al. | β | 2006 | β |
| Relationships among the level of response to alcohol and the number of alcoholic relatives in predicting alcohol-related outcomes. | Schuckit M et al. | β | 2006 | β |
| Review article: alcoholic liver disease--pathophysiological aspects and risk factors. | Gramenzi A et al. | β | 2006 | β |
| Striatal dopamine release and family history of alcoholism. | Munro CA et al. | β | 2006 | β |
| A cross-generational comparison of alcohol challenges at about age 20 in 40 father-offspring pairs. | Schuckit MA et al. | β | 2005 | β |