EEG hemispheric asymmetry as a predictor and correlate of short-term response to clozapine treatment in schizophrenia.
- Authors
- Knott, V; Labelle, A; Jones, B; Mahoney, C
- Year
- 2000
- Journal
- Clinical EEG (electroencephalography)
- PMID
- 10923202
- DOI
- 10.1177/155005940003100308
In search of early neuroleptic response predictors in schizophrenia, functional interhemispheric and intrahemispheric asymmetry indices, derived from spectrally analyzed resting electroencephalographic (EEG) activity, were examined in 17 schizophrenic patients prior to open label treatment with the atypical neuroleptic clozapine. Compared to EEG asymmetry indices derived from a normative data bank, patients exhibited significant interhemispheric (left greater than right) and intrahemispheric (anterior greater than posterior) deviations in delta, theta, alpha and beta frequency bands. Intrahemispheric indices were positively correlated with clinical ratings of positive symptoms and global psychopathology. Clozapine-induced improvements in positive and negative symptoms and global psychopathology symptom ratings were related to pretreatment intrahemispheric asymmetry only, with relationships varying with symptom, recording region and frequency band. The results are discussed in relation to the neurobiology of schizophrenia and the utility of EEG as an informative predictor of treatment response.
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In this knowledge base
| Title | Year | PMID |
|---|---|---|
| Advances in Electrophysiological Research. | 2015 | 26259089 |
External
| Title | Authors | Journal | Year | Link |
|---|---|---|---|---|
| Pharmaco-EEG of antipsychotic treatment response: a systematic review. | De Pieri M et al. | — | 2023 | → |
| A Machine Learning Approach Using Effective Connectivity to Predict Response to Clozapine Treatment. | Ciprian C et al. | — | 2020 | → |
| Biological Predictors of Clozapine Response: A Systematic Review. | Samanaite R et al. | — | 2018 | → |
| Advances in Electrophysiological Research. | Kamarajan C et al. | — | 2015 | → |
| A machine learning approach using auditory odd-ball responses to investigate the effect of Clozapine therapy. | Ravan M et al. | — | 2015 | → |
| EEG correlates of a mental arithmetic task in patients with first episode schizophrenia and schizoaffective disorder. | Garakh Z et al. | — | 2015 | → |
| Clozapine-induced seizures, electroencephalography abnormalities, and clinical responses in Japanese patients with schizophrenia. | Kikuchi YS et al. | — | 2014 | → |
| Effects of clozapine on heart rate dynamics and their relationship with therapeutic response in treatment-resistant schizophrenia. | Kim JH et al. | — | 2013 | → |
| Electroencephalographic abnormalities in clozapine-treated patients: a cross-sectional study. | Goyal N et al. | — | 2011 | → |
| Factors Associated with Response to Clozapine in Schizophrenia: A Review. | Suzuki T et al. | — | 2011 | → |
| A pilot study to determine whether machine learning methodologies using pre-treatment electroencephalography can predict the symptomatic response to clozapine therapy. | Khodayari-Rostamabad A et al. | — | 2010 | → |
| Attenuated asymmetry of functional connectivity in schizophrenia: a high-resolution EEG study. | Jalili M et al. | — | 2010 | → |
| Prediction of clinical outcomes from rTMS in depressed patients with lateral visual field stimulation: a replication. | Schiffer F et al. | — | 2008 | → |
| Determination of hemispheric emotional valence in individual subjects: a new approach with research and therapeutic implications. | Schiffer F et al. | — | 2007 | → |
| Nongenetic pathologic developments of brain-wave patterns in monozygotic twins discordant and concordant for schizophrenia. | Weisbrod M et al. | — | 2004 | → |
| EEG abnormalities and outcome in first-episode psychosis. | Manchanda R et al. | — | 2003 | → |