Abnormal ERD/ERS but unaffected BOLD response in patients with Unverricht-Lundborg disease during index extension: a simultaneous EEG-fMRI study.
- Authors
- Visani, E; Minati, L; Canafoglia, L; Gilioli, I; Granvillano, A; Varotto, G; Aquino, D; Fazio, P; Bruzzone, M G; Franceschetti, S; Panzica, F
- Year
- 2011
- Journal
- Brain topography
- PMID
- 21107673
- DOI
- 10.1007/s10548-010-0167-5
Electrophysiological studies indicate that Unverricht-Lundborg's disease (ULD), the most common form of progressive myoclonus epilepsy in Europe, is characterized by the involvement of multiple cortical regions in degenerative changes that lead to enhanced excitation and deficient inhibition. We searched for the haemodynamic correlates of these effects using functional MRI (fMRI) of self-paced index extensions, a well-accepted task highlighting significant differences. EEG and fMRI were simultaneously acquired in 11 ULD patients and 16 controls, performing the index extensions individually (event-related task) as well as repetitively (block task). ERD/ERS analysis was performed for the EEG data in the alpha and beta bands. fMRI time-series were analyzed using the traditional general linear model, as well as with an assumption-free approach, and by means of cross-region correlations representing functional connectivity. In line with the existing literature, ULD patients had enhanced desynchronization in the alpha band and reduced post-movement synchronization in the beta band. By contrast, fMRI did not reveal any difference between the two groups; there were no activation intensity, latency or extent effects, no significant engagement of additional regions, and no changes to functional connectivity. We conclude that, so long as the patients are executing a task which does not induce obvious action myoclonus, the hypothesized abnormalities in pyramidal neuron and interneuron dynamics are relatively subtle, embodied in processes which are not metabolically-demanding and take place at a time-scale invisible to fMRI.
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In this knowledge base
| Title | Year | PMID |
|---|---|---|
| Advances in Electrophysiological Research. | 2015 | 26259089 |
External
| Title | Authors | Journal | Year | Link |
|---|---|---|---|---|
| Cortical network dysfunction revealed by magnetoencephalography in carriers of spinocerebellar ataxia 1 or 2 mutation. | Visani E et al. | — | 2020 | → |
| Distortion of the cortical motor map in patients with Unverricht-Lundborg disease: A combined TMS-MRI study. | Rossi Sebastiano D et al. | — | 2020 | → |
| Cerebellar Involvement in Patients with Mild to Moderate Myoclonus Due to EPM1: Structural and Functional MRI Findings in Comparison with Healthy Controls and Ataxic Patients. | Nigri A et al. | — | 2017 | → |
| Neurophysiological and BOLD signal uncoupling of giant somatosensory evoked potentials in progressive myoclonic epilepsy: a case-series study. | Storti SF et al. | — | 2017 | → |
| The network sustaining action myoclonus: a MEG-EMG study in patients with EPM1. | Franceschetti S et al. | — | 2016 | → |
| Advances in Electrophysiological Research. | Kamarajan C et al. | — | 2015 | → |
| Hemodynamic and EEG Time-Courses During Unilateral Hand Movement in Patients with Cortical Myoclonus. An EEG-fMRI and EEG-TD-fNIRS Study. | Visani E et al. | — | 2015 | → |
| Reduced cortical activation in inferior frontal junction in Unverricht-Lundborg disease (EPM1) - A motor fMRI study. | Könönen M et al. | — | 2015 | → |
| Using Actual and Imagined Walking Related Desynchronization Features in a BCI. | Severens M et al. | — | 2015 | → |
| EEG-informed fMRI analysis during a hand grip task: estimating the relationship between EEG rhythms and the BOLD signal. | Sclocco R et al. | — | 2014 | → |
| Research on brain induced effect by extremely low frequency pulsed magnetic stimulation. | Gao X et al. | — | 2014 | → |
| TMS-EEG reveals impaired intracortical interactions and coherence in Unverricht-Lundborg type progressive myoclonus epilepsy (EPM1). | Julkunen P et al. | — | 2013 | → |
| Movement preparation and cortical processing of afferent inputs in cortical tremor: an event-related (de)synchronization (ERD/ERS) study. | Houdayer E et al. | — | 2012 | → |
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| Wavelet packet-based independent component analysis for feature extraction from motor imagery EEG of complex movements. | Zhou Z et al. | — | 2012 | → |