Pathways and networks-based analysis of candidate genes associated with nicotine addiction.
paper
Cited
Public
- Authors
- Liu, Meng; Fan, Rui; Liu, Xinhua; Cheng, Feng; Wang, Ju
- Year
- 2015
- Journal
- PloS one
- PMID
- 25965070
- DOI
- 10.1371/journal.pone.0127438
- PMCID
- PMC4429103
Nicotine is the addictive substance in tobacco and it has a broad impact on both the central and peripheral nervous systems. Over the past decades, an increasing number of genes potentially involved in nicotine addiction have been identified by different technical approaches. However, the molecular mechanisms underlying nicotine addiction remain largely unclear. Under such situation, a comprehensive analysis focusing on the overall functional characteristics of these genes, as well as how they interact with each other will provide us valuable information to understand nicotine addiction. In this study, we presented a systematic analysis on nicotine addiction-related genes to identify the major underlying biological themes. Functional analysis revealed that biological processes and biochemical pathways related to neurodevelopment, immune system and metabolism were significantly enriched in the nicotine addiction-related genes. By extracting the nicotine addiction-specific subnetwork, a number of novel genes associated with addiction were identified. Moreover, we constructed a schematic molecular network for nicotine addiction via integrating the pathways and network, providing an intuitional view to understand the development of nicotine addiction. Pathway and network analysis indicated that the biological processes related to nicotine addiction were complex. Results from our work may have important implications for understanding the molecular mechanism underlying nicotine addiction.
Pathway crosstalk among NAGenes-enriched pathways.Nodes represent pathways and edges represent crosstalk between pathways. Node size corresponds to the number of NAGenes found in the corresponding pathway. Node color corresponds to the PBH-value of the corresponding pathway. Darker color indicates lower PBH-value. Edge width corresponds to the score of the related pathways. Node shape indicates pathway categories, with ellipse for neurodevelopment, diamond for immune, triangle for metabolism, square for other pathways.
Nicotine addiction-specific network.Ellipse nodes are NAGenes and triangular nodes are non-NAGenes. Node color corresponds to its degree in the human PPI network. Darker color indicates higher degree.
Molecular network for nicotine addiction.This network is constructed based on the nicotine addiction-related pathways or pathway crosstalk identified in our study, NA-specific network and literature survey. NAGenes are highlighted in red while neurotransmitters are represented as pink ellipse. The enriched pathways are highlighted in yellow background.
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