Neuropsychological deficits are correlated with frontal hypometabolism in positron emission tomography studies of older alcoholic patients.
paper
Cited
Public
Unavailable
- Authors
- Adams, K M; Gilman, S; Koeppe, R A; Kluin, K J; Brunberg, J A; Dede, D; Berent, S; Kroll, P D
- Year
- 1993
- Journal
- Alcoholism, clinical and experimental research
- PMID
- 8488956
- DOI
- 10.1111/j.1530-0277.1993.tb00750.x
In an extension of previous work, we studied the behavioral correlates of medial frontal lobe glucose hypometabolism in chronically alcohol-dependent patients. Thirty-one male patients who were detoxified, medically stable, and free of other central nervous system risk factors for neuropsychological impairment were examined with (1) anatomic imaging (CT or MR), (2) functional imaging with [18F] fluorodeoxyglucose (18F-FDG) and positron emission tomography (PET), and (3) a battery of neuropsychological tests, including two measures of abstraction known to be generally sensitive to frontal lobe disease or dysfunction [the Wisconsin Card Sorting Test (WCST) and the Halstead Category Test (HCT)]. 18F-FDG PET data from 18 age- and sex-matched normal control subjects were used for comparison. All patients met criteria for severe alcohol dependence and for at least a mild degree of alcoholic-induced cognitive impairment. Although the mean IQ level of the alcoholic patients was in the average range, the concepts attained and the error scores on the WCST and HCT were significantly impaired in comparison with established norms. Local cerebral metabolic rate for glucose (LCMRglc) was significantly decreased in a sagittal strip of the medial frontal cortex in the alcoholic patients as compared with the normal controls. Comparison of data from PET scans and anatomic images indicated that the reduced LCMRglc could not be attributed to reduced amounts of tissue alone. A statistically significant relationship was found between LCMRglc in the medial frontal region of the cerebral cortex and performance on the WCST, but not the HCT. These findings suggest that chronic alcohol intake results in impaired function of cerebral tissue in the medial frontal region.(ABSTRACT TRUNCATED AT 250 WORDS)
No figures extracted from this document.
No chunks — full text not yet ingested.
No entities extracted from this document yet.
No uploaded files.
Not in any collection.
No citations found.
In this knowledge base
External
| Title | Authors | Journal | Year | Link |
|---|---|---|---|---|
| Beyond the Liver: Neurologic Manifestations of Alcohol Use. | Huang J et al. | — | 2024 | → |
| Does compulsion explain addiction? | Heinz A et al. | — | 2024 | → |
| Postinjury Alcohol Use Is Associated With Prolonged Recovery After Concussion in NCAA Athletes. | Chang RC et al. | — | 2024 | → |
| Fluorodeoxyglucose positron emission tomography scans in patients with alcohol use disorder. | Bralet MC et al. | — | 2022 | → |
| Neuropsychiatric Alterations in a Patient Diagnosed with Advanced Korsakoff's Syndrome: Clinical Case of Low Incidence and Prevalence in Colombia. | Alberto Hurtado Gonzalez C et al. | — | 2022 | → |
| Quantitative electroencephalographic analysis of delirium tremens development following alcohol-withdrawal seizure based on a small number of male cases. | Yoon JE et al. | — | 2022 | → |
| Addictions NeuroImaging Assessment (ANIA): Towards an integrative framework for alcohol use disorder. | Voon V et al. | — | 2020 | → |
| Changes in Hemodynamic Response Function Resulting From Chronic Alcohol Consumption. | Desmond JE et al. | — | 2020 | → |
| Intranasal Insulin: a Treatment Strategy for Addiction. | Kashyap B et al. | — | 2020 | → |
| Aging with alcohol-related brain damage: Critical brain circuits associated with cognitive dysfunction. | Nunes PT et al. | — | 2019 | → |
| Association Between Reduced Brain Glucose Metabolism and Cortical Thickness in Alcoholics: Evidence of Neurotoxicity. | Tomasi DG et al. | — | 2019 | → |
| Brain-behavior relations and effects of aging and common comorbidities in alcohol use disorder: A review. | Sullivan EV et al. | — | 2019 | → |
| On the Neurobiological Role of Oxidative Stress in Alcohol-Induced Impulsive, Aggressive and Suicidal Behavior. | Tobore TO | — | 2019 | → |
| Light social drinkers are more distracted by irrelevant information from an induced attentional bias than heavy social drinkers. | Knight HC et al. | — | 2018 | → |
| Changes in cerebral [<sup>18</sup>F]-FDG uptake induced by acute alcohol administration in a rat model of alcoholism. | Gispert JD et al. | — | 2017 | → |
| Specificity of executive functioning and processing speed problems in common psychopathology. | Nigg JT et al. | — | 2017 | → |
| Behavioral impulsivity mediates the relationship between decreased frontal gray matter volume and harmful alcohol drinking: A voxel-based morphometry study. | Gröpper S et al. | — | 2016 | → |
| Polygenic risk for alcohol dependence associates with alcohol consumption, cognitive function and social deprivation in a population-based cohort. | Clarke TK et al. | — | 2016 | → |
| Prefrontal Cortical Thickness Deficit in Detoxified Alcohol-dependent Patients. | Bae S et al. | — | 2016 | → |
| Alcohol decreases baseline brain glucose metabolism more in heavy drinkers than controls but has no effect on stimulation-induced metabolic increases. | Volkow ND et al. | — | 2015 | → |
| An Update of the Review of Neuropsychological Consequences of HIV and Substance Abuse: A Literature Review and Implications for Treatment and Future Research. | Norman LR et al. | — | 2015 | → |
| Brain perfusion in polysubstance users: relationship to substance and tobacco use, cognition, and self-regulation. | Murray DE et al. | — | 2015 | → |
| Cognitive control in alcohol use disorder: deficits and clinical relevance. | Wilcox CE et al. | — | 2014 | → |
| Mediated and moderated effects of neurocognitive impairment on outcomes of treatment for substance dependence and major depression. | Worley MJ et al. | — | 2014 | → |
| A selective insular perfusion deficit contributes to compromised salience network connectivity in recovering alcoholic men. | Sullivan EV et al. | — | 2013 | → |
| Psychosocial predictors of impulsivity in alcohol-dependent patients. | Jakubczyk A et al. | — | 2013 | → |
| Effects of Alcohol Intoxication on Response Conflict in a Flanker Task. | Marinkovic K et al. | — | 2012 | → |
| Event-Related Oscillations in Alcoholism Research: A Review. | Pandey AK et al. | — | 2012 | → |
| Function and dysfunction of prefrontal brain circuitry in alcoholic Korsakoff's syndrome. | Oscar-Berman M | — | 2012 | → |
| Greater executive and visual memory dysfunction in comorbid bipolar disorder and substance use disorder. | Marshall DF et al. | — | 2012 | → |
| Neural correlates of hot and cold executive functions in polysubstance addiction: association between neuropsychological performance and resting brain metabolism as measured by positron emission tomography. | Moreno-López L et al. | — | 2012 | → |
| Neurocognitive deficits in male alcoholics: an ERP/sLORETA analysis of the N2 component in an equal probability Go/NoGo task. | Pandey AK et al. | — | 2012 | → |
| Alcohol and the human brain: a systematic review of different neuroimaging methods. | Bühler M et al. | — | 2011 | → |
| Altered fronto-cerebellar connectivity in alcohol-naïve youth with a family history of alcoholism. | Herting MM et al. | — | 2011 | → |
| Brain functions associated with verbal working memory tasks among young males with alcohol use disorders. | Park MS et al. | — | 2011 | → |
| Effects of acamprosate on cognition in a treatment study of patients with schizophrenia spectrum disorders and comorbid alcohol dependence. | Ralevski E et al. | — | 2011 | → |
| Structural Changes in the Insular Cortex in Alcohol Dependence: A cross sectional study. | Chattopadhyay S et al. | — | 2011 | → |
| What have positron emission tomography and 'Zippy' told us about the neuropharmacology of drug addiction? | Cumming P et al. | — | 2011 | → |
| Alcohol and the prefrontal cortex. | Abernathy K et al. | — | 2010 | → |
| Effects of alcohol on tests of executive functioning in men and women: a dose response examination. | Guillot CR et al. | — | 2010 | → |
| Ethanol self-administration modulation of NMDA receptor subunit and related synaptic protein mRNA expression in prefrontal cortical fields in cynomolgus monkeys. | Acosta G et al. | — | 2010 | → |
| Extinction of drug- and withdrawal-paired cues in animal models: relevance to the treatment of addiction. | Myers KM et al. | — | 2010 | → |
| Recruitment of additional brain regions to accomplish simple motor tasks in chronic alcohol-dependent patients. | Parks MH et al. | — | 2010 | → |
| Reversible alcohol-related dementia: a five-year follow-up study using FDG-PET and neuropsychological tests. | Asada T et al. | — | 2010 | → |
| A history of alcohol dependence increases the incidence and severity of postoperative cognitive dysfunction in cardiac surgical patients. | Hudetz JA et al. | — | 2009 | → |
| Effects of alcoholism severity and smoking on executive neurocognitive function. | Glass JM et al. | — | 2009 | → |
| Executive control deficits in substance-dependent individuals: a comparison of alcohol, cocaine, and methamphetamine and of men and women. | van der Plas EA et al. | — | 2009 | → |
| Neuropsychological consequences of HIV and substance abuse: a literature review and implications for treatment and future research. | Norman LR et al. | — | 2009 | → |
| Proteomics approach in the study of the pathophysiology of alcohol-related brain damage. | Matsumoto I | — | 2009 | → |
| Alcoholism: protein expression profiles in a human hippocampal model. | Matsumoto H et al. | — | 2008 | → |
| Neurocognitive impairment in patients with co-occurring bipolar disorder and alcohol dependence upon discharge from inpatient care. | Levy B et al. | — | 2008 | → |
| Neuroinflammation as a neurotoxic mechanism in alcoholism: commentary on "Increased MCP-1 and microglia in various regions of human alcoholic brain". | Sullivan EV et al. | — | 2008 | → |
| Alcohol: effects on neurobehavioral functions and the brain. | Oscar-Berman M et al. | — | 2007 | → |
| Altered brain activation by a false recognition task in young abstinent patients with alcohol dependence. | Akine Y et al. | — | 2007 | → |
| A proteome analysis of the dorsolateral prefrontal cortex in human alcoholic patients. | Alexander-Kaufman K et al. | — | 2007 | → |
| A proteome analysis of the dorsolateral prefrontal cortex in human alcoholic patients. | Alexander-Kaufman K et al. | — | 2007 | — |
| A widespread distinct pattern of cerebral atrophy in patients with alcohol addiction revealed by voxel-based morphometry. | Mechtcheriakov S et al. | — | 2007 | → |
| Blunted rostral anterior cingulate response during a simplified decoding task of negative emotional facial expressions in alcoholic patients. | Salloum JB et al. | — | 2007 | → |
| Brain morphometry and cognitive performance in detoxified alcohol-dependents with preserved psychosocial functioning. | Chanraud S et al. | — | 2007 | → |
| CNS proteomes in alcohol and drug abuse and dependence. | Matsumoto I et al. | — | 2007 | → |
| Postoperative cognitive dysfunction in older patients with a history of alcohol abuse. | Hudetz JA et al. | — | 2007 | → |
| Reduced fMRI activation of an occipital area in recently detoxified alcohol-dependent patients in a visual and acoustic stimulation paradigm. | Hermann D et al. | — | 2007 | → |
| Short-term naturalistic treatment outcomes in cigarette smokers with substance abuse and/or mental illness. | Gershon Grand RB et al. | — | 2007 | → |
| Differential protein expression in the prefrontal white matter of human alcoholics: a proteomics study. | Alexander-Kaufman K et al. | — | 2006 | → |
| Executive function and memory in relation to olfactory deficits in alcohol-dependent patients. | Rupp CI et al. | — | 2006 | → |
| New scores for the Category Test: measures of interference for subtests 5 and 6. | Webster JS et al. | — | 2006 | → |
| Suppression of early evoked gamma band response in male alcoholics during a visual oddball task. | Padmanabhapillai A et al. | — | 2006 | → |
| GABA-benzodiazepine receptor function in alcohol dependence: a combined 11C-flumazenil PET and pharmacodynamic study. | Lingford-Hughes AR et al. | — | 2005 | → |
| The utility of neurophysiological markers in the study of alcoholism. | Porjesz B et al. | — | 2005 | → |
| Alcohol abuse and traumatic brain injury: quantitative magnetic resonance imaging and neuropsychological outcome. | Wilde EA et al. | — | 2004 | → |
| Comparisons of Korsakoff and non-Korsakoff alcoholics on neuropsychological tests of prefrontal brain functioning. | Oscar-Berman M et al. | — | 2004 | → |
| Executive functioning early in abstinence from alcohol. | Zinn S et al. | — | 2004 | → |
| Neurocognitive ability in adults coping with alcohol and drug relapse temptations. | Tapert SF et al. | — | 2004 | → |
| The role of brain oscillations as functional correlates of cognitive systems: a study of frontal inhibitory control in alcoholism. | Kamarajan C et al. | — | 2004 | → |
| Abnormal CNV in chronic heavy drinkers. | Chao LL et al. | — | 2003 | → |
| Brain fMRI activation associated with self-paced finger tapping in chronic alcohol-dependent patients. | Parks MH et al. | — | 2003 | → |
| Comparison of prefrontal cell pathology between depression and alcohol dependence. | Miguel-Hidalgo JJ et al. | — | 2003 | → |
| D2 dopamine receptor gene in psychiatric and neurologic disorders and its phenotypes. | Noble EP | — | 2003 | → |
| Disruption of frontocerebellar circuitry and function in alcoholism. | Sullivan EV et al. | — | 2003 | → |
| Electrophysiological evidence of abnormal activation of the cerebral network of involuntary attention in alcoholism. | Polo MD et al. | — | 2003 | → |
| FDG-PET findings in the Wernicke-Korsakoff syndrome. | Reed LJ et al. | — | 2003 | → |
| Impairment in cognitive functions after multiple detoxifications in alcoholic inpatients. | Duka T et al. | — | 2003 | → |
| Interaction of aging and intermittent ethanol exposure on brain cytochrome c oxidase activity levels. | Jaatinen P et al. | — | 2003 | → |
| N-methyl-D-aspartate glutamate receptors and alcoholism: reward, dependence, treatment, and vulnerability. | Krystal JH et al. | — | 2003 | → |
| Chronic alcoholism and the frontal lobe: which executive functions are imparied? | Ratti MT et al. | — | 2002 | → |
| Executive control function in psychiatric and medical illness. | Schillerstrom JE | — | 2002 | → |
| Glia pathology in the prefrontal cortex in alcohol dependence with and without depressive symptoms. | Miguel-Hidalgo JJ et al. | — | 2002 | → |
| Individual differences in latent neuropsychological abilities at addictions treatment entry. | Bates ME et al. | — | 2002 | → |
| Longitudinal brain metabolic characterization of chronic alcoholics with proton magnetic resonance spectroscopy. | Parks MH et al. | — | 2002 | → |
| Neurocognitive impairment associated with alcohol use disorders: implications for treatment. | Bates ME et al. | — | 2002 | → |
| Regional cerebral blood flow and neuropsychological functioning in early and late onset alcoholism. | Demir B et al. | — | 2002 | → |
| The cerebellum may be directly involved in cognitive functions. | Vokaer M et al. | — | 2002 | → |
| Auditory P3a deficits in male subjects at high risk for alcoholism. | Hada M et al. | — | 2001 | → |
| fMRI measurement of brain dysfunction in alcohol-dependent young women. | Tapert SF et al. | — | 2001 | → |
| Reorganization of frontal systems used by alcoholics for spatial working memory: an fMRI study. | Pfefferbaum A et al. | — | 2001 | → |
| Visual p3 in female alcoholics. | Prabhu VR et al. | — | 2001 | → |
| Addiction and its reward process through polymorphisms of the D2 dopamine receptor gene: a review. | Noble EP | — | 2000 | → |
| Alcohol-induced brain pathology and behavioral dysfunction: using an animal model to examine sex differences. | Savage LM et al. | — | 2000 | → |
| Auditory P3a assessment of male alcoholics. | Hada M et al. | — | 2000 | → |
| Frontal P300 decrements, alcohol dependence, and antisocial personality disorder. | Costa L et al. | — | 2000 | → |
| Group and case study of the dysexecutive syndrome in alcoholism without amnesia. | Ihara H et al. | — | 2000 | → |
| Neurobehavioural consequences of substance abuse and HIV infection. | Basso MR et al. | — | 2000 | → |
| The DRD2 gene in psychiatric and neurological disorders and its phenotypes. | Noble EP | — | 2000 | → |
| Hypoperfusion of the cerebellum and aging effects on cerebral cortex blood flow in abstinent alcoholics: a SPECT study. | Harris GJ et al. | — | 1999 | → |
| Structural and functional neuroimaging findings in substance-related disorders. | Netrakom P et al. | — | 1999 | → |
| Visual P3a in male alcoholics and controls. | Rodriguez Holguin S et al. | — | 1999 | → |
| Addiction and imaging of the living human brain. | Gatley SJ et al. | — | 1998 | → |
| Brain imaging. Functional consequences of ethanol in the central nervous system. | Lyons D et al. | — | 1998 | → |
| Brain imaging in alcoholism. | Estruch R et al. | — | 1998 | → |
| Decreased striatal monoaminergic terminals in severe chronic alcoholism demonstrated with (+)[11C]dihydrotetrabenazine and positron emission tomography. | Gilman S et al. | — | 1998 | → |
| Executive cognitive functioning in alcohol use disorders. | Giancola PR et al. | — | 1998 | → |
| Regional cerebral metabolism in female alcoholics of moderate severity does not differ from that of controls. | Wang GJ et al. | — | 1998 | → |
| SPECT brain blood flow changes with continuous ligand infusion during previously learned WCST performance. | Tien AY et al. | — | 1998 | → |
| The D2 dopamine receptor gene: a review of association studies in alcoholism and phenotypes. | Noble EP | — | 1998 | → |
| The significance of family history status in relation to neuropsychological test performance and cerebral glucose metabolism studied with positron emission tomography in older alcoholic patients. | Adams KM et al. | — | 1998 | → |
| A dissociation between simple and complex span impairment in alcoholics. | Rapeli P et al. | — | 1997 | → |
| D2 dopamine receptor polymorphism and brain regional glucose metabolism. | Noble EP et al. | — | 1997 | → |
| Effects of abstinence and relapse upon neuropsychological function and cerebral glucose metabolism in severe chronic alcoholism. | Johnson-Greene D et al. | — | 1997 | → |
| Frontal cortical atrophy and negative symptoms in patients with chronic alcohol dependence. | Rosse RB et al. | — | 1997 | → |
| Frontal lobe volume loss observed with magnetic resonance imaging in older chronic alcoholics. | Pfefferbaum A et al. | — | 1997 | → |
| The Halstead Category Test: a fifty year perspective. | Choca JP et al. | — | 1997 | → |
| Behavioral and cognitive measurements predict scores on the MAST: a 3-year prospective study. | Deckel AW et al. | — | 1996 | → |
| Effects of disulfiram on positron emission tomography and neuropsychological studies in severe chronic alcoholism. | Gilman S et al. | — | 1996 | → |
| Positron emission tomographic studies of cerebral benzodiazepine-receptor binding in chronic alcoholics. | Gilman S et al. | — | 1996 | → |
| Relation between executive cognitive functioning and the adverse consequences of alcohol use in social drinkers. | Giancola PR et al. | — | 1996 | → |
| Single photon emission computed tomography with iodoamphetamine-123 and neuropsychological studies in long-term abstinent alcoholics. | Dupont RM et al. | — | 1996 | → |
| Substance use disorder exacerbates brain electrophysiological abnormalities in a psychiatrically-ill population. | Braverman ER et al. | — | 1996 | → |
| Delayed P3A in abstinent elderly male chronic alcoholics. | Biggins CA et al. | — | 1995 | → |
| Imaging Studies of Aging, Neurodegenerative Disease, and Alcoholism. | Eberling JL et al. | — | 1995 | → |
| Marchiafava-Bignami disease with dementia: severe cerebral metabolic depression revealed by PET. | Pappata S et al. | — | 1994 | → |
| Neuropsychological measures and event-related potentials in alcoholics: interrelationships, long-term reliabilities, and prediction of resumption of drinking. | Parsons OA | — | 1994 | → |