A ventromedial prefrontal dysrhythmia in obsessive-compulsive disorder is attenuated by nucleus accumbens deep brain stimulation.
- Authors
- Treu, Svenja; Gonzalez-Rosa, Javier J; Soto-Leon, Vanesa; Lozano-Soldevilla, Diego; Oliviero, Antonio; Lopez-Sosa, Fernando; Reneses-Prieto, Blanca; Barcia, Juan A; Strange, Bryan A
- Year
- 2021
- Journal
- Brain stimulation
- PMID
- 33984535
- DOI
- 10.1016/j.brs.2021.04.028
BACKGROUND: Obsessive-compulsive disorder (OCD) has consistently been linked to abnormal frontostriatal activity. The electrophysiological disruption in this circuit, however, remains to be characterized. OBJECTIVE/HYPOTHESIS: The primary goal of this study was to investigate the neuronal synchronization in OCD patients. We predicted aberrant oscillatory activity in frontal regions compared to healthy control subjects, which would be alleviated by deep brain stimulation (DBS) of the nucleus accumbens (NAc). METHODS: We compared scalp EEG recordings from nine patients with OCD treated with NAc-DBS with recordings from healthy controls, matched for age and gender. Within the patient group, EEG activity was compared with DBS turned off vs. stimulation at typical clinical settings (3.5 V, frequency of stimulation 130 Hz, pulse width 60 μs). In addition, intracranial EEG was recorded directly from depth macroelectrodes in the NAc in four OCD patients. RESULTS: Cross-frequency coupling between the phase of alpha/low beta oscillations and amplitude of high gamma was significantly increased over midline frontal and parietal electrodes in patients when stimulation was turned off, compared to controls. Critically, in patients, beta (16-25 Hz) -gamma (110-166 Hz) phase amplitude coupling source localized to the ventromedial prefrontal cortex, and was reduced when NAc-DBS was active. In contrast, intracranial EEG recordings showed no beta-gamma phase amplitude coupling. The contribution of non-sinusoidal beta waveforms to this coupling are reported. CONCLUSION: We reveal an increased beta-gamma phase amplitude coupling in fronto-central scalp sensors in patients suffering from OCD, compared to healthy controls, which may derive from ventromedial prefrontal regions implicated in OCD and is normalized by DBS of the nucleus accumbens. This aberrant cross-frequency coupling could represent a biomarker of OCD, as well as a target for novel therapeutic approaches.
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| Alcohol use disorder is associated with altered frontomedial phase-amplitude coupling strength during resting state. | 2026 | 41657495 |
External
| Title | Authors | Journal | Year | Link |
|---|---|---|---|---|
| Alcohol use disorder is associated with altered frontomedial phase-amplitude coupling strength during resting state. | Richard CD et al. | — | 2026 | → |
| Electrophysiological Biomarkers Reflect Target Engagement and Response Using Deep Brain Stimulation for Obsessive-Compulsive Disorder. | Van Bogaert T et al. | — | 2026 | → |
| Frequency-dependent modulation of human reward circuitry: A comparative study of theta, gamma, and high-frequency temporal interference. | Zhang Y et al. | — | 2026 | → |
| Alcohol use disorder is associated with altered frontomedial phase-amplitude coupling strength during resting state | Richard C et al. | — | 2025 | — |
| A systematic review of EEG-based machine learning classifications for obsessive-compulsive disorder: current status and future directions. | Naderi M et al. | — | 2025 | → |
| Mechanisms of nucleus accumbens deep brain stimulation in treating mental disorders. | Ruan H et al. | — | 2025 | → |
| Dopamine Release Dynamics in the Nucleus Accumbens Are Modulated by the Timing of Electrical Stimulation Pulses When Applied to the Medial Forebrain Bundle and Medial Prefrontal Cortex. | Hamilton AR et al. | — | 2024 | → |
| Effect of Phase Clustering Bias on Phase-Amplitude Coupling for Emotional EEG. | Sheng T et al. | — | 2024 | → |
| Transcranial alternating current stimulation in affecting cognitive impairment in psychiatric disorders: a review. | Biačková N et al. | — | 2024 | → |
| In vivo phase-dependent enhancement and suppression of human brain oscillations by transcranial alternating current stimulation (tACS). | Haslacher D et al. | — | 2023 | → |
| Cross-frequency coupling in psychiatric disorders: A systematic review. | Yakubov B et al. | — | 2022 | → |
| Network analysis in Gamma Knife capsulotomy for intractable obsessive-compulsive disorder. | Bouwens van der Vlis TAM et al. | — | 2022 | → |