Probing striato-thalamic function in obsessive-compulsive disorder and Tourette syndrome using neuroimaging methods.
- Authors
- Rauch, S L; Whalen, P J; Curran, T; Shin, L M; Coffey, B J; Savage, C R; McInerney, S C; Baer, L; Jenike, M A
- Year
- 2001
- Journal
- Advances in neurology
- PMID
- 11530429
In summary, contemporary pathophysiological models of OCD and related disorders implicate CSTC circuitry. In this chapter, we have reviewed relevant concepts related to implicit learning and more specifically, the use of an implicit sequence learning paradigm as a probe of striato-thalamic function. An initial PET investigation of patients with OCD confirmed a priori hypotheses of failure to recruit right striatum, despite the absence of a performance deficit (22). A modified version of the SRT was studied in conjunction with fMRI and yielded reliable right-lateralized striatal activation in a cohort of 10 male subjects, with clear spatial dissociation of caudate and putamen activation foci (119). Subsequent studies in our laboratory suggest that this paradigm also yields a reliable temporal window of thalamic deactivation, and hence a means for assessing thalamic gating in human subjects (120). Finally, as presented in this chapter, preliminary data from the fMRI-SRT in patients with OCD and TS as well as normal control subjects appear to replicate and extend the findings from our original PET-SRT study in OCD. Future investigations in our laboratory will seek to elaborate upon these preliminary results. In particular, we intend to study psychiatric comparison groups to establish the generalizability and/or specificity of these findings across disorders. Within OCD, we hope to explore the relationship between abnormal brain-activation patterns and symptom dimensions (34). Further, by studying subjects with remitted OCD who have been successfully treated, we hope to determine whether the observed brain-activation abnormalities represent state or trait markers. Finally, we have already begun to test a hypothesis of parallel processing deficiency in OCD by using a dual-task version of the SRT that makes simultaneous demands on implicit and explicit information processing systems (128). It is our hope that this program of research will yield new insights about OCD and related disorders, including TS. Most importantly, as other teams of investigators pursue complementary lines of inquiry, it is our wish that collective efforts in this field will lead to improved diagnosis and treatment, if not cure or prevention, for those who are afflicted with these illnesses.
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In this knowledge base
| Title | Year | PMID |
|---|---|---|
| Cross-disorder genome-wide analyses suggest a complex genetic relationship between Tourette's syndrome and OCD. | 2015 | 25158072 |
External
| Title | Authors | Journal | Year | Link |
|---|---|---|---|---|
| Impact of visual stimulus complexity on associative learning and associated reaction times in migraine patients. | TΓ³t K et al. | β | 2025 | β |
| Psychometric Properties of the MOVES Scale for Tourette Syndrome and Comorbidities in a Chinese Cultural Context. | Zhang W et al. | β | 2025 | β |
| Action sequence learning, habits, and automaticity in obsessive-compulsive disorder. | Banca P et al. | β | 2024 | β |
| Action-sequence learning, habits and automaticity in obsessive-compulsive disorder | Banca P et al. | β | 2023 | β |
| Correlations between single nucleotide polymorphisms in obsessive-compulsive disorder with the clinical features or response to therapy. | Beheshti M et al. | β | 2023 | β |
| Diffusion-Weighted MRI Findings of Caudate Nucleus and Putamen in Patients With Obsessive-Compulsive Disorder. | AglamiΕ S et al. | β | 2021 | β |
| Inhibition-Related Cortical Hypoconnectivity as a Candidate Vulnerability Marker for Obsessive-Compulsive Disorder. | Hampshire A et al. | β | 2020 | β |
| Towards a computational psychiatry of juvenile obsessive-compulsive disorder. | Loosen AM et al. | β | 2020 | β |
| Mapping Compulsivity in the DSM-5 Obsessive Compulsive and Related Disorders: Cognitive Domains, Neural Circuitry, and Treatment. | Fineberg NA et al. | β | 2018 | β |
| Detrimental effect of clomipramine on hippocampus-dependent learning in an animal model of obsessive-compulsive disorder induced by sensitization with d2/d3 agonist quinpirole. | Hatalova H et al. | β | 2017 | β |
| Hypoactivation and Dysconnectivity of a Frontostriatal Circuit During Goal-Directed Planning as an Endophenotype for Obsessive-Compulsive Disorder. | Vaghi MM et al. | β | 2017 | β |
| Neuroanatomical assessment of the impact of negative emotion on explicit memory in patients with obsessive-compulsive disorder. | Jang IS et al. | β | 2017 | β |
| Rodent models of obsessive compulsive disorder: Evaluating validity to interpret emerging neurobiology. | Zike I et al. | β | 2017 | β |
| Clinical significance of psychiatric comorbidity in children and adolescents with obsessive-compulsive disorder: subtyping a complex disorder. | Ortiz AE et al. | β | 2016 | β |
| Executive functions in obsessive-compulsive disorder: An activation likelihood estimate meta-analysis of fMRI studies. | Del Casale A et al. | β | 2016 | β |
| Neuroanatomical assessment of the impact of negative emotion on implicit memory in patients with obsessive compulsive disorder. | Park SE et al. | β | 2016 | β |
| Probing Implicit Learning in Obsessive-Compulsive Disorder: Moderating Role of Medication on the Weather Prediction Task. | Kelmendi B et al. | β | 2016 | β |
| A compensatory role for declarative memory in neurodevelopmental disorders. | Ullman MT et al. | β | 2015 | β |
| Cross-disorder genome-wide analyses suggest a complex genetic relationship between Tourette's syndrome and OCD. | Yu D et al. | β | 2015 | β |
| Annual research review: The neurobehavioral development of multiple memory systems--implications for childhood and adolescent psychiatric disorders. | Goodman J et al. | β | 2014 | β |
| Neuromodulation for obsessive-compulsive disorder. | Aronson JP et al. | β | 2014 | β |
| Obsessive-compulsive disorder: a "sensory-motor" problem? | Russo M et al. | β | 2014 | β |
| Anxiety and affective disorder comorbidity related to serotonin and other neurotransmitter systems: obsessive-compulsive disorder as an example of overlapping clinical and genetic heterogeneity. | Murphy DL et al. | β | 2013 | β |
| Correlations between brain activity and components of motor learning in middle-aged adults: an fMRI study. | Wadden K et al. | β | 2013 | β |
| Discrete sequence production with and without a pause: the role of cortex, basal ganglia, and cerebellum. | Jouen AL et al. | β | 2013 | β |
| Functional neuroimaging in specific phobia. | Del Casale A et al. | β | 2012 | β |
| Resting-state functional connectivity between fronto-parietal and default mode networks in obsessive-compulsive disorder. | Stern ER et al. | β | 2012 | β |
| Role of medial cortical networks for anticipatory processing in obsessive-compulsive disorder. | Ciesielski KT et al. | β | 2012 | β |
| Genomewide linkage analysis in Costa Rican families implicates chromosome 15q14 as a candidate region for OCD. | Ross J et al. | β | 2011 | β |
| Increased anterior brain activation to correct responses on high-conflict Stroop task in obsessive-compulsive disorder. | Ciesielski KT et al. | β | 2011 | β |
| Deep brain stimulation: from neurology to psychiatry? | Krack P et al. | β | 2010 | β |
| Features of compulsive checking behavior mediated by nucleus accumbens and orbital frontal cortex. | Dvorkin A et al. | β | 2010 | β |
| Neurocognitive performance in children with ADHD and OCD. | Vloet TD et al. | β | 2010 | β |
| Altered fronto-striato-thalamic connectivity in children with Tourette syndrome assessed with diffusion tensor MRI and probabilistic fiber tracking. | Makki MI et al. | β | 2009 | β |
| Brain potentials of conflict and error-likelihood following errorful and errorless learning in obsessive-compulsive disorder. | Hammer A et al. | β | 2009 | β |
| Impaired implicit learning and reduced pre-supplementary motor cortex size in early-onset major depression with melancholic features. | Exner C et al. | β | 2009 | β |
| Transcranial magnetic stimulation in Gilles de la Tourette syndrome. | Orth M | β | 2009 | β |
| Deep brain stimulation for psychiatric disorders. | Larson PS | β | 2008 | β |
| Psychiatric morbidity with focus on obsessive-compulsive disorder in an Israeli cohort of adolescents with mild to moderate mental retardation. | Gothelf D et al. | β | 2008 | β |
| The neural bases of obsessive-compulsive disorder in children and adults. | Maia TV et al. | β | 2008 | β |
| The role of the subthalamic nucleus in 'compulsive' behavior in rats. | Winter C et al. | β | 2008 | β |
| Dissociation between MEG alpha modulation and performance accuracy on visual working memory task in obsessive compulsive disorder. | Ciesielski KT et al. | β | 2007 | β |
| Dopamine transporter density in the basal ganglia in obsessive-compulsive disorder, measured with [123I]IPT SPECT before and after treatment with serotonin reuptake inhibitors. | Kim CH et al. | β | 2007 | β |
| Hoarding in obsessive-compulsive disorder: results from the OCD Collaborative Genetics Study. | Samuels JF et al. | β | 2007 | β |
| Spontaneous magnetoencephalographic activity in patients with obsessive-compulsive disorder. | MaihΓΆfner C et al. | β | 2007 | β |
| Stimulation of subterritories of the subthalamic nucleus reveals its role in the integration of the emotional and motor aspects of behavior. | Mallet L et al. | β | 2007 | β |
| Striatal function in generalized social phobia: a functional magnetic resonance imaging study. | Sareen J et al. | β | 2007 | β |
| Abnormal thalamic volume in treatment-naΓ―ve boys with Tourette syndrome. | Lee JS et al. | β | 2006 | β |
| Deficit in schizophrenia to recruit the striatum in implicit learning: a functional magnetic resonance imaging investigation. | Reiss JP et al. | β | 2006 | β |
| How psychotherapy changes the brain--the contribution of functional neuroimaging. | Linden DE | β | 2006 | β |
| Obsessive-compulsive disorder as a disturbance of security motivation: constraints on comorbidity. | Szechtman H et al. | β | 2006 | β |
| Positron emission tomography imaging of risperidone augmentation in serotonin reuptake inhibitor-refractory patients. | Buchsbaum MS et al. | β | 2006 | β |
| Frequency of obsessive and compulsive symptoms in patients with blepharospasm and hemifacial spasm. | Munhoz RP et al. | β | 2005 | β |
| Implicit sequence learning in obsessive-compulsive disorder: further support for the fronto-striatal dysfunction model. | Kathmann N et al. | β | 2005 | β |
| Obsessive-compulsive disorder. | Leonard HL et al. | β | 2005 | β |
| Sequential super-stereotypy of an instinctive fixed action pattern in hyper-dopaminergic mutant mice: a model of obsessive compulsive disorder and Tourette's. | Berridge KC et al. | β | 2005 | β |
| Obsessive-compulsive disorder as a disturbance of security motivation. | Szechtman H et al. | β | 2004 | β |
| Organizational strategy use in obsessive-compulsive disorder. | Roth RM et al. | β | 2004 | β |
| Amygdala and insular responses to emotionally valenced human faces in small animal specific phobia. | Wright CI et al. | β | 2003 | β |
| Automatic segmentation of thalamic nuclei from diffusion tensor magnetic resonance imaging. | Wiegell MR et al. | β | 2003 | β |
| Does an imbalance between the dorsal and ventral striatopallidal systems play a role in Tourette's syndrome? A neuronal circuit approach. | Groenewegen HJ et al. | β | 2003 | β |
| Dopamine transporter density of basal ganglia assessed with [123I]IPT SPET in obsessive-compulsive disorder. | Kim CH et al. | β | 2003 | β |
| Religious thought and behaviour as by-products of brain function. | Boyer P | β | 2003 | β |
| The primate basal ganglia: parallel and integrative networks. | Haber SN | β | 2003 | β |
| WCA recommendations for the long-term treatment of obsessive-compulsive disorder in adults. | Greist JH et al. | β | 2003 | β |
| Dissociating striatal and hippocampal function developmentally with a stimulus-response compatibility task. | Casey BJ et al. | β | 2002 | β |
| Functional neuroimaging in neurology and psychiatry. | Sadek JR et al. | β | 2002 | β |
| Obsessive-compulsive disorder. | Stein DJ | β | 2002 | β |