Binge and high-intensity drinking-Associations with intravenous alcohol self-administration and underlying risk factors.
paper
Primary
Public
- Authors
- Plawecki, Martin H; Boes, Julian; Wetherill, Leah; Kosobud, Ann E K; Stangl, Bethany L; Ramchandani, Vijay A; Zimmermann, Ulrich S; Nurnberger, John I; Schuckit, Marc; Edenberg, Howard J; Pandey, Gayathri; Kamarajan, Chella; Porjesz, Bernice; Foroud, Tatiana; O'Connor, Sean
- Year
- 2022
- Journal
- Addiction biology
- PMID
- 36301209
- DOI
- 10.1111/adb.13228
- PMCID
- PMC9786574
Some styles of alcohol consumption are riskier than others. How the level and rate of alcohol exposure contribute to the increased risk of alcohol use disorder is unclear, but likely depends on the alcohol concentration time course. We hypothesized that the brain is sensitive to the alcohol concentration rate of change and that people at greater risk would self-administer faster. We developed a novel intravenous alcohol self-administration paradigm to allow participants direct and reproducible control over how quickly their breath alcohol concentration changes. We used drinking intensity and the density of biological family history of alcohol dependence as proxies for risk. Thirty-five alcohol drinking participants aged 21-28 years provided analytical data from a single, intravenous alcohol self-administration session using our computer-assisted alcohol infusion system rate control paradigm. A shorter time to reach 80 mg/dl was associated with increasing multiples of the binge drinking definition (p = 0.004), which was in turn related to higher density of family history of alcoholism (FHD, p = 0.04). Rate-dependent changes in subjective response (intoxication and stimulation) were also associated with FHD (each p = 0.001). Subsequently, given the limited sample size and FHD range, associations between multiples of the binge drinking definition and FHD were replicated and extended in analyses of the Collaborative Study on the Genetics of Alcoholism database. The rate control paradigm models binge and high-intensity drinking in the laboratory and provides a novel way to examine the relationship between the pharmacokinetics and pharmacodynamics of alcohol and potentially the risk for the development of alcohol use disorders.
Exposure rate selection and subjective response determination sequence. The task began with an initial exposure rate selection, with the display indicating no past rate of change (baseline). During each 3 min epoch, beginning at 2.5 min, a set of subjective responses were collected over approximately 20 s after which time the next exposure rate selection prompt was displayed, indicating the prior selection in the left hand (shaded) portion of the display. The choice and subjective response sequence was repeated throughout the experiment. The next exposure rate was then selected by rotation of the response button (Griffin Technologies Powermate®, depiction inset) to a position within the available range depicted in grey. The arrow position followed the button rotation in real time, and the rate chosen is confirmed by a single button press.
Alcohol self‐administration trajectories. Individual BrAC time courses and average time course for the DI groups are displayed. Mean times to reach 80 mg/dl are noted by vertical lines.
Survival analysis of time to a binge alcohol exposure of 80 mg/dl. Kaplan–Meier curves show that drinking intensity group significantly predicted the time until a subject reached binge drinking BrAC threshold (p = 0.004). Five total participants did not reach 80 mg/dl, demarcated by the high and moderate group's survival probability remaining non‐zero at 120 min.
No entities extracted from this document yet.
No uploaded files.
Not in any collection.
| Citation | PMID | DOI | Status |
|---|---|---|---|
| Adan A , Forero DA , Navarro JF . Personality traits related to binge drinking: a systematic review. Front Psych. 2017;8:134. doi:10.3389/fpsyt.2017.00134 PMC553238128804465 | — | — | — |
| Alcoholism NIoAAa . Drinking levels defined. https://www.niaaa.nih.gov/alcohol-health/overview-alcohol-consumption/moderate-binge-drinking. Accessed 6/22/21 2021. | — | — | — |
| Anton RF , Drobes DJ , Voronin K , Durazo‐Avizu R , Moak D . Naltrexone effects on alcohol consumption in a clinical laboratory paradigm: temporal effects of drinking. Psychopharmacology (Berl). 2004;173(1–2):32‐40. doi:10.1007/s00213-003-1720-7 14722705 | — | — | — |
| Bucholz KK , Cadoret R , Cloninger CR , et al. A new, semi‐structured psychiatric interview for use in genetic linkage studies: a report on the reliability of the SSAGA. JStudAlcohol. 1994;55(2):149‐158. doi:10.15288/jsa.1994.55.149 8189735 | — | — | — |
| Bush K , Kivlahan DR , McDonell MB , Fihn SD , Bradley KA . The AUDIT alcohol consumption questions (AUDIT‐C): an effective brief screening test for problem drinking. Ambulatory Care Quality Improvement Project (ACQUIP). Alcohol Use Disorders Identification Test. Arch Intern Med. 1998;158(16):1789‐1795. doi:10.1001/archinte.158.16.1789 9738608 | — | — | — |
| Carpenter RW , Merrill JE . How much and how fast: alcohol consumption patterns, drinking‐episode affect, and next‐day consequences in the daily life of underage heavy drinkers. Drug Alcohol Depend. 2021;218:108407. doi:10.1016/j.drugalcdep.2020.108407 33257198PMC7750245 | — | — | — |
| Caudill BD , Marlatt GA . Modeling influences in social drinking: an experimental analogue. J Consult Clin Psychol. 1975;43(3):405‐415. doi:10.1037/h0076689 1159130 | — | — | — |
| Clarke TK , Adams MJ , Davies G , et al. Genome‐wide association study of alcohol consumption and genetic overlap with other health‐related traits in UK Biobank (N=112 117). Mol Psychiatry. 2017;22(10):1376‐1384. doi:10.1038/mp.2017.153 28937693PMC5622124 | — | — | — |
| Collins RL , Parks GA , Marlatt GA . Social determinants of alcohol consumption: the effects of social interaction and model status on the self‐administration of alcohol. J Consult Clin Psychol. 1985;53(2):189‐200. doi:10.1037/0022-006X.53.2.189 3998247 | — | — | — |
| Corbin WR , Gearhardt A , Fromme K . Stimulant alcohol effects prime within session drinking behavior. Psychopharmacology (Berl). 2008;197(2):327‐337. doi:10.1007/s00213-007-1039-x 18084744PMC3039601 | — | — | — |
| Creswell KG , Chung T , Skrzynski CJ , et al. Drinking beyond the binge threshold in a clinical sample of adolescents. Addiction. 2020;115(8):1472‐1481. doi:10.1111/add.14979 31984600PMC8071609 | — | — | — |
| Davidson D , Palfai T , Bird C , Swift R . Effects of naltrexone on alcohol self‐administration in heavy drinkers. Alcohol Clin Exp Res. 1999;23(2):195‐203. doi:10.1111/j.1530-0277.1999.tb04099.x 10069545 | — | — | — |
| Edenberg HJ , Bierut LJ , Boyce P , et al. Description of the data from the Collaborative Study on the Genetics of Alcoholism (COGA) and single‐nucleotide polymorphism genotyping for Genetic Analysis Workshop 14. BMC Genet. 2005;6(Suppl 1):S2. doi:10.1186/1471-2156-6-S1-S2 16451628PMC1866767 | — | — | — |
| Endres HG , Gruner O . Comparison of D2O and ethanol dilutions in total body water measurements in humans. Clin Investig. 1994;72(11):830‐837.10.1007/BF001907367894207 | — | — | — |
| Fillmore MT , Vogel‐Sprott M . Behavioral impairment under alcohol: cognitive and pharmacokinetic factors. Alcohol Clin Exp Res. 1998;22(7):1476‐1482. doi:10.1097/00000374-199810000-00016 9802531 | — | — | — |
| Fish JN , Hughes TL , Russell ST . Sexual identity differences in high‐intensity binge drinking: findings from a US national sample. Addiction. 2018;113(4):749‐758. doi:10.1111/add.14041 28940778PMC5847413 | — | — | — |
| Flannery BA , Volpicelli JR , Pettinati HM . Psychometric properties of the Penn Alcohol Craving Scale. Alcohol Clin Exp Res. 1999;23(8):1289‐1295. doi:10.1111/j.1530-0277.1999.tb04349.x 10470970 | — | — | — |
| Gelernter J , Sun N , Polimanti R , et al. Genome‐wide association study of maximum habitual alcohol intake in >140,000 U.S. European and African American veterans yields novel risk loci. Biol Psychiatry. 2019;86(5):365‐376. doi:10.1016/j.biopsych.2019.03.984 31151762PMC6919570 | — | — | — |
| Gomez R , Behar KL , Watzl J , et al. Intravenous ethanol infusion decreases human cortical gamma‐aminobutyric acid and N‐acetylaspartate as measured with proton magnetic resonance spectroscopy at 4 tesla. Biol Psychiatry. 2012;71(3):239‐246. doi:10.1016/j.biopsych.2011.06.026 21855054PMC3227760 | — | — | — |
| Gowin JL , Sloan ME , Stangl BL , Vatsalya V , Ramchandani VA . Vulnerability for alcohol use disorder and rate of alcohol consumption. Am J Psychiatry. 2017;174(11):1094‐1101. doi:10.1176/appi.ajp.2017.16101180 28774194PMC5667663 | — | — | — |
| Hendershot CS , Claus ED , Ramchandani VA . Associations of OPRM1 A118G and alcohol sensitivity with intravenous alcohol self‐administration in young adults. Addict Biol. 2016;21(1):125‐135. doi:10.1111/adb.12165 25039301PMC4300289 | — | — | — |
| Hesselbrock M , Easton C , Bucholz KK , Schuckit M , Hesselbrock V . A validity study of the SSAGA‐a comparison with the SCAN. Addiction. 1999;94(9):1361‐1370. doi:10.1046/j.1360-0443.1999.94913618.x 10615721 | — | — | — |
| Hingson RW , Zha W , White AM . Drinking beyond the binge threshold: predictors, consequences, and changes in the U.S. Am J Prev Med. 2017;52(6):717‐727. doi:10.1016/j.amepre.2017.02.014 28526355 | — | — | — |
| Hingson RW , Zha W . Binge drinking above and below twice the adolescent thresholds and health‐risk behaviors. Alcohol Clin Exp Res. 2018;42(5):904‐913. doi:10.1111/acer.13627 29634085 | — | — | — |
| Jarvenpaa T , Rinne JO , Koskenvuo M , Raiha I , Kaprio J . Binge drinking in midlife and dementia risk. Epidemiology. 2005;16(6):766‐771. doi:10.1097/01.ede.0000181307.30826.6c 16222166 | — | — | — |
| Johnson EC , Sanchez‐Roige S , Acion L , et al. Polygenic contributions to alcohol use and alcohol use disorders across population‐based and clinically ascertained samples. Psychol Med. 2020;1‐10.10.1017/S0033291719004045PMC740572531955720 | — | — | — |
| Judd LL , Hubbard RB , Huey LY , Attewell PA , Janowsky DS , Takahashi KI . Lithium carbonate and ethanol induced “highs” in normal subjects. Arch Gen Psychiatry. 1977;34(4):463‐467. doi:10.1001/archpsyc.1977.01770160097008 322635 | — | — | — |
| Kapoor M , Wang JC , Wetherill L , et al. A meta‐analysis of two genome‐wide association studies to identify novel loci for maximum number of alcoholic drinks. Hum Genet. 2013;132(10):1141‐1151. doi:10.1007/s00439-013-1318-z 23743675PMC3776011 | — | — | — |
| Koob GF , Volkow ND . Neurobiology of addiction: a neurocircuitry analysis. Lancet Psychiatry. 2016;3(8):760‐773. doi:10.1016/S2215-0366(16)00104-8 27475769PMC6135092 | — | — | — |
| Kosobud AE , Wetherill L , Plawecki MH , et al. Adaptation of subjective responses to alcohol is affected by an interaction of GABRA2 genotype and recent drinking. Alcohol Clin Exp Res. 2015;39(7):1148‐1157. doi:10.1111/acer.12749 26087834PMC4490958 | — | — | — |
| Kranzler HR , Zhou H , Kember RL , et al. Genome‐wide association study of alcohol consumption and use disorder in 274,424 individuals from multiple populations. Nat Commun. 2019;10(1):1499. doi:10.1038/s41467-019-09480-8 30940813PMC6445072 | — | — | — |
| Lewinsohn PM , Seeley JR , Roberts RE , Allen NB . Center for Epidemiologic Studies Depression Scale (CES‐D) as a screening instrument for depression among community‐residing older adults. Psychol Aging. 1997;12(2):277‐287. doi:10.1037/0882-7974.12.2.277 9189988 | — | — | — |
| Lindberg L , Brauer S , Wollmer P , Goldberg L , Jones AW , Olsson SG . Breath alcohol concentration determined with a new analyzer using free exhalation predicts almost precisely the arterial blood alcohol concentration. Forensic Sci Int. 2007;168(2‐3):200‐207. doi:10.1016/j.forsciint.2006.07.018 16978819 | — | — | — |
| Linden‐Carmichael AN , Vasilenko SA , Lanza ST , Maggs JL . High‐intensity drinking versus heavy episodic drinking: prevalence rates and relative odds of alcohol use disorder across adulthood. Alcohol Clin Exp Res. 2017;41(10):1754‐1759. doi:10.1111/acer.13475 28800154PMC5626636 | — | — | — |
| Loeppky JA , Myhre LG , Venters MD , Luft UC . Total body water and lean body mass estimated by ethanol dilution. J Appl Physiol Respir Environ Exerc Physiol. 1977;42(6):803‐808. doi:10.1152/jappl.1977.42.6.803 328477 | — | — | — |
| Mallard TT , Savage JE , Johnson EC , et al. Item‐level genome‐wide association study of the alcohol use disorders identification test in three population‐based cohorts. Am J Psychiatry. 2021; PMID: appiajp202020091390.10.1176/appi.ajp.2020.20091390PMC927289533985350 | — | — | — |
| Martin CS , Earleywine M . Ascending and descending rates of change in blood alcohol concentrations and subjective intoxication ratings. J Subst Abuse. 1990;2(3):345‐352. doi:10.1016/S0899-3289(10)80006-9 2136119 | — | — | — |
| Miller JW , Naimi TS , Brewer RD , Jones SE . Binge drinking and associated health risk behaviors among high school students. Pediatrics. 2007;119(1):76‐85. doi:10.1542/peds.2006-1517 17200273 | — | — | — |
| Morean ME , Corbin WR , Treat TA . The Subjective Effects of Alcohol Scale: development and psychometric evaluation of a novel assessment tool for measuring subjective response to alcohol. Psychol Assess. 2013;25(3):780‐795. doi:10.1037/a0032542 23647036PMC3822039 | — | — | — |
| Morris DH , Amlung MT , Tsai CL , McCarthy DM . Association between overall rate of change in rising breath alcohol concentration and the magnitude of acute tolerance of subjective intoxication via the Mellanby method. Hum Psychopharmacol. 2017;32(1):e2565. doi:10.1002/hup.2565 PMC548031427925280 | — | — | — |
| Morzorati SL , Ramchandani VA , Flury L , Li TK , O'Connor S . Self‐reported subjective perception of intoxication reflects family history of alcoholism when breath alcohol levels are constant. Alcohol Clin Exp Res. 2002;26(8):1299‐1306. doi:10.1111/j.1530-0277.2002.tb02670.x 12198408 | — | — | — |
| Naimi TS , Lipscomb LE , Brewer RD , Gilbert BC . Binge drinking in the preconception period and the risk of unintended pregnancy: implications for women and their children. Pediatrics. 2003;111(5 Pt 2):1136‐1141. doi:10.1542/peds.111.S1.1136 12728126 | — | — | — |
| Newlin DB , Thomson JB . Alcohol challenge with sons of alcoholics: a critical review and analysis. Psychol Bull. 1990;108(3):383‐402. doi:10.1037/0033-2909.108.3.383 2270234 | — | — | — |
| Norberg A , Jones AW , Hahn RG , Gabrielsson JL . Role of variability in explaining ethanol pharmacokinetics: research and forensic applications. Clin Pharmacokinet. 2003;42(1):1‐31. doi:10.2165/00003088-200342010-00001 12489977 | — | — | — |
| Norberg A , Sandhagen B , Bratteby LE , et al. Do ethanol and deuterium oxide distribute into the same water space in healthy volunteers? Alcohol Clin Exp Res. 2001;25(10):1423‐1430. doi:10.1111/j.1530-0277.2001.tb02143.x 11696661 | — | — | — |
| O'Malley SS , Krishnan‐Sarin S , Farren C , Sinha R , Kreek MJ . Naltrexone decreases craving and alcohol self‐administration in alcohol‐dependent subjects and activates the hypothalamo‐pituitary‐adrenocortical axis. Psychopharmacology (Berl). 2002;160(1):19‐29. doi:10.1007/s002130100919 11862370 | — | — | — |
| Patrick ME , Evans‐Polce RJ , Parks MJ , Terry‐McElrath YM . Drinking intensity at age 29/30 as a predictor of alcohol use disorder symptoms at age 35 in a national sample. J Stud Alcohol Drugs. 2021;82(3):362‐367. doi:10.15288/jsad.2021.82.362 34100704PMC8328234 | — | — | — |
| Plawecki MH , Decarlo R , Ramchandani VA , O'Connor S . Improved transformation of morphometric measurements for a priori parameter estimation in a physiologically‐based pharmacokinetic model of ethanol. Biomed Signal Process Control. 2007;2(2):97‐110. doi:10.1016/j.bspc.2007.04.001 18379641PMC2180397 | — | — | — |
| Plawecki MH , Durrani AM , Boes J , et al. Comparison of subjective responses to oral and intravenous alcohol administration under similar systemic exposures. Alcohol Clin Exp Res. 2019;43(4):597‐606. doi:10.1111/acer.13970 30721544PMC6443482 | — | — | — |
| Plawecki MH , Wetherill L , Vitvitskiy V , et al. Voluntary intravenous self‐administration of alcohol detects an interaction between GABAergic manipulation and GABRG1 polymorphism genotype: a pilot study. Alcohol Clin Exp Res. 2013;37(Suppl 1):E152‐E160. doi:10.1111/j.1530-0277.2012.01885.x 22817768PMC4159724 | — | — | — |
| Plawecki MH , White K , Kosobud AEK , et al. Sex differences in motivation to self‐administer alcohol after 2 weeks of abstinence in young‐adult heavy drinkers. Alcohol Clin Exp Res. 2018;42(10):1897‐1908. doi:10.1111/acer.13860 30080254PMC6167142 | — | — | — |
| Plawecki MH , Windisch KA , Wetherill L , et al. Alcohol affects the P3 component of an adaptive stop signal task ERP. Alcohol. 2018;70:1‐10. doi:10.1016/j.alcohol.2017.08.012 29705707PMC5932288 | — | — | — |
| Plawecki MH , Zimmermann US , Vitvitskiy V , Doerschuk PC , Crabb D , O'Connor S . Alcohol exposure rate control through physiologically based pharmacokinetic modeling. Alcohol Clin Exp Res. 2012;36(6):1042‐1049. doi:10.1111/j.1530-0277.2011.01706.x 22486174PMC3370150 | — | — | — |
| Ramchandani VA , Flury L , Morzorati SL , et al. Recent drinking history: association with family history of alcoholism and the acute response to alcohol during a 60 mg% clamp. J Stud Alcohol. 2002;63(6):734‐744. doi:10.15288/jsa.2002.63.734 12529074 | — | — | — |
| Ramchandani VA , O'Connor S , Blekher T , et al. A preliminary study of acute responses to clamped alcohol concentration and family history of alcoholism. Alcohol Clin Exp Res. 1999;23(8):1320‐1330. doi:10.1111/j.1530-0277.1999.tb04353.x 10470974 | — | — | — |
| Ramchandani VA , Plawecki M , Li TK , O'Connor S . Intravenous ethanol infusions can mimic the time course of breath alcohol concentrations following oral alcohol administration in healthy volunteers. Alcohol Clin Exp Res. 2009;33(5):938‐944. doi:10.1111/j.1530-0277.2009.00906.x 19320632 | — | — | — |
| Rice JP , Reich T , Bucholz KK , et al. Comparison of direct interview and family history diagnoses of alcohol dependence. Alcohol Clin Exp Res. 1995;19(4):1018‐1023. doi:10.1111/j.1530-0277.1995.tb00983.x 7485811 | — | — | — |
| Rueger SY , King AC . Validation of the brief Biphasic Alcohol Effects Scale (B‐BAES). Alcohol Clin Exp Res. 2013;37(3):470‐476. doi:10.1111/j.1530-0277.2012.01941.x 23078583PMC3570663 | — | — | — |
| Sanchez‐Roige S , Palmer AA , Fontanillas P , et al. Genome‐wide association study meta‐analysis of the Alcohol Use Disorders Identification Test (AUDIT) in two population‐based cohorts. Am J Psychiatry. 2019;176(2):107‐118. doi:10.1176/appi.ajp.2018.18040369 30336701PMC6365681 | — | — | — |
| Saunders JB , Aasland OG , Babor TF , de la Fuente JR , Grant M . Development of the Alcohol Use Disorders Identification Test (AUDIT): WHO collaborative project on early detection of persons with harmful alcohol consumption—II. Addiction. 1993;88(6):791‐804. doi:10.1111/j.1360-0443.1993.tb02093.x 8329970 | — | — | — |
| Schneider VJ 2nd , Bush N , Vitus D , Carpenter RW , Robinson M , Boissoneault J . A virtual reality platform for the measurement of drinking topography. Drug Alcohol Depend. 2022;231:109246. doi:10.1016/j.drugalcdep.2021.109246 34998252PMC9358601 | — | — | — |
| Schuckit MA , Gold EO . A simultaneous evaluation of multiple markers of ethanol/placebo challenges in sons of alcoholics and controls. Arch Gen Psychiatry. 1988;45(3):211‐216. doi:10.1001/archpsyc.1988.01800270019002 3422553 | — | — | — |
| Schuckit MA , Smith TL , Kalmijn J , Tsuang J , Hesselbrock V , Bucholz K . Response to alcohol in daughters of alcoholics: a pilot study and a comparison with sons of alcoholics. Alcohol Alcohol. 2000;35(3):242‐248. doi:10.1093/alcalc/35.3.242 10869242 | — | — | — |
| Schuckit MA , Smith TL . Changes over time in the self‐reported level of response to alcohol. Alcohol Alcohol. 2004;39(5):433‐438. doi:10.1093/alcalc/agh081 15289209 | — | — | — |
| Schuckit MA . Self‐rating of alcohol intoxication by young men with and without family histories of alcoholism. J Stud Alcohol. 1980;41(3):242‐249. doi:10.15288/jsa.1980.41.242 7374142 | — | — | — |
| Schuckit MA . Subjective responses to alcohol in sons of alcoholics and control subjects. Arch Gen Psychiatry. 1984;41(9):879‐884. doi:10.1001/archpsyc.1984.01790200061008 6466047 | — | — | — |
| Schumann G , Coin LJ , Lourdusamy A , et al. Genome‐wide association and genetic functional studies identify autism susceptibility candidate 2 gene (AUTS2) in the regulation of alcohol consumption. Proc Natl Acad Sci U S a. 2011;108(17):7119‐7124. doi:10.1073/pnas.1017288108 21471458PMC3084048 | — | — | — |
| Sloan ME , Gowin JL , Janakiraman R , et al. High‐risk social drinkers and heavy drinkers display similar rates of alcohol consumption. Addict Biol. 2020;25(2):e12734. doi:10.1111/adb.12734 30821409PMC6717699 | — | — | — |
| Sobell LC , Brown J , Leo GI , Sobell MB . The reliability of the alcohol timeline followback when administered by telephone and by computer. Drug Alcohol Depend. 1996;42(1):49‐54. doi:10.1016/0376-8716(96)01263-X 8889403 | — | — | — |
| Sobell LC , Sobell MB . Timeline Follow‐Back: A Technique for Assessing Self‐Reported Alcohol Consumption. Totowa, NJ: Humana Press; 1992; doi:10.1007/978-1-4612-0357-5_3 | — | — | — |
| Stangl BL , Vatsalya V , Zametkin MR , et al. Exposure‐response relationships during free‐access intravenous alcohol self‐administration in nondependent drinkers: influence of alcohol expectancies and impulsivity. Int J Neuropsychopharmacol. 2017;20(1):31‐39. doi:10.1093/ijnp/pyw090 27742833PMC5412584 | — | — | — |
| Stoltenberg SF , Mudd SA , Blow FC , Hill EM . Evaluating measures of family history of alcoholism: density versus dichotomy. Addiction. 1998;93(10):1511‐1520. doi:10.1046/j.1360-0443.1998.931015117.x 9926555 | — | — | — |
| Sullivan JT , Sykora K , Schneiderman J , Naranjo CA , Sellers EM . Assessment of alcohol withdrawal: the revised clinical institute withdrawal assessment for alcohol scale (CIWA‐Ar). Br J Addict. 1989;84(11):1353‐1357. doi:10.1111/j.1360-0443.1989.tb00737.x 2597811 | — | — | — |
| Sundell L , Salomaa V , Vartiainen E , Poikolainen K , Laatikainen T . Increased stroke risk is related to a binge‐drinking habit. Stroke. 2008;39(12):3179‐3184. doi:10.1161/STROKEAHA.108.520817 18832741 | — | — | — |
| Watson PE . Total Body Water and Blood Alcohol Levels: Updating the Fundamentals. Boca Raton, Fla.: CRC Press; 1989. | — | — | — |
| Wetherill L , Morzorati SL , Foroud T , et al. Subjective perceptions associated with the ascending and descending slopes of breath alcohol exposure vary with recent drinking history. Alcohol Clin Exp Res. 2012;36(6):1050‐1057. doi:10.1111/j.1530-0277.2011.01642.x 21933199PMC3288407 | — | — | — |
| World Health Organization . Management of Substance Abuse Team. Geneva, Switzerland: World Health Organization. | — | — | — |
| Xu K , Kranzler HR , Sherva R , et al. Genomewide association study for maximum number of alcoholic drinks in European Americans and African Americans. Alcohol Clin Exp Res. 2015;39(7):1137‐1147. doi:10.1111/acer.12751 26036284PMC4706077 | — | — | — |
| Zimmermann US , Mick I , Laucht M , et al. Offspring of parents with an alcohol use disorder prefer higher levels of brain alcohol exposure in experiments involving computer‐assisted self‐infusion of ethanol (CASE). Psychopharmacology (Berl). 2009;202(4):689‐697. doi:10.1007/s00213-008-1349-7 18936917PMC8496509 | — | — | — |
| Zimmermann US , Mick I , Vitvitskyi V , Plawecki MH , Mann KF , O'Connor S . Development and pilot validation of computer‐assisted self‐infusion of ethanol (CASE): a new method to study alcohol self‐administration in humans. Alcohol Clin Exp Res. 2008;32(7):1321‐1328. doi:10.1111/j.1530-0277.2008.00700.x 18540908PMC8500340 | — | — | — |
No papers in this knowledge base cite this source.
External
| Title | Authors | Journal | Year | Link |
|---|---|---|---|---|
| Aversion-resistant alcohol seeking in the human laboratory. | Garrison ACS et al. | — | 2025 | → |
| Contributions of testosterone to excessive alcohol drinking in males: Potential role for interactions with the HPA axis. | Zegarelli RA et al. | — | 2025 | → |
| Left Ventral Caudate Functional Connectivity Mediates the Relationship Between Habitual Responding and Alcohol Use. | Fisher-Fox LR et al. | — | 2025 | → |
| Pace of alcohol drinking during in natural-environment drinking is associated with heightened alcohol-related reward and negative consequences in risky drinkers. | Atkinson EA et al. | — | 2025 | → |
| Binge and high-intensity drinking-Associations with intravenous alcohol self-administration and underlying risk factors. | Plawecki MH et al. | — | 2022 | → |