A role for neuropeptide Y in alcohol intake control: evidence from human and animal research.
paper
Cited
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- Authors
- Thiele, Todd E; Badia-Elder, Nancy E
- Year
- 2003
- Journal
- Physiology & behavior
- PMID
- 12818714
- DOI
- 10.1016/s0031-9384(03)00109-4
This article is based on proceedings of a symposium presented at the 2002 meeting of the Society for the Study of Ingestive Behavior and provides a brief overview of recent research suggesting a role for neuropeptide Y (NPY) in the modulation of ethanol drinking. The discussion focuses mainly on recent studies with genetic animal models including mutant mice lacking specific NPY receptor and selectively bred rodents, namely the Indiana alcohol-preferring (P) and alcohol-nonpreferring (NP) rats and the Indiana high alcohol drinking (HAD) and low alcohol drinking (LAD) rats. It is concluded that abnormal or low central NPY activity can promote high alcohol drinking and that NPY modulates alcohol consumption via the NPY Y1 and Y2 receptors.
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In this knowledge base
| Title | Year | PMID |
|---|---|---|
| Neuropeptide Y receptor genes are associated with alcohol dependence, alcohol withdrawal phenotypes, and cocaine dependence. | 2008 | 18828811 |
External
| Title | Authors | Journal | Year | Link |
|---|---|---|---|---|
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| Essential Role of Histone Methyltransferase G9a in Rapid Tolerance to the Anxiolytic Effects of Ethanol. | Berkel TDM et al. | — | 2019 | → |
| Medications development for the treatment of alcohol use disorder: insights into the predictive value of animal and human laboratory models. | Yardley MM et al. | — | 2017 | → |
| A Genetic Animal Model of Alcoholism for Screening Medications to Treat Addiction. | Bell RL et al. | — | 2016 | → |
| Caenorhabditis elegans as a Model to Study the Molecular and Genetic Mechanisms of Drug Addiction. | Engleman EA et al. | — | 2016 | → |
| Effects of chronic alcohol consumption, withdrawal and nerve growth factor on neuropeptide Y expression and cholinergic innervation of the rat dentate hilus. | Pereira PA et al. | — | 2016 | → |
| Npy deletion in an alcohol non-preferring rat model elicits differential effects on alcohol consumption and body weight. | Qiu B et al. | — | 2016 | → |
| An Assay for Measuring the Effects of Ethanol on the Locomotion Speed of Caenorhabditis elegans. | Davies AG et al. | — | 2015 | → |
| SWI/SNF chromatin remodeling regulates alcohol response behaviors in Caenorhabditis elegans and is associated with alcohol dependence in humans. | Mathies LD et al. | — | 2015 | → |
| Effects of histone deacetylase inhibitors on amygdaloid histone acetylation and neuropeptide Y expression: a role in anxiety-like and alcohol-drinking behaviours. | Sakharkar AJ et al. | — | 2014 | → |
| The omega-3 fatty acid eicosapentaenoic acid is required for normal alcohol response behaviors in C. elegans. | Raabe RC et al. | — | 2014 | → |
| Quantitative trait locus for body weight identified on rat chromosome 4 in inbred alcohol-preferring and -nonpreferring rats: potential implications for neuropeptide Y and corticotrophin releasing hormone 2. | Spence JP et al. | — | 2013 | → |
| Alcohol intake. | Corella D | — | 2012 | → |
| Association study of 45 candidate genes in nicotine dependence in Han Chinese. | Wei J et al. | — | 2012 | → |
| Neuropeptide Y signaling modulates the expression of ethanol-induced behavioral sensitization in mice. | Hayes DM et al. | — | 2012 | → |
| Central functions of neuropeptide Y in mood and anxiety disorders. | Wu G et al. | — | 2011 | → |
| Micellar nanomedicine of human neuropeptide Y. | Kuzmis A et al. | — | 2011 | → |
| Association between neuropeptide Y receptor 2 polymorphism and the smoking behavior of elderly Japanese. | Sato N et al. | — | 2010 | → |
| Association between neuropeptide Y gene and its receptor Y1 gene and methamphetamine dependence. | Okahisa Y et al. | — | 2009 | → |
| Variants in neuropeptide Y receptor 1 and 5 are associated with nutrient-specific food intake and are under recent selection in Europeans. | Elbers CC et al. | — | 2009 | → |
| Is decreased appetite for food a physiological consequence of alcohol consumption? | Kokavec A | — | 2008 | → |
| Modulation of neuropeptide Y and Y1 receptor expression in the amygdala by fluctuations in the brain content of neuroactive steroids during ethanol drinking discontinuation in Y1R/LacZ transgenic mice. | Eva C et al. | — | 2008 | → |
| Neuroendocrine pathways in benzodiazepine dependence: new targets for research and therapy. | Heberlein A et al. | — | 2008 | → |
| Neuropeptide Y receptor genes are associated with alcohol dependence, alcohol withdrawal phenotypes, and cocaine dependence. | Wetherill L et al. | — | 2008 | → |
| Persistent alterations in mesolimbic gene expression with abstinence from cocaine self-administration. | Freeman WM et al. | — | 2008 | → |
| The influence of stress on the transition from drug use to addiction. | Wand G | — | 2008 | → |
| cis-Regulatory sequences of the genes involved in apoptosis, cell growth, and proliferation may provide a target for some of the effects of acute ethanol exposure. | Uddin RK et al. | — | 2006 | → |
| Participation of alpha-melanocyte stimulating hormone in ethanol-induced anxiolysis and withdrawal anxiety in rats. | Kokare DM et al. | — | 2006 | → |
| Physiology and gene regulation of the brain NPY Y1 receptor. | Eva C et al. | — | 2006 | → |
| Role of brain neuroactive steroids in the functional interplay between the GABA(A) and the NPY-Y1 receptor mediated signals in the amygdala. | Eva C et al. | — | 2006 | → |
| Circadian activity rhythms in selectively bred ethanol-preferring and nonpreferring rats. | Rosenwasser AM et al. | — | 2005 | → |
| Comparison of basal neuropeptide Y and corticotropin releasing factor levels between the high ethanol drinking C57BL/6J and low ethanol drinking DBA/2J inbred mouse strains. | Hayes DM et al. | — | 2005 | → |
| Complex genetics of interactions of alcohol and CNS function and behavior. | Matthews DB et al. | — | 2005 | → |
| Development of medications for alcohol use disorders: recent advances and ongoing challenges. | Litten RZ et al. | — | 2005 | → |
| Effect of polymorphism on expression of the neuropeptide Y gene in inbred alcohol-preferring and -nonpreferring rats. | Spence JP et al. | — | 2005 | → |
| Role of serotonin (5-HT) in the antidepressant-like properties of neuropeptide Y (NPY) in the mouse forced swim test. | Redrobe JP et al. | — | 2005 | → |
| Sensitized effects of neuropeptide Y on multiple ingestive behaviors in P rats following ethanol abstinence. | Gilpin NW et al. | — | 2005 | → |
| The anxious amygdala: CREB signaling and predisposition to anxiety and alcoholism. | Wand G | — | 2005 | → |
| Towards unraveling ethanol-specific neuro-metabolomics based on ethanol responsive genes in vivo. | Uddin RK et al. | — | 2005 | → |
| A role for neuropeptide Y in neurobiological responses to ethanol and drugs of abuse. | Thiele TE et al. | — | 2004 | → |
| Assessment of ethanol consumption and water drinking by NPY Y(2) receptor knockout mice. | Thiele TE et al. | — | 2004 | → |
| Natural variation in the npr-1 gene modifies ethanol responses of wild strains of C. elegans. | Davies AG et al. | — | 2004 | → |
| Overlapping peptide control of alcohol self-administration and feeding. | Thiele TE et al. | — | 2004 | → |
| Peripheral and central administration of a selective neuropeptide Y Y1 receptor antagonist suppresses ethanol intake by C57BL/6J mice. | Sparta DR et al. | — | 2004 | → |
| Rats on the grog: novel pharmacotherapies for alcohol craving. | McGregor IS et al. | — | 2004 | → |
| The use of Caenorhabditis elegans in molecular neuropharmacology. | Bettinger JC et al. | — | 2004 | → |
| Alcoholism and obesity: overlapping neuropeptide pathways? | Thiele TE et al. | — | 2003 | → |
| Peptides: their role in excess alcohol drinking and their promise as a therapeutic tool. | Egli M | — | 2003 | → |