Polygenic Contributions to Suicidal Thoughts and Behaviors in a Sample Ascertained for Alcohol Use Disorders.
- Authors
- Colbert, Sarah M C; Mullins, Niamh; Chan, Grace; Meyers, Jacquelyn L; Schulman, Jessica; Kuperman, Samuel; Lai, Dongbing; Nurnberger, John; Plawecki, Martin H; Kamarajan, Chella; Anokhin, Andrey P; Bucholz, Kathleen K; Hesselbrock, Victor; Edenberg, Howard J; Kramer, John; Dick, Danielle M; Porjesz, Bernice; Agrawal, Arpana; Johnson, Emma C
- Year
- 2023
- Journal
- Complex psychiatry
- PMID
- 38058956
- DOI
- 10.1159/000529164
- PMCID
- PMC10697665
INTRODUCTION: Suicidal thoughts and behaviors have partially distinct genetic etiologies. METHODS: We used PRS-CS to create polygenic risk scores (PRSs) from GWAS of non-suicidal self-injury, broad-sense self-harm ideation, nonfatal suicide attempt, death by suicide, and depression. Using mixed-effect models, we estimated whether these PRSs were associated with a range of suicidal thoughts and behaviors in the Collaborative Study on the Genetics of Alcoholism ( = 7,526). RESULTS: All PRSs were significantly associated with suicidal ideation and suicide attempt (betas = 0.08-0.44, false discovery rate [FDR] <0.023). All PRSs except non-suicidal self-injury PRS were associated with active suicidal ideation (betas = 0.14-0.22, FDR <0.003). Several associations remained significant in models where all significant PRSs were included as simultaneous predictors, and when all PRSs predicted suicide attempt, the PRS together explained 6.2% of the variance in suicide attempt. Significant associations were also observed between some PRSs and persistent suicidal ideation, non-suicidal self-injury, compounded suicide attempt, and desire to die. CONCLUSION: Our findings suggest that PRS for depression does not explain the entirety of the variance in suicidal thoughts and behaviors, with PRS specifically for suicidal thoughts and behaviors making additional and sometimes unique contributions.
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External
| Title | Authors | Journal | Year | Link |
|---|---|---|---|---|
| Unique and shared internalizing and externalizing genetic factors associated with suicidal thoughts and behaviors: Findings from the adolescent brain cognitive development study. | Thomas NS et al. | — | 2026 | → |
| Defining suicidality phenotypes for genetic studies: perspectives of the Psychiatric Genomics Consortium Suicide Working Group. | Colbert SMC et al. | — | 2025 | → |
| Distinguishing clinical and genetic risk factors for suicidal ideation and behavior in a diverse hospital population. | Colbert SMC et al. | — | 2025 | → |
| Associations between polygenic liability to psychopathology and non-suicidal versus suicidal self-injury. | Edwards AC et al. | — | 2024 | → |
| Defining and Assessing International Classification of Disease Suicidality Phenotypes for Genetic Studies | Monson ET et al. | — | 2024 | — |
| Polygenic risk for suicide attempt is associated with lifetime suicide attempt in US soldiers independent of parental risk. | Stein MB et al. | — | 2024 | → |
| Polygenic Contributions to Suicidal Thoughts and Behaviors in a Sample Ascertained for Alcohol Use Disorders. | Colbert SMC et al. | — | 2023 | → |