Human genetic variation and its contribution to complex traits.
paper
Cited
Public
Unavailable
- Authors
- Frazer, Kelly A; Murray, Sarah S; Schork, Nicholas J; Topol, Eric J
- Year
- 2009
- Journal
- Nature reviews. Genetics
- PMID
- 19293820
- DOI
- 10.1038/nrg2554
The last few years have seen extensive efforts to catalogue human genetic variation and correlate it with phenotypic differences. Most common SNPs have now been assessed in genome-wide studies for statistical associations with many complex traits, including many important common diseases. Although these studies have provided new biological insights, only a limited amount of the heritable component of any complex trait has been identified and it remains a challenge to elucidate the functional link between associated variants and phenotypic traits. Technological advances, such as the ability to detect rare and structural variants, and a clear understanding of the challenges in linking different types of variation with phenotype, will be essential for future progress.
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| Haplotype-specific MAPT exon 3 expression regulated by common intronic polymorphisms associated with Parkinsonian disorders. | Lai MC et al. | โ | 2017 | โ |
| Identification of polymorphisms in cancer patients that differentially affect survival with age. | Doherty A et al. | โ | 2017 | โ |
| IL10 low-frequency variants in Behรงet's disease patients. | Matos M et al. | โ | 2017 | โ |
| Integrating GWAS and Co-expression Network Data Identifies Bone Mineral Density Genes SPTBN1 and MARK3 and an Osteoblast Functional Module. | Calabrese GM et al. | โ | 2017 | โ |
| Metal-DNA Interactions Improve signal in High-Resolution Melting of DNA for Species Differentiation of Plasmodium Parasite. | Jain P et al. | โ | 2017 | โ |
| Significance of functional disease-causal/susceptible variants identified by whole-genome analyses for the understanding of human diseases. | Hitomi Y et al. | โ | 2017 | โ |
| Stepwise Distributed Open Innovation Contests for Software Development: Acceleration of Genome-Wide Association Analysis. | Hill A et al. | โ | 2017 | โ |
| Structural variants in SNCA gene and the implication to synucleinopathies. | Chiba-Falek O | โ | 2017 | โ |
| The epigenetic landscape of myalgic encephalomyelitis/chronic fatigue syndrome: deciphering complex phenotypes. | de Vega WC et al. | โ | 2017 | โ |
| The PETALE study: Late adverse effects and biomarkers in childhood acute lymphoblastic leukemia survivors. | Marcoux S et al. | โ | 2017 | โ |
| Towards precision medicine in Alzheimer's disease: deciphering genetic data to establish informative biomarkers. | Chiba-Falek O et al. | โ | 2017 | โ |
| Understanding the Evolutionary Biology of CVD From Analysis of Ancestral Population Genomes. | Ibrahim M et al. | โ | 2017 | โ |
| Whole exome sequencing: Uncovering causal genetic variants for ocular diseases. | Gupta S et al. | โ | 2017 | โ |
| A Data Fusion Approach to Enhance Association Study in Epilepsy. | Marini S et al. | โ | 2016 | โ |
| An integrative approach to investigate the respective roles of single-nucleotide variants and copy-number variants in Attention-Deficit/Hyperactivity Disorder. | Lima Lde A et al. | โ | 2016 | โ |
| A risk prediction model for colorectal cancer using genome-wide association study-identified polymorphisms and established risk factors among Japanese: results from two independent case-control studies. | Hosono S et al. | โ | 2016 | โ |
| Association of Cross-Sectional and Longitudinal Change in Arterial Stiffness With Gene Expression in the Twins UK Cohort. | Cecelja M et al. | โ | 2016 | โ |
| Association of potentially functional variants in the XPG gene with neuroblastoma risk in a Chinese population. | He J et al. | โ | 2016 | โ |
| Building brains in a dish: Prospects for growing cerebral organoids from stem cells. | Mason JO et al. | โ | 2016 | โ |
| Cardiac dyssynchrony and response to cardiac resynchronisation therapy in heart failure: can genetic predisposition play a role? | Lahrouchi N et al. | โ | 2016 | โ |
| Chromatin interactions and candidate genes at ten prostate cancer risk loci. | Du M et al. | โ | 2016 | โ |
| CINOEDV: a co-information based method for detecting and visualizing n-order epistatic interactions. | Shang J et al. | โ | 2016 | โ |
| Computational challenges in modeling gene regulatory events. | Pataskar A et al. | โ | 2016 | โ |
| Crowdsourced assessment of common genetic contribution to predicting anti-TNF treatment response in rheumatoid arthritis. | Sieberts SK et al. | โ | 2016 | โ |
| DEPDC5 variants increase fibrosis progression in Europeans with chronic hepatitis C virus infection. | Burza MA et al. | โ | 2016 | โ |
| Enhancer-promoter interactions are encoded by complex genomic signatures on looping chromatin. | Whalen S et al. | โ | 2016 | โ |
| Epistatic Gene-Based Interaction Analyses for Glaucoma in eMERGE and NEIGHBOR Consortium. | Verma SS et al. | โ | 2016 | โ |
| Evaluation of GWAS-identified SNPs at 6p22 with neuroblastoma susceptibility in a Chinese population. | He J et al. | โ | 2016 | โ |
| Genes with a Combination of Over-Dominant and Epistatic Effects Underlie Heterosis in Growth of Saccharomyces cerevisiae at High Temperature. | Shapira R et al. | โ | 2016 | โ |
| Genetics of leprosy: Expected-and unexpected-developments and perspectives. | Sauer ME et al. | โ | 2016 | โ |
| Genome-Wide Association Study Identifies Novel Candidate Genes for Aggressiveness, Deoxynivalenol Production, and Azole Sensitivity in Natural Field Populations of Fusarium graminearum. | Talas F et al. | โ | 2016 | โ |
| GERV: a statistical method for generative evaluation of regulatory variants for transcription factor binding. | Zeng H et al. | โ | 2016 | โ |
| GMDR: Versatile Software for Detecting Gene-Gene and Gene-Environ- ment Interactions Underlying Complex Traits. | Xu HM et al. | โ | 2016 | โ |
| Impact of DNA mismatch repair system alterations on human fertility and related treatments. | Hu MH et al. | โ | 2016 | โ |
| Improving treatment of neurodevelopmental disorders: recommendations based on preclinical studies. | Homberg JR et al. | โ | 2016 | โ |
| In silico characterization of functional SNP within the oestrogen receptor gene. | Rebaรฏ M et al. | โ | 2016 | โ |
| In silico SNP analysis of the breast cancer antigen NY-BR-1. | Kosaloglu Z et al. | โ | 2016 | โ |
| Interactions of Methylenetetrahydrofolate Reductase C677T Polymorphism with Environmental Factors on Hypertension Susceptibility. | Fan S et al. | โ | 2016 | โ |
| Iterative Usage of Fixed and Random Effect Models for Powerful and Efficient Genome-Wide Association Studies. | Liu X et al. | โ | 2016 | โ |
| Lack of Associations between <i>XPC</i> Gene Polymorphisms and Neuroblastoma Susceptibility in a Chinese Population. | Zheng J et al. | โ | 2016 | โ |
| LMO1 gene polymorphisms contribute to decreased neuroblastoma susceptibility in a Southern Chinese population. | He J et al. | โ | 2016 | โ |
| Low-pass whole-genome sequencing in clinical cytogenetics: a validated approach. | Dong Z et al. | โ | 2016 | โ |
| Membrane-proximal binding of STAT3 revealed by cancer-associated receptor variants. | Ulaganathan VK et al. | โ | 2016 | โ |
| Molecular Genetic of Atopic dermatitis: An Update. | Al-Shobaili HA et al. | โ | 2016 | โ |
| Next generation sequencing: implications in personalized medicine and pharmacogenomics. | Rabbani B et al. | โ | 2016 | โ |
| Polyallelic structural variants can provide accurate, highly informative genetic markers focused on diagnosis and therapeutic targets: Accuracy vs. Precision. | Roses AD | โ | 2016 | โ |
| Polymorphisms in NRGN are associated with schizophrenia, major depressive disorder and bipolar disorder in the Han Chinese population. | Wen Z et al. | โ | 2016 | โ |
| Polymorphisms of the coagulation system and risk of cancer. | Tinholt M et al. | โ | 2016 | โ |
| Rapid phenotyping of knockout mice to identify genetic determinants of bone strength. | Freudenthal B et al. | โ | 2016 | โ |
| Reasoning over genetic variance information in cause-and-effect models of neurodegenerative diseases. | Naz M et al. | โ | 2016 | โ |
| Recurrent copy number variants associated with bronchopulmonary dysplasia. | Ahmad A et al. | โ | 2016 | โ |
| Revisiting Human Cholesterol Synthesis and Absorption: The Reciprocity Paradigm and its Key Regulators. | Alphonse PA et al. | โ | 2016 | โ |
| Structural variants can be more informative for disease diagnostics, prognostics and translation than current SNP mapping and exon sequencing. | Roses AD et al. | โ | 2016 | โ |
| The SSV Evaluation System: A Tool to Prioritize Short Structural Variants for Studies of Possible Regulatory and Causal Variants. | Saul R et al. | โ | 2016 | โ |
| A common variant in RAB27A gene is associated with fractional exhaled nitric oxide levels in adults. | Bouzigon E et al. | โ | 2015 | โ |
| A cytosine-thymine (CT)-rich haplotype in intron 4 of SNCA confers risk for Lewy body pathology in Alzheimer's disease and affects SNCA expression. | Lutz MW et al. | โ | 2015 | โ |
| An introductory review of parallel independent component analysis (p-ICA) and a guide to applying p-ICA to genetic data and imaging phenotypes to identify disease-associated biological pathways and systems in common complex disorders. | Pearlson GD et al. | โ | 2015 | โ |
| A review of study designs and statistical methods for genomic epidemiology studies using next generation sequencing. | Wang Q et al. | โ | 2015 | โ |
| Ayurnutrigenomics: Ayurveda-inspired personalized nutrition from inception to evidence. | Banerjee S et al. | โ | 2015 | โ |
| Biological knowledge-driven analysis of epistasis in human GWAS with application to lipid traits. | Ma L et al. | โ | 2015 | โ |
| Biology-Driven Gene-Gene Interaction Analysis of Age-Related Cataract in the eMERGE Network. | Hall MA et al. | โ | 2015 | โ |
| Combined genetic effects of EGLN1 and VWF modulate thrombotic outcome in hypoxia revealed by Ayurgenomics approach. | Aggarwal S et al. | โ | 2015 | โ |
| Common single nucleotide variants underlying drug addiction: more than a decade of research. | Bรผhler KM et al. | โ | 2015 | โ |
| Conserved Genetic Interactions between Ciliopathy Complexes Cooperatively Support Ciliogenesis and Ciliary Signaling. | Yee LE et al. | โ | 2015 | โ |
| Copy number variants and genetic polymorphisms in TBX21, GATA3, Rorc, Foxp3 and susceptibility to Behcet's disease and Vogt-Koyanagi-Harada syndrome. | Liao D et al. | โ | 2015 | โ |
| Diabetes susceptibility in Mayas: Evidence for the involvement of polymorphisms in HHEX, HNF4ฮฑ, KCNJ11, PPARฮณ, CDKN2A/2B, SLC30A8, CDC123/CAMK1D, TCF7L2, ABCA1 and SLC16A11 genes. | Lara-Riegos JC et al. | โ | 2015 | โ |
| Evaluation of genetic susceptibility of common variants in CACNA1D with schizophrenia in Han Chinese. | Guan F et al. | โ | 2015 | โ |
| Familial predisposition and genetic risk factors for lymphoma. | Cerhan JR et al. | โ | 2015 | โ |
| Fetal, neonatal, infant, and child international growth standards: an unprecedented opportunity for an integrated approach to assess growth and development. | Garza C | โ | 2015 | โ |
| Fetal programming and epigenetic mechanisms in arterial hypertension. | Scherrer U et al. | โ | 2015 | โ |
| Feto-maternal interactions: a possible clue to explain the 'missed heritability' in arterial hypertension. | Rimoldi SF et al. | โ | 2015 | โ |
| Functional and Structural Consequence of Rare Exonic Single Nucleotide Polymorphisms: One Story, Two Tales. | Gu W et al. | โ | 2015 | โ |
| Genetic predisposition to acute kidney injury--a systematic review. | Vilander LM et al. | โ | 2015 | โ |
| Genetics of leprosy: expected and unexpected developments and perspectives. | Sauer ME et al. | โ | 2015 | โ |
| Genetic variation and gastric cancer risk: a field synopsis and meta-analysis. | Mocellin S et al. | โ | 2015 | โ |
| Genome-wide association study-identified SNPs (rs3790844, rs3790843) in the NR5A2 gene and risk of pancreatic cancer in Japanese. | Ueno M et al. | โ | 2015 | โ |
| Mapping asthma-associated variants in admixed populations. | Mersha TB | โ | 2015 | โ |
| MicroRNAs in Nonalcoholic Fatty Liver Disease. | Baffy G | โ | 2015 | โ |
| Next-generation sequencing of nine atrial fibrillation candidate genes identified novel de novo mutations in patients with extreme trait of atrial fibrillation. | Tsai CT et al. | โ | 2015 | โ |
| Obesity: interactions of genome and nutrients intake. | Doo M et al. | โ | 2015 | โ |
| Perceptions and Attitudes About Genetic Counseling Among Residents of a Midwestern Rural Area. | Riesgraf RJ et al. | โ | 2015 | โ |
| Prioritization of cancer-related genomic variants by SNP association network. | Liu C et al. | โ | 2015 | โ |
| Production of Extrachromosomal MicroDNAs Is Linked to Mismatch Repair Pathways and Transcriptional Activity. | Dillon LW et al. | โ | 2015 | โ |
| Proteomic analysis of colon and rectal carcinoma using standard and customized databases. | Slebos RJ et al. | โ | 2015 | โ |
| Re-annotation of presumed noncoding disease/trait-associated genetic variants by integrative analyses. | Chen G et al. | โ | 2015 | โ |
| Recent advances in the genetics of autism spectrum disorder. | De Rubeis S et al. | โ | 2015 | โ |
| Resequencing diverse Chinese indigenous breeds to enrich the map of genomic variations in swine. | Kang H et al. | โ | 2015 | โ |
| SS1 (NAL1)- and SS2-Mediated Genetic Networks Underlying Source-Sink and Yield Traits in Rice (Oryza sativa L.). | Xu JL et al. | โ | 2015 | โ |
| Statistical analysis for genome-wide association study. | Zeng P et al. | โ | 2015 | โ |
| Strategies for Imputing and Analyzing Rare Variants in Association Studies. | Hoffmann TJ et al. | โ | 2015 | โ |
| Testing for genetic associations in arbitrarily structured populations. | Song M et al. | โ | 2015 | โ |
| The Human Genome Project, and recent advances in personalized genomics. | Wilson BJ et al. | โ | 2015 | โ |
| The Use of Non-Variant Sites to Improve the Clinical Assessment of Whole-Genome Sequence Data. | Ferrarini A et al. | โ | 2015 | โ |
| The variation game: Cracking complex genetic disorders with NGS and omics data. | Cui H et al. | โ | 2015 | โ |
| Trade-offs in the effects of the apolipoprotein E polymorphism on risks of diseases of the heart, cancer, and neurodegenerative disorders: insights on mechanisms from the Long Life Family Study. | Kulminski AM et al. | โ | 2015 | โ |
| Transcriptional Enhancers: Bridging the Genome and Phenome. | Ren B et al. | โ | 2015 | โ |
| Variation in the X-linked EFHC2 gene is associated with social cognitive abilities in males. | Startin CM et al. | โ | 2015 | โ |
| A comprehensive evaluation of collapsing methods using simulated and real data: excellent annotation of functionality and large sample sizes required. | Dering C et al. | โ | 2014 | โ |
| Allele-specific genome editing and correction of disease-associated phenotypes in rats using the CRISPR-Cas platform. | Yoshimi K et al. | โ | 2014 | โ |
| Allelic variation in Salmonella: an underappreciated driver of adaptation and virulence. | Yue M et al. | โ | 2014 | โ |
| Alpha-tryptase gene variation is associated with levels of circulating IgE and lung function in asthma. | Abdelmotelb AM et al. | โ | 2014 | โ |
| Ancestry estimation and control of population stratification for sequence-based association studies. | Wang C et al. | โ | 2014 | โ |
| ANTXR2 is a potential causative gene in the genome-wide association study of the blood pressure locus 4q21. | Park SY et al. | โ | 2014 | โ |
| AQP4 tag single nucleotide polymorphisms in patients with traumatic brain injury. | Dardiotis E et al. | โ | 2014 | โ |
| Bayesian latent variable collapsing model for detecting rare variant interaction effect in twin study. | He L et al. | โ | 2014 | โ |
| Cardiac channelopathy testing in 274 ethnically diverse sudden unexplained deaths. | Wang D et al. | โ | 2014 | โ |
| Chip-based direct genotyping of coding variants in genome wide association studies: utility, issues and prospects. | Nievergelt CM et al. | โ | 2014 | โ |
| Combining family- and population-based imputation data for association analysis of rare and common variants in large pedigrees. | Saad M et al. | โ | 2014 | โ |
| Computational approaches and resources in single amino acid substitutions analysis toward clinical research. | George Priya Doss C et al. | โ | 2014 | โ |
| Conventional and genetic talent identification in sports: will recent developments trace talent? | Breitbach S et al. | โ | 2014 | โ |
| Current Insights into the Joint Genetic Basis of Type 2 Diabetes and Coronary Heart Disease. | Dauriz M et al. | โ | 2014 | โ |
| Dental phenomics: advancing genotype to phenotype correlations in craniofacial research. | Yong R et al. | โ | 2014 | โ |
| Detecting genetic interactions in pathway-based genome-wide association studies. | Huang A et al. | โ | 2014 | โ |
| Determining effects of non-synonymous SNPs on protein-protein interactions using supervised and semi-supervised learning. | Zhao N et al. | โ | 2014 | โ |
| Efficient and scalable scaffolding using optical restriction maps. | Saha S et al. | โ | 2014 | โ |
| Embryonic exposure to corticosterone modifies aggressive behavior through alterations of the hypothalamic pituitary adrenal axis and the serotonergic system in the chicken. | Ahmed AA et al. | โ | 2014 | โ |
| Emerging technologies for hybridization based single nucleotide polymorphism detection. | Knez K et al. | โ | 2014 | โ |
| Evidence for the role of EPHX2 gene variants in anorexia nervosa. | Scott-Van Zeeland AA et al. | โ | 2014 | โ |
| Exploring genetic variants predisposing to diabetes mellitus and their association with indicators of socioeconomic status. | Schmidt B et al. | โ | 2014 | โ |
| From genome-wide association study hits to new insights into experimental hematology. | Cvejic A | โ | 2014 | โ |
| Gene-Gene and Gene-Environment Interactions Underlying Complex Traits and their Detection. | Lou XY | โ | 2014 | โ |
| Genetic association of BSF2 polymorphism and susceptibility to lung cancer. | Wang H et al. | โ | 2014 | โ |
| Genetics and behavior: a guide for practitioners. | Overall KL et al. | โ | 2014 | โ |
| Genetic variation at the CYP2C19 gene associated with metabolic syndrome susceptibility in a South Portuguese population: results from the pilot study of the European Health Examination Survey in Portugal. | Gaio V et al. | โ | 2014 | โ |
| Genome-wide association studies of atopic dermatitis. | Tamari M et al. | โ | 2014 | โ |
| Genotype-environment interactions for quantitative traits in Korea Associated Resource (KARE) cohorts. | Kim J et al. | โ | 2014 | โ |
| High burden of private mutations due to explosive human population growth and purifying selection. | Gao F et al. | โ | 2014 | โ |
| How genetic studies have advanced our understanding of age-related macular degeneration and their impact on patient care: a review. | Baird PN et al. | โ | 2014 | โ |
| How important are rare variants in common disease? | Saint Pierre A et al. | โ | 2014 | โ |
| Human genetics shape the gut microbiome. | Goodrich JK et al. | โ | 2014 | โ |
| Identification of rare genetic variants in novel loci associated with Paget's disease of bone. | Beauregard M et al. | โ | 2014 | โ |
| Individualized medicine from prewomb to tomb. | Topol EJ | โ | 2014 | โ |
| Insertion-deletions burden in copy number polymorphisms of the Tibetan population. | Veerappa AM et al. | โ | 2014 | โ |
| Introduction to genetics and genomics in asthma: genetics of asthma. | Mathias RA | โ | 2014 | โ |
| Investigating the Role of Gene-Gene Interactions in TB Susceptibility. | Daya M et al. | โ | 2014 | โ |
| Laboratory evolution of adenylyl cyclase independent learning in Drosophila and missing heritability. | Cressy M et al. | โ | 2014 | โ |
| Laying a solid foundation for Manhattan--'setting the functional basis for the post-GWAS era'. | Zhang X et al. | โ | 2014 | โ |
| Methodology for the analysis of rare genetic variation in genome-wide association and re-sequencing studies of complex human traits. | Moutsianas L et al. | โ | 2014 | โ |
| Molecular and genetic epidemiology of cancer in low- and medium-income countries. | Malhotra J | โ | 2014 | โ |
| Neurocriminology: implications for the punishment, prediction and prevention of criminal behaviour. | Glenn AL et al. | โ | 2014 | โ |
| Oxidative stress and genetic markers of suboptimal antioxidant defense in the aging brain: a theoretical review. | Salminen LE et al. | โ | 2014 | โ |
| Polymorphism of DEFA in Chinese Han population with IgA nephropathy. | Xu R et al. | โ | 2014 | โ |
| The missing story behind Genome Wide Association Studies: single nucleotide polymorphisms in gene deserts have a story to tell. | Schierding W et al. | โ | 2014 | โ |
| The OSR1 rs12329305 polymorphism contributes to the development of congenital malformations in cases of stillborn/neonatal death. | Loziฤ B et al. | โ | 2014 | โ |
| The Usage of an SNP-SNP Relationship Matrix for Best Linear Unbiased Prediction (BLUP) Analysis Using a Community-Based Cohort Study. | Lee YS et al. | โ | 2014 | โ |
| Towards a comprehensive picture of the genetic landscape of complex traits. | Wang Z et al. | โ | 2014 | โ |
| Twin studies in inherited eye disease. | Nag A et al. | โ | 2014 | โ |
| A century after Fisher: time for a new paradigm in quantitative genetics. | Nelson RM et al. | โ | 2013 | โ |
| A functional link between FOXA1 and breast cancer SNPs. | Katika MR et al. | โ | 2013 | โ |
| A genome-wide association study of total serum and mite-specific IgEs in asthma patients. | Kim JH et al. | โ | 2013 | โ |
| An erythroid enhancer of BCL11A subject to genetic variation determines fetal hemoglobin level. | Bauer DE et al. | โ | 2013 | โ |
| A network medicine approach to psychiatric genetics. | Lasky-Su J | โ | 2013 | โ |
| An evolutionary perspective on epistasis and the missing heritability. | Hemani G et al. | โ | 2013 | โ |
| A novel genetic variant in the transcription factor Islet-1 exerts gain of function on myocyte enhancer factor 2C promoter activity. | Friedrich FW et al. | โ | 2013 | โ |
| A PLSPM-based test statistic for detecting gene-gene co-association in genome-wide association study with case-control design. | Zhang X et al. | โ | 2013 | โ |
| A sequence-based variation map of zebrafish. | Patowary A et al. | โ | 2013 | โ |
| Assessment of possible association between rs3787016 and prostate cancer risk in Serbian population. | Nikoliฤ ZZ et al. | โ | 2013 | โ |
| Association of a single-nucleotide polymorphism within the miR-146a gene with susceptibility for acute-on-chronic hepatitis B liver failure. | Jiang H et al. | โ | 2013 | โ |
| A statistical framework for joint eQTL analysis in multiple tissues. | Flutre T et al. | โ | 2013 | โ |
| Building a genome analysis pipeline to predict disease risk and prevent disease. | Bromberg Y | โ | 2013 | โ |
| Cerebral radiation necrosis: a review of the pathobiology, diagnosis and management considerations. | Rahmathulla G et al. | โ | 2013 | โ |
| Child development and molecular genetics: 14 years later. | Plomin R | โ | 2013 | โ |
| Complete genome sequencing and variant analysis of a Pakistani individual. | Azim MK et al. | โ | 2013 | โ |
| Complex inheritance of melanoma and pigmentation of coat and skin in Grey horses. | Curik I et al. | โ | 2013 | โ |
| Construction of gene clusters resembling genetic causal mechanisms for common complex disease with an application to young-onset hypertension. | Lynn KS et al. | โ | 2013 | โ |
| Differentially expressed genes in cisplatin-induced premature ovarian failure in rats. | Li D et al. | โ | 2013 | โ |
| Gene-based testing of interactions in association studies of quantitative traits. | Ma L et al. | โ | 2013 | โ |
| Genes and epigenetic processes as prospective pain targets. | Crow M et al. | โ | 2013 | โ |
| Genetic architecture of carotid artery intima-media thickness in Mexican Americans. | Melton PE et al. | โ | 2013 | โ |
| Genetic association study of Dickkopf-1 and sclerostin genes with paget disease of bone. | Beauregard M et al. | โ | 2013 | โ |
| Genetic interaction networks: toward an understanding of heritability. | Baryshnikova A et al. | โ | 2013 | โ |
| Genetic predisposition to non-union: evidence today. | Dimitriou R et al. | โ | 2013 | โ |
| Genetic susceptibility to lung cancer and co-morbidities. | Yang IA et al. | โ | 2013 | โ |
| Genetic variants associated with development of TMD and its intermediate phenotypes: the genetic architecture of TMD in the OPPERA prospective cohort study. | Smith SB et al. | โ | 2013 | โ |
| Genomics of human health and aging. | Kulminski AM et al. | โ | 2013 | โ |
| "He who sees things grow from the beginning will have the finest view of them" a systematic review of genetic studies on psychological traits in infancy. | Papageorgiou KA et al. | โ | 2013 | โ |
| Higher order interactions: detection of epistasis using machine learning and evolutionary computation. | Nelson RM et al. | โ | 2013 | โ |
| High quality methylome-wide investigations through next-generation sequencing of DNA from a single archived dry blood spot. | Aberg KA et al. | โ | 2013 | โ |
| IL1RN coding variant is associated with lower risk of acute respiratory distress syndrome and increased plasma IL-1 receptor antagonist. | Meyer NJ et al. | โ | 2013 | โ |
| Integrated enrichment analysis of variants and pathways in genome-wide association studies indicates central role for IL-2 signaling genes in type 1 diabetes, and cytokine signaling genes in Crohn's disease. | Carbonetto P et al. | โ | 2013 | โ |
| Interactive effect of STAT6 and IL13 gene polymorphisms on eczema status: results from a longitudinal and a cross-sectional study. | Ziyab AH et al. | โ | 2013 | โ |
| Key issues in essential tremor genetics research: Where are we now and how can we move forward? | Testa CM | โ | 2013 | โ |
| Large-scale profiling and identification of potential regulatory mechanisms for allelic gene expression in colorectal cancer cells. | Lee RD et al. | โ | 2013 | โ |
| Linkage analysis identifies a locus for plasma von Willebrand factor undetected by genome-wide association. | Desch KC et al. | โ | 2013 | โ |
| Mapping human epigenomes. | Rivera CM et al. | โ | 2013 | โ |
| miR-9a minimizes the phenotypic impact of genomic diversity by buffering a transcription factor. | Cassidy JJ et al. | โ | 2013 | โ |
| News from the protein mutability landscape. | Hecht M et al. | โ | 2013 | โ |
| Next-Generation Sequencing in the Genetics of Human Atrial Fibrillation. | Hsieh CS et al. | โ | 2013 | โ |
| Nitric oxide modifies global histone methylation by inhibiting Jumonji C domain-containing demethylases. | Hickok JR et al. | โ | 2013 | โ |
| Pairomics, the omics way to mate choice. | Dani SU et al. | โ | 2013 | โ |
| Predicting risk of type 2 diabetes mellitus with genetic risk models on the basis of established genome-wide association markers: a systematic review. | Bao W et al. | โ | 2013 | โ |
| Random forests on Hadoop for genome-wide association studies of multivariate neuroimaging phenotypes. | Wang Y et al. | โ | 2013 | โ |
| Sclerostin: how human mutations have helped reveal a new target for the treatment of osteoporosis. | Robinson MK et al. | โ | 2013 | โ |
| Single Nucleotide Polymorphism (SNP) Detection and Genotype Calling from Massively Parallel Sequencing (MPS) Data. | Li Y et al. | โ | 2013 | โ |
| Systematic comparison of phenome-wide association study of electronic medical record data and genome-wide association study data. | Denny JC et al. | โ | 2013 | โ |
| The genetic architecture of alopecia areata. | Petukhova L et al. | โ | 2013 | โ |
| The genetic profile of bone repair. | Dimitriou R et al. | โ | 2013 | โ |
| Toward developmental models of psychiatric disorders in zebrafish. | Norton WH | โ | 2013 | โ |
| Trade-off in the effect of the APOE gene on the ages at onset of cardiocascular disease and cancer across ages, gender, and human generations. | Kulminski AM et al. | โ | 2013 | โ |
| Unraveling genetic origin of aging-related traits: evolving concepts. | Kulminski AM | โ | 2013 | โ |
| Accounting for a quantitative trait locus for plasma triglyceride levels: utilization of variants in multiple genes. | Martin LJ et al. | โ | 2012 | โ |
| A functional polymorphism in the CHRNA3 gene and risk of chronic obstructive pulmonary disease in a Korean population. | Lee JY et al. | โ | 2012 | โ |
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| Chromosomal copy number alterations are associated with persistent lymph node metastasis after chemoradiation in locally advanced rectal cancer. | Chen Z et al. | โ | 2012 | โ |
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| Evaluation of the imputation performance of the program IMPUTE in an admixed sample from Mexico City using several model designs. | Krithika S et al. | โ | 2012 | โ |
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| Genome-wide epigenetic data facilitate understanding of disease susceptibility association studies. | Hardison RC | โ | 2012 | โ |
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| Germ line variation in nucleotide excision repair genes and lung cancer risk in smokers. | Sakoda LC et al. | โ | 2012 | โ |
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| Integrative functional genomics identifies an enhancer looping to the SOX9 gene disrupted by the 17q24.3 prostate cancer risk locus. | Zhang X et al. | โ | 2012 | โ |
| Knowledge-driven analysis identifies a gene-gene interaction affecting high-density lipoprotein cholesterol levels in multi-ethnic populations. | Ma L et al. | โ | 2012 | โ |
| Large-scale gene-centric meta-analysis across 32 studies identifies multiple lipid loci. | Asselbergs FW et al. | โ | 2012 | โ |
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| Mitochondrial DNA sequence variation is associated with free-living activity energy expenditure in the elderly. | Tranah GJ et al. | โ | 2012 | โ |
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| Polymorphisms in genes of the somatotrophic axis are independently associated with milk production, udder health, survival and animal size in Holstein-Friesian dairy cattle. | Waters SM et al. | โ | 2012 | โ |
| Predicting signatures of "synthetic associations" and "natural associations" from empirical patterns of human genetic variation. | Chang D et al. | โ | 2012 | โ |
| Promising Genetic Biomarkers of Preclinical Alzheimer's Disease: The Influence of APOE and TOMM40 on Brain Integrity. | Ferencz B et al. | โ | 2012 | โ |
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| Recent explosive human population growth has resulted in an excess of rare genetic variants. | Keinan A et al. | โ | 2012 | โ |
| Regulation of the human tyrosinase gene in retinal pigment epithelium cells: the significance of transcription factor orthodenticle homeobox 2 and its polymorphic binding site. | Reinisalo M et al. | โ | 2012 | โ |
| Report of the National Heart, Lung, and Blood Institute Working Group on epigenetics and hypertension. | Cowley AW et al. | โ | 2012 | โ |
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| Sequencing of high-complexity DNA pools for identification of nucleotide and structural variants in regions associated with complex traits. | Zaboli G et al. | โ | 2012 | โ |
| Simultaneous detection of multiple mutations in epidermal growth factor receptor based on fluorescence quenching of quantum dots. | Kang T et al. | โ | 2012 | โ |
| Spectrum of large copy number variations in 26 diverse Indian populations: potential involvement in phenotypic diversity. | Gautam P et al. | โ | 2012 | โ |
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| Systematic meta-analyses and field synopsis of genetic association studies in colorectal cancer. | Theodoratou E et al. | โ | 2012 | โ |
| The contribution of FTO and UCP-1 SNPs to extreme obesity, diabetes and cardiovascular risk in Brazilian individuals. | Ramos AV et al. | โ | 2012 | โ |
| The dynorphin/ฮบ-opioid receptor system and its role in psychiatric disorders. | Tejeda HA et al. | โ | 2012 | โ |
| The genetics of kidney transplantation. | Pallet N et al. | โ | 2012 | โ |
| The need for mouse models in osteoporosis genetics research. | Ackert-Bicknell CL et al. | โ | 2012 | โ |
| The population genetics of Quechuas, the largest native South American group: autosomal sequences, SNPs, and microsatellites evidence high level of diversity. | Scliar MO et al. | โ | 2012 | โ |
| The predictive capacity of personal genome sequencing. | Roberts NJ et al. | โ | 2012 | โ |
| The QTN program and the alleles that matter for evolution: all that's gold does not glitter. | Rockman MV | โ | 2012 | โ |
| Unraveling the genetic component of systemic sclerosis. | Martรญn JE et al. | โ | 2012 | โ |
| Whole-genome sequencing in personalized therapeutics. | Cordero P et al. | โ | 2012 | โ |
| Will SNPs be useful predictors of normal tissue radiosensitivity in the future? | Andreassen CN et al. | โ | 2012 | โ |
| Adolescent idiopathic scoliosis (AIS), environment, exposome and epigenetics: a molecular perspective of postnatal normal spinal growth and the etiopathogenesis of AIS with consideration of a network approach and possible implications for medical therapy. | Burwell RG et al. | โ | 2011 | โ |
| Advances of genomic science and systems biology in renal transplantation: a review. | Perkins D et al. | โ | 2011 | โ |
| A functional alternative splicing mutation in human tryptophan hydroxylase-2. | Zhang X et al. | โ | 2011 | โ |
| A regulatory SNP in AKAP13 is associated with blood pressure in Koreans. | Hong KW et al. | โ | 2011 | โ |
| Association of -27T>C and its haplotype at the putative promoter for IgA-specific receptor gene with IgA nephropathy among the Chinese Han population. | Huang W et al. | โ | 2011 | โ |
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| Association studies in thyroid cancer susceptibility: are we on the right track? | Landa I et al. | โ | 2011 | โ |
| Association studies in thyroid cancer susceptibility: are we on the right track? | Landa I et al. | โ | 2011 | โ |
| Ayurgenomics: a new way of threading molecular variability for stratified medicine. | Sethi TP et al. | โ | 2011 | โ |
| Bioinformatics challenges for personalized medicine. | Fernald GH et al. | โ | 2011 | โ |
| Cancer evolution and individual susceptibility. | Pรฉrez-Losada J et al. | โ | 2011 | โ |
| Combining genome-wide data from humans and animal models of dyslipidemia and atherosclerosis. | Berisha SZ et al. | โ | 2011 | โ |
| Complex disease: Finding functions in the wilderness. | Skipper M | โ | 2011 | โ |
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| Cosmopolitan and ethnic-specific replication of genetic risk factors for asthma in 2 Latino populations. | Galanter JM et al. | โ | 2011 | โ |
| Coverage tradeoffs and power estimation in the design of whole-genome sequencing experiments for detecting association. | Shen Y et al. | โ | 2011 | โ |
| Discovery of genetic susceptibility factors for human birth defects: an opportunity for a National Agenda. | Olshan AF et al. | โ | 2011 | โ |
| Efficient and cost effective population resequencing by pooling and in-solution hybridization. | Bansal V et al. | โ | 2011 | โ |
| Emerging genomic applications in coronary artery disease. | Damani SB et al. | โ | 2011 | โ |
| eResponseNet: a package prioritizing candidate disease genes through cellular pathways. | Huang J et al. | โ | 2011 | โ |
| Estimation of allele frequency and association mapping using next-generation sequencing data. | Kim SY et al. | โ | 2011 | โ |
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| Evidence for PTPN22 R620W polymorphism as the sole common risk variant for rheumatoid arthritis in the 1p13.2 region. | Martรญn JE et al. | โ | 2011 | โ |
| Fast identification and removal of sequence contamination from genomic and metagenomic datasets. | Schmieder R et al. | โ | 2011 | โ |
| GATES: a rapid and powerful gene-based association test using extended Simes procedure. | Li MX et al. | โ | 2011 | โ |
| Gene--gene interaction among cytokine polymorphisms influence susceptibility to aggressive periodontitis. | Scapoli C et al. | โ | 2011 | โ |
| Genetic factors in contact allergy--review and future goals. | Schnuch A et al. | โ | 2011 | โ |
| Genetics of age-related macular degeneration: current concepts, future directions. | Deangelis MM et al. | โ | 2011 | โ |
| Genetics of complex respiratory diseases: implications for pathophysiology and pharmacology studies. | Obeidat M et al. | โ | 2011 | โ |
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| Genetics of human episodic memory: dealing with complexity. | Papassotiropoulos A et al. | โ | 2011 | โ |
| Genetic variation and its role in malignancy. | Talseth-Palmer BA et al. | โ | 2011 | โ |
| Genetic vulnerability and susceptibility to substance dependence. | Bierut LJ | โ | 2011 | โ |
| Genomewide association analysis of symptoms of alcohol dependence in the molecular genetics of schizophrenia (MGS2) control sample. | Kendler KS et al. | โ | 2011 | โ |
| Genome-wide association studies identify genetic loci related to alcohol consumption in Korean men. | Baik I et al. | โ | 2011 | โ |
| Genome-wide association studies of asthma. | Tamari M et al. | โ | 2011 | โ |
| Genotype and cardiovascular phenotype correlations with TBX1 in 1,022 velo-cardio-facial/DiGeorge/22q11.2 deletion syndrome patients. | Guo T et al. | โ | 2011 | โ |
| High-performance single-chip exon capture allows accurate whole exome sequencing using the Illumina Genome Analyzer. | Jiang T et al. | โ | 2011 | โ |
| Hip osteoarthritis susceptibility is associated with IL1B -511(G>A) and IL1 RN (VNTR) genotypic polymorphisms in Croatian Caucasian population. | Jotanovic Z et al. | โ | 2011 | โ |
| Host genetics in follicular lymphoma. | Cerhan JR | โ | 2011 | โ |
| Human genetics and genomics a decade after the release of the draft sequence of the human genome. | Naidoo N et al. | โ | 2011 | โ |
| Identification of a gene associated with avian migratory behaviour. | Mueller JC et al. | โ | 2011 | โ |
| Identification of candidate markers on bovine chromosome 14 (BTA14) under milk production trait quantitative trait loci in Holstein. | Marques E et al. | โ | 2011 | โ |
| Identification of multiple rare variants associated with a disease. | Jung J et al. | โ | 2011 | โ |
| Identifying functional single nucleotide polymorphisms in the human CArGome. | Benson CC et al. | โ | 2011 | โ |
| Increased power of mixed models facilitates association mapping of 10 loci for metabolic traits in an isolated population. | Kenny EE et al. | โ | 2011 | โ |
| Inference of population mutation rate and detection of segregating sites from next-generation sequence data. | Kang CJ et al. | โ | 2011 | โ |
| Ionising radiation and genetic risks. XVI. A genome-based framework for risk estimation in the light of recent advances in genome research. | Sankaranarayanan K et al. | โ | 2011 | โ |
| Joint analyses of disease and correlated quantitative phenotypes using next-generation sequencing data. | Melton PE et al. | โ | 2011 | โ |
| Large-scale de novo prediction of physical protein-protein association. | Elefsinioti A et al. | โ | 2011 | โ |
| Meet me halfway: when genomics meets structural bioinformatics. | Gong S et al. | โ | 2011 | โ |
| Mining the LIPG allelic spectrum reveals the contribution of rare and common regulatory variants to HDL cholesterol. | Khetarpal SA et al. | โ | 2011 | โ |
| Moving beyond genome-wide association studies. | Glazer NL | โ | 2011 | โ |
| Multifactor dimensionality reduction as a filter-based approach for genome wide association studies. | Oki NO et al. | โ | 2011 | โ |
| Nutrigenetics and nutrigenomics: viewpoints on the current status and applications in nutrition research and practice. | Fenech M et al. | โ | 2011 | โ |
| Periodontal genetics: a decade of genetic association studies mandates better study designs. | Schรคfer AS et al. | โ | 2011 | โ |
| Perioperative genomics. | Nagele P | โ | 2011 | โ |
| Perspectives on genome-wide multi-stage family-based association studies. | Van Steen K | โ | 2011 | โ |
| Pharmaceutical drug transport: the issues and the implications that it is essentially carrier-mediated only. | Kell DB et al. | โ | 2011 | โ |
| Positional information resolves structural variations and uncovers an evolutionarily divergent genetic locus in accessions of Arabidopsis thaliana. | Lai AG et al. | โ | 2011 | โ |
| Reappraisal of the relationship between the HIV-1-protective single-nucleotide polymorphism 35 kilobases upstream of the HLA-C gene and surface HLA-C expression. | Corrah TW et al. | โ | 2011 | โ |
| Recent findings in the genetics of blood pressure and hypertension traits. | Franceschini N et al. | โ | 2011 | โ |
| Regions of homozygosity and their impact on complex diseases and traits. | Ku CS et al. | โ | 2011 | โ |
| Rethinking the genetic architecture of schizophrenia. | Mitchell KJ et al. | โ | 2011 | โ |
| Site-specific integration and tailoring of cassette design for sustainable gene transfer. | Lombardo A et al. | โ | 2011 | โ |
| SNVer: a statistical tool for variant calling in analysis of pooled or individual next-generation sequencing data. | Wei Z et al. | โ | 2011 | โ |
| Somatic mosaicism in healthy human tissues. | De S | โ | 2011 | โ |
| Statistical epistasis and functional brain imaging support a role of voltage-gated potassium channels in human memory. | Heck A et al. | โ | 2011 | โ |
| Structural variation in two human genomes mapped at single-nucleotide resolution by whole genome de novo assembly. | Li Y et al. | โ | 2011 | โ |
| Suicidal ideation during antidepressant treatment: do genetic predictors exist? | Perroud N | โ | 2011 | โ |
| 'Systems biology' in human exercise physiology: is it something different from integrative physiology? | Greenhaff PL et al. | โ | 2011 | โ |
| Targeted isolation of cloned genomic regions by recombineering for haplotype phasing and isogenic targeting. | Nedelkova M et al. | โ | 2011 | โ |
| The impact of next-generation sequencing on genomics. | Zhang J et al. | โ | 2011 | โ |
| The importance of phase information for human genomics. | Tewhey R et al. | โ | 2011 | โ |
| The Next PAGE in understanding complex traits: design for the analysis of Population Architecture Using Genetics and Epidemiology (PAGE) Study. | Matise TC et al. | โ | 2011 | โ |
| The progression of hypertensive heart disease. | Drazner MH | โ | 2011 | โ |
| The search for SNPs, CNVs, and epigenetic variants associated with the complex disease of male infertility. | Carrell DT et al. | โ | 2011 | โ |
| The serotonin transporter and emotionality: risk, resilience, and new therapeutic opportunities. | Murrough JW et al. | โ | 2011 | โ |
| Trade-off in the effects of the apolipoprotein E polymorphism on the ages at onset of CVD and cancer influences human lifespan. | Kulminski AM et al. | โ | 2011 | โ |
| Transcriptional networks for alcohol sensitivity in Drosophila melanogaster. | Morozova TV et al. | โ | 2011 | โ |
| Transethnic meta-analysis of genomewide association studies. | Morris AP | โ | 2011 | โ |
| Transforming growth factor-beta signaling pathway in patients with Kawasaki disease. | Shimizu C et al. | โ | 2011 | โ |
| Using extreme phenotype sampling to identify the rare causal variants of quantitative traits in association studies. | Li D et al. | โ | 2011 | โ |
| VISTA Region Viewer (RViewer)--a computational system for prioritizing genomic intervals for biomedical studies. | Lukashin I et al. | โ | 2011 | โ |
| Which compound to select in lead optimization? Prospectively validated proteochemometric models guide preclinical development. | van Westen GJ et al. | โ | 2011 | โ |
| 8q24 prostate, breast, and colon cancer risk loci show tissue-specific long-range interaction with MYC. | Ahmadiyeh N et al. | โ | 2010 | โ |
| A catalogue of validated single nucleotide polymorphisms in bovine orthologs of mammalian imprinted genes and associations with beef production traits. | Magee DA et al. | โ | 2010 | โ |
| A combined genome-wide linkage and association approach to find susceptibility loci for platelet function phenotypes in European American and African American families with coronary artery disease. | Mathias RA et al. | โ | 2010 | โ |
| A genetic perspective on coeliac disease. | Trynka G et al. | โ | 2010 | โ |
| A glimpse into multigene rare variant genetics: triple mutations in hypertrophic cardiomyopathy. | Hershberger RE | โ | 2010 | โ |
| A knowledge-based weighting framework to boost the power of genome-wide association studies. | Li MX et al. | โ | 2010 | โ |
| Alanine-to-threonine substitutions and amyloid diseases: butyrylcholinesterase as a case study. | Podoly E et al. | โ | 2010 | โ |
| Alzheimer's disease: diagnostics, prognostics and the road to prevention. | Grossman I et al. | โ | 2010 | โ |
| Ancestry-shift refinement mapping of the C6orf97-ESR1 breast cancer susceptibility locus. | Stacey SN et al. | โ | 2010 | โ |
| A novel statistic for genome-wide interaction analysis. | Wu X et al. | โ | 2010 | โ |
| Association screening of common and rare genetic variants by penalized regression. | Zhou H et al. | โ | 2010 | โ |
| Autoinflammatory disease reloaded: a clinical perspective. | Kastner DL et al. | โ | 2010 | โ |
| A validation study of type 2 diabetes-related variants of the TCF7L2, HHEX, KCNJ11, and ADIPOQ genes in one endogamous ethnic group of north India. | Gupta V et al. | โ | 2010 | โ |
| A weighted false discovery rate control procedure reveals alleles at FOXA2 that influence fasting glucose levels. | Xing C et al. | โ | 2010 | โ |
| Bivariate genetic association of KIAA1797 with heart rate in American Indians: the Strong Heart Family Study. | Melton PE et al. | โ | 2010 | โ |
| Breast cancer in the personal genomics era. | Ellsworth RE et al. | โ | 2010 | โ |
| Building the sequence map of the human pan-genome. | Li R et al. | โ | 2010 | โ |
| Colorimetric genotyping of single nucleotide polymorphism based on selective aggregation of unmodified gold nanoparticles. | Lee H et al. | โ | 2010 | โ |
| Common predisposition alleles for moderately common cancers: bladder cancer. | Kiltie AE | โ | 2010 | โ |
| Common SNPs explain a large proportion of the heritability for human height. | Yang J et al. | โ | 2010 | โ |
| Design of association studies with pooled or un-pooled next-generation sequencing data. | Kim SY et al. | โ | 2010 | โ |
| Dissecting the clinical heterogeneity of autism spectrum disorders through defined genotypes. | Bruining H et al. | โ | 2010 | โ |
| Dyslipidemia in HIV-infected individuals: from pharmacogenetics to pharmacogenomics. | Tarr PE et al. | โ | 2010 | โ |
| Epigenetics as a unifying principle in the aetiology of complex traits and diseases. | Petronis A | โ | 2010 | โ |
| Evaluation of 172 candidate polymorphisms for association with oligozoospermia or azoospermia in a large cohort of men of European descent. | Aston KI et al. | โ | 2010 | โ |
| Exploiting sequence similarity to validate the sensitivity of SNP arrays in detecting fine-scaled copy number variations. | Wong G et al. | โ | 2010 | โ |
| Future health applications of genomics: priorities for communication, behavioral, and social sciences research. | McBride CM et al. | โ | 2010 | โ |
| Genes, mutations, and human inherited disease at the dawn of the age of personalized genomics. | Cooper DN et al. | โ | 2010 | โ |
| Genetic basis for susceptibility to lung cancer: Recent progress and future directions. | Yokota J et al. | โ | 2010 | โ |
| Genetic investigations of Meniere's disease. | Vrabec JT | โ | 2010 | โ |
| Genetic link between obesity and MMP14-dependent adipogenic collagen turnover. | Chun TH et al. | โ | 2010 | โ |
| Genetics and biology of asthma 2010: La' ci darem la mano... | Vercelli D | โ | 2010 | โ |
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| Genetic variants and their interactions in the prediction of increased pre-clinical carotid atherosclerosis: the cardiovascular risk in young Finns study. | Okser S et al. | โ | 2010 | โ |
| Genome-wide association studies and diet. | Ferguson LR | โ | 2010 | โ |
| Genome-wide association studies in diverse populations. | Rosenberg NA et al. | โ | 2010 | โ |
| Genome-wide association studies: the key to unlocking neurodegeneration? | Gandhi S et al. | โ | 2010 | โ |
| Genome-wide association study for colorectal cancer identifies risk polymorphisms in German familial cases and implicates MAPK signalling pathways in disease susceptibility. | Lascorz J et al. | โ | 2010 | โ |
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| Genotyping sleep disorders patients. | Kripke DF et al. | โ | 2010 | โ |
| Human studies on genetics of the age at natural menopause: a systematic review. | Voorhuis M et al. | โ | 2010 | โ |
| Improved detection of rare genetic variants for diseases. | Zhang L et al. | โ | 2010 | โ |
| Influence of PARP-1 polymorphisms in patients after traumatic brain injury. | Sarnaik AA et al. | โ | 2010 | โ |
| Investigation and functional characterization of rare genetic variants in the adipose triglyceride lipase in a large healthy working population. | Coassin S et al. | โ | 2010 | โ |
| Lifestyle modifies the relationship between body composition and adrenergic receptor genetic polymorphisms, ADRB2, ADRB3 and ADRA2B: a secondary analysis of a randomized controlled trial of physical activity among postmenopausal women. | Bea JW et al. | โ | 2010 | โ |
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| Linking variants from genome-wide association analysis to function via transcriptional network analysis. | Keller B et al. | โ | 2010 | โ |
| Minireview: the SRC family of coactivators: an entrรฉe to understanding a subset of polygenic diseases? | Lonard DM et al. | โ | 2010 | โ |
| Missense variants in ATM in 26,101 breast cancer cases and 29,842 controls. | Fletcher O et al. | โ | 2010 | โ |
| Missing heritability and strategies for finding the underlying causes of complex disease. | Eichler EE et al. | โ | 2010 | โ |
| Molecular epidemiology and its current clinical use in cancer management. | Hartman M et al. | โ | 2010 | โ |
| Multigenic modeling of complex disease by random forests. | Sun YV | โ | 2010 | โ |
| Multiplexed resequencing analysis to identify rare variants in pooled DNA with barcode indexing using next-generation sequencer. | Mitsui J et al. | โ | 2010 | โ |
| Nicotinic receptor gene CHRNA4 interacts with processing load in attention. | Espeseth T et al. | โ | 2010 | โ |
| Pooled association tests for rare variants in exon-resequencing studies. | Price AL et al. | โ | 2010 | โ |
| Premature ovarian failure. | Shelling AN | โ | 2010 | โ |
| Progress in cytogenetics: implications for child psychopathology. | Hoffman EJ et al. | โ | 2010 | โ |
| Prospective study of ABO blood type and the risk of pulmonary embolism in two large cohort studies. | Wolpin BM et al. | โ | 2010 | โ |
| Resequencing of nicotinic acetylcholine receptor genes and association of common and rare variants with the Fagerstrรถm test for nicotine dependence. | Wessel J et al. | โ | 2010 | โ |
| Restricted ethnic diversity in human embryonic stem cell lines. | Laurent LC et al. | โ | 2010 | โ |
| Sequence variation at multiple loci influences red cell hemoglobin concentration. | Peters LL et al. | โ | 2010 | โ |
| Sequencing technologies - the next generation. | Metzker ML | โ | 2010 | โ |
| Sex-dependent association of common variants of microcephaly genes with brain structure. | Rimol LM et al. | โ | 2010 | โ |
| Statistical analysis strategies for association studies involving rare variants. | Bansal V et al. | โ | 2010 | โ |
| Strengths and weaknesses of gene association studies in childhood acute lymphoblastic leukemia. | Semsei AF et al. | โ | 2010 | โ |
| Synthetic associations in the context of genome-wide association scan signals. | Orozco G et al. | โ | 2010 | โ |
| Test of association between variant tgฮฒ1 alleles and late adverse effects of breast radiotherapy. | Martin S et al. | โ | 2010 | โ |
| The association between the peroxisome proliferator-activated receptor-gamma2 (PPARG2) Pro12Ala gene variant and type 2 diabetes mellitus: a HuGE review and meta-analysis. | Gouda HN et al. | โ | 2010 | โ |
| The discovery of human genetic variations and their use as disease markers: past, present and future. | Ku CS et al. | โ | 2010 | โ |
| The epidemiology of diabetes in Korea: from the economics to genetics. | Cho NH | โ | 2010 | โ |
| The evolution of human genetic and phenotypic variation in Africa. | Campbell MC et al. | โ | 2010 | โ |
| The evolving discipline of molecular epidemiology of cancer. | Spitz MR et al. | โ | 2010 | โ |
| The KIF6 collapse. | Topol EJ et al. | โ | 2010 | โ |
| The prospect of genome-guided preventive medicine: a need and opportunity for genetic counselors. | O'Daniel JM | โ | 2010 | โ |
| The pursuit of genome-wide association studies: where are we now? | Ku CS et al. | โ | 2010 | โ |
| The transcriptional interactome: gene expression in 3D. | Schoenfelder S et al. | โ | 2010 | โ |
| Through a glass darkly: advances in understanding breast cancer biology, 2000-2010. | Carey LA | โ | 2010 | โ |
| To identify associations with rare variants, just WHaIT: Weighted haplotype and imputation-based tests. | Li Y et al. | โ | 2010 | โ |
| Transgenerational genetic effects of the paternal Y chromosome on daughters' phenotypes. | Nelson VR et al. | โ | 2010 | โ |
| Translating genomic analyses into improved management of coronary artery disease. | Johansen CT et al. | โ | 2010 | โ |
| Using molecular classification to predict gains in maximal aerobic capacity following endurance exercise training in humans. | Timmons JA et al. | โ | 2010 | โ |
| USING POPULATION GENOMICS TO DETECT SELECTION IN NATURAL POPULATIONS: KEY CONCEPTS AND METHODOLOGICAL CONSIDERATIONS. | Hohenlohe PA et al. | โ | 2010 | โ |
| Variation in human performance in the hypoxic mountain environment. | Martin DS et al. | โ | 2010 | โ |
| What neurobiology tells us about addiction. | Iguchi MY et al. | โ | 2010 | โ |
| Whole-genome sequencing and comprehensive variant analysis of a Japanese individual using massively parallel sequencing. | Fujimoto A et al. | โ | 2010 | โ |
| Whole-genome sequencing identifies Mendelian mutations. | Swami M | โ | 2010 | โ |
| An agenda for personalized medicine. | Ng PC et al. | โ | 2009 | โ |
| Anesthesia and pharmacogenetics. | Iravani M | โ | 2009 | โ |
| A new era in clinical genetic testing for hypertrophic cardiomyopathy. | Wheeler M et al. | โ | 2009 | โ |
| Cancer pharmacoethnicity: ethnic differences in susceptibility to the effects of chemotherapy. | O'Donnell PH et al. | โ | 2009 | โ |
| Complex renal traits: role of adrenergic genetic polymorphism. | Fung MM et al. | โ | 2009 | โ |
| Detection of recurrent copy number alterations in the genome: taking among-subject heterogeneity seriously. | Rueda OM et al. | โ | 2009 | โ |
| Elucidating the role of 8q24 in colorectal cancer. | Harismendy O et al. | โ | 2009 | โ |
| Enrichment of sequencing targets from the human genome by solution hybridization. | Tewhey R et al. | โ | 2009 | โ |
| Finding common susceptibility variants for complex disease: past, present and future. | Panoutsopoulou K et al. | โ | 2009 | โ |
| From SNPs to pathways: integration of functional effect of sequence variations on models of cell signalling pathways. | Bauer-Mehren A et al. | โ | 2009 | โ |
| Gene-environment interactions and obesity--further aspects of genomewide association studies. | Andreasen CH et al. | โ | 2009 | โ |
| Genetic gains on the obesity and metabolic disease fronts. | Clee SM | โ | 2009 | โ |
| Genetic variants and normal tissue toxicity after radiotherapy: a systematic review. | Andreassen CN et al. | โ | 2009 | โ |
| Genetic variants in association studies--review of strengths and weaknesses in study design and current knowledge of impact on cancer risk. | Andersson U et al. | โ | 2009 | โ |
| Genome-wide association data reveal a global map of genetic interactions among protein complexes. | Hannum G et al. | โ | 2009 | โ |
| Genome-wide association studies and the genetic dissection of complex traits. | Sebastiani P et al. | โ | 2009 | โ |
| Genome-wide association studies in bladder cancer: first results and potential relevance. | Kiemeney LA et al. | โ | 2009 | โ |
| Genome-wide association studies in kidney diseases: Quo Vadis? | Pesce F et al. | โ | 2009 | โ |
| Heritability and demographic analyses in the large isolated population of Val Borbera suggest advantages in mapping complex traits genes. | Traglia M et al. | โ | 2009 | โ |
| How many genetic variants remain to be discovered? | Pawitan Y et al. | โ | 2009 | โ |
| Identifying druggable disease-modifying gene products. | Dixon SJ et al. | โ | 2009 | โ |
| Insights into the nature and consequences of our variable genome. | Knight JC | โ | 2009 | โ |
| Interval-specific congenic lines reveal quantitative trait Loci with penetrant lyme arthritis phenotypes on chromosomes 5, 11, and 12. | Ma Y et al. | โ | 2009 | โ |
| Machine learning in genome-wide association studies. | Szymczak S et al. | โ | 2009 | โ |
| Microdroplet-based PCR enrichment for large-scale targeted sequencing. | Tewhey R et al. | โ | 2009 | โ |
| Molecular genetics of atrial fibrillation. | Damani SB et al. | โ | 2009 | โ |
| Network properties of complex human disease genes identified through genome-wide association studies. | Barrenas F et al. | โ | 2009 | โ |
| Novel and functional norepinephrine transporter protein variants identified in attention-deficit hyperactivity disorder. | Hahn MK et al. | โ | 2009 | โ |
| Pharmacogenetics and personal genomes. | Wagner MJ | โ | 2009 | โ |
| Progress in the study of genetic disease: bringing new light to complex problems. | Shelling A | โ | 2009 | โ |
| Sequencing genomes: from individuals to populations. | Mir KU | โ | 2009 | โ |
| Targeted capture and massively parallel sequencing of 12 human exomes. | Ng SB et al. | โ | 2009 | โ |
| The genetics of inbreeding depression. | Charlesworth D et al. | โ | 2009 | โ |
| The genetics of quantitative traits: challenges and prospects. | Mackay TF et al. | โ | 2009 | โ |
| The role of host genetics in leishmaniasis. | Sakthianandeswaren A et al. | โ | 2009 | โ |
| The variant rs1867277 in FOXE1 gene confers thyroid cancer susceptibility through the recruitment of USF1/USF2 transcription factors. | Landa I et al. | โ | 2009 | โ |