Critical need for family-based, quasi-experimental designs in integrating genetic and social science research.
paper
Cited
Public
Unavailable
- Authors
- D'Onofrio, Brian M; Lahey, Benjamin B; Turkheimer, Eric; Lichtenstein, Paul
- Year
- 2013
- Journal
- American journal of public health
- PMID
- 23927516
- DOI
- 10.2105/AJPH.2013.301252
- PMCID
- PMC3778076
Researchers have identified environmental risks that predict subsequent psychological and medical problems. Based on these correlational findings, researchers have developed and tested complex developmental models and have examined biological moderating factors (e.g., gene-environment interactions). In this context, we stress the critical need for researchers to use family-based, quasi-experimental designs when trying to integrate genetic and social science research involving environmental variables because these designs rigorously examine causal inferences by testing competing hypotheses. We argue that sibling comparison, offspring of twins or siblings, in vitro fertilization designs, and other genetically informed approaches play a unique role in bridging gaps between basic biological and social science research. We use studies on maternal smoking during pregnancy to exemplify these principles.
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| Testing the Developmental Origins of Health and Disease Hypothesis for Psychopathology Using Family-Based Quasi-Experimental Designs. | D'Onofrio BM et al. | — | 2014 | → |
| The age gauge: older fathers having children. | D'Onofrio BM et al. | — | 2014 | → |
| The impact of childhood parental loss on risk for mood, anxiety and substance use disorders in a population-based sample of male twins. | Otowa T et al. | — | 2014 | → |
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