Low level of response to alcohol as associated with serotonin transporter genotype and high alcohol intake in adolescents.
paper
Cited
Public
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- Authors
- Hinckers, Anne S; Laucht, Manfred; Schmidt, Martin H; Mann, Karl F; Schumann, Gunter; Schuckit, Marc A; Heinz, Andreas
- Year
- 2006
- Journal
- Biological psychiatry
- PMID
- 16497275
- DOI
- 10.1016/j.biopsych.2005.12.009
BACKGROUND: A low level of response to alcohol has been associated with both the genetic constitution of the regulatory region (SLC6A4) of the human serotonin (5-hydroxytryptamine, 5-HT) transporter (5-HTT) and with future alcohol intake and an increased risk for alcoholism. To date, all studies of relevant polymorphisms have been carried out in populations in the United States. METHODS: Data were extracted from a subset (n = 243) of a cohort of children who have been observed since birth through evaluation of the family history of alcoholism and psychosocial risk influences. At age 16 years, the response to alcohol was assessed with the Self-Rating of the Effects of Alcohol (SRE) questionnaire, and the average amount of alcohol intake per month was assessed during the prior 6 months. Additional variables that were measured included the 5-HTT genotype, externalizing behavior, and sociodemographic variables, such as gender and age. RESULTS: The level of response to alcohol was significantly lower among carriers of two long alleles of the 5-HTT regulatory region compared with carriers of one or two short alleles (Mann-Whitney U = 5225.0, p = .005). In a multiple regression analysis, the level of response to alcohol and externalizing behavior but not psychosocial factors significantly predicted the average amount of alcohol intake per month. CONCLUSIONS: This study demonstrates that, independent of the assessed psychosocial variables, the 5-HTT genotype correlated with the level of response to alcohol and predicted alcohol intake among 16-year-old adolescents.
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| Title | Authors | Journal | Year | Link |
|---|---|---|---|---|
| Molecular Effect of Variants in Serotonin Transporter Gene in Women with Alcohol Use Disorder. | Rychel M et al. | β | 2025 | β |
| The Dopamine System in Mediating Alcohol Effects in Humans. | Beck A et al. | β | 2025 | β |
| The role of brain serotonin signaling in excessive alcohol consumption and withdrawal: A call for more research in females. | Castle ME et al. | β | 2024 | β |
| Analytical description of adolescent binge drinking patients. | Haas C et al. | β | 2023 | β |
| Value-based decision-making predicts alcohol use and related problems in young men. | Petzold J et al. | β | 2023 | β |
| Acute Administration of Ethanol and of a D1-Receptor Antagonist Affects the Behavior and Neurochemistry of Adult Zebrafish. | Scerbina T et al. | β | 2022 | β |
| [ICD-11: changes in the diagnostic criteria of substance dependence]. | Heinz A et al. | β | 2022 | β |
| Translational dynamics of alcohol tolerance of preclinical models and human laboratory studies. | Haass-Koffler CL et al. | β | 2020 | β |
| Addiction to Legal Drugs and Medicines in Germany. | Heinz A et al. | β | 2019 | β |
| Evidence for incentive salience sensitization as a pathway to alcohol use disorder. | CofresΓ RU et al. | β | 2019 | β |
| A Critical Review of Methods and Results in the Search for Genetic Contributors to Alcohol Sensitivity. | Schuckit MA | β | 2018 | β |
| EFhd2/Swiprosin-1 is a common genetic determinator for sensation-seeking/low anxiety and alcohol addiction. | Mielenz D et al. | β | 2018 | β |
| Identification of heavy drinking in the 10-item AUDIT: Results from a prospective study among 18-21years old non-dependent German males. | Kuitunen-Paul S et al. | β | 2018 | β |
| Low Inherent Sensitivity to the Intoxicating Effects of Ethanol in Rhesus Monkeys with Low CSF Concentrations of the Serotonin Metabolite 5-Hydroxyindoleacetic Acid. | Wood EK et al. | β | 2018 | β |
| Effects of the serotonin transporter gene, sensitivity of response to alcohol, and parental monitoring on risk for problem alcohol use. | Cope LM et al. | β | 2017 | β |
| Impulse Control Disorders and Related Complications of Parkinson's Disease Therapy. | Lopez AM et al. | β | 2017 | β |
| Methylation Status of the Serotonin Transporter Promoter CpG Island Is Associated With Major Depressive Disorder in Chinese Han Population: A Case-Control Study. | Shi M et al. | β | 2017 | β |
| A Genetic Animal Model of Alcoholism for Screening Medications to Treat Addiction. | Bell RL et al. | β | 2016 | β |
| Associations of 5HTTLPR polymorphism with major depressive disorder and alcohol dependence: A systematic review and meta-analysis. | Oo KZ et al. | β | 2016 | β |
| Subjective Response to Alcohol as a Research Domain Criterion. | Ray LA et al. | β | 2016 | β |
| Interaction effects between the 5-hydroxy tryptamine transporter-linked polymorphic region (5-HTTLPR) genotype and family conflict on adolescent alcohol use and misuse. | Kim J et al. | β | 2015 | β |
| Serotonin and Dopamine Candidate Gene Variants and Alcohol- and Non-Alcohol-Related Aggression. | Preuss UW et al. | β | 2015 | β |
| Subjective response as a consideration in the pharmacogenetics of alcoholism treatment. | Roche DJ et al. | β | 2015 | β |
| Genetic influences on response to alcohol and response to pharmacotherapies for alcoholism. | Enoch MA | β | 2014 | β |
| How do we 'learn' addiction? Risk factors and mechanisms getting addicted to alcohol. | HΓ€gele C et al. | β | 2014 | β |
| Initial subjective reward: single-exposure conditioned place preference to alcohol in mice. | Grisel JE et al. | β | 2014 | β |
| Translational clinical neuroscience perspectives on the cognitive and neurobiological mechanisms underlying alcohol-related aggression. | Beck A et al. | β | 2014 | β |
| Alcohol-related aggression-social and neurobiological factors. | Beck A et al. | β | 2013 | β |
| Stability of scores and correlations with drinking behaviors over 15 years for the Self-Report of the Effects of Alcohol Questionnaire. | Schuckit MA et al. | β | 2013 | β |
| The value of extended pedigrees for next-generation analysis of complex disease in the rhesus macaque. | Vinson A et al. | β | 2013 | β |
| Alcohol increases impulsivity and abuse liability in heavy drinking women. | Reed SC et al. | β | 2012 | β |
| Animal models for medications development targeting alcohol abuse using selectively bred rat lines: neurobiological and pharmacological validity. | Bell RL et al. | β | 2012 | β |
| Serotonin transporter genomic biomarker for quantitative assessment of ondansetron treatment response in alcoholics. | Seneviratne C et al. | β | 2012 | β |
| The association between availability of serotonin transporters and time to relapse in heroin users: a two-isotope SPECT small sample pilot study. | Lin SH et al. | β | 2012 | β |
| Alcohol research: past, present, and future. | Gunzerath L et al. | β | 2011 | β |
| Cognitive and neurobiological mechanisms of alcohol-related aggression. | Heinz AJ et al. | β | 2011 | β |
| Effects of the serotonin transporter (5-HTTLPR) and Ξ±2A-adrenoceptor (C-1291G) genotypes on substance use in children and adolescents: a longitudinal study. | MerenΓ€kk L et al. | β | 2011 | β |
| Epigenetic changes of serotonin transporter in the patients with alcohol dependence: methylation of an serotonin transporter promoter CpG island. | Park BY et al. | β | 2011 | β |
| Molecular targets of alcohol action: Translational research for pharmacotherapy development and screening. | Gorini G et al. | β | 2011 | β |
| Response to alcohol in women: role of the menstrual cycle and a family history of alcoholism. | Evans SM et al. | β | 2011 | β |
| Role of GABRA2 in moderating subjective responses to alcohol. | Roh S et al. | β | 2011 | β |
| Selective breeding for magnitude of methamphetamine-induced sensitization alters methamphetamine consumption. | Scibelli AC et al. | β | 2011 | β |
| Subjective response to alcohol challenge: a quantitative review. | Quinn PD et al. | β | 2011 | β |
| The Serotonin Transporter Polymorphism (5-HTTLPR) and Alcohol Problems in Heavy Drinkers: Moderation by Depressive Symptoms. | Tartter MA et al. | β | 2011 | β |
| Alcohol response and consumption in adolescent rhesus macaques: life history and genetic influences. | Schwandt ML et al. | β | 2010 | β |
| Aversive effects of ethanol in adolescent versus adult rats: potential causes and implication for future drinking. | Schramm-Sapyta NL et al. | β | 2010 | β |
| Gender moderates the association between 5-HTTLPR and decision-making under ambiguity but not under risk. | Stoltenberg SF et al. | β | 2010 | β |
| Human and laboratory rodent low response to alcohol: is better consilience possible? | Crabbe JC et al. | β | 2010 | β |
| Interaction of SLC6A4 and DRD2 polymorphisms is associated with a history of delirium tremens. | Karpyak VM et al. | β | 2010 | β |
| Neural markers of genetic vulnerability to drug addiction. | MΓΌller DJ et al. | β | 2010 | β |
| Risky alcohol use, peer and family relationships and legal involvement in adolescents with antisocial problems. | Ybrandt H | β | 2010 | β |
| Alcohol-use disorders. | Schuckit MA | β | 2009 | β |
| Differential drinking patterns of family history positive and family history negative first semester college females. | LaBrie JW et al. | β | 2009 | β |
| Drinking histories in alcohol-use-disordered youth: preliminary findings on relationships to platelet serotonin transporter expression with genotypes of the serotonin transporter. | Dawes MA et al. | β | 2009 | β |
| Impact of age at first drink on vulnerability to alcohol-related problems: testing the marker hypothesis in a prospective study of young adults. | Buchmann AF et al. | β | 2009 | β |
| Impact of psychosocial adversity on alcohol intake in young adults: moderation by the LL genotype of the serotonin transporter polymorphism. | Laucht M et al. | β | 2009 | β |
| Interaction between the 5-HTTLPR serotonin transporter polymorphism and environmental adversity for mood and anxiety psychopathology: evidence from a high-risk community sample of young adults. | Laucht M et al. | β | 2009 | β |
| A serotonin transporter gene polymorphism (5-HTTLPR), drinking-to-cope motivation, and negative life events among college students. | Armeli S et al. | β | 2008 | β |
| Early ethanol consumption predicts relapse-like behavior in adolescent male rats. | Schramm-Sapyta NL et al. | β | 2008 | β |
| Genetic factors influencing alcohol dependence. | Mayfield RD et al. | β | 2008 | β |
| Long-term citalopram maintenance in mice: selective reduction of alcohol-heightened aggression. | Caldwell EE et al. | β | 2008 | β |
| Multiple-domain predictors of problematic alcohol use in young adulthood. | Kramer JR et al. | β | 2008 | β |
| Relationship between ethanol's acute locomotor effects and ethanol self-administration in male Long-Evans rats. | Chappell AM et al. | β | 2008 | β |
| Serotonergic responses in depressed patients with or without a history of alcohol use disorders and healthy controls. | Sher L et al. | β | 2008 | β |
| Subjective alcohol effects and drinking behavior: the relative influence of early response and acquired tolerance. | Morean ME et al. | β | 2008 | β |
| The role of dopamine in alcohol self-administration in humans: individual differences. | Barrett SP et al. | β | 2008 | β |
| The self-rating of the effects of alcohol questionnaire as a predictor of alcohol-related outcomes in 12-year-old subjects. | Schuckit MA et al. | β | 2008 | β |
| Genetic research with intermediate phenotypes: phenocopies, perspectives and pitfalls. | Heinz A et al. | β | 2007 | β |
| How gene-stress-behavior interactions can promote adolescent alcohol use: the roles of predrinking allostatic load and childhood behavior disorders. | Zimmermann US et al. | β | 2007 | β |
| Individual differences in novelty- and cocaine-induced locomotor activity as predictors of food-reinforced operant behavior in two outbred rat strains. | Gulley JM | β | 2007 | β |
| Preventing suicide in adolescents with alcohol use disorders. | Makhija NJ et al. | β | 2007 | β |
| The serotonin transporter gene and alcoholism: the two pathways to suicidal behavior. | Sher L | β | 2007 | β |
| Non-human primate models of inheritance vulnerability to alcohol use disorders. | Barr CS et al. | β | 2006 | β |