Neuropeptide Y modulation of ethanol intake: effects of ethanol drinking history and genetic background.
- Authors
- Badia-Elder, Nancy E; Gilpin, Nicholas W; Stewart, Robert B
- Year
- 2007
- Journal
- Peptides
- PMID
- 17187900
- DOI
- 10.1016/j.peptides.2006.07.028
Intracerebroventricular administration of NPY suppresses ethanol intake in selectively bred alcohol-preferring rat lines, but not in rats selectively bred for low ethanol drinking or in unselected Wistar rats, when access to ethanol is limited to 2h/day. However, when rats undergo chronic (24h/day) ethanol drinking (or exposure to ethanol by vapor inhalation) and have periods of imposed ethanol abstinence, the reductions in ethanol drinking following NPY administration are enhanced in alcohol-preferring rats and are also observed in unselected Wistar rats. Thus, sensitivity to the effects of NPY on ethanol drinking appears to be altered by selective breeding for ethanol preference and by a prior history of chronic but intermittent exposure to ethanol.
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In this knowledge base
| Title | Year | PMID |
|---|---|---|
| Neuropeptide Y receptor genes are associated with alcohol dependence, alcohol withdrawal phenotypes, and cocaine dependence. | 2008 | 18828811 |
External
| Title | Authors | Journal | Year | Link |
|---|---|---|---|---|
| Basolateral amygdala neuropeptide Y system modulates binge ethanol consumption. | Robinson SL et al. | — | 2024 | → |
| Cross talk about the role of Neuropeptide Y in CNS disorders and diseases. | Bale R et al. | — | 2023 | → |
| The Role of Neuropeptide Y (NPY) in Alcohol and Drug Abuse Disorders. | Robinson SL et al. | — | 2017 | → |
| Gut-brain peptides in corticostriatal-limbic circuitry and alcohol use disorders. | Vadnie CA et al. | — | 2014 | → |
| Neuropeptide Y and posttraumatic stress disorder. | Sah R et al. | — | 2013 | → |
| Circadian clock gene polymorphisms in alcohol use disorders and alcohol consumption. | Kovanen L et al. | — | 2010 | → |
| Neuropeptide Y signaling in the central nucleus of amygdala regulates alcohol-drinking and anxiety-like behaviors of alcohol-preferring rats. | Zhang H et al. | — | 2010 | → |
| Analysis of single nucleotide polymorphisms and haplotypes in the neuropeptide Y gene: no evidence for association with alcoholism in a German population sample. | Zill P et al. | — | 2008 | → |
| Neurobiology of addiction. An integrative review. | Goodman A | — | 2008 | → |
| Neuropeptide Y receptor genes are associated with alcohol dependence, alcohol withdrawal phenotypes, and cocaine dependence. | Wetherill L et al. | — | 2008 | → |
| The effects of neuropeptide S on ethanol drinking and other related behaviors in alcohol-preferring and -nonpreferring rats. | Badia-Elder NE et al. | — | 2008 | → |