Sedative and motor-impairing effects of neuropeptide Y and ethanol in selectively bred P and NP rats.
- Authors
- Gilpin, Nicholas W; Stewart, Robert B; Elder, Richard L; Kho, Yumi; Murphy, James M; Li, Ting-Kai; Badia-Elder, Nancy E
- Year
- 2004
- Journal
- Pharmacology, biochemistry, and behavior
- PMID
- 15159135
- DOI
- 10.1016/j.pbb.2004.02.012
Past findings suggest a positive association between endogenous neuropeptide Y (NPY) activity and ethanol-induced sedation, and there is evidence for additive effects of administered NPY with sedative-hypnotics. The present investigation examined the effects of intracerebroventricular NPY injection on ethanol-induced sedation and motor impairment in selectively bred alcohol-preferring (P) and -nonpreferring (NP) rats. In Experiment 1, P and NP rats were assessed for loss and recovery of righting reflex (RR) following infusion with either NPY (10.0 microg) or aCSF followed by ethanol injection (2.5 g/kg ip). NPY reduced time to lose RR and increased time to regain RR similarly in P and NP rats. Blood-ethanol levels (BELs) were lower at time of recovery in NPY-treated rats relative to aCSF controls. Thus, NPY enhanced ethanol-induced sedation. In Experiment 2, P and NP rats pretreated with either saline or ethanol (1.0 g/kg ip) were assessed for motor activity following infusion with either NPY (2.5, 5.0, or 10.0 microg) or aCSF. Ethanol alone and NPY alone suppressed motor activity, but there were no additive effects between the two. Taken together, these results provide partial support for past observations of additivity between NPY and drug-induced sedation, and suggest a role for NPY in the neurobehavioral effects of acute ethanol exposure.
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External
| Title | Authors | Journal | Year | Link |
|---|---|---|---|---|
| Chronic ethanol tolerance as a result of free-choice drinking in alcohol-preferring rats of the WHP line. | Dyr W et al. | — | 2012 | → |
| Corticotropin-releasing factor (CRF) and neuropeptide Y (NPY): effects on inhibitory transmission in central amygdala, and anxiety- & alcohol-related behaviors. | Gilpin NW | — | 2012 | → |
| Neuropeptide modulation of central amygdala neuroplasticity is a key mediator of alcohol dependence. | Gilpin NW et al. | — | 2012 | → |
| Genetic research: who is at risk for alcoholism. | Foroud T et al. | — | 2010 | → |
| Suppression of alcohol self-administration and reinstatement of alcohol seeking by melanin-concentrating hormone receptor 1 (MCH1-R) antagonism in Wistar rats. | Cippitelli A et al. | — | 2010 | → |
| Tolerance to ethanol sedation and withdrawal hyper-excitability is mediated via neuropeptide Y Y1 and Y5 receptors. | Bhisikar SM et al. | — | 2009 | → |
| Estradiol and neuropeptide Y (intra-lateral septal) reduce anxiety-like behavior in two animal models of anxiety. | Olivera-Lopez JI et al. | — | 2008 | → |
| Neuropeptide Y modulation of ethanol intake: effects of ethanol drinking history and genetic background. | Badia-Elder NE et al. | — | 2007 | → |
| Estrus variation in anxiolytic-like effects of intra-lateral septal infusions of the neuropeptide Y in Wistar rats in two animal models of anxiety-like behavior. | Molina-Hernández M et al. | — | 2006 | → |
| Overexpression of neuropeptide Y in the central nucleus of the amygdala decreases ethanol self-administration in "anxious" rats. | Primeaux SD et al. | — | 2006 | → |
| The neuropeptide-Y Y5 receptor antagonist L-152,804 decreases alcohol self-administration in inbred alcohol-preferring (iP) rats. | Schroeder JP et al. | — | 2005 | → |