Integration of summary data from GWAS and eQTL studies predicts complex trait gene targets.
paper
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- Authors
- Zhu, Zhihong; Zhang, Futao; Hu, Han; Bakshi, Andrew; Robinson, Matthew R; Powell, Joseph E; Montgomery, Grant W; Goddard, Michael E; Wray, Naomi R; Visscher, Peter M; Yang, Jian
- Year
- 2016
- Journal
- Nature genetics
- PMID
- 27019110
- DOI
- 10.1038/ng.3538
Genome-wide association studies (GWAS) have identified thousands of genetic variants associated with human complex traits. However, the genes or functional DNA elements through which these variants exert their effects on the traits are often unknown. We propose a method (called SMR) that integrates summary-level data from GWAS with data from expression quantitative trait locus (eQTL) studies to identify genes whose expression levels are associated with a complex trait because of pleiotropy. We apply the method to five human complex traits using GWAS data on up to 339,224 individuals and eQTL data on 5,311 individuals, and we prioritize 126 genes (for example, TRAF1 and ANKRD55 for rheumatoid arthritis and SNX19 and NMRAL1 for schizophrenia), of which 25 genes are new candidates; 77 genes are not the nearest annotated gene to the top associated GWAS SNP. These genes provide important leads to design future functional studies to understand the mechanism whereby DNA variation leads to complex trait variation.
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| Association of lipid-lowering drugs with venous thromboembolism outcomes: a phenome-wide association study and a drug-target Mendelian randomization study. | Lingyu Z et al. | β | 2025 | β |
| Association of macrophage colony-stimulating factor 1 and its locus with osteoarthritis: Mendelian randomization and colocalization analysis. | Wang J et al. | β | 2025 | β |
| Association of Vitiligo With Autoimmune Disorders: A Bidirectional Two-Sample and Summary-Based Mendelian Randomization Study. | Huang J et al. | β | 2025 | β |
| Associations between genetic variations of HLA and IGHV, vaccination schedule, and COVID-19 vaccine immunogenicity. | Ke L et al. | β | 2025 | β |
| Associations between the gut microbiota, immune cells, and different subtypes of epilepsy: A Mendelian randomization study. | Zhang X et al. | β | 2025 | β |
| Associations of 2923 plasma proteins with incident atopic dermatitis in a prospective cohort study and genetic analysis. | Deng S et al. | β | 2025 | β |
| Associations of genetic proxies for non-steroidal anti-inflammatory drugs with increased kidney stone risk: a Mendelian randomization study. | Liu J et al. | β | 2025 | β |
| A stratified treatment algorithm in psychiatry: a program on stratified pharmacogenomics in severe mental illness (Psych-STRATA): concept, objectives and methodologies of a multidisciplinary project funded by Horizon Europe. | Baune BT et al. | β | 2025 | β |
| A system genetics analysis uncovers the regulatory variants controlling drought response in wheat. | Chen B et al. | β | 2025 | β |
| Atlas of multilineage stem cell differentiation reveals TMEM88 as a developmental regulator of blood pressure. | Shen S et al. | β | 2025 | β |
| Atlas of Proteomic signatures of brain structure and its links to brain disorders. | Ren P et al. | β | 2025 | β |
| A transcriptome-wide association study integrating multi-omics bioinformatics and Mendelian randomization reveals the prognostic value of ADAMDEC1 in colon cancer. | Zhang C et al. | β | 2025 | β |
| Bayesian fine-mapping and Mendelian randomization leveraging expression quantitative trait loci reveal novel candidate causal genes for body conformation traits in cattle. | Teng J et al. | β | 2025 | β |
| Bioenergetic-related gene expression in the hippocampus predicts internalizing vs. externalizing behavior in an animal model of temperament. | Hebda-Bauer EK et al. | β | 2025 | β |
| Bioinformatics analysis of FCER1A as a key immune marker in dilated cardiomyopathy and systemic lupus erythematosus. | Xu L et al. | β | 2025 | β |
| Biological aging accelerates hepatic fibrosis: Insights from the NHANES 2017-2020 and genome-wide association study analysis. | Zhao J et al. | β | 2025 | β |
| BioWinfordMR: an online platform for comprehensive Mendelian randomization analysis. | Wang Y et al. | β | 2025 | β |
| Blood plasma proteome-wide association study implicates novel proteins in the pathogenesis of multiple cardiovascular diseases. | Wang JH et al. | β | 2025 | β |
| Canine genome-wide association study identifies <i>DENND1B</i> as an obesity gene in dogs and humans. | Wallis NJ et al. | β | 2025 | β |
| Causal analysis of uterine artery pulsatility index-related proteins and the risk of precocious puberty in girls: a Mendelian randomization study. | Gao Y et al. | β | 2025 | β |
| Causal association analysis between blood metabolomes and osteopenia and therapeutic target prediction for mechanomedicine. | Liu R et al. | β | 2025 | β |
| Causal association between mitochondrial genes and colorectal cancer: a multi-omics Mendelian randomization study. | Zhang Z et al. | β | 2025 | β |
| Causal association of immune-related genes with mouth ulcers: findings from summary-based Mendelian randomization and transcriptome-wide association analysis. | Shi M et al. | β | 2025 | β |
| Causal Associations of Insomnia With Chronic Kidney Diseases and Underlying Blood Proteins: An Observational and Mendelian Randomization Study. | Wang K et al. | β | 2025 | β |
| Causal effects of ferroptosis-related traits on ovarian dysfunction: insights from integrating genome-wide Mendelian randomization, DNA methylation, gene expression, and proteome. | Zhou Q et al. | β | 2025 | β |
| Causal Effects of Plasma Proteins in Polycystic Ovary Syndrome: A Proteome-Wide Mendelian Randomization Study. | Yu T et al. | β | 2025 | β |
| Causal Gene Identification and Biomarker Prioritization in Periodontitis via Integrative Multiomics and Mendelian Randomization. | Mo H et al. | β | 2025 | β |
| Causal Impacts of Psychiatric Disorders on Cognition and the Mediating Effect of Oxidative Stress: A Mendelian Randomization Study. | Gao Y et al. | β | 2025 | β |
| Causal links between programmed cell death and hypertrophic scars: Integrative analysis of multi-omics Mendelian randomization and preliminary experimental validation. | Zhang Y et al. | β | 2025 | β |
| Causal relationship between dietary factors and oral mucosal lesions: Two-sample Mendelian randomization analysis. | Jiang S et al. | β | 2025 | β |
| Cell-type-specific cis-eQTLs in pancreatic cell types identify novel risk genes for type 2 diabetes. | Miao XC et al. | β | 2025 | β |
| Challenges and Opportunities in Characterizing the Genetics of Stuttering: From Sample Acquisition to Functional Interpretation of the Genome. | Pruett DG et al. | β | 2025 | β |
| Characterizing Duodenal Immune Microenvironment in Functional Dyspepsia: An AutoML-Driven Diagnostic Framework. | Zhang X et al. | β | 2025 | β |
| Circulating Protein Mediators Linking Genetically Predicted Smoking to Abdominal Aortic Aneurysm: A Genomic-Proteomic Analysis. | Yuan S et al. | β | 2025 | β |
| Circulating proteins associated with histological subtypes of lung cancer from genetic and population-based perspectives. | Lyu Z et al. | β | 2025 | β |
| Circulating Proteomics and Risk of Atrial Fibrillation: A Systematic Review of Cohort Studies. | Shang L et al. | β | 2025 | β |
| c-JUN interacts with HDAC1 as a potential combinatorial therapeutic target in acute myeloid leukemia. | Wu K et al. | β | 2025 | β |
| COL6A1, LAPTM5, and ZFAND2A as Crucial Biomolecules Driving Immunoregulation in Human Nucleus Pulposus Degeneration. | Lu ZY et al. | β | 2025 | β |
| Common genetic basis and causality between central nervous system disease and cancer. | Tan S et al. | β | 2025 | β |
| Comprehensive analysis of 1,771 transcriptomes from 7 tissues enhance genetic and biological interpretations of maize complex traits. | Lei M et al. | β | 2025 | β |
| Comprehensive analysis of Mendelian randomization and scRNA-seq identify key prognostic genes and relevant functional roles in colorectal cancer. | Hu M et al. | β | 2025 | β |
| Comprehensive characterization of multi-omics landscapes between gut microbial metabolites and the druggable genome in sepsis. | Liu J et al. | β | 2025 | β |
| Comprehensive genetic analysis based on multi - omics reveals novel therapeutic targets for mitral valve prolapse and drug molecular dynamics simulation. | Chen B et al. | β | 2025 | β |
| Comprehensive Genome-Wide Analysis of Shared Genetic Factors in Gastrointestinal and Neurodegenerative Diseases. | Jiang Y et al. | β | 2025 | β |
| Comprehensive genomic insights into the genetic causality and comorbidity in urological cancers. | Zhang X et al. | β | 2025 | β |
| Comprehensive Mendelian randomization and colocalization analysis of plasma proteomics to identify new therapeutic targets for bladder cancer. | Zuo J et al. | β | 2025 | β |
| Comprehensive Multi-omics Analysis of Regulatory Variants for Body Weight in Cattle. | Niu ηηΎ€η Q et al. | β | 2025 | β |
| Conventional and genetic association between migraine and stroke with druggable genome-wide Mendelian randomization. | Wang X et al. | β | 2025 | β |
| Convergent evidence linking neonatal vitamin D status and risk of neurodevelopmental disorders: a Danish case-cohort study. | Horsdal HT et al. | β | 2025 | β |
| Coordinated, multicellular patterns of transcriptional variation that stratify patient cohorts are revealed by tensor decomposition. | Mitchel J et al. | β | 2025 | β |
| COVID-19 infection and longevity: an observational and mendelian randomization study. | Qiu S et al. | β | 2025 | β |
| Cross-ancestry and sex-stratified genome-wide association analyses of amygdala and subnucleus volumes. | Ji Y et al. | β | 2025 | β |
| Cross-ancestry genome-wide association study and systems-level integrative analyses implicate new risk genes and therapeutic targets for depression. | Li Y et al. | β | 2025 | β |
| Cross-ethnic Molecular Signatures Underpin the Adverse Impact of Statin Use on Type 2 Diabetes. | Xu F et al. | β | 2025 | β |
| Cross-population GWAS and proteomics improve risk prediction and reveal mechanisms in atrial fibrillation. | Yuan S et al. | β | 2025 | β |
| Cross-tissue transcriptome-wide association identify novel T1D susceptibility genes and drug candidates. | Liu Y et al. | β | 2025 | β |
| Cross-tissue transcriptome-wide association studies identify genetic susceptibility genes for prostate cancer. | Hua J et al. | β | 2025 | β |
| Cross-Tissue Transcriptome-Wide Association Study Identifies Novel Genes Associated With POAG. | Chen J et al. | β | 2025 | β |
| Cross-Trait Genome-Wide Association Study Identifies Shared Genetic Risk Loci Between COPD and Five Autoimmune Diseases. | Wen H et al. | β | 2025 | β |
| Deciphering genetic associations with blood pressure in peripheral blood mononuclear cells through single-cell transcriptomic profiling. | Zhang H et al. | β | 2025 | β |
| Deciphering genetic susceptibility to clear cell renal cell carcinoma. | Mandelia M et al. | β | 2025 | β |
| Deciphering the coordinated roles of the host genome, duodenal mucosal genes, and microbiota in regulating complex traits in chickens. | Lan F et al. | β | 2025 | β |
| Deciphering the influence of socioeconomic status on brain structure: insights from Mendelian randomization. | Xia C et al. | β | 2025 | β |
| Deciphering the shared genetic structure between hip osteoarthritis and femoral neck bone mineral density. | Zhou J et al. | β | 2025 | β |
| Decomposing the genetic background of chronic back pain. | Elgaeva EE et al. | β | 2025 | β |
| Development and validation of a prognostic model for endometrial carcinoma using causal genes identified by Mendelian randomization. | Yang D et al. | β | 2025 | β |
| Development of targeted drugs for diabetic retinopathy using Mendelian randomized pharmacogenomics. | Liu G et al. | β | 2025 | β |
| Direct-acting antiviral treatment impact on glycemic control in HCV-infected T2DM patients: An observational study with Mendelian randomization analysis. | Tang J et al. | β | 2025 | β |
| Discovering genetically-supported drug targets for multisite chronic pain through multi-omics Mendelian randomization and single-cell RNA-sequencing. | Cui Z et al. | β | 2025 | β |
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| Dissecting causal relationships between cortical morphology and neuropsychiatric disorders: a bidirectional Mendelian randomization study. | Lin BD et al. | β | 2025 | β |
| Dissecting regulatory non-coding GWAS loci reveals fibroblast causal genes with pathophysiological relevance to heart failure. | Gill R et al. | β | 2025 | β |
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| Dissecting the genetic determinants and biological associations between body mass index and female reproductive disorders based on genome-wide association study. | Shao H et al. | β | 2025 | β |
| Distinct methylomic signatures of high-altitude acclimatization and adaptation in the Tibetan Plateau. | Cheng F et al. | β | 2025 | β |
| DMRdb: a disease-centric Mendelian randomization database for systematically assessing causal relationships of diseases with genes, proteins, CpG sites, metabolites and other diseases. | Zheng X et al. | β | 2025 | β |
| DNA Methylation at cg18095732 Modulates ZDHHC20 Expression and Decreases Acne Vulgaris Risk. | Gong K et al. | β | 2025 | β |
| DNA methylation-mediated ADA overexpression drives pancreatic cancer progression. | Zeng J et al. | β | 2025 | β |
| DNA Methylation-Mediated Downregulation of <i>SDK1</i> Promotes COPD Progression: A Multi-Omics Mendelian Randomization Study. | Xue Z et al. | β | 2025 | β |
| DNA Methylation-Regulated ZDHHC13 Promotes the Progression of Parkinson's Disease. | Liao J et al. | β | 2025 | β |
| DNA Methylation-Regulated ZDHHC17 Promotes the Risk of Facial Skin Aging. | Cai X et al. | β | 2025 | β |
| DNA methylation regulates TREM1 expression to modulate immune responses and drive progression in colorectal neuroendocrine neoplasm as a potential therapeutic target. | Guo H et al. | β | 2025 | β |
| Druggable Genome Mendelian Randomization and GWAS-sceQTLs MR Analysis Reveal Genetic Associations Between Open-Angle Glaucoma and Immune Cells, and Identify Potential Drugs. | Ke K et al. | β | 2025 | β |
| Druggable Targets for Pelvic Inflammatory Disease: Mendelian Randomization and Experimental Validation. | Dang C et al. | β | 2025 | β |
| Druggable Targets for Postpartum Depression: A Mendelian Randomization and Colocalization Study. | Wu S et al. | β | 2025 | β |
| Drug repurposing candidates for amyotrophic lateral sclerosis using common and rare genetic variants. | Gerring ZF et al. | β | 2025 | β |
| Drug repurposing opportunities for breast cancer and seven common subtypes. | Lin Y et al. | β | 2025 | β |
| EasyOmics: A graphical interface for population-scale omics data association, integration, and visualization. | Han Y et al. | β | 2025 | β |
| Effect of smoking behaviour and related blood DNA methylation on visceral adipose tissues. | Song ZQ et al. | β | 2025 | β |
| Effects of Diabetes Mellitus and Glycemic Traits on COPD and Pulmonary Function Traits: Insights From Mendelian Randomization and NHANES. | Wang N et al. | β | 2025 | β |
| Effects of Oxidative Stress Gene Protein, Expression, and DNA Methylation on Multiple Sclerosis: A Multi-Omics Mendelian Randomized Study. | Li Y et al. | β | 2025 | β |
| Elucidating the role of SIRT2 in hepatocellular carcinoma through multi-omics and deep learning. | Chen C et al. | β | 2025 | β |
| Elucidation and application of the neuroimmune axis between depression and autoimmune diseases: A genome wide and cohort study. | Sun F et al. | β | 2025 | β |
| Emerging antihypertensive therapies and cardiovascular, kidney, and metabolic outcomes: a Mendelian randomization study. | Le NN et al. | β | 2025 | β |
| Endoplasmic reticulum stress-related genes contribute to lung cancer risk: a multiomics data integration study. | Li Z et al. | β | 2025 | β |
| Enhancer RNA Transcriptome-Wide Association Study Reveals a Distinctive Class of Pan-Cancer Susceptibility eRNAs. | Chen W et al. | β | 2025 | β |
| Enhancing disease risk gene discovery by integrating transcription factor-linked trans-variants into transcriptome-wide association analyses. | He J et al. | β | 2025 | β |
| Enhancing nonlinear transcriptome- and proteome-wide association studies via trait imputation with applications to Alzheimer's disease. | He R et al. | β | 2025 | β |
| ENTR1 affects the progression of colon cancer by regulating energy metabolism under the influence of glycolysis. | Ma A et al. | β | 2025 | β |
| EP300-mediated lactylation leads to ulcerative colitis via CD86-positive plasmacytoid dendritic cells: A Mendelian randomization and mediation analysis. | Cao X et al. | β | 2025 | β |
| EP300 Regulates CD8br AC (TBNK Panel) to Facilitate Insomnia. | Men X et al. | β | 2025 | β |
| Epigenetic Mediating Mechanisms in Parkinson's Disease: The Impact of Educational Attainment on SETD1A Expression. | Yin KF et al. | β | 2025 | β |
| Epigenome-wide association study for dilated cardiomyopathy in left ventricular heart tissue identifies putative gene sets associated with cardiac pathology and early indicators of cardiac risk. | Tan K et al. | β | 2025 | β |
| eQTL and multi-omics integration reveal PPIH as a prognostic and immunotherapeutic biomarker. | Lv F et al. | β | 2025 | β |
| Evaluating metabolome-wide causal effects on risk for psychiatric and neurodegenerative disorders. | Gilchrist L et al. | β | 2025 | β |
| Evaluating the causal effect of circulating proteome on the risk of Juvenile idiopathic arthritis: an omics pipeline study. | Wu X et al. | β | 2025 | β |
| Exploration of Circadian Clock-Related Genes in the Pathogenesis of Psoriatic Arthritis to Identify Potential Therapeutic Targets From Multi-Omics Insight: A Mendelian Randomization Study. | Liu A et al. | β | 2025 | β |
| Exploration of potential therapeutic target genes for preeclampsia through genetic analysis. | Wang H et al. | β | 2025 | β |
| Exploration of upstream and downstream mechanisms of the TAGLN2 gene in pulmonary arterial hypertension. | Pan YS et al. | β | 2025 | β |
| Exploration oxidative stress underlying gastroesophageal reflux disease and therapeutic targets identification: a multi-omics Mendelian randomization study. | Shi J et al. | β | 2025 | β |
| Exploring bidirectional causal relationships between antibody-mediated immune responses to infectious agents and systemic lupus erythematosus through Mendelian randomization and meta-analyses. | Dai Z et al. | β | 2025 | β |
| Exploring causal correlations between inflammatory response-related genes and osteoporosis: a Multi-Omics Mendelian Randomization Study. | Zhang R et al. | β | 2025 | β |
| Exploring druggable targets and inflammation-mediated pathways in cancer: a Mendelian randomization analysis integrating transcriptomic and proteomic data. | Pan H et al. | β | 2025 | β |
| Exploring new drug treatment targets for immune related bone diseases using a multi omics joint analysis strategy. | Yang W et al. | β | 2025 | β |
| Exploring Novel Biomarkers for Rosacea Through Cohort Study and Mendelian Randomisation. | Mao R et al. | β | 2025 | β |
| Exploring Potential Causality and Molecular Mechanisms between Heart Failure and Renal Failure: Insights from Mendelian Randomization Studies, the MIMIC-IV Database and the Gene Expression Omnibus Database. | Peng S et al. | β | 2025 | β |
| Exploring Synaptic Pathways in Traumatic Brain Injury: A Cross-Phenotype Genomics Approach. | Prapiadou S et al. | β | 2025 | β |
| Exploring the active ingredients and potential mechanisms of Pingchan granules in Parkinson's disease treatment through network pharmacology and transcriptomics. | Xu QH et al. | β | 2025 | β |
| Exploring the causal links between inflammation-related genes and atherosclerosis through Mendelian randomization analysis. | Zhang Z et al. | β | 2025 | β |
| Exploring the causal relationship between plasma proteins and postherpetic neuralgia: a Mendelian randomization study. | Wei Q et al. | β | 2025 | β |
| Exploring the genetic components and multi-omics sources of inflammatory bowel disease from the perspective of autoimmune disorders. | Wang Z et al. | β | 2025 | β |
| Exploring the genetic landscape of the brain-heart axis: A comprehensive analysis of pleiotropic effects between heart disease and psychiatric disorders. | Song Q et al. | β | 2025 | β |
| Exploring the impact of coffee consumption and caffeine intake on cognitive performance in older adults: a comprehensive analysis using NHANES data and gene correlation analysis. | Li J et al. | β | 2025 | β |
| Exploring the molecular basis of the genetic correlation between body mass index and brain morphological traits. | Fusco D et al. | β | 2025 | β |
| Exploring the pathogenic mechanism of RNH1 in colorectal cancer based on eQTL, Multi-omics and deep learning. | Chen C et al. | β | 2025 | β |
| EXPLORING THE POTENTIAL OF BEND7 AS AN IMMUNOMODULATORY BIOMARKER IN SEPSIS THROUGH INTEGRATIVE GENOMIC AND TRANSCRIPTOMIC ANALYSIS. | Ren C et al. | β | 2025 | β |
| Exploring the protective effect of metformin against sarcopenia: insights from cohort studies and genetics. | Hu Y et al. | β | 2025 | β |
| Exploring therapeutic targets for hepatocellular carcinoma through druggable genes. | Tang C et al. | β | 2025 | β |
| Exploring the Relationship Between Antipsychotic Drug Target Genes and Epilepsy: Evidence From Food and Drug Administration Adverse Event Reporting System Database and Mendelian Randomization. | Yin Z et al. | β | 2025 | β |
| Exploring the Relationship Between Immune Cells and Chronic Kidney Disease by Mendelian Randomization, Colocalization Analysis, and SMR. | Zhu H et al. | β | 2025 | β |
| Exploring the Relationship Between Immune Cells and Scoliosis by Mendelian Randomization, Colocalization Analysis, and SMR. | Qin C et al. | β | 2025 | β |
| Exploring the shared genetic architecture between leukocyte telomere length and renal cell carcinoma: a cross-trait analysis. | Wang L et al. | β | 2025 | β |
| Exploring the shared genetic architecture of type 2 diabetes mellitus and bone mineral density. | Feng X et al. | β | 2025 | β |
| Exploring the Shared Genetic Architectures Between Primary Open-Angle Glaucoma and Visual Pathway Regions in the Brain. | Aman AM et al. | β | 2025 | β |
| Exploring the Therapeutic Potential of Antidiabetic Drugs in Cardiac Arrhythmia Management: A Drug Target Mendelian Randomization Study. | Song ZQ et al. | β | 2025 | β |
| Exploring the Therapeutic Potential of Ginseng in Diabetic Retinopathy: A Network Pharmacology and Molecular Docking Study. | Fu Y et al. | β | 2025 | β |
| Extensive perivascular spaces burden causally affects neurodegenerative diseases and brain structure: A two-sample bidirectional Mendelian randomization study. | Wang P et al. | β | 2025 | β |
| FAHD1-mediated pyruvate metabolism in hepatocellular carcinoma: Multi-omics and causal genetic evidence. | Huang J et al. | β | 2025 | β |
| Fine-mapping causal tissues and genes at disease-associated loci. | Strober BJ et al. | β | 2025 | β |
| Fine-mapping genomic loci refines bipolar disorder risk genes. | Koromina M et al. | β | 2025 | β |
| Focusing on spinal stenosis: emerging discoveries concerning Alendronate-induced risks and genetic drug targets. | Yang N et al. | β | 2025 | β |
| From brain to heart: Causality and therapeutic potential in atrial fibrillation. | Li K et al. | β | 2025 | β |
| Functional characterization of eQTLs and asthma risk loci with scATAC-seq across immune cell types and contexts. | Wei J et al. | β | 2025 | β |
| Functional genomics in age-related macular degeneration: From genetic associations to understanding disease mechanisms. | Ratnapriya R et al. | β | 2025 | β |
| Functional Validation of Noncoding Variants Associated With Nonsyndromic Orofacial Cleft. | Zhu S et al. | β | 2025 | β |
| Further elucidation of GMPPB as a risk gene for depression through integrative multi-omics analyses. | Du Y et al. | β | 2025 | β |
| GBP1 as a machine learning-prioritized biomarker and therapeutic target for epstein-barr virus-induced clear cell renal cell carcinoma: multi-omics causal validation. | Zhu G et al. | β | 2025 | β |
| Gene-level analysis reveals the genetic aetiology and therapeutic targets of schizophrenia. | Dang X et al. | β | 2025 | β |
| Genetically predicted circulating immune cells and cytokines reveal the causal role of immune factors on female infertility: a two-sample mendelian randomization study. | Dong KX et al. | β | 2025 | β |
| Genetically predicted vitamins supplementation and risk of skin cancers: a Mendelian randomization study. | Qi P et al. | β | 2025 | β |
| Genetically Prioritized Plasma Proteins as Candidate Therapeutic Targets for Dry Age-Related Macular Degeneration. | Hou J et al. | β | 2025 | β |
| Genetically Proxied Antiplatelet Drug Target Perturbation and Risk of Aneurysmal Subarachnoid Hemorrhage: A Mendelian Randomization Analysis. | Fan YX et al. | β | 2025 | β |
| Genetically supported causality between gut microbiota, prefrontal cortex and depression: insights from multiple Mendelian randomization, multi-omics analysis, and network pharmacology. | Dong X et al. | β | 2025 | β |
| Genetic analyses identify circulating genes related to brain structures associated with Parkinson's disease. | Han Z et al. | β | 2025 | β |
| Genetic and immune landscape of keratoconus: insights from Mendelian randomization analysis. | Yu Y et al. | β | 2025 | β |
| Genetic and Plasma Proteomic Approaches to Identify Therapeutic Targets for Graves' Disease and Graves' Ophthalmopathy. | Ke C et al. | β | 2025 | β |
| Genetic architecture and mechanisms shared between kidney and ureteral stones, cardiovascular diseases, and metabolic syndrome: A comprehensive GWAS analysis. | Hua Y et al. | β | 2025 | β |
| Genetic association analysis between LDL-c lowering drugs and portal hypertension using Mendelian randomization analysis. | Xiao QA et al. | β | 2025 | β |
| Genetic association of circulating lipids and lipid-lowering drug targets with vascular calcification. | Zhang P et al. | β | 2025 | β |
| Genetic association of lipid-lowering drug target genes with cholecystitis: A summary-data-based Mendelian randomization analysis. | Zhao K et al. | β | 2025 | β |
| Genetic associations of metabolic factors and therapeutic drug targets with polycystic ovary syndrome. | Zhang C et al. | β | 2025 | β |
| Genetic associations of plasma proteins and breast cancer identify potential therapeutic drug candidates. | Quan L et al. | β | 2025 | β |
| Genetic basis and causal relationship between atrial fibrillation and sinus node dysfunction: Evidence from comprehensive genetic analysis. | Yan Z et al. | β | 2025 | β |
| Genetic characterization of preschool wheeze phenotypes. | Fischer-Rasmussen K et al. | β | 2025 | β |
| Genetic determinants of proteomic aging. | MΓΆrseburg A et al. | β | 2025 | β |
| Genetic evidence for the causal effects of air pollution on the risk of respiratory diseases. | Wu Y et al. | β | 2025 | β |
| Genetic Evidence Prioritizes Neurocognitive Decline as a Causal Driver of Sleep Disturbances: A Multi-Omics Analysis Identifying Causal Genes and Therapeutic Targets. | Du Y et al. | β | 2025 | β |
| Genetic factors associated with erectile dysfunction- mendelian randomisation analysis. | Qu Z et al. | β | 2025 | β |
| Genetic imputation of transcriptome and proteome illuminates novel therapeutic targets of cutaneous melanoma. | Xu Y et al. | β | 2025 | β |
| Genetic insights into cardiac conduction disorders from genome-wide association studies. | Li B et al. | β | 2025 | β |
| Genetic insights into colorectal cancer pathogenesis: a multi-omics and immunity perspective. | Zhou S et al. | β | 2025 | β |
| Genetic insights into idiopathic pulmonary fibrosis: a multi-omics approach to identify potential therapeutic targets. | Wen Z et al. | β | 2025 | β |
| Genetic insights into lipid traits and atherosclerosis risk: a Mendelian randomization and polygenic risk score analysis. | Zhang H et al. | β | 2025 | β |
| Genetic Insights Into Lipid Traits and Lipid-Modifying Drug Targets in Pregnancy Complications: A Two-Sample Mendelian Randomization Study. | Shao H et al. | β | 2025 | β |
| Genetic Insights Into the Interplay Between Aging and Kidney Health. | Wang Y et al. | β | 2025 | β |
| Genetic Insights into Therapeutic Targets for Neuromyelitis Optica Spectrum Disorders: A Mendelian Randomization Study. | Cao Y et al. | β | 2025 | β |
| Genetic insights into the role of mitochondria-related genes in mental disorders: An integrative multi-omics analysis. | Lu Y et al. | β | 2025 | β |
| Genetic insights of lipid metabolism and lipid-lowering drugs with Lewy body dementia risk: Evidence from Mendelian randomization. | Zhang H et al. | β | 2025 | β |
| Genetic Links between Gastrointestinal Disorders and Kidney Stone Disease: Insights from a Genome-Wide Cross-Trait Analysis. | Wang Y et al. | β | 2025 | β |
| Genetic Links Between Metabolic Syndrome and Osteoarthritis: Insights From Cross-Trait Analysis. | Huang JX et al. | β | 2025 | β |
| Genetic pleiotropy underlying obesity and autoimmune disorders: a large-scale cross-trait gwas analysis in European ancestry populations. | Jiang X et al. | β | 2025 | β |
| Genetic prioritisation of candidate drug targets for glaucoma through multi-trait and multi-omics integration. | Chen J et al. | β | 2025 | β |
| Genetic regulation of gene expression across multiple tissues in chickens. | Guan D et al. | β | 2025 | β |
| Genetic relationship between epilepsy and mental disorders: A comprehensive GWAS analysis. | Abudusalamu R et al. | β | 2025 | β |
| Genetic relationship between SjΓΆgren's syndrome and abdominal aortic aneurysm: insights from a European population's genome-wide association analysis. | Zhou Y et al. | β | 2025 | β |
| Genetic score omics regression and multitrait meta-analysis detect widespread <i>cis</i>-regulatory effects shaping bovine complex traits. | Xiang R et al. | β | 2025 | β |
| Genetic susceptibility to cerebral palsy involves complement system-mediated neuronal development and plasticity pathway. | Kun H et al. | β | 2025 | β |
| Genetic susceptibility to lung squamous cell carcinoma: new insights on 9q33.2 variants and tobacco smoking. | Ma H et al. | β | 2025 | β |
| Genetic underpinnings of the heterogeneous impact of obesity on lipid levels and cardiovascular disease. | Kim D et al. | β | 2025 | β |
| Genetic variants of LncRNA associated with splicing regulation and their impact on ovarian cancer development. | Zou L et al. | β | 2025 | β |
| Genetic Variants Specific to Critical COVID-19: Insights From Genome-Wide Association Studies and Structural Analysis. | Chen H et al. | β | 2025 | β |
| Genetic variation at 11q23.1 confers colorectal cancer risk by dysregulation of colonic tuft cell transcriptional activator <i>POU2AF2</i>. | Rajasekaran V et al. | β | 2025 | β |
| Genetic variation reveals the therapeutic potential of BRSK2 in idiopathic pulmonary fibrosis. | Chen Z et al. | β | 2025 | β |
| Genome-annotated bivariate analysis of shared heritability in autoimmune hepatitis with psychiatric comorbidity. | Liu L et al. | β | 2025 | β |
| Genome-wide analyses identify 30 loci associated with obsessive-compulsive disorder. | Strom NI et al. | β | 2025 | β |
| Genome-wide analysis identifies novel shared loci between depression and white matter microstructure. | Zhao Q et al. | β | 2025 | β |
| Genome-wide analysis of brain age identifies 59 associated loci and unveils relationships with mental and physical health. | Jawinski P et al. | β | 2025 | β |
| Genome-wide association analysis using multiple Atlantic salmon populations. | Ajasa AA et al. | β | 2025 | β |
| Genome-wide association and multi-omics analyses provide insights into the disease mechanisms of central serous chorioretinopathy. | Mori Y et al. | β | 2025 | β |
| Genome-wide association meta-analysis of human olfactory identification discovers sex-specific and sex-differential genetic variants. | FΓΆrster F et al. | β | 2025 | β |
| Genome-wide association, single-cell, and spatial transcriptomics analyses reveal the role of the STK24-expressing positive cells in LUAD progression and the tumor microenvironment, identifying STK24 as a potential therapeutic target. | Liu J et al. | β | 2025 | β |
| Genome-wide association study provides insights into the genetic basis of Lewy body dementia. | Zhu P et al. | β | 2025 | β |
| Genome-wide interaction association analysis identifies interactive effects of childhood maltreatment and kynurenine pathway on depression. | Sun Y et al. | β | 2025 | β |
| Genome-wide Pleiotropy Analysis Reveals Shared Genetic Associations between Type 2 Diabetes Mellitus and Subcortical Brain Volumes. | Zhao Q et al. | β | 2025 | β |
| Genomic and GEO data integration identifies PDGFB as a potential therapeutic target for sepsis. | Guo M et al. | β | 2025 | β |
| Genomic correlation, shared loci, and causal link between obesity and diabetic microvascular complications: A genome-wide pleiotropic analysis. | Zhang W et al. | β | 2025 | β |
| Genomics yields biological and phenotypic insights into bipolar disorder. | O'Connell KS et al. | β | 2025 | β |
| Genotype inference from aggregated chromatin accessibility data reveals genetic regulatory mechanisms. | Wenz BM et al. | β | 2025 | β |
| Global trends and risk factors in gastric cancer: a comprehensive analysis of the Global Burden of Disease Study 2021 and multi-omics data. | Zhang L et al. | β | 2025 | β |
| Glutaryl-CoA dehydrogenase (GCDH) enhances renal malignancy risk via modulating glutarylcarnitine levels. | Liu X et al. | β | 2025 | β |
| GNLY as A Novel Cis-eQTL and Cis-pQTL Mediated Susceptibility Gene in Suppressing Prostatitis. Mendelian Randomization Study. | Wang Y et al. | β | 2025 | β |
| Gut Microbiota and White Matter Integrity: A Two-Sample Mendelian Randomization Analysis. | Zhang L et al. | β | 2025 | β |
| GWAShug: a comprehensive platform for decoding the shared genetic basis between complex traits based on summary statistics. | Cao C et al. | β | 2025 | β |
| Helicobacter pylori induces GBA1 demethylation to inhibit ferroptosis in gastric cancer. | Shen C et al. | β | 2025 | β |
| High expression of Fgr in the left ventricle attenuates myocardial injury in the infarcted region via regulating the phosphorylation level of PI3K/Akt. | Shao D et al. | β | 2025 | β |
| Identification and characterization of lLF2 as a prognostic biomarker in HER2-positive breast cancer using Mendelian randomization and machine learning. | Quan X et al. | β | 2025 | β |
| Identification of Alzheimer's disease susceptibility genes by integrating eight human brain single-cell transcriptomes with genome-wide association studies. | He Y et al. | β | 2025 | β |
| Identification of Association Between Mitochondrial Dysfunction and Sarcopenia Using Summary-Data-Based Mendelian Randomization and Colocalization analyses. | Xie J et al. | β | 2025 | β |
| Identification of biomarkers and potential drug targets for esophageal cancer: a Mendelian randomization study. | Li C et al. | β | 2025 | β |
| Identification of biomarkers associated with exhausted CD8 +βT cells in the tumor microenvironment of intrahepatic cholangiocarcinoma based on Mendelian randomization and bioinformatics analysis. | Feng L et al. | β | 2025 | β |
| Identification of biomarkers for endometriosis based on summary-data-based Mendelian randomization and machine learning. | Xie Z et al. | β | 2025 | β |
| Identification of C4BPA as a genetically informed drug target in NSCLC: an integrative single-cell and multi-omics study based on the druggable genes. | Xiao Z et al. | β | 2025 | β |
| Identification of Causal Effects of Mitochondrial Dysfunction on the Risk of Multiple Autoimmune Disorders: Multi-Omics Mendelian Randomization and Colocalization Analyses. | Luo J et al. | β | 2025 | β |
| Identification of CKAP2 as a Potential Target for Prevention of Gastric Cancer Progression: A Multi-Omics Study. | Liu X et al. | β | 2025 | β |
| Identification of druggable targets in acute kidney injury by proteome- and transcriptome-wide Mendelian randomization and bioinformatics analysis. | Liu J et al. | β | 2025 | β |
| Identification of druggable targets in melanoma by multi-omics Mendelian randomization integrated with transcriptomic and spatial analysis. | Xing J et al. | β | 2025 | β |
| Identification of Drug-Targetable Genes for Eczema and Dermatitis Using Integrated Genomic and Proteomic Approaches. | Yang S et al. | β | 2025 | β |
| Identification of EPHB4 as a potential causal gene and therapeutic target for endometriosis using Mendelian randomization. | Ling S et al. | β | 2025 | β |
| Identification of genetically-supported new drug targets for osteomyelitis based on druggable genomes. | Yao R et al. | β | 2025 | β |
| Identification of immune-inflammation targets for intracranial aneurysms: a multiomics and epigenome-wide study integrating summary-data-based Mendelian randomization, single-cell-type expression analysis, and DNA methylation regulation. | Lin PW et al. | β | 2025 | β |
| Identification of key genes and diagnostic biomarkers for peripheral atherosclerosis: A multi-omics approach. | Huang L et al. | β | 2025 | β |
| Identification of key genes as diagnostic biomarkers for IBD using bioinformatics and machine learning. | Li T et al. | β | 2025 | β |
| Identification of MEG3 and MAPK3 as potential therapeutic targets for osteoarthritis through multiomics integration and machine learning. | Ma B et al. | β | 2025 | β |
| Identification of mitochondrial-related causal genes for major depression disorder via integrating multi-omics. | Li H et al. | β | 2025 | β |
| Identification of Mitochondria-Related Genes Associated with Stroke Risk Through Multi-omics Summary Data-Based MR Analysis. | Tang X et al. | β | 2025 | β |
| Identification of Mood Disorders Causal Genes by Integrating the Brain Proteome and Transcriptome. | Zhu RK et al. | β | 2025 | β |
| Identification of novel biomarkers and drug targets for frailty-related skeletal muscle aging: a multi-omics study. | Wang Q et al. | β | 2025 | β |
| Identification of novel causally related genes in adenomyosis: An integrated summary data-based Mendelian randomization study and bioinformatics analysis. | Yang Q et al. | β | 2025 | β |
| Identification of Novel Disease-Modifying Agents for Pelvic Organ Prolapse by Systematic Druggable Genome-Wide Mendelian Randomization. | Liu X et al. | β | 2025 | β |
| Identification of novel drug targets for primary open angle glaucoma and its potential side-effects by human plasma proteome. | Jia DD et al. | β | 2025 | β |
| Identification of novel drug targets through integrative PWAS of brain and plasma proteins with Ulcerative Colitis GWAS. | Liu N et al. | β | 2025 | β |
| Identification of novel proteins associated with intelligence by integrating genome-wide association data and human brain proteomics. | Zhang Z et al. | β | 2025 | β |
| Identification of novel susceptibility loci for testicular germ cell tumors through multi-omics analysis. | Xu Y et al. | β | 2025 | β |
| Identification of novel therapeutic targets for diabetic neuropathy through integrated proteomics and transcriptomics approaches. | Ding XF et al. | β | 2025 | β |
| Identification of novel type 1 and type 2 diabetes genes by co-localization of human islet eQTL and GWAS variants with colocRedRibbon. | Piron A et al. | β | 2025 | β |
| Identification of pathogenic cell types and shared genetic loci and genes for Alzheimer's disease and inflammatory bowel disease. | Zhang J et al. | β | 2025 | β |
| Identification of Plasma Protein Biomarkers and Drug Targets for Hematologic Malignancies by Proteome-wide Mendelian Randomization. | Pan T et al. | β | 2025 | β |
| Identification of plasma protein biomarkers for ankylosing spondylitis by integrating proteome with genome. | Wang M et al. | β | 2025 | β |
| Identification of Potential Biomarkers and Therapeutic Targets for Periodontitis. | Huoshen W et al. | β | 2025 | β |
| Identification of Potential Diagnostic Biomarkers and Drug Targets for Endometriosis from a Genetic Perspective: A Mendelian Randomization Study. | Wang W et al. | β | 2025 | β |
| Identification of potential drug targets for achalasia from genetic insights: a Mendelian randomization study. | Xiong K et al. | β | 2025 | β |
| Identification of potential key targets and mechanisms underlying cleft palate induced by tobacco smoke exposure through multi-omics integrated Mendelian randomization analysis. | Lin Y et al. | β | 2025 | β |
| Identification of potential therapeutic drug targets for sepsis by combining the human plasma proteome and genome: a Mendelian randomization study. | Zhou W et al. | β | 2025 | β |
| Identification of potential therapeutic targets for problematic alcohol use using multi-omics data. | Lee DJ et al. | β | 2025 | β |
| Identification of RCC2 as a Risk Gene Associated With Basal Cell Carcinoma and Experimental Validation. | Zhang Y et al. | β | 2025 | β |
| Identification of SARS2, PKN1, and IL11RA as causally-associated genes for patients with gastric cancer via immune cell activity: A multi-omics Mendelian randomization study integrating GWAS, eQTL, and pQTL data. | Tang C et al. | β | 2025 | β |
| Identification of shared diagnostic biomarkers and potential co-morbidity mechanisms between primary Sjogren's syndrome and chronic kidney disease. | Jiang S et al. | β | 2025 | β |
| Identification of Six Potential Therapeutic Targets Common to Ischemic Stroke and Vascular Dementia: Genetic Insights From an Integrated Bioinformatics Analysis. | Lyu J et al. | β | 2025 | β |
| Identification of Therapeutic Targets for Hyperuricemia: Systematic Genome-Wide Mendelian Randomization and Colocalization Analysis. | Chen N et al. | β | 2025 | β |
| Identification of therapeutic targets for neonatal respiratory distress: A systematic druggable genome-wide Mendelian randomization. | Yuan H et al. | β | 2025 | β |
| Identification of Therapeutic Targets for Premature Ovarian Failure Through Mendelian Randomization and Colocalization Analysis Using Human Plasma Proteomics. | Wang W et al. | β | 2025 | β |
| Identification of therapeutic targets for psoriatic arthritis through proteomics. | Zhang F et al. | β | 2025 | β |
| Identification of therapeutic targets in lung adenocarcinoma using Mendelian randomization and multi-omics. | Li Y et al. | β | 2025 | β |
| Identifying causal genes for prostatitis through drug-targeted Mendelian randomization. | Yan K et al. | β | 2025 | β |
| Identifying common genetic etiologies between iridocyclitis and related immune-mediated diseases. | Liu Z et al. | β | 2025 | β |
| Identifying core genes in keloid and investigating immune infiltration and pan-cancer associations using eQTL and machine learning. | He X et al. | β | 2025 | β |
| Identifying cross-tissue molecular targets of lung function by multi-omics integration analysis from DNA methylation and gene expression of diverse human tissues. | Peng S et al. | β | 2025 | β |
| Identifying CTSF and GSTM3 as chemoresistance therapeutic targets in breast cancer through multi-omics MR analysis. | Liu R et al. | β | 2025 | β |
| Identifying genes and traits associated with pre-eclampsia using summary statistics. | Zhu W et al. | β | 2025 | β |
| Identifying MTHFD1 and LGALS4 as Potential Therapeutic Targets in Prostate Cancer Through Multi-Omics Mendelian Randomization Analysis. | Han H et al. | β | 2025 | β |
| Identifying novel drug targets for calcific aortic valve disease through Mendelian randomization. | Xu D et al. | β | 2025 | β |
| Identifying novel risk targets in inflammatory skin diseases by comprehensive proteome-wide Mendelian randomization study. | Li Y et al. | β | 2025 | β |
| Identifying potential drug targets for cerebral amyloid angiopathy: A Mendelian randomization study based on the druggable genes. | Zhang J et al. | β | 2025 | β |
| Identifying potential drug targets for postoperative abdominal wall hernia using Mendelian randomization: a multi-omics study. | Sun C et al. | β | 2025 | β |
| Identifying potential drug targets for sepsis-related adult respiratory distress syndrome through comprehensive genetic analysis and druggability assessment. | Weng J et al. | β | 2025 | β |
| Identifying potential pathogenic oxidative stress-related genes in depression through multi-omics summary-data-based Mendelian randomization analysis. | Cheng J et al. | β | 2025 | β |
| Identifying the mediating role of brain atrophy on the relationship between DNA damage repair pathway and Alzheimer's disease: A Mendelian randomization analysis and mediation analysis. | Bao W et al. | β | 2025 | β |
| IL6 genetic perturbation mimicking IL-6 inhibition is associated with lower cardiometabolic risk. | Zhang L et al. | β | 2025 | β |
| IL7R<sup>+</sup> T Cell-Macrophage Crosstalk Links Asthma to Alzheimer's Pathogenesis: Integrating Mendelian Randomization and CellChat Analysis. | Yang J et al. | β | 2025 | β |
| Immune cell-specific gene expression and its causal role in osteoporosis and bone mineral density: Insights from single-cell eQTL and GWAS data integration. | Wang X et al. | β | 2025 | β |
| Immune-related gene expression with colorectal cancer risk: a Mendelian randomization analysis. | Tan X et al. | β | 2025 | β |
| Impact of common variants on brain gene expression from RNA to protein to schizophrenia risk. | Liang Q et al. | β | 2025 | β |
| Impact of lipid-lowering drug targets on genetic associations with diabetic retinopathy. | Zhang X et al. | β | 2025 | β |
| Inflammation molecular network alterations in a depressive-like primate model. | Bu S et al. | β | 2025 | β |
| Inflammatory Bowel Disease Mediates the Causal Relationship Between Gut Microbiota and Colorectal Cancer: Identification of Therapeutic Targets and Predictive Modeling. | Wang JB et al. | β | 2025 | β |
| Influence of genetic variants and omega-3 fatty acids on acute myocardial infarction: findings from a prospective cohort study. | Huang H et al. | β | 2025 | β |
| Inhibition of lactylation by LRP1 expression increases the risk of intervertebral disc degeneration: A multi-omics summary-based Mendelian randomization analysis. | Yang Y et al. | β | 2025 | β |
| Inhibition of Putative Ibrutinib Targets Promotes Atrial Fibrillation, Conduction Blocks, and Proarrhythmic Electrocardiogram Indices: A Mendelian Randomization Analysis. | Xu H et al. | β | 2025 | β |
| Insights and concerns on proteomic-based Mendelian randomization in ischemic stroke: the need for comprehensive data and methodological rigor. | Zhu X et al. | β | 2025 | β |
| Integrated Analysis of Bulk RNA Sequencing, eQTL, GWAS, and Single-Cell RNA Sequencing Reveals Key Genes in Hepatocellular Carcinoma. | Gong M et al. | β | 2025 | β |
| Integrated Bioinformatics Analysis and Cellular Experimental Validation Identify Lipoprotein Lipase Gene as a Novel Biomarker for Tumorigenesis and Prognosis in Lung Adenocarcinoma. | He W et al. | β | 2025 | β |
| Integrated Genomic and GEO Data Analysis Reveals Therapeutic Targets for Rosacea. | Deng X et al. | β | 2025 | β |
| Integrated multi-omics insight into the molecular networks of oxidative stress in triggering multiple sclerosis. | Xu Y et al. | β | 2025 | β |
| Integrated Retrospective and Post-GWAS Analyses Reveal Mechanisms Linking Nightly Short Sleep to Asthma. | Fu C et al. | β | 2025 | β |
| Integrated summary data-based Mendelian randomization and colocalization analysis reveals TNNT3 as a target of Deer-Antler-Ginseng-formula for triple-negative breast cancer. | Jia J et al. | β | 2025 | β |
| Integrated TWAS, GWAS, and RNAseq results identify candidate genes associated with reproductive traits in cows. | Hosseinzadeh S et al. | β | 2025 | β |
| Integrating a multi-omics strategy framework to screen potential targets in cognitive impairment-related epilepsy. | Xu C et al. | β | 2025 | β |
| Integrating analysis of multi-omics summary data identifies novel plasma protein biomarkers and drug targets for bladder cancer. | Cao J et al. | β | 2025 | β |
| Integrating brain proteomes and genetics to identify novel risk genes in chronic widespread musculoskeletal pain. | Dai Z et al. | β | 2025 | β |
| Integrating differential gene expression and Mendelian randomization analyses reveal novel gene for prognosis, immune response, and drug sensitivity in lung cancer. | Li M et al. | β | 2025 | β |
| Integrating Expression Quantitative Trait Loci and Genome-Wide Association Study Identifies Druggable Genes for Tinnitus. | Guo T et al. | β | 2025 | β |
| Integrating genetics and transcriptome analyses identify potential biomarkers and immune interactions in metabolic syndrome-related sarcopenia. | Fu W et al. | β | 2025 | β |
| Integrating genome-wide association studies and transcriptomics prioritizes drug targets for meningioma. | Liao WZ et al. | β | 2025 | β |
| Integrating Genomic, eQTL, and Mendelian Randomization Analyses to Identify Microglial Drug Targets in Multiple Sclerosis. | Yan W et al. | β | 2025 | β |
| Integrating multi-omics to reveal the causal effect of gut microbiota on post-traumatic stress disorder and potential drug target analysis. | Huang H et al. | β | 2025 | β |
| Integrating plasma proteomics and genome-wide association data to identify therapeutic targets for retinal neurodegenerative diseases in Europeans. | Guo YJ et al. | β | 2025 | β |
| Integrating Single-Cell Transcriptome-Wide Mendelian Randomization and Differentially Expressed Gene Analyses to Prioritize Dynamic Immune-Related Drug Targets for Cancers. | Zheng J et al. | β | 2025 | β |
| Integrating single-cell with transcriptome-proteome Mendelian randomization reveals colorectal cancer targets. | Wang S et al. | β | 2025 | β |
| Integrating transcriptomic and genomic studies for the identification of expression quantitative trait loci associated with bovine paratuberculosis. | Badia-BringuΓ© G et al. | β | 2025 | β |
| Integrating Transcriptomics and Machine Learning to Uncover the FLI1-PARP14-Immune Axis in Ulcerative Colitis Activity and Pathogenesis. | Zheng Z et al. | β | 2025 | β |
| Integration of Bulk and Single-Cell Transcriptomics Reveals BCL2L14 as a Novel IGKC+ T Cell-Associated Therapeutic Target in Breast Cancer. | He J et al. | β | 2025 | β |
| Integration of multi-omics data reveals dysregulated RNA methylation in retinal pigment epithelium drives age-related macular degeneration. | Gong YJ et al. | β | 2025 | β |
| Integration of multi-omics quantitative trait loci evidence reveals novel susceptibility genes for Alzheimer's disease. | Gao J et al. | β | 2025 | β |
| Integration of summary data from GWAS and eQTLs studies predicts causality of S1PR1 and breast cancer. | Shi H et al. | β | 2025 | β |
| Integrative Analysis of eQTL Genes Reveals Key Biomarkers and Mechanisms for Early Diagnosis of Pancreatic Ductal Adenocarcinoma. | Wang X et al. | β | 2025 | β |
| Integrative analysis of genome and transcriptome reveals a novel regulator for pork intramuscular fat content. | Zhao X et al. | β | 2025 | β |
| Integrative analysis of serum lipids and chronic gastritis: causal insights from mendelian randomization and experimental models. | Chu X et al. | β | 2025 | β |
| Integrative analysis reveals synergistic regulation of Sp7 by BRD9 and Wnt/Ξ²-catenin signaling during osteogenic differentiation. | Wu L et al. | β | 2025 | β |
| Integrative Approaches Identify Genetic Determinants of Levodopa Induced Dyskinesia. | Wan Y et al. | β | 2025 | β |
| Integrative bioinformatics approach identifies novel drug targets for hyperaldosteronism, with a focus on SHMT1 as a promising therapeutic candidate. | Jia M et al. | β | 2025 | β |
| Integrative eQTL and Mendelian randomization analysis reveals key genes in colorectal cancer. | Zhou J et al. | β | 2025 | β |
| Integrative eQTL and Mendelian randomization analysis reveals key genetic markers in mesothelioma. | Li J et al. | β | 2025 | β |
| Integrative genetics and multiomics analysis reveal mechanisms and therapeutic targets in vitiligo highlighting JAK STAT pathway regulation of CTSS. | Dong ZY et al. | β | 2025 | β |
| Integrative genome-wide analysis unveils the genetic landscape of gallstone disease and highlights novel loci with therapeutic potential. | Chen H et al. | β | 2025 | β |
| Integrative genomic analysis identifies novel causal genes of Hodgkin's and non-Hodgkin's lymphoma. | Shi P et al. | β | 2025 | β |
| Integrative genomic analysis reveals shared loci for reproduction and production traits in Yorkshire pigs. | Wei R et al. | β | 2025 | β |
| Integrative genomics sheds light on the immunogenetics of tuberculosis in cattle. | O'Grady JF et al. | β | 2025 | β |
| Integrative GWAS and Mendelian Randomization Analysis Identifies IREB2 and CD27+ Memory B Cells as Core Drivers of COPD to Lung Cancer Progression. | Yi E et al. | β | 2025 | β |
| Integrative multi-omics analysis identifies genetically supported druggable targets for inflammatory bowel disease. | Gu SC et al. | β | 2025 | β |
| Integrative multi-omics analysis identifies key genes and colocalized signals associated with colorectal cancer risk. | Xia L et al. | β | 2025 | β |
| Integrative multi-omics analysis of druggable genes for therapeutic target identification in polycystic ovary syndrome. | Xu D et al. | β | 2025 | β |
| Integrative multi-omics and Mendelian randomization identify WWOX and THBS2 as potential therapeutic targets in mature T/NK-cell lymphoma. | Qin Y et al. | β | 2025 | β |
| Integrative Multi-Omics Approach for Improving Causal Gene Identification. | King A et al. | β | 2025 | β |
| Integrative multi-omics data from early development to identify the genes and cell types underlying attention-deficit/hyperactivity disorder. | Jiao S et al. | β | 2025 | β |
| Integrative multi-omics investigation of sleep apnea: gut microbiome metabolomics, proteomics and phenome-wide association study. | Wei S et al. | β | 2025 | β |
| Integrative omics of the genetic basis for wheat WUE and drought resilience reveal the function of TaMYB7-A1. | Zhou Y et al. | β | 2025 | β |
| Integrative proteomic analysis provides novel therapeutic insights for etiological subtypes of diabetes. | Wei J et al. | β | 2025 | β |
| Integrative transcriptogenomic analyses reveal the regulatory network underlying rice eating and cooking quality and identify a role for alpha-globulin in modulating starch and sucrose metabolism. | Nawade B et al. | β | 2025 | β |
| Investigating Overlapping Genetic Factors and Novel Causal Genes in Autoimmune Diseases: A Transcriptome-Wide Association and Multiomics Study. | Fu L et al. | β | 2025 | β |
| Investigating the association between GLP-1 receptor agonists and mood disorders: A study integrating real-world data and Mendelian randomization. | Zheng X et al. | β | 2025 | β |
| Investigating the causal role of cellular senescence-related genes in preeclampsia: a multi-omics Mendelian randomization study with differential expression analysis. | Zhu H et al. | β | 2025 | β |
| Investigating the potential of oxidative stress-related gene as predictive markers in idiopathic pulmonary fibrosis. | Wang Y et al. | β | 2025 | β |
| Investigating the Shared Genetic Architecture Between Leukocyte Telomere Length and Prostate Cancer. | Li Z et al. | β | 2025 | β |
| Investigating the shared genetic architecture between obesity and depression: a large-scale genomewide cross-trait analysis. | Yuan L et al. | β | 2025 | β |
| Investigating the shared genetic information between serum concentration levels of liver enzymes and cholelithiasis. | Tian W et al. | β | 2025 | β |
| Investigation of Novel Therapeutic Targets for Rheumatoid Arthritis Through Human Plasma Proteome. | Wang H et al. | β | 2025 | β |
| Iron status mediates the causal effects of high-altitude adaptation signals in the HIF-PHD axis on pulmonary vascular and right-heart outcomes. | Zhang Y et al. | β | 2025 | β |
| JC124 confers multimodal neuroprotection in epilepsy by suppressing NLRP3 inflammasome activation: evidence from animal and human neuronal models. | Zhang P et al. | β | 2025 | β |
| Joint analysis of genome-wide cross-trait and multi-omics reveals molecular mechanisms of inflammatory bowel disease and nominates its novel therapeutic genes. | Zhu Z et al. | β | 2025 | β |
| Kidney multiome-based genetic scorecard reveals convergent coding and regulatory variants. | Liu H et al. | β | 2025 | β |
| Large-scale GWAS of strabismus identifies risk loci and provides support for a link with maternal smoking. | He W et al. | β | 2025 | β |
| Large-scale multi-trait genome-wide analysis for inflammatory bowel disease reveals new insights into its molecular mechanisms and emphasizes the roles of systemic immune regulation. | Zhu Z et al. | β | 2025 | β |
| Large-scale transcriptomic analyses of major depressive disorder reveal convergent dysregulation of synaptic pathways in excitatory neurons. | Goes FS et al. | β | 2025 | β |
| Leveraging pleiotropy for the improved treatment of psychiatric disorders. | Woodward DJ et al. | β | 2025 | β |
| Linking genomic and proteomic signatures to brain amyloid burden: insights from GR@ACE/DEGESCO. | Puerta R et al. | β | 2025 | β |
| LIPA, a risk locus for coronary artery disease: decoding the variant-to-function relationship. | Li F et al. | β | 2025 | β |
| Lipid, lipid-lowering drugs, and bleedings: A Mendelian randomization and retrospective study. | Guo S et al. | β | 2025 | β |
| Long-read sequencing reveals the RNA isoform repertoire of neuropsychiatric risk genes in human brain. | De Paoli-Iseppi R et al. | β | 2025 | β |
| Low apolipoprotein A-II levels causally contribute to increased mortality in septic shock. | Takahashi N et al. | β | 2025 | β |
| <i>DBI</i> as a Novel Immunotherapeutic Candidate in Colorectal Cancer: Dissecting Genetic Risk and the Immune Landscape via GWAS, eQTL, and pQTL. | Tian T et al. | β | 2025 | β |
| <i>VEGFB</i> is a potential therapeutic target for Alzheimer's disease: Insights from integrative multi-omics analysis. | Ye H et al. | β | 2025 | β |
| m6A demethylase Fto inhibited macrophage activation and glycolysis in diabetic nephropathy via m6A/Npas2/Hif-1Ξ± axis. | Zhu S et al. | β | 2025 | β |
| Machine learning model reveals the risk, prognosis, and drug response of histamine-related signatures in pancreatic cancer. | Li CL et al. | β | 2025 | β |
| Mapping fatigue: discovering brain regions and genes linked to fatigue susceptibility. | Zhang Y et al. | β | 2025 | β |
| Mapping the microRNA landscape in the older adult brain and its genetic contribution to neuropsychiatric conditions. | Vattathil SM et al. | β | 2025 | β |
| Mapping the regulatory genetic landscape of complex traits using a chicken advanced intercross line. | Zhu X et al. | β | 2025 | β |
| Mechanistic insights into EIF6 as a target of Apigenin in alleviating chondrocyte senescence. | Li E et al. | β | 2025 | β |
| Mendelian randomisation to uncover causal associations between conformation, metabolism, and production as potential exposure to reproduction in German Holstein dairy cattle. | Schwarz L et al. | β | 2025 | β |
| Mendelian Randomization Analysis of ITGA2 and ECM1 in Obstructive Sleep Apnea: Genetic and Tissue-Specific Evidence | Chen M et al. | β | 2025 | β |
| Mendelian randomization analysis of lipids traits and lipid-lowering drug-targets in relation to cognitive status. | Fu J et al. | β | 2025 | β |
| Mendelian randomization analysis of the association between vitamin B12 deficiency anaemia and the risk of developing lung disease. | Wang Y et al. | β | 2025 | β |
| Mendelian randomization analysis reveals the potential of the IKZF1 gene as a therapeutic target in colorectal cancer. | Lin J et al. | β | 2025 | β |
| Mendelian Randomization and Colocalization Analysis Reveal New Drug Targets for Oral Ulcer: A Mendelian Randomization Analysis. | Zhang X et al. | β | 2025 | β |
| Mendelian randomization and transcriptomic analysis reveal a positive cause-and-effect relationship between Alzheimer's disease and colorectal cancer. | Du W et al. | β | 2025 | β |
| Mendelian Randomization Assessment of the Genetic Effects of Lipid-Lowering Drugs on Digestive System Cancers. | Ma K et al. | β | 2025 | β |
| Mendelian Randomization-Based Discovery of Novel Protein Biomarkers and Drug Targets in Colorectal Cancer: Validation Through Prognostic Modeling, Single-Cell Analysis, and In Vitro Cell Experiments. | Bao X et al. | β | 2025 | β |
| Mendelian Randomization Identifies Putative Aging-Related Causal Genes With Diagnostic Potential in Ulcerative Colitis. | Zhao Q et al. | β | 2025 | β |
| Mendelian Randomization Integrating GWAS and eQTL Data Reveals DAAM1, a Potential Immune-Related Biomarker for Breast Cancer Prognosis. | Chen G et al. | β | 2025 | β |
| Mendelian randomization provides a multi-omics perspective on the regulation of genes involved in ribosome biogenesis in relation to cardiac structure and function. | Wei S et al. | β | 2025 | β |
| Mendelian Randomization Reveals Causalities Between DNA Methylation and Schizophrenia. | Wang D et al. | β | 2025 | β |
| Mendelian Randomization Reveals Potential Causal Relationships Between DNA Damage Repair-Related Genes and Inflammatory Bowel Disease. | Qi Z et al. | β | 2025 | β |
| Metabolome-wide association identifies ferredoxin-1 (FDX1) as a determinant of cholesterol metabolism and cardiovascular risk in Asian populations. | Sadhu N et al. | β | 2025 | β |
| Mitigating inconsistencies in GWAS follow-up analyses with LocusCompare2. | Liu F et al. | β | 2025 | β |
| Mitochondrial FIS1 As a Novel Drug Target for the Treatment of Erectile Dysfunction: A Multi-Omic and Epigenomic Association Study. | Zhu T et al. | β | 2025 | β |
| Mitochondrial fission genes MTFP1/MTFP2 as predictive biomarkers in prostate cancer: a mendelian randomization study. | Huangfu X et al. | β | 2025 | β |
| Mitochondrial Gene Regulation and Pain Susceptibility: A Multi-Omics Causal Inference Study. | Liu CC | β | 2025 | β |
| Mitochondrial-related genome-wide Mendelian randomization identifies putatively causal genes in the pathogenesis of sepsis. | Sun J et al. | β | 2025 | β |
| Mitochondria-Related Genome-Wide Mendelian Randomization Identifies Putatively Causal Genes for Neurodegenerative Diseases. | Wang Z et al. | β | 2025 | β |
| Molecular crosstalk and potential causal mechanisms of rheumatoid arthritis and sarcopenia co-morbidity: A gene integration analysis. | Ren Q et al. | β | 2025 | β |
| Morphological alterations and gene expression levels in the cerebral cortex causally influence susceptibility to type 2 diabetes: A Mendelian randomization study. | Ye F et al. | β | 2025 | β |
| MRBIGR: A versatile toolbox for genetic regulation inference from population-scale multi-omics data. | Xu F et al. | β | 2025 | β |
| MR-EILLS: an invariance-based Mendelian randomization method integrating multiple heterogeneous GWAS summary datasets. | Hou L et al. | β | 2025 | β |
| Multiancestry brain pQTL fine-mapping and integration with genome-wide association studies of 21 neurologic and psychiatric conditions. | Wingo AP et al. | β | 2025 | β |
| Multi-ancestry genome-wide association analyses incorporating SNP-by-psychosocial interactions identify novel loci for serum lipids. | Bentley AR et al. | β | 2025 | β |
| Multi-ancestry genome-wide meta-analysis with 472,819 individuals identifies 32 novel risk loci for psoriasis. | Zhang M et al. | β | 2025 | β |
| Multigene overlap analysis of bipolar disorder subtypes and educational attainment. | Zhang J et al. | β | 2025 | β |
| Multi-INTACT: integrative analysis of the genome, transcriptome, and proteome identifies causal mechanisms of complex traits. | Okamoto J et al. | β | 2025 | β |
| Multilevel Analysis Reveals the Critical Role of Cell Death-Related Molecules and Drugs in Temporomandibular Disorders. | Zhang Y et al. | β | 2025 | β |
| Multilevel Transcriptomic Association Analysis Reveals Key Genes and Potential Mechanisms in Endometrial, Ovarian, and Cervical Cancers. | Liu L et al. | β | 2025 | β |
| Multi-omic dissection of clinically diagnosed and self-reported major depressive disorder reveals phenotype-specific genetic and proteomic architecture in East Asian populations. | Wang W et al. | β | 2025 | β |
| Multi-omic insight into the causal networks of arsenic-related genes in the pathogenesis of type 2 diabetes mellitus. | Yang H et al. | β | 2025 | β |
| Multiomic insight into the involvement of cell aging related genes in the pathogenesis of endometriosis. | Chen L et al. | β | 2025 | β |
| Multi-Omic Insight Into the Molecular Networks in the Pathogenesis of Coronary Artery Disease. | Fang Q et al. | β | 2025 | β |
| Multi-Omic Insight Into the Molecular Networks of Mitochondrial Dysfunction in the Pathogenesis of Primary Open-Angle Glaucoma. | Chen LH et al. | β | 2025 | β |
| Multi-Omic Insight Into the Molecular Networks of Mitochondrial Dysfunction in the Pathogenesis of Schizophrenia. | Yu K et al. | β | 2025 | β |
| Multi-omic insights into mitochondrial dysfunction and prostatic disease: evidence from transcriptomics, proteomics, and methylomics. | Gong B et al. | β | 2025 | β |
| Multiomic Mendelian randomization analysis of metabolic gene methylation expression and protein levels in lung adenocarcinoma. | Wang Q et al. | β | 2025 | β |
| Multi-Omics Analysis and Validation of Cell Senescence-Related Genes Associated with Non-Alcoholic Fatty Liver Disease. | Gong J et al. | β | 2025 | β |
| Multi-omics analysis for identifying cell-type-specific and bulk-level druggable targets in Alzheimer's disease. | Liu S et al. | β | 2025 | β |
| Multi-omics analysis identifies diagnostic circulating biomarkers and potential therapeutic targets, revealing IQGAP1 as an oncogene in gastric cancer. | Deng C et al. | β | 2025 | β |
| Multi-Omics Analysis Identifies Genetic Mechanisms and Therapeutic Targets for Acne Vulgaris. | Qiu X et al. | β | 2025 | β |
| Multi-omics Analysis of Energy Metabolism Pathways Across Major Psychiatric Disorders. | Zou S et al. | β | 2025 | β |
| Multi-Omics Analysis of the Anoikis Gene <i>CASP8</i> in Prostate Cancer and Biochemical Recurrence (BCR). | Huang S et al. | β | 2025 | β |
| [Multi-omics analysis of the relationship between oxidative stress-related gene and prostate cancer]. | Ning J et al. | β | 2025 | β |
| Multi-omics analysis reveals novel causal pathways in psoriasis pathogenesis. | Guo H et al. | β | 2025 | β |
| Multi-omics analysis reveals the prognostic value and immunomodulatory role of CTSW in breast cancer. | Liu X et al. | β | 2025 | β |
| Multi-omics analysis unveiled fibroblast-mediated pathogenesis in male genital lichen sclerosus. | Lin L et al. | β | 2025 | β |
| Multi-omics and comprehensive multi-trait analysis identify shared genetic etiology of heart failure and related cancers. | Shui W et al. | β | 2025 | β |
| Multi-omics and Mendelian randomization identify <i>S1PR5</i> as a causal protective gene and NK cell-mediated prognostic biomarker in lung adenocarcinoma. | Xing Z et al. | β | 2025 | β |
| Multi-omics and Mendelian randomization study explores potential therapeutic targets for meningiomas. | Li Y et al. | β | 2025 | β |
| Multi-Omics Association Analysis of Mitochondrial Genes in Hypertrophic Scars: Application of Mendelian Randomization. | Gong T et al. | β | 2025 | β |
| Multi-omics evidence supports PROC as a potential predictor of VTE risk: A Mendelian randomization study. | Wan B et al. | β | 2025 | β |
| Multi-omics identify ribosome related causal genes methylation, splicing, and expression in prostate cancer. | Wei C et al. | β | 2025 | β |
| Multi-omics insight into the molecular networks of mental disorder related genetic pathways in the pathogenesis of inflammatory bowel disease. | Zhang M et al. | β | 2025 | β |
| Multi-omics integration analysis of the amino-acid metabolism-related genes identifies putatively causal variants of ACCS associated with hepatitis B virus-related hepatocellular carcinoma survival. | Wei X et al. | β | 2025 | β |
| Multi-Omics Integration Identifies FGF1 as a Diagnostic Biomarker and RAS-MAPK-Driven Pathogenic Factor in Osteoarthritis. | Yan Y et al. | β | 2025 | β |
| Multiomics integration prioritizes potential drug targets for multiple sclerosis. | Jiang Y et al. | β | 2025 | β |
| Multi-Omics Integration Reveals Mitochondrial Gene Regulation as a Determinant of Tuberculosis Susceptibility: A Mendelian Randomization Approach. | Fang T et al. | β | 2025 | β |
| Multi-Omics Integration Reveals PBDE-47 as an Environmental Risk Factor for Intracranial Aneurysm via F2R-Mediated Metabolic and Epigenetic Pathways. | Liu H et al. | β | 2025 | β |
| Multi-omics integrative analysis of the mechanisms linking environmental pollutant exposure to bladder cancer pathogenesis. | Zhu G et al. | β | 2025 | β |
| Multi-omics integrative analysis reveals novel genetic loci and candidate genes for ischemic stroke. | Wang M et al. | β | 2025 | β |
| Multi-omics Mendelian randomization and single-cell analysis identify novel therapeutic targets for osteosarcopenia. | Yang J et al. | β | 2025 | β |
| Multi-Omics Mendelian Randomization Identifies a DNA Methylation-ZDHHC20-Immune Axis Associated With Schizophrenia Risk. | Guo Q et al. | β | 2025 | β |
| Multi-omics nominates VDAC2 as a candidate protective locus in sepsis-associated cholesterol dysregulation. | Yao T et al. | β | 2025 | β |
| Multi-omics profiling uncovers paradoxical Epstein-Barr virus involvement in autoimmune liver disease pathogenesis. | Zheng L et al. | β | 2025 | β |
| Multi-omics reveals cross-tissue regulatory mechanisms of autism risk loci via gut microbiota-immunity-brain axis. | Liao X et al. | β | 2025 | β |
| Multi-omics reveal the role of nociception-related genes TNXB, CTNND1 and CBL in depression. | Wu Q et al. | β | 2025 | β |
| Multi-omics study of mitochondrial dysfunction in the pathogenesis of hyperuricemia. | Hong Y et al. | β | 2025 | β |
| Multi-omic underpinnings of heterogeneous aging across multiple organ systems. | Xiong J et al. | β | 2025 | β |
| Multiple strategies association revealed functional candidate FASN gene for fatty acid composition in cattle. | Zhu B et al. | β | 2025 | β |
| Multi-tissue transcriptome-wide association study identifies novel candidate genes and pleiotropy effects across four abdominal hernia subtypes. | Chaar DL et al. | β | 2025 | β |
| Multi-trait association analysis reveals shared genetic architecture between lung cancer and cardiometabolic diseases. | Lyu Q et al. | β | 2025 | β |
| Mutually reinforcing relationship between SjΓΆgren's syndrome and lung adenocarcinoma: insights from Mendelian randomisation, single-cell, and transcriptomic analyses. | Xu K et al. | β | 2025 | β |
| Neither VitD nor VitD binding protein or VitD receptor has causal effect on cancers: a Mendelian randomization study. | Wang YZ et al. | β | 2025 | β |
| NEK4: prediction of available drug targets and common genetic linkages in bipolar disorder and major depressive disorder. | Gong B et al. | β | 2025 | β |
| Neurodegeneration Promotes Tumorigenesis in Colorectal Cancer: Insights From Single-Cell and Spatial Multiomics. | Mo S et al. | β | 2025 | β |
| Neuroimmune Crossroads: Pathophysiological Links Between Bipolar Disorder and Inflammatory Bowel Disease. | Marano G et al. | β | 2025 | β |
| Neutrophil extracellular traps drive osteoporosis via NCF2-dependent signaling: integrated transcriptomics with mechanistic validation. | Guo X et al. | β | 2025 | β |
| NLRC5-Mediated Epigenetic and Proteomic Regulation of Microglial Panoptosis Drives Neuroinflammation in Multiple Sclerosis. | Yan W et al. | β | 2025 | β |
| No evidence for genetic role of the tumor necrosis factor pathway in Parkinson's disease. | Shahkhali MG et al. | β | 2025 | β |
| Noninvasive markers for warning premature ovarian insufficiency: a Mendelian randomisation study. | Tan H et al. | β | 2025 | β |
| Novel insight of critical genes involved in breast cancer brain metastasis: evidence from a cross-tissue transcriptome association study and validation through external clinical cohorts. | Liu J et al. | β | 2025 | β |
| Novel insights into causal effects of serum lipids, lipid metabolites, and lipid-modifying targets on the risk of intracerebral aneurysm. | Qiu Y et al. | β | 2025 | β |
| Novel Insights into Schizophrenia Treatment: Comprehensive Analysis Unveiling FGFR1 as a Promising Druggable Gene. | Lian K et al. | β | 2025 | β |
| Observational, causal relationship and shared genetic basis between cholelithiasis and gastroesophageal reflux disease: evidence from a cohort study and comprehensive genetic analysis. | Lyu Y et al. | β | 2025 | β |
| Ocular safety evaluation of toplic and systemic antifungal medications: A multi-source pharmacovigilance and genomic study. | Wang D et al. | β | 2025 | β |
| PARK7 is a Key Regulator of Oxidative Stress - Related Breast Cancer Risk: A Multi-Omics Study. | Wang T et al. | β | 2025 | β |
| Pathogenic genes associated with immune-related genes in graves' disease: a multi-omics Mendelian randomization analysis. | Ji Q et al. | β | 2025 | β |
| Phosphodiesterase 5 and its inhibitors with ischaemic heart disease: a Mendelian randomization analysis and a real-world study. | Xiao J et al. | β | 2025 | β |
| Pinpointing novel targets for osteoarthritis: A comprehensive cross-omics integration analysis. | Xu WB et al. | β | 2025 | β |
| Plasma proteins and onset of atherosclerosis: integrating human plasma proteogenomics, transcriptomics and in vivo evidence. | Chen K et al. | β | 2025 | β |
| Population-scale gene expression analysis reveals the contribution of expression diversity to the modern wheat improvement. | Zhang Z et al. | β | 2025 | β |
| Positive Relationships between Intraocular Pressure and Thyroid Function in Graves' Ophthalmopathy: A Three-Aspect Evidence Analysis. | Zhang W et al. | β | 2025 | β |
| Potential causal link between antiseizure medication targets and cognitive function: A mendelian randomization study. | Zhu K et al. | β | 2025 | β |
| Potential Drug Targets for Migraine Identified Through Mendelian Randomization Analysis of the Human Plasma Proteome. | Guo L et al. | β | 2025 | β |
| Potential Functions and Causal Associations of GNLY in Primary Open-Angle Glaucoma: Integration of Blood-Derived Proteome, Transcriptome, and Experimental Verification. | Wang D et al. | β | 2025 | β |
| Potentially causal associations between placental DNA methylation and schizophrenia and other neuropsychiatric disorders. | Cilleros-Portet A et al. | β | 2025 | β |
| Potential of CETP inhibition in treating dyslipidemia in systemic lupus erythematosus: Novel and comprehensive evidence from clinical studies and Mendelian randomization. | Gan Y et al. | β | 2025 | β |
| Potential of vitamin D for the prevention of 3 types of cerebrovascular diseases: A 2-sample Mendelian randomization study. | Li L et al. | β | 2025 | β |
| Potential Targets Related to Skin Aging: Based on eQTL and GWAS Datasets. | Shi H et al. | β | 2025 | β |
| Potential therapeutic targets for ovarian hyperstimulation syndrome revealed by proteome-wide mendelian randomization and colocalization analysis. | Yao B et al. | β | 2025 | β |
| Precision Target Discovery for Migraine: An Integrated GWAS-eQTL-PheWAS Pipeline. | Liu X et al. | β | 2025 | β |
| Predicting the ferroptosis-associated gene targets in atherosclerosis by integrating GWAS and eQTL studies summary data. | Li J et al. | β | 2025 | β |
| Predicting the mechanisms and targets of PFOA nephrotoxicity via network toxicology, Mendelian randomization, molecular docking and molecular dynamics simulation. | Zheng H et al. | β | 2025 | β |
| Prioritization of potential drug targets in ovarian-related diseases: Mendelian randomization and colocalization analyses. | Hong Y | β | 2025 | β |
| Prioritizing endocrine-disrupting chemicals targeting systemic lupus erythematosus genes via Mendelian randomization and colocalization analyses. | Hong Y et al. | β | 2025 | β |
| Proteome-wide association studies have predicted that the protein abundance of LSM6, GMPPB, ICA1L, and CISD2 is associated with attention-deficit/hyperactivity disorder. | Liu J | β | 2025 | β |
| Proteome-Wide Association Study for Finding Druggable Targets in Progression and Onset of Parkinson's Disease. | Gao C et al. | β | 2025 | β |
| Proteome-Wide Mendelian Randomization Identifies Therapeutic Targets for Abdominal Aortic Aneurysm. | Zhang K et al. | β | 2025 | β |
| Proteome-wide Mendelian randomization reveals causal associations between plasma proteins and autoimmune thyroid disease. | Li Y et al. | β | 2025 | β |
| Proteomic insights into chronic pancreatitis: Proteome-wide mendelian randomization to identify potential therapeutic targets. | Li Q et al. | β | 2025 | β |
| Proteomic landscape of multidimensional aging phenotypes. | Cao Z et al. | β | 2025 | β |
| Recent Advances in Experimental Functional Characterization of GWAS Candidate Genes in Osteoporosis. | MalavaΕ‘iΔ P et al. | β | 2025 | β |
| Refining breast cancer genetic risk and biology through multi-ancestry fine-mapping analyses of 192 risk regions. | Jia G et al. | β | 2025 | β |
| Regulation of RNA splicing in endometrial tissue and its association with endometriosis. | Yang F et al. | β | 2025 | β |
| Regulatory QTLs affecting miRNA-mRNA interactions in cancer: mechanisms, methods, and clinical implications. | Kumar V et al. | β | 2025 | β |
| Repurposing Antidiabetic Drugs for Cerebrovascular Diseases: Causal Evidence from Drug Target Mendelian Randomization and Colocalization. | Huang X et al. | β | 2025 | β |
| Repurposing piroxicam as an SLC7A5 antagonist to ameliorate prothrombotic state in Diane-35-treated polycystic ovary syndrome patients. | Jiang S et al. | β | 2025 | β |
| Rethinking GWAS: how lessons from genetic screens and artificial intelligence could reveal biological mechanisms. | Hazelett DJ | β | 2025 | β |
| Revealing potential drug targets in liver dysfunction through proteome-wide Mendelian randomization. | Zhang XM et al. | β | 2025 | β |
| Revealing Putative Causal Genes by Establishing the Causality Between Different Lymphomas and Immune Cells. | Lian J et al. | β | 2025 | β |
| Revealing the genetic and immunological crosstalk between SLE and ccRCC: An integrative genomic analysis approach. | Lin F et al. | β | 2025 | β |
| Revealing the genetic architectures underlying organ-specific aging based on proteomic data. | Zhu RJ et al. | β | 2025 | β |
| Review: Recent advances in unraveling the genetic architecture of kernel row number in maize. | Wang Y et al. | β | 2025 | β |
| Risk associated circulating biomarkers S100A3 identified in congenital heart disease-associated pulmonary arterial hypertension. | Zhao W et al. | β | 2025 | β |
| Risk-based screening and prognostic analysis for second primary malignancies in kidney cancer patients: a retrospective cohort study based on large-scale population and Mendelian randomization analysis. | Zou M et al. | β | 2025 | β |
| Roles of plasma proteins in mediating the causal effect of the lipid species on gastric cancer: Insights from proteomic and two-step Mendelian randomization. | Dong Z et al. | β | 2025 | β |
| Sarcopenia and immune-mediated inflammatory diseases: Evaluating causality and exploring therapeutic targets for sarcopenia through Mendelian randomization. | Wang Q et al. | β | 2025 | β |
| scTWAS Atlas: an integrative knowledgebase of single-cell transcriptome-wide association studies. | Mai J et al. | β | 2025 | β |
| Seronegative Sicca Syndrome: Diagnostic Considerations and Management Strategies. | Basheva-Kraeva YM et al. | β | 2025 | β |
| Sex Hormone-Related Pathogenic Genes in Multiple Sclerosis: A Multi-omics Mendelian Randomization Study. | Qiu J et al. | β | 2025 | β |
| Shared genetic architecture and bidirectional clinical risks within the psycho-metabolic nexus. | Guo X et al. | β | 2025 | β |
| Shared genetic architecture and causal relationship between frailty and schizophrenia. | Deng MG et al. | β | 2025 | β |
| Shared genetic architecture between anxiety, depression and erectile dysfunction: a genome-wide cross-trait analysis. | Xie L et al. | β | 2025 | β |
| Shared Genetic Architecture Between Atopic Dermatitis and Autoimmune Diseases. | Lazanas P et al. | β | 2025 | β |
| Shared genetic architecture between grip strength and cognitive function: insights from large-scale genome-wide cross-trait analysis. | Liu H et al. | β | 2025 | β |
| Shared Genetic Architecture Between Psychiatric Disorders and Keratoconus: Insights From a Large-Scale Genome-Wide Cross-Trait Analysis. | Li G et al. | β | 2025 | β |
| Shared genetic architecture of posttraumatic stress disorder with cardiovascular imaging, risk, and diagnoses. | Shen J et al. | β | 2025 | β |
| Shared genetic associations between CHA<sub>2</sub>DS<sub>2</sub>-VASc score and cardio-embolic stroke: Insights from mendelian randomization based bioinformatics analysis. | Yuan K et al. | β | 2025 | β |
| Single-cell multiomic analysis unveils the immune landscape dynamics of graves' ophthalmopathy. | Ke S et al. | β | 2025 | β |
| Single-cell RNA-seq reveals cell type-specific molecular and genetic associations with primary open-angle glaucoma. | Tian H et al. | β | 2025 | β |
| Single-cell transcriptome-wide Mendelian randomization and colocalization analyses uncover cell-specific mechanisms in atherosclerotic cardiovascular disease. | Ray A et al. | β | 2025 | β |
| Smoking, Genetic Susceptibility and Early Menopause: Unveiling Biological Mechanisms and Potential Therapy Targets. | Liang Y et al. | β | 2025 | β |
| SMR-Portal: an online platform for integrative analysis of GWAS and xQTL data to identify complex trait genes. | Guo Y et al. | β | 2025 | β |
| SNP-associated differential methylation in <i>ARHGEF38</i>: insights into genetic-epigenetic interactions. | KovΓ‘cs EHC et al. | β | 2025 | β |
| Spatially resolved mapping of cells associated with human complex traits. | Song L et al. | β | 2025 | β |
| Spatial transcriptomics unravels the interactive network of aflatoxin B1-driven gastric cancer: Multi-omics integration of transcriptome and mendelian randomization. | Li YL et al. | β | 2025 | β |
| Spatiotemporal dynamics of RERE in schizophrenia pathogenesis: insights from multi-omics and single-cell sequencing. | Shen J et al. | β | 2025 | β |
| SREBF1, a target gene of multiple sclerosis and coronary heart disease: based on mendelian randomization study. | Du L et al. | β | 2025 | β |
| Statins and hemorrhagic stroke: New insight from a Mendelian randomization study. | Gu X et al. | β | 2025 | β |
| Statins' protective effects on focal epilepsy are independent of LDL-C. | Sun Z et al. | β | 2025 | β |
| Structural framework to address variant-gene relationship in primary open-angle glaucoma. | Singh N et al. | β | 2025 | β |
| SUMMER: A Practical Tool for Identifying Factors and Biomarkers Associated with Pan-cancer Survival. | Xin J et al. | β | 2025 | β |
| Synovial transcriptome-wide association study implicates novel genes underlying rheumatoid arthritis risk. | Hu SY et al. | β | 2025 | β |
| SysNatMed: rational natural medicine discovery by systems genetics. | Ye CQ et al. | β | 2025 | β |
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| Systematic Druggable-Proteome-Wide Mendelian Randomization Identifies Potential Therapeutic Targets for Allergic Conjunctivitis. | Chen J et al. | β | 2025 | β |
| Systematic Exploration of Potential Druggable Genes for Ischemic Stroke Employing Genome-Wide Mendelian Randomization Analysis. | Zhang P et al. | β | 2025 | β |
| Systematic functional characterization of non-coding regulatory SNPs associated with central obesity. | Dong SS et al. | β | 2025 | β |
| Systematic Mendelian Randomization Exploring Druggable Genes for Hemorrhagic Strokes. | Yang LZ et al. | β | 2025 | β |
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| TEX10: A Novel Drug Target and Potential Therapeutic Direction for Sleep Apnea Syndrome. | Fan Z et al. | β | 2025 | β |
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| The impact of educational attainment on gestational diabetes mellitus is mediated by body mass index: A Mendelian randomization study. | Zhu S et al. | β | 2025 | β |
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| Trans-ancestry transcriptome-wide association and functional studies to uncover novel susceptibility genes and therapeutic targets for colorectal cancer. | Wang L et al. | β | 2025 | β |
| Transcriptome-wide analyses delineate the genetic architecture of expression variation in atopic dermatitis. | Antonatos C et al. | β | 2025 | β |
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| Uncovering Novel Susceptible Genes and Therapeutic Targets of Prostate Cancer: a Multi-omics Study Integrating Summary-based Mendelian Randomization Analysis and Molecular Docking. | Qiu X et al. | β | 2025 | β |
| Uncovering Potential Susceptibility Genes for Multiple Sclerosis-Induced Neuropathic Bladder: A Mendelian Randomization Analysis. | Xu Y et al. | β | 2025 | β |
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| Unraveling the genetic links between depression and type 2 diabetes. | Baranova A et al. | β | 2025 | β |
| Unraveling the Genetic Links: The Impacts of Antidiabetic Drugs on Stroke Risk. | Chen J et al. | β | 2025 | β |
| Unraveling the relationship between metabolic syndrome and epigenetic aging: evidence from NHANES 1999-2002 and Mendelian randomization study. | Zhang Y et al. | β | 2025 | β |
| Unraveling the Shared Genetic Architecture and Polygenic Overlap Between Loneliness, Major Depressive Disorder, and Sleep-Related Traits. | Rehman Z et al. | β | 2025 | β |
| Unraveling the shared genetic foundations of neurodevelopmental and psychiatric disorders: Insights from comprehensive genome-wide analyses. | Maimaiti A et al. | β | 2025 | β |
| Unveiling causal immune cell-gene associations in multiple myeloma: insights from systematic reviews and Mendelian randomization analyses. | Zhang H et al. | β | 2025 | β |
| Unveiling genetic and biological links: exploring the intersection of autoimmune and psychiatric disorders. | Liwayiding A et al. | β | 2025 | β |
| Unveiling genetic signatures of immune response in immune-related diseases through single-cell eQTL analysis across diverse conditions. | Zhang Z et al. | β | 2025 | β |
| Unveiling migraine subtype heterogeneity and risk loci: integrated genome-wide association study and single-cell transcriptomics discovery. | Wei S et al. | β | 2025 | β |
| Unveiling novel potential drug targets for lung cancer through Mendelian randomization analysis. | Huang Y et al. | β | 2025 | β |
| Unveiling the genetic networks: Exploring the dynamic interaction of photosynthetic phenotypes in woody plants across varied light gradients. | Lu K et al. | β | 2025 | β |
| Unveiling the genetic overlap and causal links between gastroesophageal reflux disease and asthma. | Zhang Y et al. | β | 2025 | β |
| Unveiling the genetic pleiotropy between anxiety disorders and autoimmune diseases: insights from large-scale genome-wide cross-trait analysis. | Lin H et al. | β | 2025 | β |
| Unveiling the shared etiology between gastrointestinal disorders and valvular heart diseases through a genome-wide pleiotropy study. | Xu J et al. | β | 2025 | β |
| Unveiling the therapeutic potential of senescence-related IQGAP2 in pancreatic Cancer through post-GWAS genomic and scRNA-seq analyses. | Bai Z et al. | β | 2025 | β |
| VAMP8 as a biomarker and potential therapeutic target for endothelial cell dysfunction in atherosclerosis. | Yang L et al. | β | 2025 | β |
| ZDHHC5 and ZDHHC14 promote depression via the mediation of double-negative T cells. | Lu G et al. | β | 2025 | β |
| ZDHHC5 Mediates Immune Dysregulation Driving Generalized Anxiety Disorder Risk. | Sun F et al. | β | 2025 | β |
| Abdominal aortic aneurysm and cardiometabolic traits share strong genetic susceptibility to lipid metabolism and inflammation. | Zheng S et al. | β | 2024 | β |
| Accurate identification of genes associated with brain disorders by integrating heterogeneous genomic data into a Bayesian framework. | He D et al. | β | 2024 | β |
| A commentary on 'Association of glucagon-like peptide-1 receptor agonists with risk of cancers-evidence from a drug target Mendelian randomization and clinical trials'. | Zhang G et al. | β | 2024 | β |
| A comprehensive assessment of the association between common drugs and psychiatric disorders using Mendelian randomization and real-world pharmacovigilance database. | Chen Z et al. | β | 2024 | β |
| A cross-tissue transcriptome-wide association study identifies WDPCP as a potential susceptibility gene for coronary atherosclerosis. | Hu X et al. | β | 2024 | β |
| A cross-tissue transcriptome-wide association study reveals GRK4 as a novel susceptibility gene for COPD. | Chen G et al. | β | 2024 | β |
| A genetic study to identify pathogenic mechanisms and drug targets for benign prostatic hyperplasia: a multi-omics Mendelian randomization study. | Liu B et al. | β | 2024 | β |
| A genome-wide investigation into the underlying genetic architecture of personality traits and overlap with psychopathology. | Gupta P et al. | β | 2024 | β |
| A Mendelian randomisation approach to explore genetic factors associated with erectile dysfunction based on pooled genomic data. | Mao H et al. | β | 2024 | β |
| A multi-omics study of brain tissue transcription and DNA methylation revealing the genetic pathogenesis of ADHD. | Wang J et al. | β | 2024 | β |
| Analyses of GWAS signal using GRIN identify additional genes contributing to suicidal behavior. | Sullivan KA et al. | β | 2024 | β |
| An atlas of the shared genetic architecture between atopic and gastrointestinal diseases. | Qi C et al. | β | 2024 | β |
| A scoping review of statistical methods to investigate colocalization between genetic associations and microRNA expression in osteoarthritis. | Zang K et al. | β | 2024 | β |
| Assessing the causal relationship between plasma proteins and osteoporosis: novel insights into pathological mechanisms and therapeutic implications. | Wang L et al. | β | 2024 | β |
| Association between biological ageing and periodontitis: Evidence from a cross-sectional survey and multi-omics Mendelian randomization analysis. | Huang Z et al. | β | 2024 | β |
| Association between GATM gene polymorphism and progression of chronic kidney disease: a mitochondrial related genome-wide Mendelian randomization study. | Liu B et al. | β | 2024 | β |
| Association between genetically proxied PPARG activation and psoriasis vulgaris: a Mendelian randomization study. | Xue Y et al. | β | 2024 | β |
| Association between lipid-lowering agents with intervertebral disc degeneration, sciatica and low back pain: a drug-targeted mendelian randomized study and cross-sectional observation. | Liu C et al. | β | 2024 | β |
| Associations between antagonistic SNPs for neuropsychiatric disorders and human brain structure. | Federmann LM et al. | β | 2024 | β |
| Associations between genetically predicted concentrations of plasma proteins and the risk of prostate cancer. | Sun W et al. | β | 2024 | β |
| Associations between lipid-lowering drugs and urate and gout outcomes: a Mendelian randomization study. | Liu M et al. | β | 2024 | β |
| Blood-derived mitochondrial DNA copy number is associated with Alzheimer disease, Alzheimer-related biomarkers and serum metabolites. | Tong T et al. | β | 2024 | β |
| Cancer pharmacoinformatics: Databases and analytical tools. | Kamble P et al. | β | 2024 | β |
| Causal and mediating effects of lipid and facial aging: association study integrating GWAS, eQTL, mQTL, and pQTL data. | Zhao M et al. | β | 2024 | β |
| Causal effect of COVID-19 on longitudinal volumetric changes in subcortical structures: A mendelian randomization study. | Wang Z et al. | β | 2024 | β |
| Causal Effects of Oxidative Stress on Diabetes Mellitus and Microvascular Complications: Insights Integrating Genome-Wide Mendelian Randomization, DNA Methylation, and Proteome. | Liu K et al. | β | 2024 | β |
| Causal gene identification using mitochondria-associated genome-wide mendelian randomization in atrial fibrillation. | Chen Y et al. | β | 2024 | β |
| Causal links between serum micronutrients and epilepsy: a Mendelian randomization analysis. | Chen H et al. | β | 2024 | β |
| Causal relationship between circulating plasma lipids and atopic dermatitis risk: potential drug targets and therapeutic strategies. | He A et al. | β | 2024 | β |
| CCN3/NOV as a potential therapeutic target for diverticular disease: A proteome-wide Mendelian randomization study. | Yoshikawa M et al. | β | 2024 | β |
| CDKN1A as a target of senescence in heart failure: insights from a multiomics study. | Bian R et al. | β | 2024 | β |
| Circadian gene signatures in the progression of obesity based on machine learning and Mendelian randomization analysis. | Cheng Z et al. | β | 2024 | β |
| Circulating immune cells and risk of osteosarcoma: a Mendelian randomization analysis. | Li L et al. | β | 2024 | β |
| Comprehensive mendelian randomization reveals atrial fibrillation-breast cancer relationship and explores common druggable targets. | Qi F et al. | β | 2024 | β |
| Cross-ancestry analysis of brain QTLs enhances interpretation of schizophrenia genome-wide association studies. | Chen Y et al. | β | 2024 | β |
| Cross-population enhancement of PrediXcan predictions with a gnomAD-based east Asian reference framework. | Chan HC et al. | β | 2024 | β |
| Crosstalk between epitranscriptomic and epigenomic modifications and its implication in human diseases. | Li C et al. | β | 2024 | β |
| Cross-Tissue Regulatory Network Analyses Reveal Novel Susceptibility Genes and Potential Mechanisms for Endometriosis. | Zou M et al. | β | 2024 | β |
| CSGDN: contrastive signed graph diffusion network for predicting crop gene-phenotype associations. | Pan Y et al. | β | 2024 | β |
| Deciphering cell-specific genetic insights: Unraveling the immunogenetic landscape of systemic lupus erythematosus. | Zhang H et al. | β | 2024 | β |
| Deciphering the molecular landscape of rheumatoid arthritis offers new insights into the stratified treatment for the condition. | Chang MJ et al. | β | 2024 | β |
| Decoding the genetic landscape of juvenile dermatomyositis: insights from phosphorylation-associated single nucleotide polymorphisms. | Zhang H et al. | β | 2024 | β |
| DENND5B Gene Expression as a Trigger for the Development of Diabetes Mellitus-Peripheral Artery Disease: Insights from a Univariate and Multivariate Mendelian Randomization Study. | Li Q et al. | β | 2024 | β |
| Disease coverage of human genome-wide association studies and pharmaceutical research and development. | Gordillo-MaraΓ±Γ³n M et al. | β | 2024 | β |
| Dissecting shared genetic architecture between depression and body mass index. | Zhang H et al. | β | 2024 | β |
| Dissecting the association between blood pressure traits, hypertension, antihypertensive medications and epilepsy: A Mendelian randomization study. | Yu C et al. | β | 2024 | β |
| Dissecting the shared genetic architecture between anti-MΓΌllerian hormone and age at menopause based on genome-wide association study. | Long P et al. | β | 2024 | β |
| DNA methylation biomarkers and myopia: a multi-omics study integrating GWAS, mQTL and eQTL data. | Dong XX et al. | β | 2024 | β |
| Druggable genome-wide Mendelian randomization for identifying the role of integrated stress response in therapeutic targets of bipolar disorder. | Zhai T | β | 2024 | β |
| Druggable targets for Parkinson's disease: transcriptomics based Mendelian randomization study. | Lyu Q et al. | β | 2024 | β |
| Drug risks associated with sarcopenia: a real-world and GWAS study. | Zhang Z et al. | β | 2024 | β |
| Drug targets for lung cancer: A multi-omics Mendelian randomization study. | Huang N et al. | β | 2024 | β |
| Effects of brain microRNAs in cognitive trajectory and Alzheimer's disease. | Vattathil SM et al. | β | 2024 | β |
| Effects of genetically proxied statins on diabetic nephropathy and retinopathy: a Mendelian randomization study. | Zhao R et al. | β | 2024 | β |
| ELF1 serves as a potential biomarker for the disease activity and renal involvement in systemic lupus erythematosus. | Zhang Y et al. | β | 2024 | β |
| Employing Informatics Strategies in Alzheimer's Disease Research: A Review from Genetics, Multiomics, and Biomarkers to Clinical Outcomes. | Bao J et al. | β | 2024 | β |
| Exploring antidiabetic drug targets as potential disease-modifying agents in osteoarthritis. | Fu K et al. | β | 2024 | β |
| Exploring novel drug targets for atopic dermatitis through plasma proteome with genome. | Wu W et al. | β | 2024 | β |
| Exploring novel drug targets for erectile dysfunction through plasma proteome with genome. | Qiu Z et al. | β | 2024 | β |
| Exploring Pathogenic Genes in Frozen Shoulder through weighted gene co-expression network analysis and Mendelian Randomization. | Wen D et al. | β | 2024 | β |
| Exploring potential causal genetic variants and genes for endometrial cancer: Open Targets Genetics, Mendelian randomization, and multi-tissue transcriptome-wide association analysis. | Zhang G et al. | β | 2024 | β |
| Exploring the causal effect of placental physiology in susceptibility to mental and addictive disorders: a Mendelian randomization study. | JΓ‘come-Ferrer P et al. | β | 2024 | β |
| Exploring the Mechanisms and Preventive Strategies for the Progression from Idiopathic Pulmonary Fibrosis to Lung Cancer: Insights from Transcriptomics and Genetic Factors. | Xie K et al. | β | 2024 | β |
| FABIO: TWAS fine-mapping to prioritize causal genes for binary traits. | Zhang H et al. | β | 2024 | β |
| From proteome to pathogenesis: investigating polycystic ovary syndrome with Mendelian randomization analysis. | Zhang J et al. | β | 2024 | β |
| Genetic association of lipid-lowering drugs with aortic aneurysms: a Mendelian randomization study. | Gao X et al. | β | 2024 | β |
| Genetic association of type 2 diabetes and antidiabetic drug target with skin cancer. | Zhao J et al. | β | 2024 | β |
| Genetic correlation between smoking behavior and gastroesophageal reflux disease: insights from integrative multi-omics data. | Yan Z et al. | β | 2024 | β |
| Genetic proxy of lipid-lowering drugs and calcific aortic valve stenosis: A Mendelian randomization study. | Hou Y et al. | β | 2024 | β |
| Genome-wide association analyses identify distinct genetic architectures for age-related macular degeneration across ancestries. | Gorman BR et al. | β | 2024 | β |
| Genome-wide association studies for pelvic organ prolapse in the Japanese population. | Matsunami M et al. | β | 2024 | β |
| Genome-wide association study and polygenic risk score analysis for schizophrenia in a Korean population. | Lee D et al. | β | 2024 | β |
| Genome-wide identification of cell type-specific susceptibility genes for Juvenile dermatomyositis through the analysis of N<sup>6</sup>-methyladenosine-associated SNPs. | Zhang H et al. | β | 2024 | β |
| Genome-Wide Mendelian Randomization Identifies Ferroptosis-Related Drug Targets for Alzheimer's Disease. | Wang Y et al. | β | 2024 | β |
| Genome-wide meta-analysis identifies 22 loci for normal tension glaucoma with significant overlap with high tension glaucoma. | Diaz-Torres S et al. | β | 2024 | β |
| Genomic analysis of intracranial and subcortical brain volumes yields polygenic scores accounting for variation across ancestries. | GarcΓa-MarΓn LM et al. | β | 2024 | β |
| Global genomic profile of hippocampal endothelial cells by single-nuclei RNA sequencing in female diabetic mice is associated with cognitive dysfunction. | Milenkovic D et al. | β | 2024 | β |
| Gut microbiota and risk of ankylosing spondylitis. | Jiang X et al. | β | 2024 | β |
| GWAS breakthroughs: mapping the journey from one locus to 393 significant coronary artery disease associations. | Aherrahrou R et al. | β | 2024 | β |
| Harnessing transcriptomic signals for amyotrophic lateral sclerosis to identify novel drugs and enhance risk prediction. | Pain O et al. | β | 2024 | β |
| Hierarchical joint analysis of marginal summary statistics-Part II: High-dimensional instrumental analysis of omics data. | Jiang L et al. | β | 2024 | β |
| HMGCR as a promising molecular target for therapeutic intervention in aortic aneurisms: a mendelian randomization study. | Zheng PF et al. | β | 2024 | β |
| Host genetics and gut microbiota synergistically regulate feed utilization in egg-type chickens. | Zhang W et al. | β | 2024 | β |
| Identification of Biomarkers Associated with Oxidative Stress in Aortic Dissection Based on Bulk Transcriptome Analyses. | Li Z et al. | β | 2024 | β |
| Identification of candidate genes for endometrial cancer in multi-omics: a Mendelian randomization analysis. | Qin LH et al. | β | 2024 | β |
| Identification of Causal Genes and Potential Drug Targets for Restless Legs Syndrome: A Comprehensive Mendelian Randomization Study. | Qian R et al. | β | 2024 | β |
| Identification of drug targets for SjΓΆgren's syndrome: multi-omics Mendelian randomization and colocalization analyses. | Bai Y et al. | β | 2024 | β |
| Identification of genetic association between mitochondrial dysfunction and knee osteoarthritis through integrating multi-omics: a summary data-based Mendelian randomization study. | Xie J et al. | β | 2024 | β |
| Identification of JAZF1, KNOP1, and PLEKHA1 as causally associated genes and drug targets for Alzheimer's disease: a summary data-based Mendelian randomization study. | Zhai Y et al. | β | 2024 | β |
| Identification of lipid-modifying drug targets for autoimmune diseases: insights from drug target mendelian randomization. | Hu X et al. | β | 2024 | β |
| Identification of novel drug targets for liver cirrhosis and its potential side-effects by human plasma proteome. | Xiao QA et al. | β | 2024 | β |
| Identification of novel therapeutic targets for chronic kidney disease and kidney function by integrating multi-omics proteome with transcriptome. | Si S et al. | β | 2024 | β |
| Identification of potential pathogenic genes for urolithiasis through multi-omics Mendelian randomization analysis. | Yan K et al. | β | 2024 | β |
| Identification of shared genetic etiology of cardiovascular and cerebrovascular diseases through common cardiometabolic risk factors. | Ding K et al. | β | 2024 | β |
| Identifying Common Genetic Etiologies Between Inflammatory Bowel Disease and Related Immune-Mediated Diseases. | Liu X et al. | β | 2024 | β |
| Identifying new biomarkers and potential therapeutic targets for breast cancer through the integration of human plasma proteomics: a Mendelian randomization study and colocalization analysis. | Song J et al. | β | 2024 | β |
| Identifying novel potential drug targets for endometriosis via plasma proteome screening. | Tao T et al. | β | 2024 | β |
| Identifying potential therapeutic targets in lung adenocarcinoma: a multi-omics approach integrating bulk and single-cell RNA sequencing with Mendelian randomization. | Chen Y et al. | β | 2024 | β |
| Identifying prioritization of therapeutic targets for ankylosing spondylitis: a multi-omics Mendelian randomization study. | Dai L et al. | β | 2024 | β |
| Identifying therapeutic targets for primary ovarian insufficiency through integrated genomic analyses. | Du H et al. | β | 2024 | β |
| Impact of diabetes mellitus on the risk of Alzheimer's disease: a mendelian randomization study. | Wang W et al. | β | 2024 | β |
| Integrated analyses of Mendelian randomization, eQTL, and single-cell transcriptome identify CCN3 as a potential biomarker in aortic dissection. | Ran H et al. | β | 2024 | β |
| Integrated Mendelian randomization and single-cell RNA-sequencing analyses identified OAS1 as a novel therapeutic target for erectile dysfunction via targeting fibroblasts. | Wang Y et al. | β | 2024 | β |
| Integrating transcriptomics, eQTL, and Mendelian randomization to dissect monocyte roles in severe COVID-19 and gout flare. | Li J et al. | β | 2024 | β |
| Integration of multi-omics transcriptome-wide analysis for the identification of novel therapeutic drug targets in diabetic retinopathy. | Yi G et al. | β | 2024 | β |
| Integration of single-cell sequencing with machine learning and Mendelian randomization analysis identifies the NAP1L1 gene as a predictive biomarker for Alzheimer's disease. | Chen R et al. | β | 2024 | β |
| Integrative genomic analysis of RNA-modification-single nucleotide polymorphisms associated with kidney function. | Liu X et al. | β | 2024 | β |
| Integrative multiomic analysis unveils the molecular nexus of mitochondrial dysfunction in the pathogenesis of age-related macular degeneration. | Chen J et al. | β | 2024 | β |
| Integrative multi-omics analysis reveals genetic and heterotic contributions to male fertility and yield in potato. | Li D et al. | β | 2024 | β |
| Integrative multi-omics summary-based mendelian randomization identifies key oxidative stress-related genes as therapeutic targets for atrial fibrillation and flutter. | Chen S et al. | β | 2024 | β |
| Intestinal flora and inflammatory bowel disease: Causal relationships and predictive models. | Bi GW et al. | β | 2024 | β |
| Investigating the association of the effect of genetically proxied PCSK9i with mood disorders using cis-pQTLs: A drug-target Mendelian randomization study. | Aman A et al. | β | 2024 | β |
| Lack of genetic evidence for NLRP3 inflammasome involvement in Parkinson's disease pathogenesis. | Senkevich K et al. | β | 2024 | β |
| Leveraging large-scale multi-omics evidences to identify therapeutic targets from genome-wide association studies. | Lessard S et al. | β | 2024 | β |
| Lipid-lowering drugs and risk of rapid renal function decline: a mendelian randomization study. | Zhao Z et al. | β | 2024 | β |
| Macular structural integrity estimates are associated with Parkinson's disease genetic risk. | Diaz-Torres S et al. | β | 2024 | β |
| Mendelian randomization analyses support causal relationships between gut microbiome and longevity. | Chen S et al. | β | 2024 | β |
| Mendelian randomization analysis identified potential genes pleiotropically associated with gout. | Wang Y et al. | β | 2024 | β |
| Mendelian randomization analysis of the brain, cerebrospinal fluid, and plasma proteome identifies potential drug targets for attention deficit hyperactivity disorder. | Zhang C et al. | β | 2024 | β |
| Mendelian randomization based on genome-wide association studies and expression quantitative trait loci, predicting gene targets for the complexity of osteoarthritis as well as the clinical prognosis of the condition. | Yan Y et al. | β | 2024 | β |
| Mendelian randomization reveals potential causal relationships between cellular senescence-related genes and multiple cancer risks. | Qiu X et al. | β | 2024 | β |
| Mitochondrial dysfunction and onset of type 2 diabetes along with its complications: a multi-omics Mendelian randomization and colocalization study. | Li Y et al. | β | 2024 | β |
| Multiome-wide Association Studies: Novel Approaches for Understanding Diseases. | Shao M et al. | β | 2024 | β |
| Multi-omic characterization of air pollution effects: Applications of AirSigOmniTWP Hub. | Liu W et al. | β | 2024 | β |
| Multiomic integration analysis identifies atherogenic metabolites mediating between novel immune genes and cardiovascular risk. | Carreras-Torres R et al. | β | 2024 | β |
| Multiomics identification of ALDH9A1 as a crucial immunoregulatory molecule involved in calcific aortic valve disease. | Chen LZ et al. | β | 2024 | β |
| Multi-omics Mendelian randomization integrating GWAS, eQTL and pQTL data revealed GSTM4 as a potential drug target for migraine. | Sun X et al. | β | 2024 | β |
| Multi-trait association analysis reveals shared genetic loci between Alzheimer's disease and cardiovascular traits. | Koskeridis F et al. | β | 2024 | β |
| Multivariate genomic analysis of 5βmillion people elucidates the genetic architecture of shared components of the metabolic syndrome. | Park S et al. | β | 2024 | β |
| New Insights on the Therapeutic Potential of Runt-Related Transcription FactorΒ 2 for Osteoarthritis: Evidence from Mendelian Randomization. | Xie J et al. | β | 2024 | β |
| Noncoding variation near UBE2E2 orchestrates cardiometabolic pathophenotypes through polygenic effectors. | Zhang Y et al. | β | 2024 | β |
| Olanzapine enhances early brain maturation through activation of the NODAL/FOXH1 axis. | Teng Z et al. | β | 2024 | β |
| Omnibus proteome-wide association study identifies 43 risk genes for Alzheimer disease dementia. | Hu T et al. | β | 2024 | β |
| Pathogen stimulations and immune cells synergistically affect the gene expression profile characteristics of porcine peripheral blood mononuclear cells. | Yang J et al. | β | 2024 | β |
| Plasma genome-wide mendelian randomization identifies potentially causal genes in idiopathic pulmonary fibrosis. | Zhang K et al. | β | 2024 | β |
| Potentially causal association between immunoglobulin G N-glycans and cardiometabolic diseases: Bidirectional two-sample Mendelian randomization study. | Meng X et al. | β | 2024 | β |
| Powerful Test of Heterogeneity in Two-Sample Summary-Data Mendelian Randomization. | Wang K et al. | β | 2024 | β |
| Prediction of causal genes at GWAS loci with pleiotropic gene regulatory effects using sets of correlated instrumental variables. | Khan M et al. | β | 2024 | β |
| Proteome-wide Mendelian randomization and functional studies uncover therapeutic targets for polycystic ovarian syndrome. | Ni F et al. | β | 2024 | β |
| Proteome-wide Mendelian randomization and single-cell sequencing analysis identify the association between plasma proteins and gastric cancer. | Jin Y et al. | β | 2024 | β |
| Proteome-wide Mendelian randomization provides novel insights into the pathogenesis and druggable targets of osteoporosis. | Yan J et al. | β | 2024 | β |
| Quantitative omnigenic model discovers interpretable genome-wide associations. | RuΕΎiΔkovΓ‘ N et al. | β | 2024 | β |
| Relationship between inflammation/immunity and epilepsy: A multi-omics mendelian randomization study integrating GWAS, eQTL, and mQTL data. | Mu J et al. | β | 2024 | β |
| Revealing genetic causality between blood-based biomarkers and major depression in east Asian ancestry. | Mo X et al. | β | 2024 | β |
| SCARF2 is a target for chronic obstructive pulmonary disease: Evidence from multi-omics research and cohort validation. | Wang S et al. | β | 2024 | β |
| Schizophrenia genomics: genetic complexity and functional insights. | Sullivan PF et al. | β | 2024 | β |
| Shared genetic architecture between COVID-19 and irritable bowel syndrome: a large-scale genome-wide cross-trait analysis. | Liu X et al. | β | 2024 | β |
| Shared genetic architecture of cortical thickness alterations in major depressive disorder and schizophrenia. | Wang H et al. | β | 2024 | β |
| Shared genetic basis connects smoking behaviors and bone health: insights from a genome-wide cross-trait analysis. | Qin C et al. | β | 2024 | β |
| Single-cell RNA sequencing of peripheral blood links cell-type-specific regulation of splicing to autoimmune and inflammatory diseases. | Tian C et al. | β | 2024 | β |
| Single-nucleus sequencing unveils heterogeneity in renal cell carcinomas microenvironment: Insights into pathogenic origins and treatment-responsive cellular subgroups. | Zhang C et al. | β | 2024 | β |
| Study of the role of leukocyte telomere length-related lncRNA NBR2 in Alzheimer's disease. | Li W et al. | β | 2024 | β |
| Summary data-based Mendelian randomization and single-cell RNA sequencing analyses identify immune associations with low-level LGALS9 in sepsis. | Yang Y et al. | β | 2024 | β |
| Systematic druggable genome-wide Mendelian randomization identifies therapeutic targets for hyperemesis gravidarum. | Wang F et al. | β | 2024 | β |
| Systematic prioritization of functional variants and effector genes underlying colorectal cancer risk. | Law PJ et al. | β | 2024 | β |
| Systematic proteome-wide Mendelian randomization to prioritize causal plasma proteins for skin cancers. | Yoshikawa M et al. | β | 2024 | β |
| The causal nexus between diverse smoking statuses, potential therapeutic targets, and NSCLC: insights from Mendelian randomization and mediation analysis. | Cao Z et al. | β | 2024 | β |
| The goldmine of GWAS summary statistics: a systematic review of methods and tools. | Kontou PI et al. | β | 2024 | β |
| The impact of immunity on the risk of coronary artery disease: insights from a multiomics study. | Bian R et al. | β | 2024 | β |
| The influence of CLEC5A on early macrophage-mediated inflammation in COPD progression. | Li Q et al. | β | 2024 | β |
| Therapeutic targets for lung cancer: genome-wide Mendelian randomization and colocalization analyses. | Luan Y et al. | β | 2024 | β |
| The relationship between innate/adaptive immunity and gastrointestinal cancer : a multi-omics Mendelian randomization study. | Lv CX et al. | β | 2024 | β |
| Transcriptome-wide Mendelian randomization during CD4<sup>+</sup> T cell activation reveals immune-related drug targets for cardiometabolic diseases. | Wu X et al. | β | 2024 | β |
| TWAS facilitates gene-scale trait genetic dissection through gene expression, structural variations, and alternative splicing in soybean. | Li D et al. | β | 2024 | β |
| TWAS-GKF: a novel method for causal gene identification in transcriptome-wide association studies with knockoff inference. | Wang A et al. | β | 2024 | β |
| Uncovering genetic loci and biological pathways associated with age-related cataracts through GWAS meta-analysis. | Diaz-Torres S et al. | β | 2024 | β |
| Uncovering immune cell-associated genes in breast cancer: based on summary data-based Mendelian randomized analysis and colocalization study. | Liu J et al. | β | 2024 | β |
| Understanding the genetic complexity of puberty timing across the allele frequency spectrum. | Kentistou KA et al. | β | 2024 | β |
| Unlike common pneumonia, COVID-19 is a risk factor for multiple cardiovascular diseases: A two-sample Mendelian randomization study. | Li C et al. | β | 2024 | β |
| Unraveling genetic threads: Identifying novel therapeutic targets for allergic rhinitis through Mendelian randomization. | Huang X et al. | β | 2024 | β |
| Unraveling the heart-brain axis: shared genetic mechanisms in cardiovascular diseases and Schizophrenia. | Shen J et al. | β | 2024 | β |
| Unveiling new protein biomarkers and therapeutic targets for acne through integrated analysis of human plasma proteomics and genomics. | Deng S et al. | β | 2024 | β |
| Unveiling Novel Protein Biomarkers for Psoriasis Through Integrated Analysis of Human Plasma Proteomics and Mendelian Randomization. | Mao R et al. | β | 2024 | β |
| Unveiling potential drug targets for lung squamous cell carcinoma through the integration of druggable genome and genome-wide association data. | Wu W et al. | β | 2024 | β |
| Unveiling the Mechanism of Retinoic Acid Therapy for Cutaneous Warts: Insights from Multi-Omics Integration. | Dong ZY et al. | β | 2024 | β |
| Validation of TYK2 and exploration of PRSS36 as drug targets for psoriasis using Mendelian randomization. | Guo X et al. | β | 2024 | β |
| Valid inference for machine learning-assisted genome-wide association studies. | Miao J et al. | β | 2024 | β |
| Whole genome sequencing based analysis of inflammation biomarkers in the Trans-Omics for Precision Medicine (TOPMed) consortium. | Jiang MZ et al. | β | 2024 | β |