Genetic analysis of AUTS2 as a susceptibility gene of heroin dependence.
- Authors
- Chen, Yun-Hsiang; Liao, Ding-Lieh; Lai, Chih-Hao; Chen, Chia-Hsiang
- Year
- 2013
- Journal
- Drug and alcohol dependence
- PMID
- 22995765
- DOI
- 10.1016/j.drugalcdep.2012.08.029
BACKGROUND: Both alcoholism and heroin dependence are common substance use disorders with a high genetic basis. A recent genetic study reported that the autism susceptibility candidate 2 gene (AUTS2) was involved in regulating the alcohol drinking behavior. In our previous total gene expression profiling study, we found that the AUTS2 transcript was significantly down-regulated in lymphoblastoid cell lines (LCL) in heroin dependent individuals compared with control subjects, which prompted us to investigate whether AUTS2 is associated with heroin dependence. METHODS: We compared the AUTS2 transcript level of LCL between 124 heroin dependent males and 116 control males using real-time quantitative PCR, and conducted a genetic association study of the rs6943555 of AUTS2 with heroin dependence using a sample of 546 heroin dependent males and 373 control males. RESULTS: We first verified that the average transcript level of AUTS2 in the heroin dependent group was significantly lower than that in the control group (p=0.017). In the genetic association analysis, we found that AA homozygotes of rs6943555 were significantly over-represented in the heroin dependent subjects compared with the control subjects (odds ratio=1.7, 95% confidence interval: 1.08-2.74, p=0.017). Analyzing the sample from the AUTS2 transcript experiment, we found that AA carriers (n=19) had significantly lower AUTS2 mRNA levels in their LCL compared to TT carriers (n=97, p=0.002) and AT carriers (n=91, p=0.005). CONCLUSIONS: Our data indicate that the AUTS2 gene might be associated with heroin dependence, and reduced AUTS2 gene expression might confer increased susceptibility to heroin dependence.
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In this knowledge base
| Title | Year | PMID |
|---|---|---|
| Genetics and alcoholism. | 2013 | 23712313 |
External
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|---|---|---|---|---|
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| Cerebral organoids containing an AUTS2 missense variant model microcephaly. | Fair SR et al. | — | 2023 | → |
| Differential expression of miR-1249-3p and miR-34b-5p between vulnerable and resilient phenotypes of cocaine addiction. | Domingo-Rodriguez L et al. | — | 2022 | → |
| Viral vector-mediated gene therapy for opioid use disorders. | Wang T et al. | — | 2021 | → |
| Effect of AUTS2 gene rs6943555 variant in male patients with schizophrenia in a Turkish population. | Ozsoy F et al. | — | 2020 | → |
| A 3' UTR SNP rs885863, a cis-eQTL for the circadian gene VIPR2 and lincRNA 689, is associated with opioid addiction. | Levran O et al. | — | 2019 | → |
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