Molecular pathways involved in neuronal cell adhesion and membrane scaffolding contribute to schizophrenia and bipolar disorder susceptibility.
paper
Cited
Public
Unavailable
- Authors
- O'Dushlaine, C; Kenny, E; Heron, E; Donohoe, G; Gill, M; Morris, D; International Schizophrenia Consortium; Corvin, A
- Year
- 2011
- Journal
- Molecular psychiatry
- PMID
- 20157312
- DOI
- 10.1038/mp.2010.7
Susceptibility to schizophrenia and bipolar disorder may involve a substantial, shared contribution from thousands of common genetic variants, each of small effect. Identifying whether risk variants map to specific molecular pathways is potentially biologically informative. We report a molecular pathway analysis using the single-nucleotide polymorphism (SNP) ratio test, which compares the ratio of nominally significant (P<0.05) to nonsignificant SNPs in a given pathway to identify the 'enrichment' for association signals. We applied this approach to the discovery (the International Schizophrenia Consortium (n=6909)) and validation (Genetic Association Information Network (n=2729)) of schizophrenia genome-wide association study (GWAS) data sets. We investigated each of the 212 experimentally validated pathways described in the Kyoto Encyclopaedia of Genes and Genomes in the discovery sample. Nominally significant pathways were tested in the validation sample, and five pathways were found to be significant (P=0.03-0.001); only the cell adhesion molecule (CAM) pathway withstood conservative correction for multiple testing. Interestingly, this pathway was also significantly associated with bipolar disorder (Wellcome Trust Case Control Consortium (n=4847)) (P=0.01). At a gene level, CAM genes associated in all three samples (NRXN1 and CNTNAP2), which were previously implicated in specific language disorder, autism and schizophrenia. The CAM pathway functions in neuronal cell adhesion, which is critical for synaptic formation and normal cell signaling. Similar pathways have also emerged from a pathway analysis of autism, suggesting that mechanisms involved in neuronal cell adhesion may contribute broadly to neurodevelopmental psychiatric phenotypes.
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|---|---|---|---|---|
| Mapping the Cerebral Organoid Landscape: A Systematic Review of Preclinical 3D Models in Neuroscience. | Wolfram A et al. | β | 2026 | β |
| Molecular regulatory mechanisms of schizophrenia-associated functional non-coding variants. | Dai SS et al. | β | 2026 | β |
| Powering the mind: deciphering the shared genetic architecture between mitochondrial DNA copy number and major psychiatric disorders. | Xue H et al. | β | 2026 | β |
| A Module-Level Polygenic Risk Score-Based NetWAS Framework for Identifying AD Genetic Modules Mediated by Amygdala: An ADNI Study. | Luo H et al. | β | 2025 | β |
| A plasma proteome-mediated Mendelian randomization study reveals the impact of rheumatoid arthritis on mental disorders in a European population. | Wang J et al. | β | 2025 | β |
| A review of post-GWAS studies in schizophrenia. | Maserrat S et al. | β | 2025 | β |
| Early-life adversities compromise behavioral development in male and female mice heterozygous for CNTNAP2. | Chelini G et al. | β | 2025 | β |
| miRNA-Based Diagnosis of Schizophrenia Using Machine Learning. | Heda V et al. | β | 2025 | β |
| Calcium Signaling and Molecular Adhesion Processes May Hold the Key to Genetic Risk for Autism: A Molecular Pathway Analysis on Two Independent Samples. | Drago A et al. | β | 2024 | β |
| Distinct patterns of cell adhesion, migration, and morphology in olfactory neuroepithelium cells of bipolar disorder patients. | Delgado-Sequera A et al. | β | 2024 | β |
| Exploring mood disorders and treatment options using human stem cells. | Hudock A et al. | β | 2024 | β |
| Methylome-wide and meQTL analysis helps to distinguish treatment response from non-response and pathogenesis markers in schizophrenia. | Polakkattil BK et al. | β | 2024 | β |
| The role of cell adhesion molecule IgSF9b at the inhibitory synapse and psychiatric disease. | Clarin JD et al. | β | 2024 | β |
| Maternal SARS-CoV-2 exposure alters infant DNA methylation. | Hill RA et al. | β | 2023 | β |
| The differences in serum C1q levels between first-episode patients with bipolar disorder and major depressive disorder. | Chen Q et al. | β | 2022 | β |
| DNA methylation meta-analysis reveals cellular alterations in psychosis and markers of treatment-resistant schizophrenia. | Hannon E et al. | β | 2021 | β |
| Identification of Hub Genes Related to Alzheimer's Disease and Major Depressive Disorder. | Cheng Y et al. | β | 2021 | β |
| Integrin adhesion in brain assembly: From molecular structure to neuropsychiatric disorders. | Jaudon F et al. | β | 2021 | β |
| NoRCE: non-coding RNA sets cis enrichment tool. | Olgun G et al. | β | 2021 | β |
| Suicide Related Phenotypes in a Bipolar Sample: Genetic Underpinnings. | Lybech LKM et al. | β | 2021 | β |
| Association of Candidate Single Nucleotide Polymorphisms Related to Candidate Genes in Patients With Schizophrenia. | Karimian SS et al. | β | 2020 | β |
| Circulating exosomal microRNAs in bipolar disorder. | Ceylan D et al. | β | 2020 | β |
| Lack of Sez6 Family Proteins Impairs Motor Functions, Short-Term Memory, and Cognitive Flexibility and Alters Dendritic Spine Properties. | Nash A et al. | β | 2020 | β |
| MiRNA-532-5p Regulates CUMS-Induced Depression-Like Behaviors and Modulates LPS-Induced Proinflammatory Cytokine Signaling by Targeting STAT3. | Yan X et al. | β | 2020 | β |
| Neurodevelopmental pathways in bipolar disorder. | Kloiber S et al. | β | 2020 | β |
| Reduced levels of circulating adhesion molecules in adolescents with early-onset psychosis. | Wedervang-Resell K et al. | β | 2020 | β |
| SLC1A3 C3590T but not BDNF G196A is a predisposition factor for stress as well as depression, in an adolescent eastern Indian population. | Ghosh M et al. | β | 2020 | β |
| Compositional epistasis detection using a few prototype disease models. | Cheng L et al. | β | 2019 | β |
| Disrupted AMPA Receptor Function upon Genetic- or Antibody-Mediated Loss of Autism-Associated CASPR2. | Fernandes D et al. | β | 2019 | β |
| Genome-wide association studies of severe P. falciparum malaria susceptibility: progress, pitfalls and prospects. | Damena D et al. | β | 2019 | β |
| Hapln2 in Neurological Diseases and Its Potential as Therapeutic Target. | Wang Q et al. | β | 2019 | β |
| <i>In Vitro</i> Modeling of the Bipolar Disorder and Schizophrenia Using Patient-Derived Induced Pluripotent Stem Cells with Copy Number Variations of <i>PCDH1</i>5 and <i>RELN</i>. | Ishii T et al. | β | 2019 | β |
| In the line-up: deleted genes associated with DiGeorge/22q11.2 deletion syndrome: are they all suspects? | Motahari Z et al. | β | 2019 | β |
| Pleiotropic Meta-Analysis of Cognition, Education, and Schizophrenia Differentiates Roles of Early Neurodevelopmental and Adult Synaptic Pathways. | Lam M et al. | β | 2019 | β |
| Rare variants in MYH15 modify amyotrophic lateral sclerosis risk. | Kim H et al. | β | 2019 | β |
| Translational bioinformatics in mental health: open access data sources and computational biomarker discovery. | Tenenbaum JD et al. | β | 2019 | β |
| A systems biology approach to predictive developmental neurotoxicity of a larvicide used in the prevention of Zika virus transmission. | Audouze K et al. | β | 2018 | β |
| Convergent roles of de novo mutations and common variants in schizophrenia in tissue-specific and spatiotemporal co-expression network. | Jia P et al. | β | 2018 | β |
| Genome-Wide Association Studies of malaria susceptibility and resistance: progress, pitfalls and prospects | Damena D et al. | β | 2018 | β |
| Integrin activity in neuronal connectivity. | Lilja J et al. | β | 2018 | β |
| Phototransduction and circadian entrainment are the key pathways in the signaling mechanism for the baculovirus induced tree-top disease in the lepidopteran larvae. | Bhattarai UR et al. | β | 2018 | β |
| sVCAM-1, sICAM-1, TNF-Ξ± and IL-6 levels in bipolar disorder type I: Acute, longitudinal and therapeutic implications. | PantoviΔ-StefanoviΔ M et al. | β | 2018 | β |
| Cell migration in schizophrenia: Patient-derived cells do not regulate motility in response to extracellular matrix. | Tee JY et al. | β | 2017 | β |
| CRISPR/Cas9-mediated heterozygous knockout of the autism gene CHD8 and characterization of its transcriptional networks in cerebral organoids derived from iPS cells. | Wang P et al. | β | 2017 | β |
| Disruption of Ninjurin1 Leads to Repetitive and Anxiety-Like Behaviors in Mice. | Le H et al. | β | 2017 | β |
| DNA methylation in schizophrenia in different patient-derived cell types. | Vitale AM et al. | β | 2017 | β |
| Effect of Clozapine on DNA Methylation in Peripheral Leukocytes from Patients with Treatment-Resistant Schizophrenia. | Kinoshita M et al. | β | 2017 | β |
| Evidence for genetic heterogeneity between clinical subtypes of bipolar disorder. | Charney AW et al. | β | 2017 | β |
| Exome array analysis suggests an increased variant burden in families with schizophrenia. | McCarthy NS et al. | β | 2017 | β |
| Genetic variation in the exome: Associations with alcohol and tobacco co-use. | Otto JM et al. | β | 2017 | β |
| Increased Excitatory Synaptic Transmission of Dentate Granule Neurons in Mice Lacking PSD-95-Interacting Adhesion Molecule Neph2/Kirrel3 during the Early Postnatal Period. | Roh JD et al. | β | 2017 | β |
| Pathway-wide association study identifies five shared pathways associated with schizophrenia in three ancestral distinct populations. | Liu C et al. | β | 2017 | β |
| Sharing of Genes and Pathways Across Complex Phenotypes: A Multilevel Genome-Wide Analysis. | Gui H et al. | β | 2017 | β |
| The role of cell adhesion molecules in brain wiring and neuropsychiatric disorders. | Sakurai T | β | 2017 | β |
| Two-dimensional enrichment analysis for mining high-level imaging genetic associations. | Yao X et al. | β | 2017 | β |
| Comprehensive analysis of schizophrenia-associated loci highlights ion channel pathways and biologically plausible candidate causal genes. | Pers TH et al. | β | 2016 | β |
| From Linkage Studies to Epigenetics: What We Know and What We Need to Know in the Neurobiology of Schizophrenia. | Cariaga-Martinez A et al. | β | 2016 | β |
| Genetics of long-term treatment outcome in bipolar disorder. | Fabbri C et al. | β | 2016 | β |
| Identification of Susceptible Loci and Enriched Pathways for Bipolar II Disorder Using Genome-Wide Association Studies. | Kao CF et al. | β | 2016 | β |
| Joint sparse canonical correlation analysis for detecting differential imaging genetics modules. | Fang J et al. | β | 2016 | β |
| Multivariate Genetic Correlates of the Auditory Paired Stimuli-Based P2 Event-Related Potential in the Psychosis Dimension From the BSNIP Study. | Mokhtari M et al. | β | 2016 | β |
| Neurodevelopmental origins of bipolar disorder: iPSC models. | O'Shea KS et al. | β | 2016 | β |
| Systematically characterizing dysfunctional long intergenic non-coding RNAs in multiple brain regions of major psychosis. | Hu J et al. | β | 2016 | β |
| A significant risk locus on 19q13 for bipolar disorder identified using a combined genome-wide linkage and copy number variation analysis. | Lekman M et al. | β | 2015 | β |
| Computational dissection of human episodic memory reveals mental process-specific genetic profiles. | Luksys G et al. | β | 2015 | β |
| Converging models of schizophrenia--Network alterations of prefrontal cortex underlying cognitive impairments. | Sakurai T et al. | β | 2015 | β |
| DNA methylation patterns of protein coding genes and long noncoding RNAs in female schizophrenic patients. | Liao Q et al. | β | 2015 | β |
| Evidence for Association of Cell Adhesion Molecules Pathway and NLGN1 Polymorphisms with Schizophrenia in Chinese Han Population. | Zhang Z et al. | β | 2015 | β |
| Failed drug discovery in psychiatry: time for human genome-guided solutions. | Papassotiropoulos A et al. | β | 2015 | β |
| Genetic Analysis of Association Between Calcium Signaling and Hippocampal Activation, Memory Performance in the Young and Old, and Risk for Sporadic Alzheimer Disease. | Heck A et al. | β | 2015 | β |
| Genetic disruption of voltage-gated calcium channels in psychiatric and neurological disorders. | Heyes S et al. | β | 2015 | β |
| Genetics of complex traits in psychiatry. | Gelernter J | β | 2015 | β |
| Genetic Sources of Subcomponents of Event-Related Potential in the Dimension of Psychosis Analyzed From the B-SNIP Study. | Narayanan B et al. | β | 2015 | β |
| Genetic underpinnings of white matter 'connectivity': heritability, risk, and heterogeneity in schizophrenia. | Voineskos AN | β | 2015 | β |
| Genome-wide pathway-based association study implicates complement system in the development of Kashin-Beck disease in Han Chinese. | Zhang F et al. | β | 2015 | β |
| Genomic and network patterns of schizophrenia genetic variation in human evolutionary accelerated regions. | Xu K et al. | β | 2015 | β |
| Integration of gene expression and GWAS results supports involvement of calcium signaling in Schizophrenia. | Hertzberg L et al. | β | 2015 | β |
| Multivariate genetic determinants of EEG oscillations in schizophrenia and psychotic bipolar disorder from the BSNIP study. | Narayanan B et al. | β | 2015 | β |
| Network-Based Analysis of Schizophrenia Genome-Wide Association Data to Detect the Joint Functional Association Signals. | Chang S et al. | β | 2015 | β |
| Pathway analysis of genome-wide association datasets of personality traits. | Kim HN et al. | β | 2015 | β |
| Pathway analysis of genome-wide association study and transcriptome data highlights new biological pathways in colorectal cancer. | Quan B et al. | β | 2015 | β |
| Psychiatric genome-wide association study analyses implicate neuronal, immune and histone pathways. | Network and Pathway Analysis Subgroup of Psychiatric Genomics Consortium | β | 2015 | β |
| Synapse assembly and neurodevelopmental disorders. | Washbourne P | β | 2015 | β |
| Synaptic abnormalities and cytoplasmic glutamate receptor aggregates in contactin associated protein-like 2/Caspr2 knockout neurons. | Varea O et al. | β | 2015 | β |
| The molecular genetic architecture of attention deficit hyperactivity disorder. | Hawi Z et al. | β | 2015 | β |
| The uniform-score gene set analysis for identifying common pathways associated with different diabetes traits. | Mei H et al. | β | 2015 | β |
| Two-dimensional Enrichment Analysis for Mining High-level Imaging Genetic Associations. | Yao X et al. | β | 2015 | β |
| A functional SNP catalog of overlapping miRNA-binding sites in genes implicated in prion disease and other neurodegenerative disorders. | Saba R et al. | β | 2014 | β |
| A hypothesis-driven pathway analysis reveals myelin-related pathways that contribute to the risk of schizophrenia and bipolar disorder. | Yu H et al. | β | 2014 | β |
| Converging genetic and functional brain imaging evidence links neuronal excitability to working memory, psychiatric disease, and brain activity. | Heck A et al. | β | 2014 | β |
| Excess of rare novel loss-of-function variants in synaptic genes in schizophrenia and autism spectrum disorders. | Kenny EM et al. | β | 2014 | β |
| Genetic variants in CDC42 and NXPH1 as susceptibility factors for constipation and diarrhoea predominant irritable bowel syndrome. | Wouters MM et al. | β | 2014 | β |
| Genome-wide association study of sleep duration in the Finnish population. | Ollila HM et al. | β | 2014 | β |
| Genomic view of bipolar disorder revealed by whole genome sequencing in a genetic isolate. | Georgi B et al. | β | 2014 | β |
| Identification of gene ontologies linked to prefrontal-hippocampal functional coupling in the human brain. | Dixson L et al. | β | 2014 | β |
| Identification of pathways for bipolar disorder: a meta-analysis. | Nurnberger JI et al. | β | 2014 | β |
| Integrated pathway-based approach identifies association between genomic regions at CTCF and CACNB2 and schizophrenia. | Juraeva D et al. | β | 2014 | β |
| Multivariate analysis reveals genetic associations of the resting default mode network in psychotic bipolar disorder and schizophrenia. | Meda SA et al. | β | 2014 | β |
| Pathway analyses implicate glial cells in schizophrenia. | Duncan LE et al. | β | 2014 | β |
| Pathway analysis of cervical cancer genome-wide association study highlights the MHC region and pathways involved in response to infection. | Chen D et al. | β | 2014 | β |
| Protein-interaction-network-based analysis for genome-wide association analysis of schizophrenia in Han Chinese population. | Yu H et al. | β | 2014 | β |
| Specific glial functions contribute to schizophrenia susceptibility. | Goudriaan A et al. | β | 2014 | β |
| Synaptic plasticity, neural circuits, and the emerging role of altered short-term information processing in schizophrenia. | Crabtree GW et al. | β | 2014 | β |
| The node of Ranvier in CNS pathology. | Arancibia-Carcamo IL et al. | β | 2014 | β |
| The one and the many: effects of the cell adhesion molecule pathway on neuropsychological function in psychosis. | Hargreaves A et al. | β | 2014 | β |
| Widespread differences in cortex DNA methylation of the "language gene" CNTNAP2 between humans and chimpanzees. | Schneider E et al. | β | 2014 | β |
| A comprehensive family-based replication study of schizophrenia genes. | Aberg KA et al. | β | 2013 | β |
| A missense mutation in the ITGA8 gene, a cell adhesion molecule gene, is associated with schizophrenia in Japanese female patients. | Supriyanto I et al. | β | 2013 | β |
| BDgene: a genetic database for bipolar disorder and its overlap with schizophrenia and major depressive disorder. | Chang SH et al. | β | 2013 | β |
| CNTNAP2 polymorphisms and structural brain connectivity: a diffusion-tensor imaging study. | Clemm von Hohenberg C et al. | β | 2013 | β |
| Coupling diffusion imaging with histological and gene expression analysis to examine the dynamics of cortical areas across the fetal period of human brain development. | Huang H et al. | β | 2013 | β |
| Decreased cerebrospinal fluid secretogranin II concentrations in severe forms of bipolar disorder. | Jakobsson J et al. | β | 2013 | β |
| Focal adhesion dynamics are altered in schizophrenia. | Fan Y et al. | β | 2013 | β |
| Genetic variation throughout the folate metabolic pathway influences negative symptom severity in schizophrenia. | Roffman JL et al. | β | 2013 | β |
| Genome-wide gene-set analysis for identification of pathways associated with alcohol dependence. | Biernacka JM et al. | β | 2013 | β |
| Human genome-guided identification of memory-modulating drugs. | Papassotiropoulos A et al. | β | 2013 | β |
| Integrated enrichment analysis of variants and pathways in genome-wide association studies indicates central role for IL-2 signaling genes in type 1 diabetes, and cytokine signaling genes in Crohn's disease. | Carbonetto P et al. | β | 2013 | β |
| Pathway analysis using information from allele-specific gene methylation in genome-wide association studies for bipolar disorder. | Chuang LC et al. | β | 2013 | β |
| Pathways to neurodegeneration: mechanistic insights from GWAS in Alzheimer's disease, Parkinson's disease, and related disorders. | Ramanan VK et al. | β | 2013 | β |
| Schizophrenia at a genetics crossroads: where to now? | Corvin A | β | 2013 | β |
| "Selfish spermatogonial selection": a novel mechanism for the association between advanced paternal age and neurodevelopmental disorders. | Goriely A et al. | β | 2013 | β |
| Significant association of close homologue of L1 gene polymorphism rs2272522 with schizophrenia in Qatar. | Shaltout TE et al. | β | 2013 | β |
| TCF4 (e2-2; ITF2): a schizophrenia-associated gene with pleiotropic effects on human disease. | Navarrete K et al. | β | 2013 | β |
| The emerging spectrum of allelic variation in schizophrenia: current evidence and strategies for the identification and functional characterization of common and rare variants. | Mowry BJ et al. | β | 2013 | β |
| The genetic basis of Gilles de la Tourette Syndrome. | Paschou P | β | 2013 | β |
| The genomic psychiatry cohort: partners in discovery. | Pato MT et al. | β | 2013 | β |
| What psychiatric genetics has taught us about the nature of psychiatric illness and what is left to learn. | Kendler KS | β | 2013 | β |
| White matter integrity as an intermediate phenotype: exploratory genome-wide association analysis in individuals at high risk of bipolar disorder. | Sprooten E et al. | β | 2013 | β |
| A bias-reducing pathway enrichment analysis of genome-wide association data confirmed association of the MHC region with schizophrenia. | Jia P et al. | β | 2012 | β |
| Avoiding mouse traps in schizophrenia genetics: lessons and promises from current and emerging mouse models. | Kvajo M et al. | β | 2012 | β |
| Candidate autism gene screen identifies critical role for cell-adhesion molecule CASPR2 in dendritic arborization and spine development. | Anderson GR et al. | β | 2012 | β |
| Cell adhesion molecules contribute to Alzheimer's disease: multiple pathway analyses of two genome-wide association studies. | Liu G et al. | β | 2012 | β |
| Common genetic variants and gene-expression changes associated with bipolar disorder are over-represented in brain signaling pathway genes. | Pedroso I et al. | β | 2012 | β |
| dbPTB: a database for preterm birth. | Uzun A et al. | β | 2012 | β |
| De novo mutations in human genetic disease. | Veltman JA et al. | β | 2012 | β |
| Dynamics of subcellular proteomes during brain development. | McClatchy DB et al. | β | 2012 | β |
| Functional gene group analysis identifies synaptic gene groups as risk factor for schizophrenia. | Lips ES et al. | β | 2012 | β |
| Genetic and cognitive windows into circuit mechanisms of psychiatric disease. | Arguello PA et al. | β | 2012 | β |
| Genetic variability in the NMDA-dependent AMPA trafficking cascade is associated with alcohol dependence. | Karpyak VM et al. | β | 2012 | β |
| Genome-wide association study in a Swedish population yields support for greater CNV and MHC involvement in schizophrenia compared with bipolar disorder. | Bergen SE et al. | β | 2012 | β |
| Genome-wide survey of large rare copy number variants in Alzheimer's disease among Caribbean hispanics. | Ghani M et al. | β | 2012 | β |
| Identifying the genetic variation of gene expression using gene sets: application of novel gene Set eQTL approach to PharmGKB and KEGG. | Abo R et al. | β | 2012 | β |
| Implications of genetic findings for understanding schizophrenia. | Owen MJ | β | 2012 | β |
| Knockdown of the psychosis susceptibility gene ZNF804A alters expression of genes involved in cell adhesion. | Hill MJ et al. | β | 2012 | β |
| Multi-locus genome-wide association analysis supports the role of glutamatergic synaptic transmission in the etiology of major depressive disorder. | Lee PH et al. | β | 2012 | β |
| Mutations of ANK3 identified by exome sequencing are associated with autism susceptibility. | Bi C et al. | β | 2012 | β |
| Pathway analysis of smoking quantity in multiple GWAS identifies cholinergic and sensory pathways. | Harari O et al. | β | 2012 | β |
| Prevalence of autoimmune diseases in in-patients with schizophrenia: nationwide population-based study. | Chen SJ et al. | β | 2012 | β |
| Psychopathology and the human connectome: toward a transdiagnostic model of risk for mental illness. | Buckholtz JW et al. | β | 2012 | β |
| RNA-Seq analysis implicates dysregulation of the immune system in schizophrenia. | Xu J et al. | β | 2012 | β |
| The relationship between Toxoplasma gondii infection and mood disorders in the third National Health and Nutrition Survey. | Pearce BD et al. | β | 2012 | β |
| A common genetic variant in the neurexin superfamily member CNTNAP2 is associated with increased risk for selective mutism and social anxiety-related traits. | Stein MB et al. | β | 2011 | β |
| Combinations of SNPs related to signal transduction in bipolar disorder. | Koefoed P et al. | β | 2011 | β |
| Convergent functional genomic studies of Ο-3 fatty acids in stress reactivity, bipolar disorder and alcoholism. | Le-Niculescu H et al. | β | 2011 | β |
| Database of genetic studies of bipolar disorder. | Piletz JE et al. | β | 2011 | β |
| Development of patient-specific neurons in schizophrenia using induced pluripotent stem cells. | Pedrosa E et al. | β | 2011 | β |
| Gene set analysis of genome-wide association studies: methodological issues and perspectives. | Wang L et al. | β | 2011 | β |
| Genetic regulation of Nrxn1 [corrected] expression: an integrative cross-species analysis of schizophrenia candidate genes. | Mozhui K et al. | β | 2011 | β |
| Genome arrays for the detection of copy number variations in idiopathic mental retardation, idiopathic generalized epilepsy and neuropsychiatric disorders: lessons for diagnostic workflow and research. | Hochstenbach R et al. | β | 2011 | β |
| Genome-wide association study of the child behavior checklist dysregulation profile. | Mick E et al. | β | 2011 | β |
| Progress in defining the biological causes of schizophrenia. | Pickard B | β | 2011 | β |
| RNA-Seq of human neurons derived from iPS cells reveals candidate long non-coding RNAs involved in neurogenesis and neuropsychiatric disorders. | Lin M et al. | β | 2011 | β |
| Schizophrenia: a pathogenetic autoimmune disease caused by viruses and pathogens and dependent on genes. | Carter CJ | β | 2011 | β |
| The shock of the new: progress in schizophrenia genomics. | Moore S et al. | β | 2011 | β |
| White matter neuron alterations in schizophrenia and related disorders. | Connor CM et al. | β | 2011 | β |
| Analysing biological pathways in genome-wide association studies. | Wang K et al. | β | 2010 | β |
| Common variants conferring risk of schizophrenia: a pathway analysis of GWAS data. | Jia P et al. | β | 2010 | β |
| Functional impact of global rare copy number variation in autism spectrum disorders. | Pinto D et al. | β | 2010 | β |
| Genetic advances in the study of speech and language disorders. | Newbury DF et al. | β | 2010 | β |
| Neuronal cell adhesion genes: Key players in risk for schizophrenia, bipolar disorder and other neurodevelopmental brain disorders? | Corvin AP | β | 2010 | β |
| RAPID detection of gene-gene interactions in genome-wide association studies. | Brinza D et al. | β | 2010 | β |