STIM1 heteromultimerizes TRPC channels to determine their function as store-operated channels.
paper
Cited
Public
Unavailable
- Authors
- Yuan, Joseph P; Zeng, Weizhong; Huang, Guo N; Worley, Paul F; Muallem, Shmuel
- Year
- 2007
- Journal
- Nature cell biology
- PMID
- 17486119
- DOI
- 10.1038/ncb1590
- PMCID
- PMC2699187
Stromal interacting molecule 1 (STIM1) is a Ca(2+) sensor that conveys the Ca(2+) load of the endoplasmic reticulum to store-operated channels (SOCs) at the plasma membrane. Here, we report that STIM1 binds TRPC1, TRPC4 and TRPC5 and determines their function as SOCs. Inhibition of STIM1 function inhibits activation of TRPC5 by receptor stimulation, but not by La(3+), suggesting that STIM1 is obligatory for activation of TRPC channels by agonists, but STIM1 is not essential for channel function. Through a distinct mechanism, STIM1 also regulates TRPC3 and TRPC6. STIM1 does not bind TRPC3 and TRPC6, and regulates their function indirectly by mediating the heteromultimerization of TRPC3 with TRPC1 and TRPC6 with TRPC4. TRPC7 is not regulated by STIM1. We propose a new definition of SOCs, as channels that are regulated by STIM1 and require the store depletion-mediated clustering of STIM1. By this definition, all TRPC channels, except TRPC7, function as SOCs.
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| How to make a good egg!: The need for remodeling of oocyte Ca(2+) signaling to mediate the egg-to-embryo transition. | Nader N et al. | β | 2013 | β |
| Intramolecular shielding maintains the ER CaΒ²βΊ sensor STIM1 in an inactive conformation. | Yu F et al. | β | 2013 | β |
| Mechanism of capsaicin receptor TRPV1-mediated toxicity in pain-sensing neurons focusing on the effects of Na(+)/Ca(2+) fluxes and the Ca(2+)-binding protein calretinin. | Pecze L et al. | β | 2013 | β |
| miR-195 competes with HuR to modulate stim1 mRNA stability and regulate cell migration. | Zhuang R et al. | β | 2013 | β |
| Multifaceted roles of STIM proteins. | Hooper R et al. | β | 2013 | β |
| Nonspecific sarcolemmal cation channels are critical for the pathogenesis of malignant hyperthermia. | Eltit JM et al. | β | 2013 | β |
| Phosphorylation of STIM1 at ERK1/2 target sites regulates interaction with the microtubule plus-end binding protein EB1. | Pozo-Guisado E et al. | β | 2013 | β |
| STIMulating stress fibers in endothelial cells. | Gudermann T et al. | β | 2013 | β |
| Store-independent Orai1/3 channels activated by intracrine leukotriene C4: role in neointimal hyperplasia. | GonzΓ‘lez-Cobos JC et al. | β | 2013 | β |
| Store-operated Ca(2+) entry in proliferating and retinoic acid-differentiated N- and S-type neuroblastoma cells. | Bell N et al. | β | 2013 | β |
| The polybasic lysine-rich domain of plasma membrane-resident STIM1 is essential for the modulation of store-operated divalent cation entry by extracellular calcium. | Jardin I et al. | β | 2013 | β |
| The regulation of STIM1 by phosphorylation. | Pozo-Guisado E et al. | β | 2013 | β |
| Transient receptor potential channels and mechanosensation. | Eijkelkamp N et al. | β | 2013 | β |
| TRPC1 protein forms only one type of native store-operated channels in HEK293 cells. | Skopin A et al. | β | 2013 | β |
| 2-APB-potentiated channels amplify CatSper-induced Ca(2+) signals in human sperm. | LefiΓ¨vre L et al. | β | 2012 | β |
| Calcium signaling in mouse oocyte maturation: the roles of STIM1, ORAI1 and SOCE. | GΓ³mez-FernΓ‘ndez C et al. | β | 2012 | β |
| Calcium signaling in vascular smooth muscle cells: from physiology to pathology. | Marchand A et al. | β | 2012 | β |
| Calumin, a CaΒ²βΊ-binding protein on the endoplasmic reticulum, alters the ion permeability of CaΒ²βΊ release-activated CaΒ²βΊ (CRAC) channels. | Konno M et al. | β | 2012 | β |
| Cardiomyocyte calcineurin signaling in subcellular domains: from the sarcolemma to the nucleus and beyond. | Heineke J et al. | β | 2012 | β |
| Different binding property of STIM1 and its novel splice variant STIM1L to Orai1, TRPC3, and TRPC6 channels. | Horinouchi T et al. | β | 2012 | β |
| Distinct contributions of Orai1 and TRPC1 to agonist-induced [Ca(2+)](i) signals determine specificity of Ca(2+)-dependent gene expression. | Ong HL et al. | β | 2012 | β |
| Dynamic regulation of sarcoplasmic reticulum Ca(2+) stores by stromal interaction molecule 1 and sarcolipin during muscle differentiation. | Seth M et al. | β | 2012 | β |
| Dystrophin/Ξ±1-syntrophin scaffold regulated PLC/PKC-dependent store-operated calcium entry in myotubes. | Sabourin J et al. | β | 2012 | β |
| Enhanced store-operated CaΒ²+ entry and TRPC channel expression in pulmonary arteries of monocrotaline-induced pulmonary hypertensive rats. | Liu XR et al. | β | 2012 | β |
| Mechanisms and roles of muscarinic activation in guinea-pig adrenal medullary cells. | Inoue M et al. | β | 2012 | β |
| Mitochondrial dynamics and their impact on T cell function. | Quintana A et al. | β | 2012 | β |
| Molecular mechanism of pancreatic and salivary gland fluid and HCO3 secretion. | Lee MG et al. | β | 2012 | β |
| On the role of endothelial TRPC3 channels in endothelial dysfunction and cardiovascular disease. | Smedlund K et al. | β | 2012 | β |
| Opposite regulatory effects of TRPC1 and TRPC5 on neurite outgrowth in PC12 cells. | Heo DK et al. | β | 2012 | β |
| Orai1 and Ca2+-independent phospholipase A2 are required for store-operated Icat-SOC current, Ca2+ entry, and proliferation of primary vascular smooth muscle cells. | Yang B et al. | β | 2012 | β |
| Pathogenic role of store-operated and receptor-operated ca(2+) channels in pulmonary arterial hypertension. | Fernandez RA et al. | β | 2012 | β |
| Polarization of calcium signaling and fluid secretion in salivary gland cells. | Ambudkar IS | β | 2012 | β |
| Potential effect of resistin on the ET-1-increased reactions of blood pressure in rats and Ca2+ signaling in vascular smooth muscle cells. | Chuang TY et al. | β | 2012 | β |
| STIM1 is required for attenuation of PMCA-mediated Ca2+ clearance during T-cell activation. | Ritchie MF et al. | β | 2012 | β |
| STIM/Orai signalling complexes in vascular smooth muscle. | Trebak M | β | 2012 | β |
| STIM proteins: dynamic calcium signal transducers. | Soboloff J et al. | β | 2012 | β |
| Store-independent pathways for cytosolic STIM1 clustering in the regulation of store-operated Ca(2+) influx. | Zeng B et al. | β | 2012 | β |
| Store-operated Ca(2+) entry. | Berna-Erro A et al. | β | 2012 | β |
| Store-operated Ca2+ entry is remodelled and controls in vitro angiogenesis in endothelial progenitor cells isolated from tumoral patients. | Lodola F et al. | β | 2012 | β |
| Store-operated channels regulate intracellular calcium in mammalian rods. | Molnar T et al. | β | 2012 | β |
| Structure of the neuromuscular junction: function and cooperative mechanisms in the synapse. | Takamori M | β | 2012 | β |
| The Ca(2+) sensor stromal interaction molecule 1 (STIM1) is necessary and sufficient for the store-operated Ca(2+) entry function of transient receptor potential canonical (TRPC) 1 and 4 channels in endothelial cells. | Sundivakkam PC et al. | β | 2012 | β |
| The closing and opening of TRPC channels by Homer1 and STIM1. | Yuan JP et al. | β | 2012 | β |
| The other side of cardiac Ca(2+) signaling: transcriptional control. | DomΓnguez-RodrΓguez A et al. | β | 2012 | β |
| The Role of TRP Proteins in Mast Cells. | Freichel M et al. | β | 2012 | β |
| The TR (i)P to CaΒ²βΊ signaling just got STIMy: an update on STIM1 activated TRPC channels. | Pani B et al. | β | 2012 | β |
| TRP channels in normal and dystrophic skeletal muscle. | Gailly P | β | 2012 | β |
| TRP, TRPL and cacophony channels mediate Ca2+ influx and exocytosis in photoreceptors axons in Drosophila. | Astorga G et al. | β | 2012 | β |
| Two-pore channel 2 (TPC2) modulates store-operated Ca(2+) entry. | LΓ³pez J et al. | β | 2012 | β |
| Unraveling STIM2 function. | LΓ³pez E et al. | β | 2012 | β |
| Urotensin-II signaling mechanism in rat coronary artery: role of STIM1 and Orai1-dependent store operated calcium influx in vasoconstriction. | DomΓnguez-RodrΓguez A et al. | β | 2012 | β |
| A TRPC5-regulated calcium signaling pathway controls dendrite patterning in the mammalian brain. | Puram SV et al. | β | 2011 | β |
| Calcium store sensor stromal-interaction molecule 1-dependent signaling plays an important role in cervical cancer growth, migration, and angiogenesis. | Chen YF et al. | β | 2011 | β |
| Contribution of TRPC1 and Orai1 to Ca(2+) entry activated by store depletion. | Cheng KT et al. | β | 2011 | β |
| Critical role for stromal interaction molecule 1 in cardiac hypertrophy. | Hulot JS et al. | β | 2011 | β |
| Dissection of calcium signaling events in exocrine secretion. | Ambudkar IS | β | 2011 | β |
| Enhanced Ca2+ entry due to Orai1 plasma membrane insertion increases IL-8 secretion by cystic fibrosis airways. | Balghi H et al. | β | 2011 | β |
| Gating mechanisms of canonical transient receptor potential channel proteins: role of phosphoinositols and diacylglycerol. | Albert AP | β | 2011 | β |
| Genetic and pharmacologic inhibition of the Ca2+ influx channel TRPC3 protects secretory epithelia from Ca2+-dependent toxicity. | Kim MS et al. | β | 2011 | β |
| Heteromeric TRPV4-C1 channels contribute to store-operated Ca(2+) entry in vascular endothelial cells. | Ma X et al. | β | 2011 | β |
| mGluR1/TRPC3-mediated Synaptic Transmission and Calcium Signaling in Mammalian Central Neurons. | Hartmann J et al. | β | 2011 | β |
| ORAI1-mediated calcium influx in lactation and in breast cancer. | McAndrew D et al. | β | 2011 | β |
| Orai1-mediated I (CRAC) is essential for neointima formation after vascular injury. | Zhang W et al. | β | 2011 | β |
| Overexpression of transient receptor potential canonical type 1 (TRPC1) alters both store operated calcium entry and depolarization-evoked calcium signals in C2C12 cells. | OlΓ‘h T et al. | β | 2011 | β |
| Polarized but differential localization and recruitment of STIM1, Orai1 and TRPC channels in secretory cells. | Hong JH et al. | β | 2011 | β |
| Properties and therapeutic potential of transient receptor potential channels with putative roles in adversity: focus on TRPC5, TRPM2 and TRPA1. | Jiang LH et al. | β | 2011 | β |
| Redox regulation of calcium ion channels: chemical and physiological aspects. | Bogeski I et al. | β | 2011 | β |
| Regulators of Ca(2+) signaling in mast cells: potential targets for treatment of mast cell-related diseases? | Ma HT et al. | β | 2011 | β |
| Remodelling of the endoplasmic reticulum during store-operated calcium entry. | Shen WW et al. | β | 2011 | β |
| Role of reactive oxygen species and redox in regulating the function of transient receptor potential channels. | Song MY et al. | β | 2011 | β |
| Sensing cellular stress through STIM proteins. | Soboloff J et al. | β | 2011 | β |
| STIM1 and STIM2 are located in the acidic Ca2+ stores and associates with Orai1 upon depletion of the acidic stores in human platelets. | Zbidi H et al. | β | 2011 | β |
| STIM1 as a key regulator for Ca2+ homeostasis in skeletal-muscle development and function. | Kiviluoto S et al. | β | 2011 | β |
| STIM proteins and the endoplasmic reticulum-plasma membrane junctions. | Carrasco S et al. | β | 2011 | β |
| Subunit stoichiometry of human Orai1 and Orai3 channels in closed and open states. | Demuro A et al. | β | 2011 | β |
| Temperature-dependent STIM1 activation induces CaΒ²+ influx and modulates gene expression. | Xiao B et al. | β | 2011 | β |
| Thapsigargin activates CaΒ²+ entry both by store-dependent, STIM1/Orai1-mediated, and store-independent, TRPC3/PLC/PKC-mediated pathways in human endothelial cells. | Antigny F et al. | β | 2011 | β |
| The dynamic complexity of the TRPC1 channelosome. | Ong HL et al. | β | 2011 | β |
| The role of store-operated calcium influx in skeletal muscle signaling. | Stiber JA et al. | β | 2011 | β |
| The role of trp ion channels in testicular function. | Kumar PG et al. | β | 2011 | β |
| The TRPC ion channels: association with Orai1 and STIM1 proteins and participation in capacitative and non-capacitative calcium entry. | Salido GM et al. | β | 2011 | β |
| Transcriptional mechanisms regulating Ca(2+) homeostasis. | Ritchie MF et al. | β | 2011 | β |
| Transient receptor proteins illuminated: current views on TRPs and disease. | Nelson PL et al. | β | 2011 | β |
| TRPC channels as effectors of cardiac hypertrophy. | Eder P et al. | β | 2011 | β |
| TRP expression pattern and the functional importance of TRPC3 in primary human T-cells. | Wenning AS et al. | β | 2011 | β |
| WNK1 promotes PIPβ synthesis to coordinate growth factor and GPCR-Gq signaling. | An SW et al. | β | 2011 | β |
| Activation and regulation of store-operated calcium entry. | Smyth JT et al. | β | 2010 | β |
| Activation of TRPC6 channels promotes endocannabinoid biosynthesis in neuronal CAD cells. | Bardell TK et al. | β | 2010 | β |
| An endoplasmic reticulum/plasma membrane junction: STIM1/Orai1/TRPCs. | Lee KP et al. | β | 2010 | β |
| Attenuation of store-operated Ca2+ entry and enhanced expression of TRPC channels in caudal artery smooth muscle from Type 2 diabetic Goto-Kakizaki rats. | Mita M et al. | β | 2010 | β |
| Constitutive recycling of the store-operated Ca2+ channel Orai1 and its internalization during meiosis. | Yu F et al. | β | 2010 | β |
| Effect of cell swelling on ER/PM junctional interactions and channel assembly involved in SOCE. | Liu X et al. | β | 2010 | β |
| Hypoxia-induced changes in pulmonary and systemic vascular resistance: where is the O2 sensor? | Waypa GB et al. | β | 2010 | β |
| Impaired Orai1-mediated resting Ca2+ entry reduces the cytosolic [Ca2+] and sarcoplasmic reticulum Ca2+ loading in quiescent junctophilin 1 knock-out myotubes. | Li H et al. | β | 2010 | β |
| Molecular basis of calcium signaling in lymphocytes: STIM and ORAI. | Hogan PG et al. | β | 2010 | β |
| Orai1 interacts with STIM1 and mediates capacitative Ca2+ entry in mouse pulmonary arterial smooth muscle cells. | Ng LC et al. | β | 2010 | β |
| Phosphorylation of STIM1 at ERK1/2 target sites modulates store-operated calcium entry. | Pozo-Guisado E et al. | β | 2010 | β |
| Polymodal TRPC signaling: Emerging role in phenotype switching and tissue remodeling. | Groschner K | β | 2010 | β |
| Regulation of store-operated Ca2+ entry during the cell cycle. | Arredouani A et al. | β | 2010 | β |
| Role of TRPC1 channel in skeletal muscle function. | Zanou N et al. | β | 2010 | β |
| STIM1-dependent and STIM1-independent function of transient receptor potential canonical (TRPC) channels tunes their store-operated mode. | Lee KP et al. | β | 2010 | β |
| STIM1 translocation to the plasma membrane enhances intestinal epithelial restitution by inducing TRPC1-mediated Ca2+ signaling after wounding. | Rao JN et al. | β | 2010 | β |
| The contribution of TRPC1 and STIM1 to capacitative Ca(2+) entry in pulmonary artery. | Ng LC et al. | β | 2010 | β |
| The phospholipid-binding protein SESTD1 is a novel regulator of the transient receptor potential channels TRPC4 and TRPC5. | Miehe S et al. | β | 2010 | β |
| The role of transient receptor potential cation channels in Ca2+ signaling. | Gees M et al. | β | 2010 | β |
| Transient receptor potential channels and vascular function. | Earley S et al. | β | 2010 | β |
| TRPC6 channels and their binding partners in podocytes: role in glomerular filtration and pathophysiology. | Dryer SE et al. | β | 2010 | β |
| TRPC channels in pheromone sensing. | Kiselyov K et al. | β | 2010 | β |
| TRPC channels in smooth muscle cells. | Gonzalez-Cobos JC et al. | β | 2010 | β |
| TRP-ing up heart and vessels: canonical transient receptor potential channels and cardiovascular disease. | Rowell J et al. | β | 2010 | β |
| TRUSS, TNF-R1, and TRPC ion channels synergistically reverse endoplasmic reticulum Ca2+ storage reduction in response to m1 muscarinic acetylcholine receptor signaling. | Mace KE et al. | β | 2010 | β |
| Activation of TRPC1 by STIM1 in ER-PM microdomains involves release of the channel from its scaffold caveolin-1. | Pani B et al. | β | 2009 | β |
| A role for Orai in TRPC-mediated Ca2+ entry suggests that a TRPC:Orai complex may mediate store and receptor operated Ca2+ entry. | Liao Y et al. | β | 2009 | β |
| A Stim1-dependent, noncapacitative Ca2+-entry pathway is activated by B-cell-receptor stimulation and depletion of Ca2+. | Morita T et al. | β | 2009 | β |
| Biochemical and functional properties of the store-operated Ca2+ channels. | Salido GM et al. | β | 2009 | β |
| B-lymphocyte calcium influx. | King LB et al. | β | 2009 | β |
| Ca2+ pathway involved in the refilling of store sites in rat adrenal medullary cells. | Matsuoka H et al. | β | 2009 | β |
| Calcium signaling in immune cells. | Vig M et al. | β | 2009 | β |
| Capacitative Ca2+ entry via Orai1 and stromal interacting molecule 1 (STIM1) regulates adenylyl cyclase type 8. | Martin AC et al. | β | 2009 | β |
| Capacitative calcium entry: from concept to molecules. | Putney JW | β | 2009 | β |
| Deletion of TRPC3 in mice reduces store-operated Ca2+ influx and the severity of acute pancreatitis. | Kim MS et al. | β | 2009 | β |
| Drosophila photoreceptors and signaling mechanisms. | Katz B et al. | β | 2009 | β |
| Effect of nifedipine on capacitive calcium entry in Jurkat T lymphocytes. | Colucci A et al. | β | 2009 | β |
| Homer regulates calcium signalling in growth cone turning. | Gasperini R et al. | β | 2009 | β |
| Interaction between TRPC1/TRPC4 assembly and STIM1 contributes to store-operated Ca2+ entry in mesangial cells. | Sours-Brothers S et al. | β | 2009 | β |
| Involvement of STIM1 in the proteinase-activated receptor 1-mediated Ca2+ influx in vascular endothelial cells. | Hirano K et al. | β | 2009 | β |
| Ion channel regulation of intracellular calcium and airway smooth muscle function. | Perez-Zoghbi JF et al. | β | 2009 | β |
| IP3 receptors: some lessons from DT40 cells. | Taylor CW et al. | β | 2009 | β |
| Knockdown of stromal interaction molecule 1 attenuates store-operated Ca2+ entry and Ca2+ responses to acute hypoxia in pulmonary arterial smooth muscle. | Lu W et al. | β | 2009 | β |
| Lipids in Ca2+ signalling--an introduction. | Hardie RC et al. | β | 2009 | β |
| Mechanisms of hypoxic pulmonary vasoconstriction and their roles in pulmonary hypertension: new findings for an old problem. | Ward JP et al. | β | 2009 | β |
| Molecular determinants of fast Ca2+-dependent inactivation and gating of the Orai channels. | Lee KP et al. | β | 2009 | β |
| Native Store-operated Ca2+ Influx Requires the Channel Function of Orai1 and TRPC1. | Kim MS et al. | β | 2009 | β |
| Obligatory role for phosphatidylinositol 4,5-bisphosphate in activation of native TRPC1 store-operated channels in vascular myocytes. | Saleh SN et al. | β | 2009 | β |
| Orai1 (CRACM1) is the platelet SOC channel and essential for pathological thrombus formation. | Braun A et al. | β | 2009 | β |
| Peptidyl-prolyl isomerase FKBP52 controls chemotropic guidance of neuronal growth cones via regulation of TRPC1 channel opening. | Shim S et al. | β | 2009 | β |
| Physiological function and molecular basis of STIM1-mediated calcium entry in immune cells. | Baba Y et al. | β | 2009 | β |
| Plasticity in Ca2+ selectivity of Orai1/Orai3 heteromeric channel. | Schindl R et al. | β | 2009 | β |
| Reduction in TRPC4 expression specifically attenuates G-protein coupled receptor-stimulated increases in intracellular calcium in human myometrial cells. | Ulloa A et al. | β | 2009 | β |
| Regulation by scaffolding proteins of canonical transient receptor potential channels in striated muscle. | Sabourin J et al. | β | 2009 | β |
| Regulation of Ca2+ signaling with particular focus on mast cells. | Ma HT et al. | β | 2009 | β |
| Regulation of TRPC1 and TRPC4 cation channels requires an alpha1-syntrophin-dependent complex in skeletal mouse myotubes. | Sabourin J et al. | β | 2009 | β |
| Relocalization of STIM1 in mouse oocytes at fertilization: early involvement of store-operated calcium entry. | GΓ³mez-FernΓ‘ndez C et al. | β | 2009 | β |
| Role of phosphoinositol 4,5-bisphosphate and diacylglycerol in regulating native TRPC channel proteins in vascular smooth muscle. | Large WA et al. | β | 2009 | β |
| SOAR and the polybasic STIM1 domains gate and regulate Orai channels. | Yuan JP et al. | β | 2009 | β |
| STIM1: a new therapeutic target in occlusive vascular disease? | Agrotis A et al. | β | 2009 | β |
| STIMulating store-operated Ca(2+) entry. | Cahalan MD | β | 2009 | β |
| Store-operated Ca2+ channels and microdomains of Ca2+ in liver cells. | Barritt GJ et al. | β | 2009 | β |
| Store-operated Ca2+ influx and subplasmalemmal mitochondria. | Korzeniowski MK et al. | β | 2009 | β |
| Store-operated cyclic AMP signalling mediated by STIM1. | Lefkimmiatis K et al. | β | 2009 | β |
| The functional network of ion channels in T lymphocytes. | Cahalan MD et al. | β | 2009 | β |
| The TRPC class of ion channels: a critical review of their roles in slow, sustained increases in intracellular Ca(2+) concentrations. | Birnbaumer L | β | 2009 | β |
| TRPC1 and STIM1 mediate capacitative Ca2+ entry in mouse pulmonary arterial smooth muscle cells. | Ng LC et al. | β | 2009 | β |
| TRPC5 is a Ca2+-activated channel functionally coupled to Ca2+-selective ion channels. | Gross SA et al. | β | 2009 | β |
| TRPC6 mutations associated with focal segmental glomerulosclerosis cause constitutive activation of NFAT-dependent transcription. | SchlΓΆndorff J et al. | β | 2009 | β |
| TRPC channels and store-operated Ca(2+) entry. | Salido GM et al. | β | 2009 | β |
| TRPC channels function independently of STIM1 and Orai1. | DeHaven WI et al. | β | 2009 | β |
| ATP depletion induces translocation of STIM1 to puncta and formation of STIM1-ORAI1 clusters: translocation and re-translocation of STIM1 does not require ATP. | Chvanov M et al. | β | 2008 | β |
| Ca(2+) -permeable channels in the hepatocyte plasma membrane and their roles in hepatocyte physiology. | Barritt GJ et al. | β | 2008 | β |
| Capacitative calcium entry and transient receptor potential canonical 6 expression control human hepatoma cell proliferation. | El Boustany C et al. | β | 2008 | β |
| Cytosolic Ca2+ prevents the subplasmalemmal clustering of STIM1: an intrinsic mechanism to avoid Ca2+ overload. | Malli R et al. | β | 2008 | β |
| Depletion of calcium stores regulates calcium influx and signal transmission in rod photoreceptors. | Szikra T et al. | β | 2008 | β |
| Differences in STIM1 and TRPC expression in proximal and distal pulmonary arterial smooth muscle are associated with differences in Ca2+ responses to hypoxia. | Lu W et al. | β | 2008 | β |
| Discrete influx events refill depleted Ca2+ stores in a chick retinal neuron. | Borges S et al. | β | 2008 | β |
| Dynamic movement of the calcium sensor STIM1 and the calcium channel Orai1 in activated T-cells: puncta and distal caps. | Barr VA et al. | β | 2008 | β |
| Formation of a new receptor-operated channel by heteromeric assembly of TRPP2 and TRPC1 subunits. | Bai CX et al. | β | 2008 | β |
| Functional interactions among Orai1, TRPCs, and STIM1 suggest a STIM-regulated heteromeric Orai/TRPC model for SOCE/Icrac channels. | Liao Y et al. | β | 2008 | β |
| Functional requirement for Orai1 in store-operated TRPC1-STIM1 channels. | Cheng KT et al. | β | 2008 | β |
| Hyperactive intracellular calcium dynamics in B lymphoblasts from patients with bipolar I disorder. | Perova T et al. | β | 2008 | β |
| Increasing the expression of calcium-permeable TRPC3 and TRPC7 channels enhances constitutive secretion. | Lavender V et al. | β | 2008 | β |
| Interactions, functions, and independence of plasma membrane STIM1 and TRPC1 in vascular smooth muscle cells. | Li J et al. | β | 2008 | β |
| Lipid rafts determine clustering of STIM1 in endoplasmic reticulum-plasma membrane junctions and regulation of store-operated Ca2+ entry (SOCE). | Pani B et al. | β | 2008 | β |
| Neuronal TRP channels: thermometers, pathfinders and life-savers. | Talavera K et al. | β | 2008 | β |
| New developments in mast cell biology. | Kalesnikoff J et al. | β | 2008 | β |
| New developments in the signaling mechanisms of the store-operated calcium entry pathway. | Potier M et al. | β | 2008 | β |
| Orai, STIM1 and iPLA2beta: a view from a different perspective. | Bolotina VM | β | 2008 | β |
| Pancreatitis and calcium signalling: report of an international workshop. | Sutton R et al. | β | 2008 | β |
| Regulation of superoxide production in neutrophils: role of calcium influx. | BrΓ©chard S et al. | β | 2008 | β |
| Regulation of the cellular localization and function of human transient receptor potential channel 1 by other members of the TRPC family. | Alfonso S et al. | β | 2008 | β |
| Reversible translocation of EYFP-tagged STIM1 is coupled to calcium influx in insulin secreting beta-cells. | Tamarina NA et al. | β | 2008 | β |
| [Roles of Snapin in alpha(1A)-adrenoceptor-induced calcium influx through TRPC6 channels]. | Suzuki F | β | 2008 | β |
| Sildenafil inhibits human pulmonary artery smooth muscle cell proliferation by decreasing capacitative Ca2+ entry. | Wang C et al. | β | 2008 | β |
| Skeletal muscle dressed in SOCs. | Shin DM et al. | β | 2008 | β |
| STIM1 converts TRPC1 from a receptor-operated to a store-operated channel: moving TRPC1 in and out of lipid rafts. | Alicia S et al. | β | 2008 | β |
| STIM1 gates TRPC channels, but not Orai1, by electrostatic interaction. | Zeng W et al. | β | 2008 | β |
| STIM1 signalling controls store-operated calcium entry required for development and contractile function in skeletal muscle. | Stiber J et al. | β | 2008 | β |
| The spectrin cytoskeleton influences the surface expression and activation of human transient receptor potential channel 4 channels. | Odell AF et al. | β | 2008 | β |
| TRPC1 regulates skeletal myoblast migration and differentiation. | Louis M et al. | β | 2008 | β |
| TRPC3-interacting triadic proteins in skeletal muscle. | Woo JS et al. | β | 2008 | β |
| TRPV4 channel participates in receptor-operated calcium entry and ciliary beat frequency regulation in mouse airway epithelial cells. | Lorenzo IM et al. | β | 2008 | β |
| VEGF-mediated elevated intracellular calcium and angiogenesis in human microvascular endothelial cells in vitro are inhibited by dominant negative TRPC6. | Hamdollah Zadeh MA et al. | β | 2008 | β |
| Association of VASP with TRPC4 in PKG-mediated inhibition of the store-operated calcium response in mesangial cells. | Wang X et al. | β | 2007 | β |
| Attenuation of store-operated Ca2+ current impairs salivary gland fluid secretion in TRPC1(-/-) mice. | Liu X et al. | β | 2007 | β |
| Mitogenic signaling pathways induced by G protein-coupled receptors. | Rozengurt E | β | 2007 | β |
| Multiple activation mechanisms of store-operated TRPC channels in smooth muscle cells. | Albert AP et al. | β | 2007 | β |
| VASP: a TRPC4-associated phosphoprotein that mediates PKG-induced inhibition of store-operated calcium influx. | O'Neil RG | β | 2007 | β |