History of medical ethics and perspectives on disparities in minority recruitment and involvement in health research.
The legitimate and successful recruitment of minorities as research participants in clinical trials should be addressed from an ethical and historical perspective. To gain an appreciation of the challenges, to develop strategies and to overcome the disparities of minority involvement in clinic trials, it is essential to be cognizant of previous violations and abuses of ethics and human rights. Also significant are major legislation, regulations and federal initiatives that resulted from those abuses. From history, we have learned we cannot generalize data and assume that, if we have the majority group in clinical trials, then we can accurately apply that data to minorities. There are cultural and environmental differences; thus, it is absolutely crucial that researchers approach recruitment of minority groups with cultural competence and cultural sensitivity. Federal regulations and legislation set the framework for protection of human participants in research.
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In this knowledge base
| Title | Year | PMID |
|---|---|---|
| Post-GWAS in Psychiatric Genetics: A Developmental Perspective on the "Other" Next Steps. | 2018 | 29227573 |
External
| Title | Authors | Journal | Year | Link |
|---|---|---|---|---|
| Motivations for and against Participation in Neonatal Research: Insights from Interviews of Diverse Parents Approached for Neonatal Research in the United States. | Weiss EM et al. | — | 2024 | → |
| Diverse Research Teams and Underrepresented Groups in Clinical Studies. | Bains A et al. | — | 2023 | → |
| The Impact of African Ancestry on Prostate Cancer Disparities in the Era of Precision Medicine. | Lewis DD et al. | — | 2020 | → |
| Post-GWAS in Psychiatric Genetics: A Developmental Perspective on the "Other" Next Steps. | Dick DM et al. | — | 2018 | → |
| African American men's and women's perceptions of clinical trials research: focusing on prostate cancer among a high-risk population in the South. | Owens OL et al. | — | 2013 | → |
| Surrogate consent for genetic testing, the reconsent process, and consent for long-term outcomes in acute respiratory distress syndrome trials. | Smart A et al. | — | 2013 | → |
| Creating a cadre of junior investigators to address the challenges of cancer-related health disparities: lessons learned from the community networks program. | Felder TM et al. | — | 2012 | → |
| Genetic and environmental influences on the ratio of 3'hydroxycotinine to cotinine in plasma and urine. | Swan GE et al. | — | 2009 | → |
| Policies to address disparities in clinical trials: the EDICT Project. | Spiker CA et al. | — | 2009 | → |
| An exploration of ethical issues in research in children's health and the environment. | Paulson JA | — | 2006 | → |
| The legacy of Tuskegee and trust in medical care: is Tuskegee responsible for race differences in mistrust of medical care? | Brandon DT et al. | — | 2005 | → |