D2 dopamine receptor and GABA(A) receptor beta3 subunit genes and alcoholism.
paper
Cited
Public
Unavailable
- Authors
- Noble, E P; Zhang, X; Ritchie, T; Lawford, B R; Grosser, S C; Young, R M; Sparkes, R S
- Year
- 1998
- Journal
- Psychiatry research
- PMID
- 9858031
- DOI
- 10.1016/s0165-1781(98)00084-5
As the dopaminergic and GABAergic systems have been implicated in alcohol-related behaviors, variants of the D2 dopamine receptor (DRD2) and GABA(A) receptor beta3 subunit (GABRB3) genes were determined in a population-based association study of Caucasian non-alcoholic and alcoholic subjects. In severe alcoholics, compared to non-alcoholics, a significant increase was found in the prevalence (P = 1.7 x 10(-5)) and frequency (P = 1.6 x 10(-5)) of the DRD2 minor (A1) allele. Moreover, a significant progressive increase was observed in A1 allelic prevalence (P = 3.1 x 10(-6)) and frequency (P = 2.7 x 10(-6)) in the order of non-alcoholics, less severe and severe alcoholics. In severe alcoholics, compared to non-alcoholics, a significant decrease was found in the prevalence (P = 4.5 x 10(-3)) and frequency (P = 2.7 x 10(-2)) of the GABRB3 major (G1) allele. Furthermore, a significant progressive decrease was noted in G1 allelic prevalence (P = 2.4 x 10(-3)) and frequency (P = 1.9 x 10(-2)) in non-alcoholics, less severe and severe alcoholics, respectively. In sum, in the same population of non-alcoholics and alcoholics studied, variants of both the DRD2 and GABRB3 genes independently contribute to the risk for alcoholism, with the DRD2 variants revealing a stronger effect than the GABRB3 variants. However, when the DRD2 and the GABRB3 variants are combined, the risk for alcoholism is more robust than when these variants are considered separately.
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| Title | Authors | Journal | Year | Link |
|---|---|---|---|---|
| GABAergic mechanisms in alcohol dependence. | Uusi-Oukari M et al. | β | 2024 | β |
| Sex differences in GABA<sub>A</sub> receptor subunit transcript expression are mediated by genotype in subjects with alcohol-related cirrhosis of the liver. | Ashton MK et al. | β | 2022 | β |
| High Mobility Group Box 1/Toll-like Receptor 4 Signaling Increases <i>GABRB3</i> Expression in Alcohol Exposure. | Sun G et al. | β | 2021 | β |
| The Streetlight Effect: Reappraising the Study of Addiction in Light of the Findings of Genome-wide Association Studies. | Hall FS et al. | β | 2020 | β |
| Introducing Precision Addiction Management of Reward Deficiency Syndrome, the Construct That Underpins All Addictive Behaviors. | Blum K et al. | β | 2018 | β |
| Neuroepigenetics and addiction. | Walker DM et al. | β | 2018 | β |
| Promising pharmacogenetic targets for treating alcohol use disorder: evidence from preclinical models. | Rinker JA et al. | β | 2017 | β |
| A Genetic Animal Model of Alcoholism for Screening Medications to Treat Addiction. | Bell RL et al. | β | 2016 | β |
| More than Meets the Eye: Eye Color and Alcoholism. | Eissenberg JC | β | 2016 | β |
| A Shared Molecular and Genetic Basis for Food and Drug Addiction: Overcoming Hypodopaminergic Trait/State by Incorporating Dopamine Agonistic Therapy in Psychiatry. | Gold MS et al. | β | 2015 | β |
| Association analysis of GABRB3 promoter variants with heroin dependence. | Chen CH et al. | β | 2014 | β |
| Genetic Addiction Risk Score (GARS): molecular neurogenetic evidence for predisposition to Reward Deficiency Syndrome (RDS). | Blum K et al. | β | 2014 | β |
| Genetics of alcoholism. | Iyer-Eimerbrink PA et al. | β | 2014 | β |
| Hypothesizing dopaminergic genetic antecedents in schizophrenia and substance seeking behavior. | Blum K et al. | β | 2014 | β |
| Using genetic information from candidate gene and genome-wide association studies in risk prediction for alcohol dependence. | Yan J et al. | β | 2014 | β |
| Dopamine Genetics and Function in Food and Substance Abuse. | Blum K et al. | β | 2013 | β |
| Implications of genome wide association studies for addiction: are our a priori assumptions all wrong? | Hall FS et al. | β | 2013 | β |
| Substance use disorders: a theory-driven approach to the integration of genetics and neuroimaging. | Karoly HC et al. | β | 2013 | β |
| Amygdala 14-3-3ΞΆ as a novel modulator of escalating alcohol intake in mice. | Lesscher HM et al. | β | 2012 | β |
| Behavioral Addiction versus Substance Addiction: Correspondence of Psychiatric and Psychological Views. | Alavi SS et al. | β | 2012 | β |
| Pathway based analysis of genotypes in relation to alcohol dependence. | Reimers MA et al. | β | 2012 | β |
| Genetic, personality, and environmental predictors of drug use in adolescents. | Conner BT et al. | β | 2010 | β |
| Neurogenetics of dopaminergic receptor supersensitivity in activation of brain reward circuitry and relapse: proposing "deprivation-amplification relapse therapy" (DART). | Blum K et al. | β | 2009 | β |
| The interaction of reward genes with environmental factors in contribution to alcoholism in mexican americans. | Du Y et al. | β | 2009 | β |
| Association study of dopamine D2, D4 receptor gene, GABAA receptor beta subunit gene, serotonin transporter gene polymorphism with children of alcoholics in Korea: a preliminary study. | Namkoong K et al. | β | 2008 | β |
| Meta-analysis of the association of the Taq1A polymorphism with the risk of alcohol dependency: a HuGE gene-disease association review. | Smith L et al. | β | 2008 | β |
| Systems genetics of alcoholism. | Sloan CD et al. | β | 2008 | β |
| The genetics of alcohol and other drug dependence. | Dick DM et al. | β | 2008 | β |
| The role of dopamine in alcohol self-administration in humans: individual differences. | Barrett SP et al. | β | 2008 | β |
| Manipulation of catechol-O-methyl-transferase (COMT) activity to influence the attenuation of substance seeking behavior, a subtype of Reward Deficiency Syndrome (RDS), is dependent upon gene polymorphisms: a hypothesis. | Blum K et al. | β | 2007 | β |
| GABA(A) receptor subtypes as targets for neuropsychiatric drug development. | Korpi ER et al. | β | 2006 | β |
| The genetics of alcohol dependence. | Dick DM et al. | β | 2006 | β |
| Internet addiction: a review of current assessment techniques and potential assessment questions. | Beard KW | β | 2005 | β |
| Alcoholic subtypes: are two sufficient? | Windle M et al. | β | 2004 | β |
| Alcohol-related expectancies are associated with the D2 dopamine receptor and GABAA receptor beta3 subunit genes. | Young RM et al. | β | 2004 | β |
| Association of GABRG3 with alcohol dependence. | Dick DM et al. | β | 2004 | β |
| Motor impairing effects of ethanol and diazepam in rats selectively bred for high and low ethanol consumption in a limited-access paradigm. | Shram MJ et al. | β | 2004 | β |
| Polymorphisms of the dopamine D2 receptor, serotonin transporter, and GABA(A) receptor beta(3) subunit genes and alcoholism in Mexican-Americans. | Konishi T et al. | β | 2004 | β |
| [The role of genetics in alcohol dependence]. | Messas GP et al. | β | 2004 | β |
| Association of GABA(A) receptors and alcohol dependence and the effects of genetic imprinting. | Song J et al. | β | 2003 | β |
| Candidate genes for alcohol dependence: a review of genetic evidence from human studies. | Dick DM et al. | β | 2003 | β |
| Challenges and complexities in estimating both the functional impact and the disease risk associated with the extensive genetic variation in human DNA repair genes. | Mohrenweiser HW et al. | β | 2003 | β |
| GABA-A receptor beta3 and alpha5 subunit gene cluster on chromosome 15q11-q13 and bipolar disorder: a genetic association study. | Papadimitriou GN et al. | β | 2001 | β |
| GABA(A) receptor beta 3 subunit gene and psychiatric morbidity in a post-traumatic stress disorder population. | Feusner J et al. | β | 2001 | β |
| Association analysis of the GABA(A) receptor subunit genes cluster on 5q33-34 and alcohol dependence in a Japanese population. | Loh EW et al. | β | 2000 | β |
| Comparison of the role of dopamine, serotonin, and noradrenaline genes in ADHD, ODD and conduct disorder: multivariate regression analysis of 20 genes. | Comings DE et al. | β | 2000 | β |
| Evaluation of the role of the D2 dopamine receptor in myoclonus dystonia. | Klein C et al. | β | 2000 | β |
| Family-based study of DRD2 alleles in alcohol and drug dependence. | Blomqvist O et al. | β | 2000 | β |
| Reward deficiency syndrome: a biogenetic model for the diagnosis and treatment of impulsive, addictive, and compulsive behaviors. | Blum K et al. | β | 2000 | β |
| Role of the GABA(A)beta2, GABA(A)alpha6, GABA(A)alpha1 and GABA(A)gamma2 receptor subunit genes cluster in drug responses and the development of alcohol dependence. | Loh EW et al. | β | 2000 | β |
| The DRD2 gene in psychiatric and neurological disorders and its phenotypes. | Noble EP | β | 2000 | β |
| Association of a missense change in the D2 dopamine receptor with myoclonus dystonia. | Klein C et al. | β | 1999 | β |