Alcohol preference in mice lacking the Avpr1a vasopressin receptor.
- Authors
- Sanbe, Atsushi; Takagi, Norio; Fujiwara, Yoko; Yamauchi, Junji; Endo, Toshiya; Mizutani, Reiko; Takeo, Satoshi; Tsujimoto, Gozoh; Tanoue, Akito
- Year
- 2008
- Journal
- American journal of physiology. Regulatory, integrative and comparative physiology
- PMID
- 18305023
- DOI
- 10.1152/ajpregu.00708.2007
[Arg(8)]-vasopressin (Avp), a nonapeptide hormone, is known to regulate blood pressure, water balance, and a variety of behaviors such as anxiety, aggression, and bonding. Although some evidence that Avp modifies ethanol consumption and some of the effects of ethanol on behavior have been reported, the role of Avp in alcohol consumption and preference is poorly understood. The Avp1a receptor (Avpr1a) is ubiquitously expressed in the central nervous system. To determine the role of Avp signaling on the behavioral effects of alcohol, we examined voluntary ethanol consumption in mice with targeted disruptions of the Avpr1a knockout (Avpr1a KO) gene. Avpr1a KO mice displayed both increased ethanol consumption and preference compared with wild-type (WT) mice. Enhanced ethanol consumption was dramatically and reversibly reduced by treatment with N-methyl-D-aspartic acid antagonists. Basal glutamate release was elevated around the striatum in Avpr1a KO mice. Elevation of extracellular glutamate was also produced in WT mice by local application of an Avpr1a antagonist though a dialysis probe, and this elevation was quickly reversed by stopping the perfusion. These results suggest that Avp can inhibit the release of glutamate from the presynaptic terminal via the Avp1a receptor and that elevation of glutamate levels owing to loss of the inhibitory effect via Avp-Avpr1a signaling may play an important role in the preference for ethanol.
No figures extracted from this document.
No chunks β full text not yet ingested.
No entities extracted from this document yet.
No uploaded files.
No citations found.
In this knowledge base
External
| Title | Authors | Journal | Year | Link |
|---|---|---|---|---|
| Impact of adolescent intermittent ethanol exposure in male and female rats on social drinking and neuropeptide gene expression. | Towner TT et al. | β | 2022 | β |
| Oxytocin and vasopressin: Signalling, behavioural modulation and potential therapeutic effects. | Rae M et al. | β | 2022 | β |
| Activation of hypothalamic oxytocin neurons reduces binge-like alcohol drinking through signaling at central oxytocin receptors. | King CE et al. | β | 2021 | β |
| Ethanol modulation of hippocampal neuroinflammation, myelination, and neurodevelopment in a postnatal mouse model of fetal alcohol spectrum disorders. | Niedzwiedz-Massey VM et al. | β | 2021 | β |
| DNA Microarray Analysis of Differential Gene Expression in the Dorsal Root Ganglia of Four Different Neuropathic Pain Mouse Models. | Yokoyama H et al. | β | 2020 | β |
| GPCR and Alcohol-Related Behaviors in Genetically Modified Mice. | Neasta J et al. | β | 2020 | β |
| Bidirectional relationship between alcohol intake and sensitivity to social defeat: association with Tacr1 and Avp expression. | Nelson BS et al. | β | 2018 | β |
| Effects of alcohol and psychostimulants on the vasopressin system: behavioral implications. | Godino A et al. | β | 2018 | β |
| Impact of obesity on the toxicity of a multi-ingredient dietary supplement, OxyELITE Proβ’ (New Formula), using the novel NZO/HILtJ obese mouse model: Physiological and mechanistic assessments. | Skinner CM et al. | β | 2018 | β |
| Vasopressin and alcohol: a multifaceted relationship. | Harper KM et al. | β | 2018 | β |
| Genes and Alcohol Consumption: Studies with Mutant Mice. | Mayfield J et al. | β | 2016 | β |
| Social housing conditions and oxytocin and vasopressin receptors contribute to ethanol conditioned social preference in female mice. | Wood RI et al. | β | 2015 | β |
| Vasopressin V1a and V1b receptor modulators: a patent review (2012 - 2014). | Εlusarz MJ | β | 2015 | β |
| Ethanol-induced conditioned partner preference in female mice. | Wood RI et al. | β | 2013 | β |
| Identification of subpopulations of prairie voles differentially susceptible to peer influence to decrease high alcohol intake. | Anacker AM et al. | β | 2013 | β |
| Vasopressin V1a and V1b receptors: from molecules to physiological systems. | Koshimizu TA et al. | β | 2012 | β |
| Alcohol preference drinking in a mouse line selectively bred for high drinking in the dark. | Crabbe JC et al. | β | 2011 | β |
| Involvement of arginine vasopressin and V1b receptor in alcohol drinking in Sardinian alcohol-preferring rats. | Zhou Y et al. | β | 2011 | β |
| The AVPR1A gene and substance use disorders: association, replication, and functional evidence. | Maher BS et al. | β | 2011 | β |
| Biological contribution to social influences on alcohol drinking: evidence from animal models. | Anacker AM et al. | β | 2010 | β |
| Consilient research approaches in studying gene x environment interactions in alcohol research. | Sher KJ et al. | β | 2010 | β |
| Enhanced effect of neuropeptide Y on food intake caused by blockade of the V(1A) vasopressin receptor. | Aoyagi T et al. | β | 2009 | β |