An association study of DRD5 with smoking initiation and progression to nicotine dependence.
- Authors
- Sullivan, P F; Neale, M C; Silverman, M A; Harris-Kerr, C; Myakishev, M V; Wormley, B; Webb, B T; Ma, Y; Kendler, K S; Straub, R E
- Year
- 2001
- Journal
- American journal of medical genetics
- PMID
- 11353446
- DOI
- 10.1002/ajmg.1301
A large body of genetic epidemiological data strongly implicate genetic factors in the etiology of smoking behavior. Polymorphisms of genes in the dopaminergic system are plausible functional candidate genes and a linkage and an association study suggested that the type 5 dopamine receptor gene (DRD5) may be etiologically involved. We investigated the association of four DRD5 polymorphisms with smoking initiation and progression to nicotine dependence in a population-based sample of over 900 subjects. For smoking initiation, there was no significant association with the four DRD5 markers we studied; however, maximum likelihood analyses suggested the presence of a haplotype protective against smoking initiation. For progression to nicotine dependence, there were no strongly significant associations with the four DRD5 markers or for the estimated haplotypes. These data are not consistent with a strong etiological role for DRD5 in the etiology of these complex smoking behaviors.
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In this knowledge base
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External
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| The association of genetic polymorphisms within the dopaminergic system with nicotine dependence: A narrative review. | Yang J et al. | — | 2024 | → |
| Smoking Genes: A Case-Control Study of Dopamine Transporter Gene (<i>SLC6A3</i>) and Dopamine Receptor Genes (<i>DRD1</i>, <i>DRD2</i> and <i>DRD3</i>) Polymorphisms and Smoking Behaviour in a Malay Male Cohort. | Ruzilawati AB et al. | — | 2020 | → |
| The genetic epidemiology of substance use disorder: A review. | Prom-Wormley EC et al. | — | 2017 | → |
| mRNA expression of dopamine receptors in peripheral blood lymphocytes of computer game addicts. | Vousooghi N et al. | — | 2015 | → |
| Association study of 45 candidate genes in nicotine dependence in Han Chinese. | Wei J et al. | — | 2012 | → |
| Psychogenetics of post-traumatic stress disorder: a short review. | Rady A et al. | — | 2010 | → |
| Genetics of dopamine receptors and drug addiction: a comprehensive review. | Le Foll B et al. | — | 2009 | → |
| Genetic variation as a predictor of smoking cessation success. A promising preventive and intervention tool for chronic respiratory diseases? | Quaak M et al. | — | 2009 | → |
| Implications of gene-drug interactions in smoking cessation for improving the prevention of chronic degenerative diseases. | Quaak M et al. | — | 2009 | → |
| SNP discovery and haplotype analysis in the segmentally duplicated DRD5 coding region. | Housley DJ et al. | — | 2009 | → |
| A coalescent simulation of marker selection strategy for candidate gene association studies. | Cole SM et al. | — | 2008 | → |
| A community-based study of cigarette smoking behavior in relation to variation in three genes involved in dopamine metabolism: Catechol-O-methyltransferase (COMT), dopamine beta-hydroxylase (DBH) and monoamine oxidase-A (MAO-A). | Shiels MS et al. | — | 2008 | → |
| ADHD and smoking: from genes to brain to behavior. | McClernon FJ et al. | — | 2008 | → |
| Catechol-O-methyltransferase contributes to genetic susceptibility shared among anxiety spectrum phenotypes. | Hettema JM et al. | — | 2008 | → |
| Evidence for a two-stage model of dependence using the NESARC and its implications for genetic association studies. | Heiman GA et al. | — | 2008 | → |
| Genes and cigarette smoking. | Munafò MR et al. | — | 2008 | → |
| Overview of the pharmacogenomics of cigarette smoking. | Ho MK et al. | — | 2007 | → |
| The genetic background to PTSD. | Broekman BF et al. | — | 2007 | → |
| Association between glutamic acid decarboxylase genes and anxiety disorders, major depression, and neuroticism. | Hettema JM et al. | — | 2006 | → |
| Association of the phosphatase and tensin homolog gene (PTEN) with smoking initiation and nicotine dependence. | Zhang L et al. | — | 2006 | → |
| Gene-based analysis suggests association of the nicotinic acetylcholine receptor beta1 subunit (CHRNB1) and M1 muscarinic acetylcholine receptor (CHRM1) with vulnerability for nicotine dependence. | Lou XY et al. | — | 2006 | → |
| [Heritability and candidate genes in tobacco use]. | Hamdani N et al. | — | 2006 | → |
| The effect of dopamine D2, D5 receptor and transporter (SLC6A3) polymorphisms on the cue-elicited heroin craving in Chinese. | Li Y et al. | — | 2006 | → |
| Genetic influences on smoking: a brief review. | Al Koudsi N et al. | — | 2005 | → |
| Nicotine addiction through a neurogenomic prism: ethics, public health, and smoking. | Caron L et al. | — | 2005 | → |
| The use of race variables in genetic studies of complex traits and the goal of reducing health disparities: a transdisciplinary perspective. | Shields AE et al. | — | 2005 | → |
| Population stratification in the candidate gene study: fatal threat or red herring? | Hutchison KE et al. | — | 2004 | → |
| Progress in searching for susceptibility loci and genes for smoking-related behaviour. | Li MD et al. | — | 2004 | → |
| [Tobacco use in childhood and adolescence]. | Sánchez Agudo L | — | 2004 | → |
| Effects of dopamine transporter and receptor polymorphisms on smoking cessation in a bupropion clinical trial. | Lerman C et al. | — | 2003 | → |
| Genetic influences on smoking behavior and nicotine dependence: a review. | Yoshimasu K et al. | — | 2003 | → |
| Prevention of tobacco use in adolescents: review of current findings and implications for healthcare providers. | Vickers KS et al. | — | 2002 | → |