The relationship between serotonin receptor 1B polymorphisms A-161T and alcohol dependence.
- Authors
- Lee, Sheng-Yu; Lin, Wei-Wen; Huang, San-Yuan; Kuo, Po-Hsiu; Wang, Chen-Lin; Wu, Pei-Lin; Chen, Shiou-Lan; Wu, Jo Yung-Wei; Ko, Huei-Chen; Lu, Ru-Band
- Year
- 2009
- Journal
- Alcoholism, clinical and experimental research
- PMID
- 19519719
- DOI
- 10.1111/j.1530-0277.2009.00990.x
BACKGROUND: Several studies have suggested that the serotonin receptor 1B gene (5HT1B) may be important in the pathogenesis of alcohol dependence (alcoholism; ALC; AD). We examined whether 5HT1B gene A-161T polymorphisms (rs130058) are a susceptibility factor for total AD and subgroups of AD. We further explored correlation of this 5HT1B gene variant between anxiety-depression alcoholism (ANX/DEP ALC) and antisocial alcoholism (antisocial ALC) subgroups because of the high comorbidity of anxiety-depression, antisocial personality disorder, and AD. METHODS: We recruited 522 Han Chinese in Taiwan for this study: 322 AD patients and 200 controls. The patient group was recruited primarily from medical teaching hospitals; patients with antisocial alcoholism were recruited from Taiwanese prisons. Individuals with AD were classified into 3 homogeneous clinical subgroups -- pure alcoholism (pure ALC), ANX/DEP ALC, and antisocial ALC -- using DSM-IV diagnosis. The 5HT1B gene A-161T polymorphism was determined using PCR-RFLP. RESULTS: No significant differences in genotypic and allelic frequencies were found between controls and the total AD group or between controls and the 3 AD subgroups. However, there were significant differences in the 5HT1B gene A-161T polymorphism at both the genotype and allelic levels between the ANX/DEP ALC and antisocial ALC subgroups. CONCLUSIONS: This study suggests that the 5HT1B gene A-161T polymorphism alone is not a risk factor for increasing susceptibility to either AD or its subtypes. However, 5HT1B gene A-161T polymorphisms might be one of the common genetic factors between the ANX/DEP ALC and antisocial ALC subgroups.
No figures extracted from this document.
No chunks — full text not yet ingested.
No entities extracted from this document yet.
No uploaded files.
No citations found.
In this knowledge base
| Title | Year | PMID |
|---|---|---|
| Genome-wide association study of comorbid depressive syndrome and alcohol dependence. | 2012 | 22064162 |
External
| Title | Authors | Journal | Year | Link |
|---|---|---|---|---|
| The Association between a MAOB Variable Number Tandem Repeat Polymorphism and Cocaine and Opiate Addictions in Polyconsumers. | Mateu C et al. | — | 2021 | → |
| Genetic Correlates of Spirituality/Religion and Depression: A Study in Offspring and Grandchildren at High and Low Familial Risk for Depression. | Anderson MR et al. | — | 2017 | → |
| Promising pharmacogenetic targets for treating alcohol use disorder: evidence from preclinical models. | Rinker JA et al. | — | 2017 | → |
| Regulation of nucleus accumbens transcript levels in mice by early-life social stress and cocaine. | Lo Iacono L et al. | — | 2016 | → |
| Common single nucleotide variants underlying drug addiction: more than a decade of research. | Bühler KM et al. | — | 2015 | → |
| The role of serotonin in drug use and addiction. | Müller CP et al. | — | 2015 | → |
| Dopamine D3 and 5-HT1B receptor dysregulation as a result of psychostimulant intake and forced abstinence: Implications for medications development. | Neisewander JL et al. | — | 2014 | → |
| Pharmacological evidence for an abstinence-induced switch in 5-HT1B receptor modulation of cocaine self-administration and cocaine-seeking behavior. | Pentkowski NS et al. | — | 2014 | → |
| Associations of the 5-hydroxytryptamine (serotonin) receptor 1B gene (HTR1B) with alcohol, cocaine, and heroin abuse. | Cao J et al. | — | 2013 | → |
| Association study of DRD2 and MAOA genes with subtyped alcoholism comorbid with bipolar disorder in Han Chinese. | Hu MC et al. | — | 2013 | → |
| Polymorphisms of genes in neurotransmitter systems were associated with alcohol use disorders in a Tibetan population. | Xu Y et al. | — | 2013 | → |
| A haplotype analysis is consistent with the role of functional HTR1B variants in alcohol dependence. | Contini V et al. | — | 2012 | → |
| Genome-wide association study of comorbid depressive syndrome and alcohol dependence. | Edwards AC et al. | — | 2012 | → |
| Interaction between ALDH2*1*1 and DRD2/ANKK1 TaqI A1A1 genes may be associated with antisocial personality disorder not co-morbid with alcoholism. | Lu RB et al. | — | 2012 | → |
| Interaction between serotonin transporter and serotonin receptor 1 B genes polymorphisms may be associated with antisocial alcoholism. | Wang TY et al. | — | 2012 | → |
| Protracted withdrawal from cocaine self-administration flips the switch on 5-HT(1B) receptor modulation of cocaine abuse-related behaviors. | Pentkowski NS et al. | — | 2012 | → |
| Role of the serotonergic system in alcohol dependence: from animal models to clinics. | Sari Y et al. | — | 2011 | → |