Neurobiology and clinical aspects of neuropeptide Y.
paper
Cited
Public
Unavailable
- Authors
- Heilig, M; WiderlΓΆv, E
- Year
- 1995
- Journal
- Critical reviews in neurobiology
- PMID
- 8581979
Although a large and still increasing number of neuroactive peptides have been discovered in the mammalian brain over the years, it has been difficult to link most of these molecules with specific brain functions and/or brain diseases. A lack of pharmacological tools has hampered the study of brain peptide systems and the elucidation of which among these systems have retained important physiological functions through phylogenesis. Neuropeptide Y (NPY) is one the most abundant neuropeptides in the mammalian brain. A combination of basic and clinical studies has made it possible to circumvent some of these difficulties and provides evidence for a role of NPY in the control of endocrine hypothalamic and pituitary functions, in hypothalamic control of food intake and circadian rhythm, and in limbic emotional integration. Of particular interest is NPY's unique action as an endogenous anxiolytic and its possible role in clinical states of anxiety and depression. Here, we review the biology, anatomy, and physiology of central NPY systems and studies of these systems in various disease states.
No figures extracted from this document.
No chunks β full text not yet ingested.
No entities extracted from this document yet.
No uploaded files.
Not in any collection.
No citations found.
In this knowledge base
External
| Title | Authors | Journal | Year | Link |
|---|---|---|---|---|
| Effect of 60 Hz magnetic fields on social feeding behavior of <i>npr-1</i> receptor mutants in <i>Caenorhabditis elegans</i>. | Kakikawa M et al. | β | 2025 | β |
| Epistasis in neurotransmitter receptors linked to posttraumatic stress disorder and major depressive disorder comorbidity in traumatized Chinese. | Xu L et al. | β | 2024 | β |
| Exploring the Anxiolytic Potential of NPY by a Dipeptidyl Peptidase-IV Inhibitor in an Animal Model of PTSD. | Dahan M et al. | β | 2024 | β |
| Neuropeptide Y in PTSD, MDD, and chronic stress: A systematic review and meta-analysis. | Tural U et al. | β | 2020 | β |
| The Effect of Acute Erythromycin Exposure on the Swimming Ability of Zebrafish (<i>Danio rerio</i>) and Medaka (<i>Oryzias latipes</i>). | Li Y et al. | β | 2020 | β |
| A Critical Review of Methods and Results in the Search for Genetic Contributors to Alcohol Sensitivity. | Schuckit MA | β | 2018 | β |
| Neuropeptide Y Y2 antagonist treated ovariectomized mice exhibit greater bone mineral density. | Seldeen KL et al. | β | 2018 | β |
| Adapting to Stress: Understanding the Neurobiology of Resilience. | OsΓ³rio C et al. | β | 2017 | β |
| Neuropeptide Y Impairs Retrieval of Extinguished Fear and Modulates Excitability of Neurons in the Infralimbic Prefrontal Cortex. | Vollmer LL et al. | β | 2016 | β |
| Effect of Acetaldehyde Intoxication and Withdrawal on NPY Expression: Focus on Endocannabinoidergic System Involvement. | Plescia F et al. | β | 2014 | β |
| Modulation of orexigenic and anorexigenic peptides gene expression in the rat DVC and hypothalamus by acute immobilization stress. | Chigr F et al. | β | 2014 | β |
| NPY Y1 receptors differentially modulate GABAA and NMDA receptors via divergent signal-transduction pathways to reduce excitability of amygdala neurons. | Molosh AI et al. | β | 2013 | β |
| Stress susceptibility-specific phenotype associated with different hippocampal transcriptomic responses to chronic tricyclic antidepressant treatment in mice. | Lisowski P et al. | β | 2013 | β |
| Gene expression patterns in the hippocampus and amygdala of endogenous depression and chronic stress models. | Andrus BM et al. | β | 2012 | β |
| Histone deacetylases (HDAC)-induced histone modifications in the amygdala: a role in rapid tolerance to the anxiolytic effects of ethanol. | Sakharkar AJ et al. | β | 2012 | β |
| Neuropeptide Y (NPY) in the extended amygdala is recruited during the transition to alcohol dependence. | Gilpin NW | β | 2012 | β |
| The neuropeptide Y (NPY)-ergic system is associated with behavioral resilience to stress exposure in an animal model of post-traumatic stress disorder. | Cohen H et al. | β | 2012 | β |
| Zofia Zukowska | McEwen B | β | 2012 | β |
| Countervailing modulation of Ih by neuropeptide Y and corticotrophin-releasing factor in basolateral amygdala as a possible mechanism for their effects on stress-related behaviors. | Giesbrecht CJ et al. | β | 2010 | β |
| Neuropeptide Y signaling in the central nucleus of amygdala regulates alcohol-drinking and anxiety-like behaviors of alcohol-preferring rats. | Zhang H et al. | β | 2010 | β |
| Brain chromatin remodeling: a novel mechanism of alcoholism. | Pandey SC et al. | β | 2008 | β |
| Neurobiology of addiction. An integrative review. | Goodman A | β | 2008 | β |
| Neuroendocrine pathways in benzodiazepine dependence: new targets for research and therapy. | Heberlein A et al. | β | 2008 | β |
| Neuropeptide Y receptor genes are associated with alcohol dependence, alcohol withdrawal phenotypes, and cocaine dependence. | Wetherill L et al. | β | 2008 | β |
| Behavioral profiling of NPY in aggression and neuropsychiatric diseases. | Karl T et al. | β | 2007 | β |
| Neuropeptide Y modulation of ethanol intake: effects of ethanol drinking history and genetic background. | Badia-Elder NE et al. | β | 2007 | β |
| Anxiolytic-like effect of the selective neuropeptide Y Y2 receptor antagonist BIIE0246 in the elevated plus-maze. | Bacchi F et al. | β | 2006 | β |
| Distribution of NPY Y5-like immunoreactivity in the rat brain. | Morin SM et al. | β | 2006 | β |
| Effects of maternal separation on neuropeptide Y and calcitonin gene-related peptide in "depressed" Flinders Sensitive Line rats: a study of gene-environment interactions. | WΓΆrtwein G et al. | β | 2006 | β |
| Neuropeptides in interneurons of the insect brain. | NΓ€ssel DR et al. | β | 2006 | β |
| Comparison of basal neuropeptide Y and corticotropin releasing factor levels between the high ethanol drinking C57BL/6J and low ethanol drinking DBA/2J inbred mouse strains. | Hayes DM et al. | β | 2005 | β |
| Effects of neuropeptide Y on appetitive and consummatory behaviors associated with alcohol drinking in wistar rats with a history of ethanol exposure. | Thorsell A et al. | β | 2005 | β |
| [From the biology of trauma to secondary preventive pharmalogical measures for post-traumatic stress disorders]. | Ducrocq F et al. | β | 2005 | β |
| Neuropeptide expression in rats exposed to chronic mild stresses. | Sergeyev V et al. | β | 2005 | β |
| Sensitized effects of neuropeptide Y on multiple ingestive behaviors in P rats following ethanol abstinence. | Gilpin NW et al. | β | 2005 | β |
| Suppression of ethanol self-administration by the neuropeptide Y (NPY) Y2 receptor antagonist BIIE0246: evidence for sensitization in rats with a history of dependence. | Rimondini R et al. | β | 2005 | β |
| The psychobiology of depression and resilience to stress: implications for prevention and treatment. | Southwick SM et al. | β | 2005 | β |
| Adaptive and maladaptive psychobiological responses to severe psychological stress: implications for the discovery of novel pharmacotherapy. | Bonne O et al. | β | 2004 | β |
| Aged neuropeptide Y transgenic rats are resistant to acute stress but maintain spatial and non-spatial learning. | Carvajal CC et al. | β | 2004 | β |
| A role for neuropeptide Y in neurobiological responses to ethanol and drugs of abuse. | Thiele TE et al. | β | 2004 | β |
| Assessment of ethanol consumption and water drinking by NPY Y(2) receptor knockout mice. | Thiele TE et al. | β | 2004 | β |
| Central NPY receptor-mediated alteration of heart rate dynamics in mice during expression of fear conditioned to an auditory cue. | Tovote P et al. | β | 2004 | β |
| Cerebrospinal neuropeptide Y and substance P in suicide attempters during long-term antidepressant treatment. | Olsson A et al. | β | 2004 | β |
| Characterization of neuropeptide Y Y2 and Y5 receptor expression in the mouse hypothalamus. | Fetissov SO et al. | β | 2004 | β |
| Effect of neuropeptide Y microinjected into the hypothalamus on ethanol consumption. | Lucas LA et al. | β | 2004 | β |
| Levetiracetam prevents changes in levels of brain-derived neurotrophic factor and neuropeptide Y mRNA and of Y1- and Y5-like receptors in the hippocampus of rats undergoing amygdala kindling: implications for antiepileptogenic and mood-stabilizing properties. | Husum H et al. | β | 2004 | β |
| Neuropeptide Y in the paraventricular nucleus of the hypothalamus increases ethanol intake in high- and low-alcohol-drinking rats. | Gilpin NW et al. | β | 2004 | β |
| Overlapping peptide control of alcohol self-administration and feeding. | Thiele TE et al. | β | 2004 | β |
| Peripheral and central administration of a selective neuropeptide Y Y1 receptor antagonist suppresses ethanol intake by C57BL/6J mice. | Sparta DR et al. | β | 2004 | β |
| Psychopharmacological possibilities in the acute disaster setting. | Simon A et al. | β | 2004 | β |
| Two Wistar rat lines selectively bred for anxiety-related behavior show opposite reactions in elevated plus maze and fear-sensitized acoustic startle tests. | Yilmazer-Hanke DM et al. | β | 2004 | β |
| Agonistic encounters in aged male mouse potentiate the expression of endogenous brain NGF and BDNF: possible implication for brain progenitor cells' activation. | Fiore M et al. | β | 2003 | β |
| Alcoholism: allostasis and beyond. | Koob GF | β | 2003 | β |
| Alcoholism and obesity: overlapping neuropeptide pathways? | Thiele TE et al. | β | 2003 | β |
| Alcohol withdrawal increases neuropeptide Y immunoreactivity in rat brain. | Bison S et al. | β | 2003 | β |
| A role for neuropeptide Y in alcohol intake control: evidence from human and animal research. | Thiele TE et al. | β | 2003 | β |
| Central neuropeptide Y alters ethanol-induced sedation, but not ethanol intake, in C57BL/6 mice. | Thiele TE et al. | β | 2003 | β |
| Effects of haloperidol and clozapine on neuropeptide Y-like immunoreactivity in the nucleus accumbens and striatum of rats pretreated with psychostimulants. | Obuchowicz E et al. | β | 2003 | β |
| Effects of neuropeptide Y on sucrose and ethanol intake and on anxiety-like behavior in high alcohol drinking (HAD) and low alcohol drinking (LAD) rats. | Badia-Elder NE et al. | β | 2003 | β |
| Effects of PKA modulation on the expression of neuropeptide Y in rat amygdaloid structures during ethanol withdrawal. | Zhang H et al. | β | 2003 | β |
| Neuropeptide y and alcoholism: genetic, molecular, and pharmacological evidence. | Pandey SC et al. | β | 2003 | β |
| Neuropeptide Y reduces oral ethanol intake in alcohol-preferring (P) rats following a period of imposed ethanol abstinence. | Gilpin NW et al. | β | 2003 | β |
| Recent developments in our understanding of the physiological role of PP-fold peptide receptor subtypes. | Berglund MM et al. | β | 2003 | β |
| Toward early pharmacological posttraumatic stress intervention. | Morgan CA et al. | β | 2003 | β |
| Blockade of central neuropeptide Y (NPY) Y2 receptors reduces ethanol self-administration in rats. | Thorsell A et al. | β | 2002 | β |
| Calcitonin gene-related peptide and calcitonin in the CSF of patients with dementia and depression: possible disease markers. | MathΓ© AA et al. | β | 2002 | β |
| Clinical potentials of neuropeptide Y family of hormones. | Balasubramaniam A | β | 2002 | β |
| Contribution of amygdala neurons containing peptides and calcium-binding proteins to fear-potentiated startle and exploration-related anxiety in inbred Roman high- and low-avoidance rats. | Yilmazer-Hanke DM et al. | β | 2002 | β |
| Evaluation of an anxiety-related phenotype in galanin overexpressing transgenic mice. | Holmes A et al. | β | 2002 | β |
| Expression of the neuropeptide Y Y1 receptor in the CNS of rat and of wild-type and Y1 receptor knock-out mice. Focus on immunohistochemical localization. | Kopp J et al. | β | 2002 | β |
| The decreased cellular expression of neuropeptide Y protein in rat brain structures during ethanol withdrawal after chronic ethanol exposure. | Roy A et al. | β | 2002 | β |
| The neurocircuitry and receptor subtypes mediating anxiolytic-like effects of neuropeptide Y. | Kask A et al. | β | 2002 | β |
| Anatomical distribution of NPY-like immunoreactivity in the domestic chick brain (Gallus domesticus). | Esposito V et al. | β | 2001 | β |
| Effect of neuropeptide Y (NPY) on oral ethanol intake in Wistar, alcohol-preferring (P), and -nonpreferring (NP) rats. | Badia-Elder NE et al. | β | 2001 | β |
| Effect of substituted benzamides on feeding and hypothalamic neuropeptide Y-like immunoreactivity (NPY-LI) in rats. | PawΕowski J et al. | β | 2001 | β |
| Inhibitory effect of neuropeptide Y on morphine withdrawal is accompanied by reduced c-fos expression in specific brain regions. | Clausen TR et al. | β | 2001 | β |
| Intrahippocampal infusion of antisense oligodeoxynucleotide to the GABA(A) receptor gamma2 subunit enhances neuropeptide Y gene expression. | Mikkelsen JD et al. | β | 2001 | β |
| Neuroendocrinology of stress. | Habib KE et al. | β | 2001 | β |
| Recent insights into body weight control: from physiology to pathology. | Krysiak R et al. | β | 2001 | β |
| The molecular neurobiology of stress--evidence from genetic and epigenetic models. | Steckler T | β | 2001 | β |
| BIIE0246, a potent and highly selective non-peptide neuropeptide Y Y(2) receptor antagonist. | Dumont Y et al. | β | 2000 | β |
| Conditioned fear-induced changes in neuropeptide Y-like immunoreactivity in rats: the effect of diazepam and buspirone. | Krysiak R et al. | β | 2000 | β |
| Design, synthesis and SAR of a series of 2-substituted 4-amino-quinazoline neuropeptide Y Y5 receptor antagonists. | Rueeger H et al. | β | 2000 | β |
| Molecular cloning and characterisation of GPR74 a novel G-protein coupled receptor closest related to the Y-receptor family. | Parker RM et al. | β | 2000 | β |
| Neurobiological responses to ethanol in mutant mice lacking neuropeptide Y or the Y5 receptor. | Thiele TE et al. | β | 2000 | β |
| Peptide YY-2 (PYY2) and pancreatic polypeptide-2 (PPY2): species-specific evolution of novel members of the neuropeptide Y gene family. | Couzens M et al. | β | 2000 | β |
| Potent and selective tools to investigate neuropeptide Y receptors in the central and peripheral nervous systems: BIB03304 (Y1) and CGP71683A (Y5). | Dumont Y et al. | β | 2000 | β |
| 1999 Jonathan E. Rhoads lecture. Isotopic metaprobes, nutrition, and the roads ahead. | Young VR et al. | β | 1999 | β |
| Clozapine decreases neuropeptide Y-like immunoreactivity and neuropeptide Y mRNA levels in rat nucleus accumbens. | Obuchowicz E et al. | β | 1999 | β |
| Conservation of expression of neuropeptide Y5 receptor between human and rat hypothalamus and limbic regions suggests an integral role in central neuroendocrine control. | Nichol KA et al. | β | 1999 | β |
| Diazepam and buspirone alter neuropeptide Y-like immunoreactivity in rat brain. | Krysiak R et al. | β | 1999 | β |
| Effects of acute or long-term treatment with chlorpromazine, haloperidol or sulpiride on neuropeptide Y-like immunoreactivity concentrations in the nucleus accumbens of rat. | Obuchowicz E et al. | β | 1999 | β |
| Electrophysiological response to neuropeptide Y (NPY): in alcohol-naive preferring and non-preferring rats. | Ehlers CL et al. | β | 1999 | β |
| Innate differences of neuropeptide Y (NPY) in hypothalamic nuclei and central nucleus of the amygdala between selectively bred rats with high and low alcohol preference. | Hwang BH et al. | β | 1999 | β |
| Regional distribution of Y-receptor subtype mRNAs in rat brain. | Parker RM et al. | β | 1999 | β |
| Role of norepinephrine in the pathophysiology and treatment of posttraumatic stress disorder. | Southwick SM et al. | β | 1999 | β |
| The pituitary-skin connection in amphibians. Reciprocal regulation of melanotrope cells and dermal melanocytes. | Vaudry H et al. | β | 1999 | β |
| Anxiogenic-like effect of the NPY Y1 receptor antagonist BIBP3226 administered into the dorsal periaqueductal gray matter in rats. | Kask A et al. | β | 1998 | β |
| Characterization of the neuropeptide Y5 receptor in the human hypothalamus: a lack of correlation between Y5 mRNA levels and binding sites. | Statnick MA et al. | β | 1998 | β |
| Comparison of Y-receptor subtype expression in the rat hippocampus. | Parker RM et al. | β | 1998 | β |
| Complementary and overlapping expression of Y1, Y2 and Y5 receptors in the developing and adult mouse nervous system. | Naveilhan P et al. | β | 1998 | β |
| Ethanol consumption and resistance are inversely related to neuropeptide Y levels. | Thiele TE et al. | β | 1998 | β |
| Expression and characterization of the neuropeptide Y Y5 receptor subtype in the rat brain. | Dumont Y et al. | β | 1998 | β |
| Food intake in free-feeding and energy-deprived lean rats is mediated by the neuropeptide Y5 receptor. | Criscione L et al. | β | 1998 | β |
| Influence of typical and atypical antipsychotics on neuropeptide Y-like immunoreactivity and NPY mRNA expression in rat striatum. | Obuchowicz E et al. | β | 1998 | β |
| Natural variation in a neuropeptide Y receptor homolog modifies social behavior and food response in C. elegans. | de Bono M et al. | β | 1998 | β |
| Neuropeptide Y and limbic seizures. | Baraban SC | β | 1998 | β |
| Neuropeptide Y-induced feeding and its control. | Heinrichs SC et al. | β | 1998 | β |
| Neuropeptide Y levels in ethanol-naive alcohol-preferring and nonpreferring rats and in Wistar rats after ethanol exposure. | Ehlers CL et al. | β | 1998 | β |
| Reduced mRNA expression of neuropeptide Y in the limbic system of tenascin gene disrupted mouse brain. | Fukamauchi F et al. | β | 1998 | β |
| The effects of central administration of neuropeptide Y on behavior of tenascin-gene knockout mice. | Fukamauchi F et al. | β | 1998 | β |
| Adenovirus vector-mediated gene transfer into human epileptogenic brain slices: prospects for gene therapy in epilepsy. | O'Connor WM et al. | β | 1997 | β |
| Differential pre- and postsynaptic modulation of chemical transmission in the squid giant synapse by tyrosine phosphorylation. | LlinΓ‘s R et al. | β | 1997 | β |
| Effects of electroconvulsive stimuli and MK-801 on neuropeptide Y, neurokinin A, and calcitonin gene-related peptide in rat brain. | MathΓ© AA et al. | β | 1997 | β |
| Identification of multiple neuropeptide Y receptor subtypes in the human frontal cortex. | Statnick MA et al. | β | 1997 | β |
| Neuropeptide Y family of hormones: receptor subtypes and antagonists. | Balasubramaniam AA | β | 1997 | β |
| Why do we eat? A neural systems approach. | Levine AS et al. | β | 1997 | β |
| Neuroendocrinology of stress. | β | β | 1987 | β |