Impulsivity (delay discounting) as a predictor of acquisition of IV cocaine self-administration in female rats.
paper
Cited
Public
Unavailable
- Authors
- Perry, Jennifer L; Larson, Erin B; German, Jonathan P; Madden, Gregory J; Carroll, Marilyn E
- Year
- 2005
- Journal
- Psychopharmacology
- PMID
- 15338104
- DOI
- 10.1007/s00213-004-1994-4
RATIONALE: Previous research in humans suggests a relationship between drug abuse and impulsivity as shown by selection of a smaller immediate reward over a larger delayed reward. However, it is not clear whether impulsivity precedes drug abuse or drug abuse influences impulsivity. OBJECTIVE: The hypothesis of the present experiment was that rats selected for choosing smaller, immediate over larger, delayed food would acquire IV cocaine self-administration faster than those choosing larger, delayed food rewards. METHODS: Female rats were screened for locomotor activity and trained on a delay discounting procedure that allowed them access to two response levers and a food pellet dispenser. Under a fixed-ratio (FR) 1 schedule, responding on one lever resulted in immediate delivery of one 45 mg pellet, while responding on the other lever resulted in delivery of three 45 mg pellets after a variable delay that increased after responses on the delay lever and decreased after responses on the immediate lever. For each rat, a mean adjusted delay (MAD) was calculated for each daily session, and stability was defined as MADs varying less than 5 s across 5 days. Based on their average MADs, rats were separated into low impulsive (LoI) and high impulsive (HiI) groups, implanted with an indwelling IV catheter, and trained to lever press for cocaine (0.2 mg/kg) under an FR1 schedule. RESULTS: There were no differences in locomotor activity between the LoI and HiI groups; however, a greater percentage of the HiI group acquired cocaine self-administration, and they did so at a significantly faster rate than the LoI rats. CONCLUSIONS: Performance on the delay discounting model of impulsivity predicted vulnerability to subsequent acquisition of cocaine self-administration.
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| Similarities and Differences in Diagnostic Criteria. | Chen Y et al. | — | 2025 | → |
| The mesocorticolimbic system in stimulant use disorder. | London ED et al. | — | 2025 | → |
| Aberrant glutamatergic systems underlying impulsive behaviors: Insights from clinical and preclinical research. | Yates JR | — | 2024 | → |
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| Selective chemogenetic inactivation of corticoaccumbal projections disrupts trait choice impulsivity. | Wenzel JM et al. | — | 2023 | → |
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| Delay Discounting of Monetary and Social Media Rewards: Magnitude and Trait Effects. | Schulz van Endert T et al. | — | 2022 | → |
| Exploratory examination of the effects of d-amphetamine on active-state functional connectivity: Influence of impulsivity and sensation-seeking status. | Smith AP et al. | — | 2022 | → |
| Interactions between impulsivity and MDPV self-administration in rats. | Abbott MS et al. | — | 2022 | → |
| REL-1017 (esmethadone; D-methadone) does not cause reinforcing effect, physical dependence and withdrawal signs in Sprague Dawley rats. | Henningfield J et al. | — | 2022 | → |
| Spontaneously hypertensive rats show higher impulsive action, but equal impulsive choice with both positive and aversive consequences. | González-Barriga F et al. | — | 2022 | → |
| Animal Models of the Behavioral Symptoms of Substance Use Disorders. | Vanderschuren LJMJ et al. | — | 2021 | → |
| Behavioral predictors of individual differences in opioid addiction vulnerability as measured using i.v. self-administration in rats. | Swain Y et al. | — | 2021 | → |
| Bidirectional causality between addiction and cognitive deficits. | Melugin PR et al. | — | 2021 | → |
| Choice bundling, unpacked: Observed and predicted effects on intertemporal choice in an additive model of hyperbolic delay discounting. | Stein JS et al. | — | 2021 | → |
| Discounting of food and water in rats shows trait- and state-like characteristics. | Haynes JM et al. | — | 2021 | → |
| Effects of a high-fat diet on impulsive choice in rats. | Garman TS et al. | — | 2021 | → |
| Heritable variation in locomotion, reward sensitivity and impulsive behaviors in a genetically diverse inbred mouse panel. | Bailey LS et al. | — | 2021 | → |
| Individual differences in dopamine uptake in the dorsomedial striatum prior to cocaine exposure predict motivation for cocaine in male rats. | Shaw JK et al. | — | 2021 | → |
| Neurochemical substrates linked to impulsive and compulsive phenotypes in addiction: A preclinical perspective. | Jones JA et al. | — | 2021 | → |
| Reducing impulsive choice VII: effects of duration of delay-exposure training. | Renda CR et al. | — | 2021 | → |
| Sensitivity to food and cocaine cues are independent traits in a large sample of heterogeneous stock rats. | King CP et al. | — | 2021 | → |
| Unlocking the reinforcement-learning circuits of the orbitofrontal cortex. | Groman SM et al. | — | 2021 | → |
| Distinct relationships between risky decision making and cocaine self-administration under short- and long-access conditions. | Orsini CA et al. | — | 2020 | → |
| Modelling Differential Vulnerability to Substance Use Disorder in Rodents: Neurobiological Mechanisms. | Jupp B et al. | — | 2020 | → |
| Steep Discounting of Future Rewards as an Impulsivity Phenotype: A Concise Review. | Levitt E et al. | — | 2020 | → |
| This is your teen brain on drugs: In search of biological factors unique to dependence toxicity in adolescence. | Kwan LY et al. | — | 2020 | → |
| Transition to substance use disorders: impulsivity for reward and learning from reward. | Poulton A et al. | — | 2020 | → |
| Changing Delay Discounting and Impulsive Choice: Implications for Addictions, Prevention, and Human Health. | Rung JM et al. | — | 2019 | → |
| Cocaine self-administration is increased after frontal traumatic brain injury and associated with neuroinflammation. | Vonder Haar C et al. | — | 2019 | → |
| Ethanol pre-exposure does not increase delay discounting in P rats, but does impair the ability to dynamically adapt behavioral allocation to changing reinforcer contingencies. | Beckwith SW et al. | — | 2019 | → |
| Interventions aimed at changing impulsive choice in rats: Effects of immediate and relatively long delay to reward training. | Fox AE et al. | — | 2019 | → |
| Juvenile exposure to methylphenidate and guanfacine in rats: effects on early delay discounting and later cocaine-taking behavior. | Freund N et al. | — | 2019 | → |
| Neural circuitry and mechanisms of waiting impulsivity: relevance to addiction. | Dalley JW et al. | — | 2019 | → |
| Repeated administration of synthetic cathinone 3,4-methylenedioxypyrovalerone persistently increases impulsive choice in rats. | Hyatt WS et al. | — | 2019 | → |
| The 5-HT<sub>2A</sub> Receptor (5-HT<sub>2A</sub>R) Regulates Impulsive Action and Cocaine Cue Reactivity in Male Sprague-Dawley Rats. | Sholler DJ et al. | — | 2019 | → |
| The neurobiology of impulsivity and substance use disorders: implications for treatment. | Kozak K et al. | — | 2019 | → |
| Top-down control of the medial orbitofrontal cortex to nucleus accumbens core pathway in decisional impulsivity. | Wang Z et al. | — | 2019 | → |
| A low-cost touchscreen operant chamber using a Raspberry Pi™. | O'Leary JD et al. | — | 2018 | → |
| An improved within-session self-adjusting delay discounting procedure for the study of choice impulsivity in rats. | Wahab M et al. | — | 2018 | → |
| Beyond simple tests of value: measuring addiction as a heterogeneous disease of computation-specific valuation processes. | Sweis BM et al. | — | 2018 | → |
| Cross-Sectional and Longitudinal Evaluation of the Social Network Use Disorder and Internet Gaming Disorder Criteria. | Bouna-Pyrrou P et al. | — | 2018 | → |
| Dissecting drug effects in preclinical models of impulsive choice: emphasis on glutamatergic compounds. | Yates JR | — | 2018 | → |
| Effects of morphine/CP55940 mixtures on an impulsive choice task in rhesus monkeys. | Minervini V et al. | — | 2018 | → |
| Executive (dys)function after traumatic brain injury: special considerations for behavioral pharmacology. | Ozga JE et al. | — | 2018 | → |
| Experimental reductions of delay discounting and impulsive choice: A systematic review and meta-analysis. | Rung JM et al. | — | 2018 | → |
| Females in the forefront: time-based intervention effects on impulsive choice and interval timing in female rats. | Stuebing SL et al. | — | 2018 | → |
| Good Things for Those Who Wait: Predictive Modeling Highlights Importance of Delay Discounting for Income Attainment. | Hampton WH et al. | — | 2018 | → |
| Impulsive choice and pre-exposure to delays: iv. effects of delay- and immediacy-exposure training relative to maturational changes in impulsivity. | Renee Renda C et al. | — | 2018 | → |
| Impulsive choice does not predict binge-like eating in rats. | Moore CF et al. | — | 2018 | → |
| Increased Striatal Dopamine Synthesis Capacity in Gambling Addiction. | van Holst RJ et al. | — | 2018 | → |
| Individual decision-making in the causal pathway to addiction: contributions and limitations of rodent models. | Ahmed SH | — | 2018 | → |
| Pair Housing Alters Delay Discounting in Lewis and Fischer 344 Rats. | Turturici M et al. | — | 2018 | → |
| Sex-specific attenuation of impulsive action by progesterone in a go/no-go task for cocaine in rats. | Swalve N et al. | — | 2018 | → |
| Shaping vulnerability to addiction - the contribution of behavior, neural circuits and molecular mechanisms. | Egervari G et al. | — | 2018 | → |
| The impact of drugs of abuse on executive function: characterizing long-term changes in neural correlates following chronic drug exposure and withdrawal in rats. | Brockett AT et al. | — | 2018 | → |
| Trait determinants of impulsive behavior: a comprehensive analysis of 188 rats. | Soares AR et al. | — | 2018 | → |
| Blunted Dopamine Transmission in Addiction: Potential Mechanisms and Implications for Behavior. | Trifilieff P et al. | — | 2017 | → |
| Cdh13 and AdipoQ gene knockout alter instrumental and Pavlovian drug conditioning. | King CP et al. | — | 2017 | → |
| Cocaine administration dose-dependently increases sexual desire and decreases condom use likelihood: The role of delay and probability discounting in connecting cocaine with HIV. | Johnson MW et al. | — | 2017 | → |
| Contribution of Impulsivity and Serotonin Receptor Neuroadaptations to the Development of an MDMA ('Ecstasy') Substance Use Disorder. | Schenk S et al. | — | 2017 | → |
| Differential effects of social and novelty enrichment on individual differences in impulsivity and behavioral flexibility. | Wang MZ et al. | — | 2017 | → |
| Dissociable frontostriatal white matter connectivity underlies reward and motor impulsivity. | Hampton WH et al. | — | 2017 | → |
| Effects of N-methyl-D-aspartate receptor ligands on sensitivity to reinforcer magnitude and delayed reinforcement in a delay-discounting procedure. | Yates JR et al. | — | 2017 | → |
| RETRACTED ARTICLE: A Clock mutation enhances light-phase responsiveness to cocaine in locomotor activity and self-administration with impulsive-like responding in mice. | Meng H et al. | — | 2017 | → |
| Risk-preferring rats make worse decisions and show increased incubation of craving after cocaine self-administration. | Ferland JN et al. | — | 2017 | → |
| Sex differences, gender and addiction. | Becker JB et al. | — | 2017 | → |
| Similarities and Differences in Diagnostic Criterion. | Wei Z et al. | — | 2017 | → |
| Choice between delayed food and immediate oxycodone in rats. | Secci ME et al. | — | 2016 | → |
| Cocaine self-administration and reinstatement in female rats selectively bred for high and low voluntary running. | Smethells JR et al. | — | 2016 | → |
| Delay discounting: Pigeon, rat, human--does it matter? | Vanderveldt A et al. | — | 2016 | → |
| Delay discounting predicts binge-eating in Wistar rats. | Cano AM et al. | — | 2016 | → |
| How to study sex differences in addiction using animal models. | Carroll ME et al. | — | 2016 | → |
| Impulsive choice and pre-exposure to delays: III. Four-month test-retest outcomes in male wistar rats. | Renda CR et al. | — | 2016 | → |
| Impulsivity, Stimulant Abuse, and Dopamine Receptor Signaling. | London ED | — | 2016 | → |
| Increased self-reported impulsivity in methamphetamine users maintaining drug abstinence. | Jones HW et al. | — | 2016 | → |
| Individual differences in impulsive action and dopamine transporter function in rat orbitofrontal cortex. | Yates JR et al. | — | 2016 | → |
| In search of predictive endophenotypes in addiction: insights from preclinical research. | Belin D et al. | — | 2016 | → |
| Low Impulsive Action, but not Impulsive Choice, Predicts Greater Conditioned Reinforcer Salience and Augmented Nucleus Accumbens Dopamine Release. | Zeeb FD et al. | — | 2016 | → |
| Measuring Delay Discounting in Humans Using an Adjusting Amount Task. | Frye CC et al. | — | 2016 | → |
| Modulation of meso-limbic reward processing by motivational tendencies in young adolescents and adults. | Joseph JE et al. | — | 2016 | → |
| Time discounting and time preference in animals: A critical review. | Hayden BY | — | 2016 | → |
| Translatable and Back-Translatable Measurement of Impulsivity and Compulsivity: Convergent and Divergent Processes. | Voon V et al. | — | 2016 | → |
| Brief cognitive training interventions in young adulthood promote long-term resilience to drug-seeking behavior. | Boivin JR et al. | — | 2015 | → |
| Cocaine choice procedures in animals, humans, and treatment-seekers: Can we bridge the divide? | Moeller SJ et al. | — | 2015 | → |
| Delay discounting and the use of mindful attention versus distraction in the treatment of drug addiction: a conceptual review. | Ashe ML et al. | — | 2015 | → |
| Delay discounting of food by rhesus monkeys: Cocaine and food choice in isomorphic and allomorphic situations. | Huskinson SL et al. | — | 2015 | → |
| Discrepant effects of acute cocaine on impulsive choice (delay discounting) in female rats during an increasing- and adjusting-delay procedure. | Smethells JR et al. | — | 2015 | → |
| Effect of environmental enrichment on dopamine and serotonin transporters and glutamate neurotransmission in medial prefrontal and orbitofrontal cortex. | Darna M et al. | — | 2015 | → |
| Effects of the combination of wheel running and atomoxetine on cue- and cocaine-primed reinstatement in rats selected for high or low impulsivity. | Zlebnik NE et al. | — | 2015 | → |
| Experimental manipulations of delay discounting & related processes: an introduction to the special issue. | Bickel WK et al. | — | 2015 | → |
| Impulsive choice, alcohol consumption, and pre-exposure to delayed rewards: II. Potential mechanisms. | Stein JS et al. | — | 2015 | → |
| Impulsive choice predicts anxiety-like behavior, but not alcohol or sucrose consumption, in male Long-Evans rats. | Stein JS et al. | — | 2015 | → |
| Impulsivity in cocaine-dependent individuals with and without attention-deficit/hyperactivity disorder. | Stevens L et al. | — | 2015 | → |
| Irrational beliefs, biases and gambling: exploring the role of animal models in elucidating vulnerabilities for the development of pathological gambling. | Cocker PJ et al. | — | 2015 | → |
| Left Hemispheric Imbalance and Reward Mechanisms Affect Gambling Behavior: The Contribution of the Metacognition and Cortical Brain Oscillations. | Balconi M et al. | — | 2015 | → |
| Monetary discounting and ventral striatal dopamine receptor availability in nontreatment-seeking alcoholics and social drinkers. | Oberlin BG et al. | — | 2015 | → |
| Nicotinic alteration of decision-making. | Naudé J et al. | — | 2015 | → |
| Role of serotonin transporter function in rat orbitofrontal cortex in impulsive choice. | Darna M et al. | — | 2015 | → |
| Sex Differences in Behavioral Dyscontrol: Role in Drug Addiction and Novel Treatments. | Carroll ME et al. | — | 2015 | → |
| Working-memory training: effects on delay discounting in male Long Evans rats. | Renda CR et al. | — | 2015 | → |
| Addictions and Personality Traits: Impulsivity and Related Constructs. | Mitchell MR et al. | — | 2014 | → |
| Adolescent risk taking, cocaine self-administration, and striatal dopamine signaling. | Mitchell MR et al. | — | 2014 | → |
| Altering impulsive decision making with an acceptance-based procedure. | Morrison KL et al. | — | 2014 | → |
| Assessing delay discounting in mice. | Mitchell SH | — | 2014 | → |
| Cocaine-, caffeine-, and stress-evoked cocaine reinstatement in high vs. low impulsive rats: treatment with allopregnanolone. | Regier PS et al. | — | 2014 | → |
| Connecting the pathology of posttraumatic stress and substance use disorders: monoamines and neuropeptides. | Enman NM et al. | — | 2014 | → |
| Dissecting impulsivity and its relationships to drug addictions. | Jentsch JD et al. | — | 2014 | → |
| Dissociable effects of basolateral amygdala lesions on decision making biases in rats when loss or gain is emphasized. | Tremblay M et al. | — | 2014 | → |
| Do the adjusting-delay and increasing-delay tasks measure the same construct: delay discounting? | Craig AR et al. | — | 2014 | → |
| Imaging addiction: D2 receptors and dopamine signaling in the striatum as biomarkers for impulsivity. | Trifilieff P et al. | — | 2014 | → |
| Impulsive choice predicts poor working memory in male rats. | Renda CR et al. | — | 2014 | → |
| Increased delay discounting tracks with a high ethanol-seeking phenotype and subsequent ethanol seeking but not consumption. | Beckwith SW et al. | — | 2014 | → |
| Individual differences in cocaine addiction: maladaptive behavioural traits. | Homberg JR et al. | — | 2014 | → |
| Intake-dependent effects of cocaine self-administration on impulsive choice in a delay discounting task. | Mitchell MR et al. | — | 2014 | → |
| New developments in human neurocognition: clinical, genetic, and brain imaging correlates of impulsivity and compulsivity. | Fineberg NA et al. | — | 2014 | → |
| Rated and measured impulsivity in children is associated with diminished cardiac reactions to acute psychological stress. | Bennett C et al. | — | 2014 | → |
| Recent Translational Findings on Impulsivity in Relation to Drug Abuse. | Weafer J et al. | — | 2014 | → |
| Role of medial prefrontal and orbitofrontal monoamine transporters and receptors in performance in an adjusting delay discounting procedure. | Yates JR et al. | — | 2014 | → |
| Serotonin at the nexus of impulsivity and cue reactivity in cocaine addiction. | Cunningham KA et al. | — | 2014 | → |
| Sweet taste liking is associated with impulsive behaviors in humans. | Weafer J et al. | — | 2014 | → |
| The behavioral- and neuro-economic process of temporal discounting: A candidate behavioral marker of addiction. | Bickel WK et al. | — | 2014 | → |
| The behavioral economics of substance use disorders: reinforcement pathologies and their repair. | Bickel WK et al. | — | 2014 | → |
| The effects of social learning on the acquisition of cocaine self-administration. | Smith MA et al. | — | 2014 | → |
| Viral over-expression of D1 dopamine receptors in the prefrontal cortex increase high-risk behaviors in adults: comparison with adolescents. | Sonntag KC et al. | — | 2014 | → |
| White problem gamblers discount delayed rewards less steeply than their African American and Hispanic counterparts. | Andrade LF et al. | — | 2014 | → |
| A multistep general theory of transition to addiction. | Piazza PV et al. | — | 2013 | → |
| Animal studies of addictive behavior. | Vanderschuren LJ et al. | — | 2013 | → |
| Cocaine self-administration behavior in inbred mouse lines segregating different capacities for inhibitory control. | Cervantes MC et al. | — | 2013 | → |
| Cocaine self-administration punished by i.v. histamine in rat models of high and low drug abuse vulnerability: effects of saccharin preference, impulsivity, and sex. | Holtz NA et al. | — | 2013 | → |
| Decision making: from neuroscience to psychiatry. | Lee D | — | 2013 | → |
| Developmental exposure to polychlorinated biphenyls reduces amphetamine behavioral sensitization in Long-Evans rats. | Poon E et al. | — | 2013 | → |
| Early and prolonged exposure to reward delay: effects on impulsive choice and alcohol self-administration in male rats. | Stein JS et al. | — | 2013 | → |
| Effects of acute and sub-chronic nicotine on impulsive choice in rats in a probabilistic delay-discounting task. | Kelsey JE et al. | — | 2013 | → |
| Effects of reward bundling on male rats' preference for larger-later food rewards. | Stein JS et al. | — | 2013 | → |
| Escalation of drug self-administration as a hallmark of persistent addiction liability. | Edwards S et al. | — | 2013 | → |
| Highly impulsive rats: modelling an endophenotype to determine the neurobiological, genetic and environmental mechanisms of addiction. | Jupp B et al. | — | 2013 | → |
| How emotional traits and affective temperaments relate to cocaine experimentation, abuse and dependence in a large sample. | Fuscaldo LV et al. | — | 2013 | → |
| Impulsivity and apathy in Parkinson's disease. | Sinha N et al. | — | 2013 | → |
| Individual differences and social influences on the neurobehavioral pharmacology of abused drugs. | Bardo MT et al. | — | 2013 | → |
| Individual differences in discount rate are associated with demand for self-administered cocaine, but not sucrose. | Koffarnus MN et al. | — | 2013 | → |
| Inhibition and impulsivity: behavioral and neural basis of response control. | Bari A et al. | — | 2013 | → |
| Integrating behavioral economics and behavioral genetics: delayed reward discounting as an endophenotype for addictive disorders. | MacKillop J | — | 2013 | → |
| Milnacipran enhances the control of impulsive action by activating D₁-like receptors in the infralimbic cortex. | Tsutsui-Kimura I et al. | — | 2013 | → |
| Personality and the acute subjective effects of d-amphetamine in humans. | Kirkpatrick MG et al. | — | 2013 | → |
| Rats classified as low or high cocaine locomotor responders: a unique model involving striatal dopamine transporters that predicts cocaine addiction-like behaviors. | Yamamoto DJ et al. | — | 2013 | → |
| Strong genetic influences on measures of behavioral-regulation among inbred rat strains. | Richards JB et al. | — | 2013 | → |
| The effects of alcohol problems and smoking on delay discounting in individuals with gambling problems. | Andrade LF et al. | — | 2013 | → |
| The relationship between cocaine self-administration and actigraphy-based measures of sleep in adult rhesus monkeys. | Brutcher RE et al. | — | 2013 | → |
| The uncompetitive NMDA receptor antagonists ketamine and memantine preferentially increase the choice for a small, immediate reward in low-impulsive rats. | Cottone P et al. | — | 2013 | → |
| Translating positron emission tomography studies in animals to stimulant addiction: promises and pitfalls. | Caprioli D et al. | — | 2013 | → |
| A modified adjusting delay task to assess impulsive choice between isocaloric reinforcers in non-deprived male rats: effects of 5-HT₂A/C and 5-HT₁A receptor agonists. | Blasio A et al. | — | 2012 | → |
| An efficient operant choice procedure for assessing delay discounting in humans: initial validation in cocaine-dependent and control individuals. | Johnson MW | — | 2012 | → |
| Applications of positron emission tomography in animal models of neurological and neuropsychiatric disorders. | Virdee K et al. | — | 2012 | → |
| A theoretical account of cognitive effects in delay discounting. | Kurth-Nelson Z et al. | — | 2012 | → |
| A translational behavioral model of mood-based impulsivity: Implications for substance abuse. | Gipson CD et al. | — | 2012 | → |
| A within-subject analysis of d-amphetamine exposure on delay discounting in rats. | Slezak JM et al. | — | 2012 | → |
| Characterization of a semi-rapid method for assessing delay discounting in rodents. | Foscue EP et al. | — | 2012 | → |
| Cocaine-induced c-Fos expression in rats selectively bred for high or low saccharin intake and in rats selected for high or low impulsivity. | Regier PS et al. | — | 2012 | → |
| Cognitive control and the dopamine D₂-like receptor: a dimensional understanding of addiction. | Groman SM et al. | — | 2012 | → |
| Delay discounting in Lewis and Fischer 344 rats: steady-state and rapid-determination adjusting-amount procedures. | Stein JS et al. | — | 2012 | → |
| Dissociable effects of monoamine reuptake inhibitors on distinct forms of impulsive behavior in rats. | Baarendse PJ et al. | — | 2012 | → |
| High impulsivity in rats predicts amphetamine conditioned place preference. | Yates JR et al. | — | 2012 | → |
| Human laboratory paradigms in alcohol research. | Plebani JG et al. | — | 2012 | → |
| Impaired control over alcohol use: An under-addressed risk factor for problem drinking in young adults? | Leeman RF et al. | — | 2012 | → |
| Individual differences in impulsive choice and timing in rats. | Galtress T et al. | — | 2012 | → |
| Individual differences in the effects of environmental stimuli on cocaine choice in socially housed male cynomolgus monkeys. | Czoty PW et al. | — | 2012 | → |
| Interactions between deliberation and delay-discounting in rats. | Papale AE et al. | — | 2012 | → |
| Intertemporal choice in lemurs. | Stevens JR et al. | — | 2012 | → |
| Linking ADHD, impulsivity, and drug abuse: a neuropsychological perspective. | Urcelay GP et al. | — | 2012 | → |
| Neuroeconomics and the study of addiction. | Monterosso J et al. | — | 2012 | → |
| Suppression of cocaine self-administration in monkeys: effects of delayed punishment. | Woolverton WL et al. | — | 2012 | → |
| Towards an animal model of food addiction. | de Jong JW et al. | — | 2012 | → |
| Advances in animal models of drug addiction. | Heidbreder C | — | 2011 | → |
| A multivariate assessment of individual differences in sensation seeking and impulsivity as predictors of amphetamine self-administration and prefrontal dopamine function in rats. | Marusich JA et al. | — | 2011 | → |
| Baclofen has opposite effects on escalation of cocaine self-administration: increased intake in rats selectively bred for high (HiS) saccharin intake and decreased intake in those selected for low (LoS) saccharin intake. | Holtz NA et al. | — | 2011 | → |
| Behavioral and emotional regulation and adolescent substance use problems: a test of moderation effects in a dual-process model. | Wills TA et al. | — | 2011 | → |
| Behavioral characterization of adult male and female rhesus monkeys exposed to cocaine throughout gestation. | Hamilton LR et al. | — | 2011 | → |
| Cocaine self-administration leads to alterations in temporal responses to cocaine challenge in limbic and motor circuitry. | Chen YI et al. | — | 2011 | → |
| Contributions of serotonin in addiction vulnerability. | Kirby LG et al. | — | 2011 | → |
| Delayed reward discounting and addictive behavior: a meta-analysis. | MacKillop J et al. | — | 2011 | → |
| Effect of environmental enrichment on methylphenidate-induced locomotion and dopamine transporter dynamics. | Wooters TE et al. | — | 2011 | → |
| High impulsivity predicting vulnerability to cocaine addiction in rats: some relationship with novelty preference but not novelty reactivity, anxiety or stress. | Molander AC et al. | — | 2011 | → |
| Impulsive choice, as measured in a delay discounting paradigm, remains stable after chronic heroin administration. | Harty SC et al. | — | 2011 | → |
| Impulsivity, compulsivity, and top-down cognitive control. | Dalley JW et al. | — | 2011 | → |
| Methylphenidate and fluphenazine, but not amphetamine, differentially affect impulsive choice in spontaneously hypertensive, Wistar-Kyoto and Sprague-Dawley rats. | Wooters TE et al. | — | 2011 | → |
| Novelty seeking, incentive salience and acquisition of cocaine self-administration in the rat. | Beckmann JS et al. | — | 2011 | → |
| Prefrontal cortex and drug abuse vulnerability: translation to prevention and treatment interventions. | Perry JL et al. | — | 2011 | → |
| Serotonin (5-hydroxytryptamine) 5-HT(2A) receptor: association with inherent and cocaine-evoked behavioral disinhibition in rats. | Anastasio NC et al. | — | 2011 | → |
| Strain differences in the dose-response relationship for morphine self-administration and impulsive choice between Lewis and Fischer 344 rats. | García-Lecumberri C et al. | — | 2011 | → |
| The neural mechanisms of inter-temporal decision-making: understanding variability. | Peters J et al. | — | 2011 | → |
| The role of impulsivity in the aetiology of drug dependence: reward sensitivity versus automaticity. | Hogarth L | — | 2011 | → |
| Translational research in addiction: toward a framework for the development of novel therapeutics. | Paterson NE | — | 2011 | → |
| What have positron emission tomography and 'Zippy' told us about the neuropharmacology of drug addiction? | Cumming P et al. | — | 2011 | → |
| Associations with substance abuse treatment completion among drug court participants. | Brown R | — | 2010 | → |
| DAT1 and COMT effects on delay discounting and trait impulsivity in male adolescents with attention deficit/hyperactivity disorder and healthy controls. | Paloyelis Y et al. | — | 2010 | → |
| Differences in D2 dopamine receptor availability and reaction to novelty in socially housed male monkeys during abstinence from cocaine. | Czoty PW et al. | — | 2010 | → |
| Dopamine receptor D1/D5 gene expression in the medial prefrontal cortex predicts impulsive choice in rats. | Loos M et al. | — | 2010 | → |
| Effects of acute and repeated nicotine administration on delay discounting in Lewis and Fischer 344 rats. | Anderson KG et al. | — | 2010 | → |
| Impulsive choice and response in dopamine agonist-related impulse control behaviors. | Voon V et al. | — | 2010 | → |
| Insight into the relationship between impulsivity and substance abuse from studies using animal models. | Winstanley CA et al. | — | 2010 | → |
| Nicotine provokes impulsive-like action by stimulating alpha4beta2 nicotinic acetylcholine receptors in the infralimbic, but not in the prelimbic cortex. | Tsutsui-Kimura I et al. | — | 2010 | → |
| Pharmacologic dissociation between impulsivity and alcohol drinking in high alcohol preferring mice. | Oberlin BG et al. | — | 2010 | → |
| Self-administered cocaine causes long-lasting increases in impulsive choice in a delay discounting task. | Mendez IA et al. | — | 2010 | → |
| Understanding the construct of impulsivity and its relationship to alcohol use disorders. | Dick DM et al. | — | 2010 | → |
| Amphetamine decreases behavioral inhibition by stimulation of dopamine D2, but not D3, receptors. | van Gaalen MM et al. | — | 2009 | → |
| Behavioural characterisation of high impulsivity on the 5-choice serial reaction time task: specific deficits in 'waiting' versus 'stopping'. | Robinson ES et al. | — | 2009 | → |
| Delay of smoking gratification as a laboratory model of relapse: effects of incentives for not smoking, and relationship with measures of executive function. | Mueller ET et al. | — | 2009 | → |
| Differences in impulsivity on a delay-discounting task predict self-administration of a low unit dose of methylphenidate in rats. | Marusich JA et al. | — | 2009 | → |
| Does delay discounting play an etiological role in smoking or is it a consequence of smoking? | Audrain-McGovern J et al. | — | 2009 | → |
| Effects of allopregnanolone on the reinstatement of cocaine-seeking behavior in male and female rats. | Anker JJ et al. | — | 2009 | → |
| Effects of chronic administration of drugs of abuse on impulsive choice (delay discounting) in animal models. | Setlow B et al. | — | 2009 | → |
| High-alcohol preferring mice are more impulsive than low-alcohol preferring mice as measured in the delay discounting task. | Oberlin BG et al. | — | 2009 | → |
| Impulsivity predicts the escalation of cocaine self-administration in rats. | Anker JJ et al. | — | 2009 | → |
| Modeling risk factors for nicotine and other drug abuse in the preclinical laboratory. | Carroll ME et al. | — | 2009 | → |
| Modelling human drug abuse and addiction with dedicated small animal positron emission tomography. | Dalley JW et al. | — | 2009 | → |
| Pathological gamblers discount probabilistic rewards less steeply than matched controls. | Madden GJ et al. | — | 2009 | → |
| Performance under a Go/No-go task in rats selected for high and low impulsivity with a delay-discounting procedure. | Anker JJ et al. | — | 2009 | → |
| Poor response inhibition: at the nexus between substance abuse and attention deficit/hyperactivity disorder. | Groman SM et al. | — | 2009 | → |
| Prior chronic cocaine exposure in mice induces persistent alterations in cognitive function. | Krueger DD et al. | — | 2009 | → |
| Strain differences in delay discounting using inbred rats. | Wilhelm CJ et al. | — | 2009 | → |
| The medial prefrontal cortex regulates the differential expression of morphine-conditioned place preference following a single exposure to controllable or uncontrollable stress. | Rozeske RR et al. | — | 2009 | → |
| A cocaine hydrolase engineered from human butyrylcholinesterase selectively blocks cocaine toxicity and reinstatement of drug seeking in rats. | Brimijoin S et al. | — | 2008 | → |
| An algorithm for identifying nonsystematic delay-discounting data. | Johnson MW et al. | — | 2008 | → |
| A unified framework for addiction: vulnerabilities in the decision process. | Redish AD et al. | — | 2008 | → |
| Behavioral characteristics and neurobiological substrates shared by Pavlovian sign-tracking and drug abuse. | Tomie A et al. | — | 2008 | → |
| Effects of acute and repeated administration of caffeine on temporal discounting in rats. | Diller JW et al. | — | 2008 | → |
| Effects of altering reinforcer magnitude and reinforcement schedule on phencyclidine (PCP) self-administration in monkeys using an adjusting delay task. | Newman JL et al. | — | 2008 | → |
| High impulsivity predicts the switch to compulsive cocaine-taking. | Belin D et al. | — | 2008 | → |
| Impulsive choice and environmental enrichment: effects of d-amphetamine and methylphenidate. | Perry JL et al. | — | 2008 | → |
| Impulsive choice and impulsive action predict vulnerability to distinct stages of nicotine seeking in rats. | Diergaarde L et al. | — | 2008 | → |
| Impulsivity as a vulnerability marker for substance-use disorders: review of findings from high-risk research, problem gamblers and genetic association studies. | Verdejo-García A et al. | — | 2008 | → |
| Impulsivity in Animal Models for Drug Abuse Disorders. | Jentsch JD | — | 2008 | → |
| Impulsivity on a Go/No-go task for intravenous cocaine or food in male and female rats selectively bred for high and low saccharin intake. | Anker JJ et al. | — | 2008 | → |
| Neurobehavioral mechanisms of impulsivity: fronto-striatal systems and functional neurochemistry. | Dalley JW et al. | — | 2008 | → |
| Rats bred for high alcohol drinking are more sensitive to delayed and probabilistic outcomes. | Wilhelm CJ et al. | — | 2008 | → |
| Review. Positron emission tomography imaging studies of dopamine receptors in primate models of addiction. | Nader MA et al. | — | 2008 | → |
| Selective breeding for differential saccharin intake as an animal model of drug abuse. | Carroll ME et al. | — | 2008 | → |
| Steady-state assessment of impulsive choice in Lewis and Fischer 344 rats: between-condition delay manipulations. | Madden GJ et al. | — | 2008 | → |
| The relationship between the locomotor response to a novel environment and behavioral disinhibition in rats. | Stoffel EC et al. | — | 2008 | → |
| The role of impulsive behavior in drug abuse. | Perry JL et al. | — | 2008 | → |
| A comparison of two algorithms in computerized temporal discounting procedures. | Kowal BP et al. | — | 2007 | → |
| Acquisition of i.v. cocaine self-administration in adolescent and adult male rats selectively bred for high and low saccharin intake. | Perry JL et al. | — | 2007 | → |
| Behavioral and neuroeconomics of drug addiction: competing neural systems and temporal discounting processes. | Bickel WK et al. | — | 2007 | → |
| Cocaine exposure causes long-term increases in impulsive choice. | Simon NW et al. | — | 2007 | → |
| Cognitive impulsivity in cocaine and heroin polysubstance abusers. | Verdejo-García AJ et al. | — | 2007 | → |
| Decision making and binge drinking: a longitudinal study. | Goudriaan AE et al. | — | 2007 | → |
| Delay discounting predicts cigarette smoking in a laboratory model of abstinence reinforcement. | Dallery J et al. | — | 2007 | → |
| Higher locomotor response to cocaine in female (vs. male) rats selectively bred for high (HiS) and low (LoS) saccharin intake. | Carroll ME et al. | — | 2007 | → |
| How to make a rat addicted to cocaine. | Roberts DC et al. | — | 2007 | → |
| Impulsivity and chronic stress are associated with amphetamine-induced striatal dopamine release. | Oswald LM et al. | — | 2007 | → |
| Impulsivity (delay discounting) for food and cocaine in male and female rats selectively bred for high and low saccharin intake. | Perry JL et al. | — | 2007 | → |
| Nucleus accumbens D2/3 receptors predict trait impulsivity and cocaine reinforcement. | Dalley JW et al. | — | 2007 | → |
| Regulation of intravenous cocaine self-administration in rats selectively bred for high (HiS) and low (LoS) saccharin intake. | Carroll ME et al. | — | 2007 | → |
| Toward an animal model of gambling: delay discounting and the allure of unpredictable outcomes. | Madden GJ et al. | — | 2007 | → |
| A comparison of Lewis and Fischer rat strains on autoshaping (sign-tracking), discrimination reversal learning and negative auto-maintenance. | Kearns DN et al. | — | 2006 | → |
| Adolescent rats are protected from the conditioned aversive properties of cocaine and lithium chloride. | Schramm-Sapyta NL et al. | — | 2006 | → |
| A method for single-session cocaine self-administration in the mouse. | Olsen CM et al. | — | 2006 | → |
| Electrolytic lesions of the nucleus accumbens enhance locomotor sensitization to nicotine in rats. | Kelsey JE et al. | — | 2006 | → |
| Escalation of i.v. cocaine self-administration and reinstatement of cocaine-seeking behavior in rats bred for high and low saccharin intake. | Perry JL et al. | — | 2006 | → |
| Impact of strain and D-amphetamine on impulsivity (delay discounting) in inbred mice. | Helms CM et al. | — | 2006 | → |
| Neuropsychological function and delay discounting in methamphetamine-dependent individuals. | Hoffman WF et al. | — | 2006 | → |
| Three-month stability of delay and probability discounting measures. | Ohmura Y et al. | — | 2006 | → |
| Translation in tobacco and drug abuse prevention research. | Pentz MA et al. | — | 2006 | → |
| What came first? Comment on Dom et al. (2006). | Bickel WK et al. | — | 2006 | → |
| Discounting delayed and probabilistic monetary gains and losses by smokers of cigarettes. | Ohmura Y et al. | — | 2005 | → |
| Effect of short- vs. long-term estrogen on reinstatement of cocaine-seeking behavior in female rats. | Larson EB et al. | — | 2005 | → |
| Wheel running as a predictor of cocaine self-administration and reinstatement in female rats. | Larson EB et al. | — | 2005 | → |
| Measuring impulsivity and modeling its association with cigarette smoking. | Mitchell SH | — | 2004 | → |