Using genetically informed, randomized prevention trials to test etiological hypotheses about child and adolescent drug use and psychopathology.
- Authors
- Brody, Gene H; Beach, Steven R H; Hill, Karl G; Howe, George W; Prado, Guillermo; Fullerton, Stephanie M
- Year
- 2013
- Journal
- American journal of public health
- PMID
- 23927515
- DOI
- 10.2105/AJPH.2012.301080
- PMCID
- PMC3783004
In this essay, we describe a new era of public health research in which prevention science principles are combined with genomic science to produce gene × intervention (G × I) research. We note the roles of behavioral and molecular genetics in risk and protective mechanisms for drug use and psychopathology among children and adolescents, and the results of first-generation genetically informed prevention trials are reviewed. We also consider the need for second-generation research that focuses on G × I effects on mediators or intermediate processes. This research can be used to further understanding of etiological processes, to identify individual differences in children's and adolescents' responses to risk, and to increase the precision of prevention programs. We note the caveats about using genetic data to select intervention participants.
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In this knowledge base
External
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|---|---|---|---|---|
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| Developmental Change in Adolescent Delinquency: Modeling Time-Varying Effects of a Preventative Intervention and GABRA2 Halpotype Linked to Alcohol Use. | Schlomer GL et al. | — | 2019 | → |
| Peer Alcohol Use Differentially Amplifies Genetic and Environmental Effects on Different Developmental Trajectories of Adolescent Alcohol Use. | Zheng Y et al. | — | 2019 | → |
| Commentary for Special Issue of Prevention Science "Using Genetics in Prevention: Science Fiction or Science Fact?" | Dick DM | — | 2018 | → |
| Glucocorticoid Receptor (NR3C1) Gene Polymorphism Moderate Intervention Effects on the Developmental Trajectory of African-American Adolescent Alcohol Abuse. | Zheng Y et al. | — | 2018 | → |
| Post-GWAS in Psychiatric Genetics: A Developmental Perspective on the "Other" Next Steps. | Dick DM et al. | — | 2018 | → |
| Shared genetic influences do not explain the association between parent-offspring relationship quality and offspring internalizing problems: results from a Children-of-Twins study. | Hannigan LJ et al. | — | 2018 | → |
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| An Adolescent Substance Prevention Model Blocks the Effect of CHRNA5 Genotype on Smoking During High School. | Vandenbergh DJ et al. | — | 2016 | → |
| Application of environmental sensitivity theories in personalized prevention for youth substance abuse: a transdisciplinary translational perspective. | Thibodeau EL et al. | — | 2016 | → |
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| Differential susceptibility to prevention: GABAergic, dopaminergic, and multilocus effects. | Brody GH et al. | — | 2013 | → |