D2 dopamine receptor gene TaqI A1 and B1 restriction fragment length polymorphisms: enhanced frequencies in psychostimulant-preferring polysubstance abusers.
paper
Cited
Public
Unavailable
- Authors
- Persico, A M; Bird, G; Gabbay, F H; Uhl, G R
- Year
- 1996
- Journal
- Biological psychiatry
- PMID
- 8894071
- DOI
- 10.1016/0006-3223(95)00483-1
Several lines of evidence suggest that presence of a D2 dopamine receptor (DRD2) gene variant marked by TaqI restriction fragment length polymorphisms (RFLPs) might contribute to vulnerability to substance abuse. Psychostimulants display the most robust enhancement of dopamine activity in mesolimbic/mesocortical circuits important for behavioral reward. The present study tests the hypothesis that a DRD2 gene variant might be more prominent in polysubstance users who preferentially use psychostimulants than in addicts with preferential opiate use or in those with no drug preference. Polysubstance users with histories of heavy daily preferential psychostimulant use more often displayed one or two copies of the TaqI A1 (27/62 = 43.5% vs 33/119 = 27.7% for controls), and B1 (20/62 = 32.3% vs 23/119 = 19.8% for controls) markers at the DRD2 locus. DRD2 gene marker distributions in abusers with more prominent opiate use, or those with no history of drug preference, were similar to control genotypes. Psychostimulant-preferring drug users also reported earlier onset of psychostimulant use. Our data are consistent with the hypothesis that DRD2 gene variants marked by these polymorphisms may work, probably in concert with other genetic and environmental factors, to enhance vulnerability to psychostimulant abuse.
No figures extracted from this document.
No chunks — full text not yet ingested.
No entities extracted from this document yet.
No uploaded files.
Not in any collection.
No citations found.
In this knowledge base
External
| Title | Authors | Journal | Year | Link |
|---|---|---|---|---|
| Gene Interaction of Dopaminergic Synaptic Pathway Genes in Attention-Deficit Hyperactivity Disorder: a Case-Control Study in Chinese Children. | Zhong L et al. | — | 2024 | → |
| Evidence for the <i>DRD2</i> Gene as a Determinant of Reward Deficiency Syndrome (RDS). | Blum K et al. | — | 2023 | → |
| Invited Expert Opinion- Bioinformatic and Limitation Directives to Help Adopt Genetic Addiction Risk Screening and Identify Preaddictive Reward Dysregulation: Required Analytic Evidence to Induce Dopamine Homeostatsis. | Blum K et al. | — | 2023 | → |
| FOXN3 and GDNF Polymorphisms as Common Genetic Factors of Substance Use and Addictive Behaviors. | Vereczkei A et al. | — | 2022 | → |
| Pharmacogenetics of Addiction Therapy. | Graham DP et al. | — | 2022 | → |
| The <i>Drosophila</i> brain on cocaine at single-cell resolution. | Baker BM et al. | — | 2021 | → |
| Neuropharmacological and Neurogenetic Correlates of Opioid Use Disorder (OUD) As a Function of Ethnicity: Relevance to Precision Addiction Medicine. | Abijo T et al. | — | 2020 | → |
| The Streetlight Effect: Reappraising the Study of Addiction in Light of the Findings of Genome-wide Association Studies. | Hall FS et al. | — | 2020 | → |
| Contributions of an Internalizing Symptoms Polygenic Risk Score and Contextual Factors to Alcohol-Related Disorders in African American Young Adults. | Rabinowitz JA et al. | — | 2019 | → |
| Genetics of cocaine and methamphetamine consumption and preference in Drosophila melanogaster. | Highfill CA et al. | — | 2019 | → |
| The Ankyrin Repeat and Kinase Domain Containing 1 Gene Polymorphism (<i>ANKK1</i><i>Taq1A</i>) and Personality Traits in Addicted Subjects. | Grzywacz A et al. | — | 2019 | → |
| Violence exposure in an urban city: A GxE interaction with aggressive and impulsive behaviors. | Musci RJ et al. | — | 2019 | → |
| A longitudinal assessment of change in marijuana use with other substance use problems. | Choi NG et al. | — | 2018 | → |
| Evaluating the genetic susceptibility to peer reported bullying behaviors. | Musci RJ et al. | — | 2018 | → |
| Genetics of Cocaine and Methamphetamine Consumption and Preference in<i>Drosophila melanogaster</i> | Highfill CA et al. | — | 2018 | — |
| Introducing Precision Addiction Management of Reward Deficiency Syndrome, the Construct That Underpins All Addictive Behaviors. | Blum K et al. | — | 2018 | → |
| Polymorphisms of dopamine receptor genes DRD2 and DRD4 in African populations of Hadza and Datoga differing in the level of culturally permitted aggression. | Sukhodolskaya EM et al. | — | 2018 | → |
| The dopamine D2 receptor mediates approach-avoidance tendencies in smokers. | Zlomuzica A et al. | — | 2018 | → |
| The interplay between externalizing disorders polygenic risk scores and contextual factors on the development of marijuana use disorders. | Rabinowitz JA et al. | — | 2018 | → |
| Trace Amines and Their Receptors. | Gainetdinov RR et al. | — | 2018 | → |
| Acute effects of cocaine and cannabis on reversal learning as a function of COMT and DRD2 genotype. | Spronk DB et al. | — | 2016 | → |
| Prediction of striatal D2 receptor binding by DRD2/ANKK1 TaqIA allele status. | Eisenstein SA et al. | — | 2016 | → |
| The effects of the interplay of genetics and early environmental risk on the course of internalizing symptoms from late childhood through adolescence. | Musci RJ et al. | — | 2016 | → |
| Association between DRD2/ANKK1 TaqIA polymorphism and common illicit drug dependence: evidence from a meta-analysis. | Deng XD et al. | — | 2015 | → |
| Coupling Neurogenetics (GARS™) and a Nutrigenomic Based Dopaminergic Agonist to Treat Reward Deficiency Syndrome (RDS): Targeting Polymorphic Reward Genes for Carbohydrate Addiction Algorithms. | Blum K et al. | — | 2015 | → |
| Updated findings of the association and functional studies of DRD2/ANKK1 variants with addictions. | Ma Y et al. | — | 2015 | → |
| A variant in ANKK1 modulates acute subjective effects of cocaine: a preliminary study. | Spellicy CJ et al. | — | 2014 | → |
| Pharmacogenetics of addiction therapy. | Nielsen DA et al. | — | 2014 | → |
| Smoking quit success genotype score predicts quit success and distinct patterns of developmental involvement with common addictive substances. | Uhl GR et al. | — | 2014 | → |
| ANKK1 and DRD2 pharmacogenetics of disulfiram treatment for cocaine abuse. | Spellicy CJ et al. | — | 2013 | → |
| HIV-related cognitive impairment shows bi-directional association with dopamine receptor DRD1 and DRD2 polymorphisms in substance-dependent and substance-independent populations. | Jacobs MM et al. | — | 2013 | → |
| Implications of genome wide association studies for addiction: are our a priori assumptions all wrong? | Hall FS et al. | — | 2013 | → |
| Multivariate analysis of dopaminergic gene variants as risk factors of heroin dependence. | Vereczkei A et al. | — | 2013 | → |
| Toxicity of amphetamines: an update. | Carvalho M et al. | — | 2012 | → |
| Association between polymorphisms of DRD2 and DRD4 and opioid dependence: evidence from the current studies. | Chen D et al. | — | 2011 | → |
| Genomic regions identified by overlapping clusters of nominally-positive SNPs from genome-wide studies of alcohol and illegal substance dependence. | Johnson C et al. | — | 2011 | → |
| Neuro-chemical activation of brain reward meso-limbic circuitry is associated with relapse prevention and drug hunger: a hypothesis. | Blum K et al. | — | 2011 | → |
| "Replicated" genome wide association for dependence on illegal substances: genomic regions identified by overlapping clusters of nominally positive SNPs. | Drgon T et al. | — | 2011 | → |
| Association analysis between polymorphisms in the dopamine D2 receptor (DRD2) and dopamine transporter (DAT1) genes with cocaine dependence. | Lohoff FW et al. | — | 2010 | → |
| Association study between the DAT1, DBH and DRD2 genes and cocaine dependence in a Spanish sample. | Fernàndez-Castillo N et al. | — | 2010 | → |
| Could the inter-individual variability in cocaine-induced psychotic effects influence the development of cocaine addiction? Towards a new pharmacogenetic approach to addictions. | Brousse G et al. | — | 2010 | → |
| Genome wide association for addiction: replicated results and comparisons of two analytic approaches. | Drgon T et al. | — | 2010 | → |
| Imaging the effects of genetic polymorphisms on radioligand binding in the living human brain: A review on genetic neuroreceptor imaging of monoaminergic systems in psychiatry. | Willeit M et al. | — | 2010 | → |
| Pharmacogenetics: a tool for identifying genetic factors in drug dependence and response to treatment. | Mroziewicz M et al. | — | 2010 | → |
| Pharmacogenetics of drug dependence: role of gene variations in susceptibility and treatment. | Khokhar JY et al. | — | 2010 | → |
| Population-based case-control study of DRD2 gene polymorphisms and alcoholism. | Bhaskar LV et al. | — | 2010 | → |
| Addiction genetics and pleiotropic effects of common haplotypes that make polygenic contributions to vulnerability to substance dependence. | Uhl GR et al. | — | 2009 | → |
| Association analysis between polymorphisms in the conserved dopamine neurotrophic factor (CDNF) gene and cocaine dependence. | Lohoff FW et al. | — | 2009 | → |
| Association of dopamine transporter and monoamine oxidase molecular polymorphisms with sudden infant death syndrome and stillbirth: new insights into the serotonin hypothesis. | Filonzi L et al. | — | 2009 | → |
| Convergent genome wide association results for bipolar disorder and substance dependence. | Johnson C et al. | — | 2009 | → |
| Dopamine transporter (DAT1) VNTR polymorphism in 12 Indian populations. | Bhaskar LV et al. | — | 2009 | → |
| Drosophila, a genetic model system to study cocaine-related behaviors: a review with focus on LIM-only proteins. | Heberlein U et al. | — | 2009 | → |
| Gene-environment interactions across development: Exploring DRD2 genotype and prenatal smoking effects on self-regulation. | Wiebe SA et al. | — | 2009 | → |
| Genetic variants of D2 but not D3 or D4 dopamine receptor gene are associated with rapid onset and poor prognosis of methamphetamine psychosis. | Ujike H et al. | — | 2009 | → |
| Genome-wide association for nicotine dependence and smoking cessation success in NIH research volunteers. | Drgon T et al. | — | 2009 | → |
| Genome-wide association for smoking cessation success: participants in a trial with adjunctive denicotinized cigarettes. | Drgon T et al. | — | 2009 | → |
| The ANKK1 kinase gene and psychiatric disorders. | Ponce G et al. | — | 2009 | → |
| Addiction Reviews. Preface. | Uhl GR | — | 2008 | → |
| Allelic variation and haplotype structure of the dopamine receptor gene DRD2 in nine Indian populations. | Bhaskar LV et al. | — | 2008 | → |
| Association of dopamine and opioid receptor genetic polymorphisms with response to methadone maintenance treatment. | Crettol S et al. | — | 2008 | → |
| Association of PTPRB gene polymorphism with drug addiction. | Ishiguro H et al. | — | 2008 | → |
| Genetic variants in the cocaine- and amphetamine-regulated transcript gene (CARTPT) and cocaine dependence. | Lohoff FW et al. | — | 2008 | → |
| Genome wide association for substance dependence: convergent results from epidemiologic and research volunteer samples. | Johnson C et al. | — | 2008 | → |
| "Higher order" addiction molecular genetics: convergent data from genome-wide association in humans and mice. | Uhl GR et al. | — | 2008 | → |
| Meta-analysis of the association of the Taq1A polymorphism with the risk of alcohol dependency: a HuGE gene-disease association review. | Smith L et al. | — | 2008 | → |
| Molecular genetics of addiction and related heritable phenotypes: genome-wide association approaches identify "connectivity constellation" and drug target genes with pleiotropic effects. | Uhl GR et al. | — | 2008 | → |
| Neurobiology of addiction. An integrative review. | Goodman A | — | 2008 | → |
| Genetics of dopamine and its contribution to cocaine addiction. | Haile CN et al. | — | 2007 | → |
| Molecular genetics of nicotine dependence and abstinence: whole genome association using 520,000 SNPs. | Uhl GR et al. | — | 2007 | → |
| Nucleus accumbens D2/3 receptors predict trait impulsivity and cocaine reinforcement. | Dalley JW et al. | — | 2007 | → |
| Polymorphisms TaqI A of the DRD2, BalI of the DRD3, exon III repeat of the DRD4, and 3' UTR VNTR of the DAT: association with childhood ADHD in male African-Caribbean cocaine dependents? | Ballon N et al. | — | 2007 | → |
| Variation in a bicarbonate co-transporter gene family member SLC4A7 is associated with propensity to addictions: a study using fine-mapping and three samples. | Ishiguro H et al. | — | 2007 | → |
| Addiction molecular genetics: 639,401 SNP whole genome association identifies many "cell adhesion" genes. | Liu QR et al. | — | 2006 | → |
| Association between the DRD2 A1 allele and response to methadone and buprenorphine maintenance treatments. | Barratt DT et al. | — | 2006 | → |
| Imaging gene-substance interactions: the effect of the DRD2 TaqIA polymorphism and the dopamine agonist bromocriptine on the brain activation during the anticipation of reward. | Kirsch P et al. | — | 2006 | → |
| NrCAM in addiction vulnerability: positional cloning, drug-regulation, haplotype-specific expression, and altered drug reward in knockout mice. | Ishiguro H et al. | — | 2006 | → |
| Perspectives on current directions in the neurobiology of addiction disorders relevant to genetic risk factors. | Hurd YL | — | 2006 | → |
| Allelic association of a dopamine transporter gene polymorphism with antisocial behaviour in heroin-dependent patients. | Gerra G et al. | — | 2005 | → |
| Association study of dopamine D2 and D3 receptor gene polymorphisms with cocaine dependence. | Messas G et al. | — | 2005 | → |
| Effects of dopamine D2 receptor (DRD2) and transporter (SLC6A3) polymorphisms on smoking cue-induced cigarette craving among African-American smokers. | Erblich J et al. | — | 2005 | → |
| Genetic determinants of addiction to opioids and cocaine. | Saxon AJ et al. | — | 2005 | → |
| Pharmacogenetics and human molecular genetics of opiate and cocaine addictions and their treatments. | Kreek MJ et al. | — | 2005 | → |
| Pooled association genome scanning: validation and use to identify addiction vulnerability loci in two samples. | Liu QR et al. | — | 2005 | → |
| Sequence variation in the human dopamine transporter gene in children with attention deficit hyperactivity disorder. | Mazei-Robison MS et al. | — | 2005 | → |
| Advances in molecular genetics and the prevention and treatment of substance misuse: Implications of association studies of the A1 allele of the D2 dopamine receptor gene. | Young RM et al. | — | 2004 | → |
| Alcohol-related expectancies are associated with the D2 dopamine receptor and GABAA receptor beta3 subunit genes. | Young RM et al. | — | 2004 | → |
| Lack of association between VNTR polymorphism of dopamine transporter gene (SLC6A3) and schizophrenia in a Brazilian sample. | Cordeiro Q et al. | — | 2004 | → |
| Molecular genetics of substance abuse vulnerability: remarkable recent convergence of genome scan results. | Uhl GR | — | 2004 | → |
| Molecular genetic underpinnings of human substance abuse vulnerability: likely contributions to understanding addiction as a mnemonic process. | Uhl GR | — | 2004 | → |
| Stress-induced cigarette craving: effects of the DRD2 TaqI RFLP and SLC6A3 VNTR polymorphisms. | Erblich J et al. | — | 2004 | → |
| The human serotonin receptor 2B: coding region polymorphisms and association with vulnerability to illegal drug abuse. | Lin Z et al. | — | 2004 | → |
| Association of seven polymorphisms of the D2 dopamine receptor gene with brain receptor-binding characteristics. | Ritchie T et al. | — | 2003 | → |
| D2 dopamine receptor gene in psychiatric and neurologic disorders and its phenotypes. | Noble EP | — | 2003 | → |
| Dopamine D2 receptor binding, Drd2 expression and the number of dopamine neurons in the BXD recombinant inbred series: genetic relationships to alcohol and other drug associated phenotypes. | Hitzemann R et al. | — | 2003 | → |
| No association for D2 and D4 dopamine receptor polymorphisms and methamphetamine abuse in Chinese males. | Tsai SJ et al. | — | 2002 | → |
| [VNTR polymorphisms of the serotonin transporter and dopamine transporter genes in male opiate addicts]. | Galeeva AR et al. | — | 2002 | → |
| Attention deficit/hyperactivity disorder and substance abuse. Diagnostic and therapeutic considerations. | Sullivan MA et al. | — | 2001 | → |
| Imaging neurochemical endophenotypes: promises and pitfalls. | Martinez D et al. | — | 2001 | → |
| Overexpression of dopamine D2 receptors reduces alcohol self-administration. | Thanos PK et al. | — | 2001 | → |
| Polysubstance abuse-vulnerability genes: genome scans for association, using 1,004 subjects and 1,494 single-nucleotide polymorphisms. | Uhl GR et al. | — | 2001 | → |
| Addiction and its reward process through polymorphisms of the D2 dopamine receptor gene: a review. | Noble EP | — | 2000 | → |
| Family-based study of DRD2 alleles in alcohol and drug dependence. | Blomqvist O et al. | — | 2000 | → |
| Haplotypes at the DRD2 locus and severe alcoholism. | Noble EP et al. | — | 2000 | → |
| Pharmacogenomics and addiction to opiates. | Lichtermann D et al. | — | 2000 | → |
| Polymorphisms in dopamine receptors: what do they tell us? | Wong AH et al. | — | 2000 | → |
| Reward deficiency syndrome: a biogenetic model for the diagnosis and treatment of impulsive, addictive, and compulsive behaviors. | Blum K et al. | — | 2000 | → |
| The D(2) dopamine receptor A(1) allele and opioid dependence: association with heroin use and response to methadone treatment. | Lawford BR et al. | — | 2000 | → |
| The DRD2 gene in psychiatric and neurological disorders and its phenotypes. | Noble EP | — | 2000 | → |
| Global variation of a 40-bp VNTR in the 3'-untranslated region of the dopamine transporter gene (SLC6A3). | Kang AM et al. | — | 1999 | → |
| No association between D2 dopamine receptor (DRD2) alleles or haplotypes and cocaine dependence or severity of cocaine dependence in European- and African-Americans. | Gelernter J et al. | — | 1999 | → |
| Lack of association between dopamine transporter gene polymorphisms and delusional disorder. | Persico AM et al. | — | 1998 | → |
| The D2 dopamine receptor gene: a review of association studies in alcoholism and phenotypes. | Noble EP | — | 1998 | → |
| Genotypic association between dopamine transporter gene polymorphisms and schizophrenia. | Persico AM et al. | — | 1997 | → |