Deep brain stimulation: current and future clinical applications.
paper
Cited
Public
Unavailable
- Authors
- Lyons, Mark K
- Year
- 2011
- Journal
- Mayo Clinic proceedings
- PMID
- 21646303
- DOI
- 10.4065/mcp.2011.0045
- PMCID
- PMC3127561
Deep brain stimulation (DBS) has developed during the past 20 years as a remarkable treatment option for several different disorders. Advances in technology and surgical techniques have essentially replaced ablative procedures for most of these conditions. Stimulation of the ventralis intermedius nucleus of the thalamus has clearly been shown to markedly improve tremor control in patients with essential tremor and tremor related to Parkinson disease. Symptoms of bradykinesia, tremor, gait disturbance, and rigidity can be significantly improved in patients with Parkinson disease. Because of these improvements, a decrease in medication can be instrumental in reducing the disabling features of dyskinesias in such patients. Primary dystonia has been shown to respond well to DBS of the globus pallidus internus. The success of these procedures has led to application of these techniques to multiple other debilitating conditions such as neuropsychiatric disorders, intractable pain, epilepsy, camptocormia, headache, restless legs syndrome, and Alzheimer disease. The literature analysis was performed using a MEDLINE search from 1980 through 2010 with the term deep brain stimulation, and several double-blind and larger case series were chosen for inclusion in this review. The exact mechanism of DBS is not fully understood. This review summarizes many of the current and potential future clinical applications of this technology.
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| Title | Year | PMID |
|---|---|---|
| Advances in Electrophysiological Research. | 2015 | 26259089 |
External
| Title | Authors | Journal | Year | Link |
|---|---|---|---|---|
| Applications of Endovascular Brain-Computer Interface in Patients with Alzheimer's Disease. | Sun Y et al. | — | 2025 | → |
| Chronic Pain and Obsessive-Compulsive Disorder: A Scoping Review. | Sloley C et al. | — | 2025 | → |
| Efficacy and safety of multiple-target deep brain stimulation in non-parkinsonian movement disorders: a systematic review. | Kalogirou E et al. | — | 2025 | → |
| Electrophysiology of gliomas: current science, implications, and opportunities. | Minns HE et al. | — | 2025 | → |
| Soft, Multifunctional MXene-Coated Fiber Microelectrodes for Biointerfacing. | Bi L et al. | — | 2024 | → |
| The Cortical and Subcortical Neural Control of Swallowing: A Narrative Review. | Wei KC et al. | — | 2024 | → |
| Current state of the art and future directions for implantable sensors in medical technology: Clinical needs and engineering challenges. | Yogev D et al. | — | 2023 | → |
| Electrophysiologic Evidence That Directional Deep Brain Stimulation Activates Distinct Neural Circuits in Patients With Parkinson Disease. | Peeters J et al. | — | 2023 | → |
| Liquid Crystal Polymer-Based Miniaturized Fully Implantable Deep Brain Stimulator. | Ahn SH et al. | — | 2023 | → |
| Preliminary Experience with a Four-Lead Implantable Pulse Generator for Deep Brain Stimulation. | Rusheen AE et al. | — | 2023 | → |
| Suppression of seizure in childhood absence epilepsy using robust control of deep brain stimulation: a simulation study. | Rouhani E et al. | — | 2023 | → |
| The influence of prior awareness on views about psychiatric electroceutical interventions among non-clinician stakeholders. | Tyron JM et al. | — | 2023 | → |
| Biomarkers for Deep Brain Stimulation in Animal Models of Depression. | Yuen J et al. | — | 2022 | → |
| Current Steering Using Multiple Independent Current Control Deep Brain Stimulation Technology Results in Distinct Neurophysiological Responses in Parkinson's Disease Patients. | Peeters J et al. | — | 2022 | → |
| Developments in Deep Brain Stimulators for Successful Aging Towards Smart Devices-An Overview. | Silverio AA et al. | — | 2022 | → |
| Method Matters: Exploring Alkoxysulfonate-Functionalized Poly(3,4-ethylenedioxythiophene) and Its Unintentional Self-Aggregating Copolymer toward Injectable Bioelectronics. | Mousa AH et al. | — | 2022 | → |
| Neurostimulation as a Method of Treatment and a Preventive Measure in Canine Drug-Resistant Epilepsy: Current State and Future Prospects. | Nowakowska M et al. | — | 2022 | → |
| Protocol to assess rewarding brain stimulation as a learning and memory modulating treatment: Comparison between self-administration and experimenter-administration. | Vila-Solés L et al. | — | 2022 | → |
| Acupuncture for Parkinson's Disease: Efficacy Evaluation and Mechanisms in the Dopaminergic Neural Circuit. | Zhao Y et al. | — | 2021 | → |
| Botulinum Toxin Monotherapy for the Treatment of Essential Tremor: Life Quality Effect. | Demiryurek BE | — | 2021 | → |
| Neuromodulation for Intractable Childhood Epilepsy. | Hyslop A et al. | — | 2021 | → |
| Remote video-based outcome measures of patients with Parkinson's disease after deep brain stimulation using smartphones: a pilot study. | Xu X et al. | — | 2021 | → |
| Restless Legs Syndrome: Contemporary Diagnosis and Treatment. | Gossard TR et al. | — | 2021 | → |
| Soft Electronics Based on Stretchable and Conductive Nanocomposites for Biomedical Applications. | Llerena Zambrano B et al. | — | 2021 | → |
| The development of an implantable deep brain stimulation device with simultaneous chronic electrophysiological recording and stimulation in humans. | Goyal A et al. | — | 2021 | → |
| Cross-Frequency Phase-Amplitude Coupling between Hippocampal Theta and Gamma Oscillations during Recall Destabilizes Memory and Renders It Susceptible to Reconsolidation Disruption. | Radiske A et al. | — | 2020 | → |
| Epitranscriptome of the ventral tegmental area in a deep brain-stimulated chronic unpredictable mild stress mouse model. | Song N et al. | — | 2020 | → |
| How experimental neuroscientists can fix the hard problem of consciousness. | Klein C et al. | — | 2020 | → |
| Novel Botulinum Toxin Injection Protocols for Parkinson Tremor and Essential Tremor - the Yale Technique and Sensor-Based Kinematics Procedure for Safe and Effective Treatment. | Mittal SO et al. | — | 2020 | → |
| Slim electrodes for improved targeting in deep brain stimulation. | Villalobos J et al. | — | 2020 | → |
| Deep Brain Stimulation and Cognitive Outcomes Among Patients With Parkinson's Disease: A Historical Cohort Study. | Hansen AL et al. | — | 2019 | → |
| Deep brain stimulation hardware-related infections: 10-year experience at a single institution. | Abode-Iyamah KO et al. | — | 2019 | → |
| Effect of anesthesia on motor responses evoked by spinal neural prostheses during intraoperative procedures. | Toossi A et al. | — | 2019 | → |
| Ratbot navigation using deep brain stimulation in ventral posteromedial nucleus. | Khajei S et al. | — | 2019 | → |
| A guide towards long-term functional electrodes interfacing neuronal tissue. | Renz AF et al. | — | 2018 | → |
| A minimally invasive neurostimulation method for controlling abnormal synchronisation in the neuronal activity. | Asllani M et al. | — | 2018 | → |
| An Invasive Method for the Activation of the Mouse Dentate Gyrus by High-frequency Stimulation. | Zhao Z et al. | — | 2018 | → |
| Botulinum toxin in essential hand tremor - A randomized double-blind placebo-controlled study with customized injection approach. | Mittal SO et al. | — | 2018 | → |
| Deep Brain Stimulation Modified Autism-Like Deficits via the Serotonin System in a Valproic Acid-Induced Rat Model. | Wu HF et al. | — | 2018 | → |
| Focal stimulation of the sheep motor cortex with a chronically implanted minimally invasive electrode array mounted on an endovascular stent. | Opie NL et al. | — | 2018 | → |
| Nanofabricated Ultraflexible Electrode Arrays for High-Density Intracortical Recording. | Wei X et al. | — | 2018 | → |
| Removing deep brain stimulation artifacts from the electroencephalogram: Issues, recommendations and an open-source toolbox. | Lio G et al. | — | 2018 | → |
| Resting-State Functional Connectivity of the Subthalamic Nucleus to Limbic, Associative, and Motor Networks. | Arnold Anteraper S et al. | — | 2018 | → |
| Wearable and Implantable Sensors for Biomedical Applications. | Koydemir HC et al. | — | 2018 | → |
| Botulinum Toxin in Parkinson Disease Tremor: A Randomized, Double-Blind, Placebo-Controlled Study With a Customized Injection Approach. | Mittal SO et al. | — | 2017 | → |
| Deep brain stimulation for obsessive-compulsive disorder: Knowledge and concerns among psychiatrists, psychotherapists and patients. | Naesström M et al. | — | 2017 | → |
| Meta-Analysis of the Relationship between Deep Brain Stimulation in Patients with Parkinson's Disease and Performance in Evaluation Tests for Executive Brain Functions. | Martínez-Martínez AM et al. | — | 2017 | → |
| Neurofeedback Control in Parkinsonian Patients Using Electrocorticography Signals Accessed Wirelessly With a Chronic, Fully Implanted Device. | Khanna P et al. | — | 2017 | → |
| Neurostimulation Devices for the Treatment of Neurologic Disorders. | Edwards CA et al. | — | 2017 | → |
| Suppression of cortical seizures by optic stimulation of the reticular thalamus in PV-mhChR2-YFP BAC transgenic mice. | Chang WJ et al. | — | 2017 | → |
| The Basic Steps of Evolution of Brain Surgery. | Nikova A et al. | — | 2017 | → |
| Thirty-Day Readmission Rates Following Deep Brain Stimulation Surgery. | Ramayya AG et al. | — | 2017 | → |
| Brainjacking: Implant Security Issues in Invasive Neuromodulation. | Pycroft L et al. | — | 2016 | → |
| Electrophysiological Source Imaging of Brain Networks Perturbed by Low-Intensity Transcranial Focused Ultrasound. | Yu K et al. | — | 2016 | → |
| History of Neural Stem Cell Research and Its Clinical Application. | Takagi Y | — | 2016 | → |
| Improvement of Advanced Parkinson's Disease Manifestations with Deep Brain Stimulation of the Subthalamic Nucleus: A Single Institution Experience. | Rabie A et al. | — | 2016 | → |
| Miniaturized and Wireless Optical Neurotransmitter Sensor for Real-Time Monitoring of Dopamine in the Brain. | Kim MH et al. | — | 2016 | → |
| Organic Photovoltaics and Bioelectrodes Providing Electrical Stimulation for PC12 Cell Differentiation and Neurite Outgrowth. | Hsiao YS et al. | — | 2016 | → |
| Preanesthetic evaluation of a patient with a deep brain stimulator: a practical guide and checklist for patient safety. | Weinstein AS et al. | — | 2016 | → |
| Response to Deep Brain Stimulation in Three Brain Targets with Implications in Mental Disorders: A PET Study in Rats. | Casquero-Veiga M et al. | — | 2016 | → |
| Role of Neuromodulation and Optogenetic Manipulation in Pain Treatment. | Liu S et al. | — | 2016 | → |
| Advances in Electrophysiological Research. | Kamarajan C et al. | — | 2015 | → |
| Analysis of gene expression changes in the rat hippocampus after deep brain stimulation of the anterior thalamic nucleus. | Selvakumar T et al. | — | 2015 | → |
| Cognitive disorders: Deep brain stimulation for Rett syndrome. | Cobb SR | — | 2015 | → |
| Deep Brain Stimulation: Expanding Applications. | Tekriwal A et al. | — | 2015 | → |
| Hippocampal deep brain stimulation reduces glucose utilization in the healthy rat brain. | Van Den Berge N et al. | — | 2015 | → |
| Long-Term Migration of a Deep Brain Stimulation (DBS) Lead in the Third Ventricle Caused by Cerebral Atrophy in a Patient with Anterior Thalamic Nucleus DBS. | Choi JG et al. | — | 2015 | → |
| Patterned, but not tonic, optogenetic stimulation in motor thalamus improves reaching in acute drug-induced Parkinsonian rats. | Seeger-Armbruster S et al. | — | 2015 | → |
| Postmortem diffusion MRI of the human brainstem and thalamus for deep brain stimulator electrode localization. | Calabrese E et al. | — | 2015 | → |
| Striatal Transplantation of Human Dopaminergic Neurons Differentiated From Induced Pluripotent Stem Cells Derived From Umbilical Cord Blood Using Lentiviral Reprogramming. | Effenberg A et al. | — | 2015 | → |
| Computational modeling of an endovascular approach to deep brain stimulation. | Teplitzky BA et al. | — | 2014 | → |
| Historical and present state of neuromodulation in chronic pain. | Kumar K et al. | — | 2014 | → |
| Improvements in memory after medial septum stimulation are associated with changes in hippocampal cholinergic activity and neurogenesis. | Jeong DU et al. | — | 2014 | → |
| Localization of ultrasound-induced in vivo neurostimulation in the mouse model. | King RL et al. | — | 2014 | → |
| Personalized medicine in neurodegenerative diseases: how far away? | Gotovac K et al. | — | 2014 | → |
| Thalamic neuromodulation and its implications for executive networks. | Varela C | — | 2014 | → |
| The glial response to intracerebrally delivered therapies for neurodegenerative disorders: is this a critical issue? | Cicchetti F et al. | — | 2014 | → |
| The study on a real-time remote monitoring system for Parkinson's disease patients with deep brain stimulators. | Chen Y et al. | — | 2014 | → |
| [The use of neuromodulation for the treatment of tremor]. | Bendersky D et al. | — | 2014 | → |
| Thinking Ahead on Deep Brain Stimulation: An Analysis of the Ethical Implications of a Developing Technology. | Johansson V et al. | — | 2014 | → |
| Treatment of chronic pain: diffusion tensor imaging identification of the ventroposterolateral nucleus confirmed with successful deep brain stimulation. | Kovanlikaya I et al. | — | 2014 | → |
| Bilateral deep brain stimulation of the subthalamic nucleus effectively relieves dystonia secondary to Fahr's disease: a case report. | Ma Y et al. | — | 2013 | → |
| Centromedian-parafascicular deep brain stimulation induces differential functional inhibition of the motor, associative, and limbic circuits in large animals. | Kim JP et al. | — | 2013 | → |
| Deep brain stimulation of the subthalamic nucleus increases premature responding in a rat gambling task. | Aleksandrova LR et al. | — | 2013 | → |
| Detection and monitoring of neurotransmitters--a spectroscopic analysis. | Manciu FS et al. | — | 2013 | → |
| Effective parameters for ultrasound-induced in vivo neurostimulation. | King RL et al. | — | 2013 | → |
| Epidural direct current stimulation over the left medial prefrontal cortex facilitates spatial working memory performance in rats. | de Souza Custódio JC et al. | — | 2013 | → |
| Myo-cortical crossed feedback reorganizes primate motor cortex output. | Lucas TH et al. | — | 2013 | → |
| Neural stem cell-based treatment for neurodegenerative diseases. | Kim SU et al. | — | 2013 | → |
| Neurostimulation for the treatment of epilepsy: a review of current surgical interventions. | Wu C et al. | — | 2013 | → |
| Neurostimulation in cluster headache: a review of current progress. | Pedersen JL et al. | — | 2013 | → |
| Optogenetic investigation of neuropsychiatric diseases. | Huang F et al. | — | 2013 | → |
| Point-of-Care Programming for Neuromodulation: A Feasibility Study Using Remote Presence. | Mendez I et al. | — | 2013 | → |
| Short and long term outcome of bilateral pallidal stimulation in chorea-acanthocytosis. | Miquel M et al. | — | 2013 | → |
| Subthalamic deep brain stimulation with a new device in Parkinson's disease: an open-label trial. | Liu HG et al. | — | 2013 | → |
| The cuneiform nucleus may be involved in the regulation of skeletal muscle tone by motor pathway: a virally mediated trans-synaptic tracing study in surgically sympathectomized mice. | Xiang HB et al. | — | 2013 | → |
| The use of deep brain stimulation in Tourette's syndrome. | Rotsides J et al. | — | 2013 | → |
| Treatment of neurological and psychiatric disorders with deep brain stimulation; raising hopes and future challenges. | Sharifi MS | — | 2013 | → |
| World Federation of Societies of Biological Psychiatry (WFSBP) guidelines for biological treatment of schizophrenia, part 2: update 2012 on the long-term treatment of schizophrenia and management of antipsychotic-induced side effects. | Hasan A et al. | — | 2013 | → |
| Contribution of decreased serotonin release to the antidyskinetic effects of deep brain stimulation in a rodent model of tardive dyskinesia: comparison of the subthalamic and entopeduncular nuclei. | Creed MC et al. | — | 2012 | → |
| Deep brain stimulation for movement disorders. | Pizzolato G et al. | — | 2012 | → |
| Deep brain stimulation for neurological disorders. | Oluigbo CO et al. | — | 2012 | → |
| Deep brain stimulation for the treatment of Parkinson's disease: efficacy and safety. | Pouratian N et al. | — | 2012 | → |
| Deep brain stimulation in tourette syndrome: a description of 3 patients with excellent outcome. | Savica R et al. | — | 2012 | → |
| Dissecting DBS Dynamics through quantitative behavioral assessments and statistical modeling: a commentary on Cooper et al. 2011. | Schiff ND | — | 2012 | → |
| Functional imaging of seizures and epilepsy: evolution from zones to networks. | Laufs H | — | 2012 | → |
| Linking restless legs syndrome with Parkinson's disease: clinical, imaging and genetic evidence. | Peeraully T et al. | — | 2012 | → |
| Mood-stabilizing drugs: mechanisms of action. | Schloesser RJ et al. | — | 2012 | → |
| Neuroanesthesiology update. | Pasternak JJ et al. | — | 2012 | → |
| New insights into the mechanisms underlying efficacious deep brain stimulation. | Sirven JI et al. | — | 2012 | → |
| Novel applications of deep brain stimulation. | Sankar T et al. | — | 2012 | → |
| Pediatric indications for deep brain stimulation. | DiFrancesco MF et al. | — | 2012 | → |
| The ethics of research on deep brain stimulation for depression: decisional capacity and therapeutic misconception. | Fisher CE et al. | — | 2012 | → |
| [The role of neurologists in DBS treatment on Parkinson's disease]. | Shimo Y | — | 2012 | → |
| Three-dimensional brain reconstruction of in vivo electrode tracks for neuroscience and neural prosthetic applications. | Markovitz CD et al. | — | 2012 | → |
| Wireless fast-scan cyclic voltammetry measurement of histamine using WINCS--a proof-of-principle study. | Chang SY et al. | — | 2012 | → |