Human dopamine transporter gene polymorphism (VNTR) and alcoholism.
- Authors
- Parsian, A; Zhang, Z H
- Year
- 1997
- Journal
- American journal of medical genetics
- PMID
- 9342195
- DOI
- 10.1002/(sici)1096-8628(19970919)74:5<480::aid-ajmg4>3.0.co;2-s
The dopamine transporter (DAT1) is responsible for taking released dopamine back up into presynaptic terminals and terminating dopaminergic activity. It has been shown that cocaine binds to the dopamine transporter and blocks dopamine reuptake in a fashion that correlates with cocaine reward and reinforcement. To determine the role of this gene in the development of alcoholism, we have used two approaches, relative risk and haplotype relative risk. The relative risk approach involved 162 alcoholic probands who were categorized into type I and type II, and 89 unrelated normal controls. In the haplotype relative risk approach, 29 trios (father, mother, and proband) were genotyped with dopamine transporter gene polymorphism. Comparison of allele frequencies between total alcoholics, subtypes of alcoholics, and normal controls were negative. The results of haplotype relative risk, differences between alleles transmitted and nontransmitted, were also negative. However, both approaches produced similar results. Therefore, we concluded that the VNTR polymorphism in DAT1 gene is not associated with alcoholism susceptibility genes in our samples.
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In this knowledge base
| Title | Year | PMID |
|---|---|---|
| A Critical Review of Methods and Results in the Search for Genetic Contributors to Alcohol Sensitivity. | 2018 | 29623680 |
External
| Title | Authors | Journal | Year | Link |
|---|---|---|---|---|
| A Critical Review of Methods and Results in the Search for Genetic Contributors to Alcohol Sensitivity. | Schuckit MA | — | 2018 | → |
| Genetic influences of dopamine transport gene on alcohol dependence: a pooled analysis of 13 studies with 2483 cases and 1753 controls. | Xu M et al. | — | 2011 | → |
| Relationship between SLC6A3 genotype and striatal dopamine transporter availability: a meta-analysis of human single photon emission computed tomography studies. | Costa A et al. | — | 2011 | → |
| The association between the SLC6A3 VNTR 9-repeat allele and alcoholism-a meta-analysis. | Du Y et al. | — | 2011 | → |
| Association between polymorphisms of the DBH and DAT1 genes and attention deficit hyperactivity disorder in children from Jordan. | Gharaibeh MY et al. | — | 2010 | → |
| An interaction between DAT1 and having an alcoholic father predicts serious alcohol problems in a sample of males. | Vaske J et al. | — | 2009 | → |
| Association between harmful alcohol consumption behavior and dopamine transporter (DAT1) gene polymorphisms in a male Finnish population. | Lind PA et al. | — | 2009 | → |
| Polymorphisms in the dopamine transporter gene (SLC6A3/DAT1) and alcohol dependence in humans: a systematic review. | van der Zwaluw CS et al. | — | 2009 | → |
| Pharmacogenomic strategy for individualizing antidepressant therapy. | Lin KM et al. | — | 2008 | → |
| The 3' part of the dopamine transporter gene DAT1/SLC6A3 is associated with withdrawal seizures in patients with alcohol dependence. | Le Strat Y et al. | — | 2008 | → |
| Allelic association of a dopamine transporter gene polymorphism with antisocial behaviour in heroin-dependent patients. | Gerra G et al. | — | 2005 | → |
| Dopamine and alcoholism: neurobiological basis of ethanol abuse. | Tupala E et al. | — | 2004 | → |
| Nine- or fewer repeat alleles in VNTR polymorphism of the dopamine transporter gene is a strong risk factor for prolonged methamphetamine psychosis. | Ujike H et al. | — | 2003 | → |
| Sex-dependent modulation of ethanol consumption in vesicular monoamine transporter 2 (VMAT2) and dopamine transporter (DAT) knockout mice. | Hall FS et al. | — | 2003 | → |
| Toward a molecular architecture of personality. | Reif A et al. | — | 2003 | → |
| Polymorphisms in the 3'-untranslated region of human and monkey dopamine transporter genes affect reporter gene expression. | Miller GM et al. | — | 2002 | → |
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| Genetic polymorphisms of the promoter region of dopamine D2 receptor and dopamine transporter genes and alcoholism among four aboriginal groups and Han Chinese in Taiwan. | Chen WJ et al. | — | 2001 | → |
| Measurement of the striatal dopamine transporter density and heterogeneity in type 1 alcoholics using human whole hemisphere autoradiography. | Tupala E et al. | — | 2001 | → |
| Serotonin transporter (5-HTT) gene polymorphisms and susceptibility to cocaine dependence among African-American individuals. | Patkar AA et al. | — | 2001 | → |
| Single nucleotide polymorphisms distinguish multiple dopamine transporter alleles in primates: implications for association with attention deficit hyperactivity disorder and other neuropsychiatric disorders. | Miller GM et al. | — | 2001 | → |
| Genome polymorphism and alcoholism. | Thome J et al. | — | 2000 | → |
| Haplotype and allele frequencies for three genes of the dopaminergic system in South American Indians. | Hutz MH et al. | — | 2000 | → |
| An intronic polymorphic domain often associated with susceptibility to affective disorders has allele dependent differential enhancer activity in embryonic stem cells. | Fiskerstrand CE et al. | — | 1999 | → |
| DAT1 gene polymorphism in alcoholism: a family-based association study. | Franke P et al. | — | 1999 | → |