Recent genetic findings in schizophrenia and their therapeutic relevance.
paper
Cited
Public
- Authors
- Harrison, Paul J
- Year
- 2015
- Journal
- Journal of psychopharmacology (Oxford, England)
- PMID
- 25315827
- DOI
- 10.1177/0269881114553647
- PMCID
- PMC4361495
Over 100 loci are now associated with schizophrenia risk as identified by single nucleotide polymorphisms (SNPs) in genome-wide association studies. These findings mean that 'genes for schizophrenia' have unquestionably been found. However, many questions remain unanswered, including several which affect their therapeutic significance. The SNPs individually have minor effects, and even cumulatively explain only a modest fraction of the genetic predisposition. The remainder likely results from many more loci, from rare variants, and from gene-gene and gene-environment interactions. The risk SNPs are almost all non-coding, meaning that their biological significance is unclear; probably their effects are mediated via an influence on gene regulation, and emerging evidence suggests that some key molecular events occur during early brain development. The loci include novel genes of unknown function as well as genes and pathways previously implicated in the pathophysiology of schizophrenia, e.g. NMDA receptor signalling. Genes in the latter category have the clearer therapeutic potential, although even this will be a challenging process because of the many complexities concerning the genetic architecture and mediating mechanisms. This review summarises recent schizophrenia genetic findings and some key issues they raise, particularly with regard to their implications for identifying and validating novel drug targets.
No figures extracted from this document.
β Prev
21β28 of 28
| Name | Type |
|---|---|
| 22q11.2 hemideletion local | variant |
| 22q11 hemideletion local | variant |
| 2p16.3 deletion local | variant |
| 7q36.3 duplication local | variant |
| AKT1 | gene |
| Alzheimer's disease | phenotype |
| ARC | gene |
| autism | phenotype |
| bipolar disorder | phenotype |
| CACNA1C | gene |
| CACNB2 | gene |
| Cancer drugs local | drug |
| cannabis use | phenotype |
| causal variants | cohort |
| CNV | variant |
| CNVs | variant |
| cognition | phenotype |
| common variants | cohort |
| Cross Disorder Group of the Psychiatric Genomics Consortium local | cohort |
| CYT-1 ERBB4 local | variant |
| Disease-associated genes local | gene |
| drug | drug |
| DYPD | gene |
| ERBB4 | gene |
| Existing rheumatoid arthritis drugs local | drug |
| Family trios local | cohort |
| gene | gene |
| glutamate | drug |
| GRIA1 | gene |
| GRIN2A | gene |
| GRIN2A SNP local | variant |
| GRM3 | gene |
| GSK3B | gene |
| HLA | gene |
| Huntington's disease | phenotype |
| implicated gene product local | gene |
| indel | variant |
| large CNVs | variant |
| learning disabilities | phenotype |
| MHC locus | gene |
| MIR137 | gene |
| neurodevelopmental impairment local | phenotype |
| Neurodevelopmental impairment local | phenotype |
| NMDAR | drug |
| NMDA receptor | drug |
| NRG1 | gene |
| NRXN1 | gene |
| p100Ξ΄ PI3K local | variant |
| PGC | cohort |
| PI3K | gene |
| Psychiatric Genomics Consortium | cohort |
| rare CNVs | variant |
| Rare single nucleotide coding variants local | variant |
| rare variant | cohort |
| Rett syndrome | phenotype |
| rheumatoid arthritis | phenotype |
| risk loci | cohort |
| schizophrenia | phenotype |
| SNP | cohort |
| SRR | drug |
| tag SNPs | cohort |
| TCF7L2 | gene |
| type IV NRG1 local | variant |
| Velocardiofacial syndrome | phenotype |
| VIPR2 | gene |
| ZNF804A | gene |
No uploaded files.
Not in any collection.
| Citation | PMID | DOI | Status |
|---|---|---|---|
| AbbottA (2008) Psychiatric genetics: The brains of the family. Nature 454: 154β157.1861505610.1038/454154a | β | β | β |
| AllenNCBagadeSMcQueenMB (2008) Systematic meta-analyses and field synopsis of genetic association studies in schizophrenia: The SzGene database. Nat Genet 40: 827β834.1858397910.1038/ng.171 | β | β | β |
| AndreassenOAThompsonWKSchorkAJ (2013) Improved detection of common variants associated with schizophrenia and bipolar disorder using pleiotropy-informed conditional false discovery rates. PLoS Genet 9: e1003455.2363762510.1371/journal.pgen.1003455PMC3636100 | β | β | β |
| ArranzMJRiveraMMunroJC (2011) Pharmacogenetics of response to antipsychotics in patients with schizophrenia. CNS Drugs 25:933β969.2205411910.2165/11595380-000000000-00000 | β | β | β |
| BaluDTLiYPuhlMD (2013) Multiple risk pathways for schizophrenia converge in serine racemase knockout mice, a mouse model of NMDA receptor hypofunction. Proc Natl Acad Sci U S A 110: E2400βE2409.2372981210.1073/pnas.1304308110PMC3696825 | β | β | β |
| BanerjeeAMacdonaldMLBorgmann-WinterKE (2010) Neuregulin 1-erbB4 pathway in schizophrenia: From genes to an interactome. Brain Res Bull 83:132β139.2043390910.1016/j.brainresbull.2010.04.011PMC5050041 | β | β | β |
| BarkusCSandersonDJWaltonME (2014) What causes aberrant salience in schizophrenia? A role for impaired short-term habituation and the GluA1 AMPA receptor. Mol Psychiatry 19: 1060β1070.2522426010.1038/mp.2014.91PMC4189912 | β | β | β |
| BarrieESSmithRMSanfordJC (2012) mRNA transcript diversity creates new opportunities for pharmacological intervention. Mol Pharmacology 81: 620β630.10.1124/mol.111.076604PMC333680622319206 | β | β | β |
| BeaulieuJMGainetdinovRR (2011) The physiology, signaling, and pharmacology of dopamine receptors. Pharmacol Rev 63:182β217.2130389810.1124/pr.110.002642 | β | β | β |
| BergenSEOβDushlaineCTLeePH (2014) Genetic modifiers and subtypes in schizophrenia: Investigations of age at onset, severity, sex and family history. Schizophr Res 154: 48β53.2458154910.1016/j.schres.2014.01.030PMC4422643 | β | β | β |
| BerridgeMJ (2014) Calcium signalling and psychiatric disease: Bipolar disorder and schizophrenia. Cell Tissue Res 357: 477β492.2457762210.1007/s00441-014-1806-z | β | β | β |
| BhatSDaoDTTerrillionCE (2012) CACNA1C (Cav1.2) in the pathophysiology of psychiatric disease. Prog Neurobiol 99: 1β14.2270541310.1016/j.pneurobio.2012.06.001PMC3459072 | β | β | β |
| BoudreauRLJiangPGilmoreBL (2014) Transcriptome-wide discovery of microRNA binding sites in human brain. Neuron 81: 294β305.2438900910.1016/j.neuron.2013.10.062PMC4108341 | β | β | β |
| BrandonNJSawaA (2011) Linking neurodevelopmental and synaptic theories of mental illness through DISC1. Nat Rev Neurosci 12: 707β722.2209506410.1038/nrn3120PMC3954824 | β | β | β |
| BΓΈrglumADDemontisDGroveJ (2014) Genome-wide association and interaction with maternal cytomegalovirus infection suggests new schizophrenia loci. Mol Psychiatry 19: 325β333.2335816010.1038/mp.2013.2PMC3932405 | β | β | β |
| CarterCSBullmoreETHarrisonPJ (2014) Is there a flame in the brain in psychosis? Biol Psychiatry 75: 258β259.2443955310.1016/j.biopsych.2013.10.023 | β | β | β |
| CasamassimaFHayACBenedettiA (2010) L-type calcium channels and psychiatric disorders: A brief review. Am J Med Genet B Neuropsychiatr Genet 153B: 1373β1390.2088654310.1002/ajmg.b.31122 | β | β | β |
| ChakravartiAClarkAGMoothaVK (2013) Distilling pathophysiology from complex disease genetics. Cell 155: 21β36.2407485810.1016/j.cell.2013.09.001PMC4244836 | β | β | β |
| CollierDALiT. (2003) The genetics of schizophrenia: glutamate not dopamine? Eur J Pharmacol 480:177β184.1462336110.1016/j.ejphar.2003.08.105 | β | β | β |
| CooperD (2010) Functional intronic polymorphisms: Buried treasure awaiting discovery within our genes. Hum Genomics 4: 284β288.2065081710.1186/1479-7364-4-5-284PMC3500160 | β | β | β |
| CorvinAMorrisDW (2014) Genome-wide association studies: Findings at the Major Histocompatibility Complex locus in psychosis. Biol Psychiatry 75: 276β283.2419966410.1016/j.biopsych.2013.09.018 | β | β | β |
| CostainGLionelACMericoD (2013) Pathogenic rare copy number variants in community-based schizophrenia suggest a potential role for clinical microarrays. Hum Mol Genet 22: 4485β4501.2381397610.1093/hmg/ddt297PMC3889806 | β | β | β |
| CousijnHRijpkemaMHarteveldA (2013) Schizophrenia risk gene ZNF804A does not influence macroscopic brain structure: An MRI study in 892 volunteers. Mol Psychiatry. 17:1155β1157.2227047610.1038/mp.2011.181PMC3504377 | β | β | β |
| CoyleJTTsaiGGoffD (2003) Converging evidence of NMDA receptor hypofunction in the pathophysiology of schizophrenia. Ann N Y Acad Sci. 1003:318β327.1468445510.1196/annals.1300.020 | β | β | β |
| Cross-Disorder Group of the Psychiatric Genomics Consortium (2013a) Identifcation of risk loci with shared effects on five major psychiatric disorders: a genome-wide analysis. Lancet 9875: 1371β1379.10.1016/S0140-6736(12)62129-1PMC371401023453885 | β | β | β |
| Cross-Disorder Group of the Psychiatric Genomics Consortium (2013b) Genetic relationship between five psychiatric disorders estimated from genome-wide SNPs. Nature Genet 45: 984β994.2393382110.1038/ng.2711PMC3800159 | β | β | β |
| DaxingerLWhitelawE (2012) Understanding transgenerational epigenetic inheritance via the gametes in mammals. Nat Rev Genetics 12: 153β162.2229045810.1038/nrg3188 | β | β | β |
| del ReECBergenSEMesholam-GatelyRI (2014) Analysis of schizophrenia-related genes and electrophysiological measures reveals ZNF804A association with amplitude of P300b elicited by novel sounds. Transl Psychiatry 4: e346.2442439210.1038/tp.2013.117PMC3905227 | β | β | β |
| DempsterEVianaJPidsleyR (2013) Epigenetic studies of schizophrenia: Progress, predicaments, and promises for the future. Schizophr Bull 39: 11β16.2321139810.1093/schbul/sbs139PMC3523917 | β | β | β |
| Di FortiMIyegbeCSallisH (2012) Confirmation that the AKT1 (rs2494732) genotype influences the risk of psychosis in cannabis users. Biol Psychiatry 72: 811β816.2283198010.1016/j.biopsych.2012.06.020 | β | β | β |
| DickinsonDStraubRETrampushJW (2014) Differential effects of common variants in SCN2A on general cognitive ability, brain physiology, and messenger RNA expression in schizophrenia cases and control individuals. JAMA Psychiatry 71: 647β656.2471890210.1001/jamapsychiatry.2014.157PMC4160812 | β | β | β |
| DietzHC (2010) New therapeutic approaches to Mendelian disorders. N Engl J Med 363: 852β863.2081884610.1056/NEJMra0907180 | β | β | β |
| DwyerSWilliamsHHolmansP (2010) No evidence that rare coding variants in ZNF804A confer risk of schizophrenia. Am J Med Genet B Neuropsychiatr Genet 153B: 1411β1416.2086269610.1002/ajmg.b.31117 | β | β | β |
| EdwardsSLBeesleyJFrenchJD (2013) Beyond GWASs: Illuminating the dark road from association to function. Am J Hum Genet 93: 779β797.2421025110.1016/j.ajhg.2013.10.012PMC3824120 | β | β | β |
| EmamianESHallDBirnbaumMJ (2004) Convergent evidence for impaired AKT1-GSK3beta signaling in schizophrenia. Nat Genet 36: 131-137.1474544810.1038/ng1296 | β | β | β |
| EsslingerCWalterHKirschP (2009) Neural mechanisms of a genome-wide supported psychosis variant. Science 324: 605β605.1940719310.1126/science.1167768 | β | β | β |
| FieldJRWalkerAGConnPJ (2011) Targeting glutamate synapses in schizophrenia. Trends Mol Med 17: 689β698.2195540610.1016/j.molmed.2011.08.004PMC3225651 | β | β | β |
| FilippichCWolvetangEJMowryBJ (2013) Will brain cells derived from induced pluripotent stem cells or directly converted from somatic cells (iNs) Be useful for schizophrenia research? Schizophr Bull 39: 948β954.2388435110.1093/schbul/sbt103PMC3756797 | β | β | β |
| ForrestMPHillMJQuantockAJ (2014) The emerging roles of TCF4 in disease and development. Trends Mol Med 20: 322β331.2459426510.1016/j.molmed.2014.01.010 | β | β | β |
| FourgeaudLDavenportCMTylerCM (2010) MHC class I modulates NMDA receptor function and AMPA receptor trafficking. Proc Natl Acad Sci U S A 107: 22278β22283.2113523310.1073/pnas.0914064107PMC3009822 | β | β | β |
| FreybergZFerrandoSJJavitchJA (2010) Roles of the Akt/GSK-3 and Wnt signaling pathways in schizophrenia and antipsychotic drug action. Am J Psychiatry 167:388β396.1991759310.1176/appi.ajp.2009.08121873PMC3245866 | β | β | β |
| FrohlichJVan HornJD (2014) Reviewing the ketamine model for schizophrenia. J Psychopharmacol 28: 287β302.2425781110.1177/0269881113512909PMC4133098 | β | β | β |
| FromerMPocklingtonAJKavanaghDH (2014) De novo mutations in schizophrenia implicate synaptic networks. Nature 506:179β184.2446350710.1038/nature12929PMC4237002 | β | β | β |
| FrumanDARommelC (2014) PI3K and cancer: Lessons, challenges and opportunities. Nat Rev Drug Disc 13: 140β156.10.1038/nrd4204PMC399498124481312 | β | β | β |
| GadallaKKEBaileyMESCobbSR (2011) MeCP2 and Rett syndrome: Reversibility and potential avenues for therapy. Biochem J 439: 1β14.2191684310.1042/BJ20110648 | β | β | β |
| GibsonG (2012) Rare and common variants: Twenty arguments. Nat Rev Genet 13: 135β145.2225187410.1038/nrg3118PMC4408201 | β | β | β |
| GilmanSRChangJXuB (2012) Diverse types of genetic variation converge on functional gene networks involved in schizophrenia. Nat Neurosci 15: 1723β1728.2314352110.1038/nn.3261PMC3689007 | β | β | β |
| GirgentiMJLoTurcoJJMaherBJ (2012) ZNF804a regulates expression of the schizophrenia-associated genes PRSS16, COMT, PDE4B, and DRD2. PLoS One 7: e32404.2238424310.1371/journal.pone.0032404PMC3288100 | β | β | β |
| Giusti-RodriguezPSullivanPF (2013) The genomics of schizophrenia: Update and implications. J Clin Invest 123: 4557β4563.2417746510.1172/JCI66031PMC3809776 | β | β | β |
| GlessnerJTReillyMPKimCE (2010) Strong synaptic transmission impact by copy number variations in schizophrenia. Proc Natl Acad Sci U S A 107: 10584β10589.2048917910.1073/pnas.1000274107PMC2890845 | β | β | β |
| GrattenJWrayNRKellerMC (2014) Large-scale genomics unveils the genetic architecture of psychiatric disorders. Nat Neurosci 17: 782β790.2486604410.1038/nn.3708PMC4112149 | β | β | β |
| GreenEDGuyerMS and National Human Genome Research Institute (2011) Charting a course for genomic medicine from base pairs to bedside. Nature 470: 204β213.2130793310.1038/nature09764 | β | β | β |
| GrozevaDKirovGIvanovD (2010) Rare copy number variants: A point of rarity in genetic risk for bipolar disorder and schizophrenia. Mol Psychiatry 67: 318β327.10.1001/archgenpsychiatry.2010.25PMC447602720368508 | β | β | β |
| GuellaISequeiraARollinsB (2014) Evidence of allelic imbalance in the schizophrenia susceptibility gene ZNF804A in human dorsolateral prefrontal cortex. Schizophr Res 152: 111β116.2431571710.1016/j.schres.2013.11.021PMC3947280 | β | β | β |
| GulsunerSWalshTWattsAC (2013) Spatial and temporal mapping of de novo mutations in schizophrenia to a fetal prefrontal cortical network. Cell 154: 518β529.2391131910.1016/j.cell.2013.06.049PMC3894107 | β | β | β |
| HarrisonPJ (2014) The current and potential impact of genetics and genomics on neuropsychopharmacology. Eur Neuropsychopharm Epub ahead of print, 22 3 2013. 10.1016/j.euroneuro.2013.02.005).23528807 | β | β | β |
| HarrisonPJEastwoodSL (1998) Preferential involvement of excitatory neurons in medial temporal lobe in schizophrenia. Lancet 352: 1669β1673.985344010.1016/S0140-6736(98)03341-8 | β | β | β |
| HarrisonPJLawAJ (2006) Neuregulin 1 and schizophrenia: genetics, gene expression, and neurobiology. Biol Psychiatry 60: 132β140.1644208310.1016/j.biopsych.2005.11.002 | β | β | β |
| HarrisonPJLyonLSartoriusLJ (2008) The group II metabotropic glutamate receptor 3 (mGluR3, mGlu3, GRM3): expression, function and involvement in schizophrenia. J Psychopharmacol 22: 308β322.1854162610.1177/0269881108089818 | β | β | β |
| HarrisonPJOwenMJ (2003) Genes for schizophrenia? Recent findings and their pathophysiological implications. Lancet 361: 417β419.1257338810.1016/S0140-6736(03)12379-3 | β | β | β |
| HarrisonPJWeinbergerDR (2005) Schizophrenia genes, gene expression, and neuropathology: On the matter of their convergence. Mol Psychiatry 10: 40β68.1526390710.1038/sj.mp.4001558 | β | β | β |
| HarrisonPJWestVA (2006) Six degrees of separation: on the prior probability that schizophrenia susceptibility genes converge on synapses, glutamate and NMDA receptors. Mol Psychiatry 11: 981β983.1706318210.1038/sj.mp.4001886 | β | β | β |
| HatzimanolisAMcGrathJAWangR (2013) Multiple variants aggregate in the neuregulin signalling pathway in a subset of schizophrenia patients. Transl Psychiatry 3: e264.2371529910.1038/tp.2013.33PMC3669920 | β | β | β |
| HeckAFastenrathMAckermannS (2014) Converging genetic and functional brain imaging evidence links neuronal excitability to working memory, psychiatric disease, and brain activity. Neuron 81: 1203β1213.2452998010.1016/j.neuron.2014.01.010PMC4205276 | β | β | β |
| HessJLGlattSJ (2013) How might ZNF804A variants influence risk for schizophrenia and bipolar disorder? A literature review, synthesis, and bioinformatic analysis. Am J Med Genet B Neuropsychiatr Genet 165: 28β40.2412394810.1002/ajmg.b.32207 | β | β | β |
| HillMBrayN (2011) Allelic differences in nuclear protein binding at a genome-wide significant risk variant for schizophrenia in ZNF804A. Mol Psychiatry 16: 787β789.2135871310.1038/mp.2011.21PMC3351974 | β | β | β |
| HillMJBrayNJ (2012) Evidence that schizophrenia risk variation in the ZNF804A gene exerts its effects during fetal brain development. Am J Psychiatry 169: 1301β1308.2321206110.1176/appi.ajp.2012.11121845 | β | β | β |
| HillMJJeffriesARDobsonRJB (2012) Knockdown of the psychosis susceptibility gene ZNF804A alters expression of genes involved in cell adhesion. Hum Mol Genet 21: 1018β1024.2208083410.1093/hmg/ddr532 | β | β | β |
| HuangYDMuckeL (2012). Alzheimer mechanisms and therapeutic strategies. Cell 148: 1204β1222.2242423010.1016/j.cell.2012.02.040PMC3319071 | β | β | β |
| HymanSE (2014) Revitalizing psychiatric therapeutics. Neuropsychopharmacology 39: 220β229.2431730710.1038/npp.2013.181PMC3857646 | β | β | β |
| IyegbeCCampbellDButlerA (2014) The emerging molecular architecture of schizophrenia, polygenic risk scores and the clinical implications for GxE research. Soc Psychiatry Psychiatr Epidemiol 49:169β182.2443509210.1007/s00127-014-0823-2 | β | β | β |
| KantrowitzJTJavittDC (2010) N-methyl-D-aspartate (NMDA) receptor dysfunction or dysregulation: The final common pathway on the road to schizophrenia? Brain Res Bull 83: 108β121.2041769610.1016/j.brainresbull.2010.04.006PMC2941541 | β | β | β |
| KennyEMCormicanPFurlongS (2014) Excess of rare novel loss-of-function variants in synaptic genes in schizophrenia and autism spectrum disorders. Mol Psychiatry 19: 872β879.2412692610.1038/mp.2013.127 | β | β | β |
| KimAHParkerEKWilliamsonV (2012) Experimental validation of candidate schizophrenia gene ZNF804A as target for hsa-miR-137. Schizophr Res 141: 60β64.2288335010.1016/j.schres.2012.06.038PMC4104606 | β | β | β |
| KircherMWittenDMJainP (2014) A general framework for estimating the relative pathogenicity of human genetic variants. Nat Genet. 46: 310β316.2448727610.1038/ng.2892PMC3992975 | β | β | β |
| KirovGPocklingtonAJHolmansP (2012) De novo CNV analysis implicates specific abnormalities of postsynaptic signalling complexes in the pathogenesis of schizophrenia. Mol Psychiatry 17: 142β153.2208372810.1038/mp.2011.154PMC3603134 | β | β | β |
| KirovGReesEWaltersJTR (2014) The penetrance of copy number variations for schizophrenia and developmental delay. Biol Psychiatry 75: 378β385.2399292410.1016/j.biopsych.2013.07.022PMC4229045 | β | β | β |
| KleinmanJELawAJLipskaBK (2011) Genetic neuropathology of schizophrenia: New approaches to an old question and new uses for postmortem human brains. Biol Psychiatry 69: 140β145.2118300910.1016/j.biopsych.2010.10.032PMC4351748 | β | β | β |
| KwonEWangWTsaiLH (2013) Validation of schizophrenia-associated genes CSMD1, C10orf26, CACNA1C and TCF4 as miR-137 targets. Mol Psychiatry 18: 11β12.2218293610.1038/mp.2011.170 | β | β | β |
| LawAJKleinmanJEWeinbergerDR (2007) Disease-associated intronic variants in the ERBB4 gene are related to altered ERBB4 splice-variant expression in the brain in schizophrenia. Hum Mol Genet 16: 129β141.1716426510.1093/hmg/ddl449 | β | β | β |
| LawAJLipskaBKWeickertCS (2006) Neuregulin 1 transcripts are differentially expressed in schizophrenia and regulated by 5β SNPs associated with the disease. Proc Natl Acad Sci U S A 103: 6747β6752.1661893310.1073/pnas.0602002103PMC1458952 | β | β | β |
| LawAJWangYSeiY (2012) Neuregulin 1-ErbB4-PI3K signaling in schizophrenia and phosphoinositide 3-kinase-p110Ξ΄ inhibition as a potential therapeutic strategy. Proc Natl Acad Sci U S A 109: 12165β12170.2268994810.1073/pnas.1206118109PMC3409795 | β | β | β |
| LeeHBrottBKKirkbyLA (2014) Synapse elimination and learning rules co-regulated by MHC class I H2-Db. Nature 509: 195β200.2469523010.1038/nature13154PMC4016165 | β | β | β |
| LeeSHDeCandidaTRRipkeS (2012) Estimating the proportion of variation in susceptibility to schizophrenia captured by common SNPs. Nat Genet 44: 247β250.2234422010.1038/ng.1108PMC3327879 | β | β | β |
| LeeSHWrayNRGoddardME (2011) Estimating missing heritability for disease from genome-wide association studies. Am J Hum Genet 88: 294β305.2137630110.1016/j.ajhg.2011.02.002PMC3059431 | β | β | β |
| LettTAChakavartyMMFelskyD (2013) The genome-wide supported microRNA-137 variant predicts phenotypic heterogeneity within schizophrenia. Mol Psychiatry 18: 443β450.2345946610.1038/mp.2013.17 | β | β | β |
| LichtensteinPYipBHBjorkC (2009) Common genetic determinants of schizophrenia and bipolar disorder in Swedish families: A population-based study. Lancet 373: 234β239.1915070410.1016/S0140-6736(09)60072-6PMC3879718 | β | β | β |
| LiMSuB (2013) Meta-analysis supports association of a non-synonymous SNP in ZNF804A with schizophrenia. Schizophr Res 149: 188β189.2381597310.1016/j.schres.2013.06.002 | β | β | β |
| LipscombeDAndradeAAllenSE (2013) Alternative splicing: Functional diversity among voltage-gated calcium channels and behavioral consequences. Biochim Biophys Acta 1828: 1522β1529.2302228210.1016/j.bbamem.2012.09.018PMC3625486 | β | β | β |
| LipsESCornelisseLNToonenRF (2012) Functional gene group analysis identifies synaptic gene groups as risk factor for schizophrenia. Mol Psychiatry 17: 996β1006.2193132010.1038/mp.2011.117PMC3449234 | β | β | β |
| MacArthurDGManolioTADimmockDP (2014) Guidelines for investigating causality of sequence variants in human disease. Nature 508: 469β476.2475940910.1038/nature13127PMC4180223 | β | β | β |
| MackayTF (2014) Epistasis and quantitative traits: using model organisms to study gene-gene interactions. Nat Rev Genet 15: 22β33.2429653310.1038/nrg3627PMC3918431 | β | β | β |
| MalhotraDMcCarthySMichaelsonJJ (2011) High frequencies of de novo CNVs in bipolar disorder and schizophrenia. Neuron 72: 951β963.2219633110.1016/j.neuron.2011.11.007PMC3921625 | β | β | β |
| MalhotraDSebatJ (2012) CNVs: Harbingers of a rare variant revolution in psychiatric genetics. Cell 148: 1223β1241.2242423110.1016/j.cell.2012.02.039PMC3351385 | β | β | β |
| ManolioTA (2013) Bringing genome-wide association findings into clinical use. Nat Rev Genet 14: 549β558.2383544010.1038/nrg3523 | β | β | β |
| ManolioTACollinsFSCoxNJ (2009) Finding the missing heritability of complex diseases. Nature 461: 747β753.1981266610.1038/nature08494PMC2831613 | β | β | β |
| MarekGJBehlBBespalovAY (2010) Glutamatergic (N-methyl-D-aspartate receptor) hypofrontality in schizophrenia: Too little juice or a miswired brain? Mol Pharmacol 77: 317β326.1993377410.1124/mol.109.059865 | β | β | β |
| MauranoMTHumbertRRynesE (2012) Systematic localization of common disease-associated variation in regulatory DNA. Science 337: 1190β1195.2295582810.1126/science.1222794PMC3771521 | β | β | β |
| McAllisterAK (2014) Major histocompatibility complex I in brain development and schizophrenia. Biol Psychiatry 75: 262β268.2419966310.1016/j.biopsych.2013.10.003PMC4354937 | β | β | β |
| McCarrollSAHymanSE (2013) Progress in the genetics of polygenic brain disorders: Significant new challenges for neurobiology. Neuron 80: 578β587.2418301110.1016/j.neuron.2013.10.046PMC4066986 | β | β | β |
| McCarthySEMcCombieWRCorvinA (2014) Unlocking the treasure trove: From genes to schizophrenia biology. Schizophr Bull 40: 492β496.2467481210.1093/schbul/sbu042PMC3984532 | β | β | β |
| McGuffinP (1979) Is schizophrenia an HLA-associated disease? Psychol Med 9: 721β728.9279710.1017/s0033291700034036 | β | β | β |
| McGuffinPPowerRA (2013) Schizophrenia as a human leukocyte antigen-associated disease revisited. Am J Psychiatry 170: 821β823.2390332910.1176/appi.ajp.2013.13030336 | β | β | β |
| MeiLNaveK-A (2014) Neuregulin-ERBB signaling in the nervous system and neuropsychiatric diseases. Neuron 83: 27β49.2499195310.1016/j.neuron.2014.06.007PMC4189115 | β | β | β |
| MeiLXiongWC (2008) Neuregulin 1 in neural development, synaptic plasticity and schizophrenia. Nat Rev Neurosci 9: 437β452.1847803210.1038/nrn2392PMC2682371 | β | β | β |
| MizunoMSotoyamaHNambaH (2013) ErbB inhibitors ameliorate behavioral impairments of an animal model for schizophrenia: implication of their dopamine-modulatory actions. Transl Psychiatry 3: e252.2363245610.1038/tp.2013.29PMC3641415 | β | β | β |
| MoghaddamB (2003) Bringing order to the glutamate chaos in schizophrenia. Neuron 40: 881β884.1465908710.1016/s0896-6273(03)00757-8 | β | β | β |
| MoghaddamBJavittD (2012) From revolution to evolution: The glutamate hypothesis of schizophrenia and its implication for treatment. Neuropsychopharmacology 37: 4β15.2195644610.1038/npp.2011.181PMC3238069 | β | β | β |
| MoosmangSHaiderNKlugbauerN (2005) Role of hippocampal Cav1.2 Ca2+ channels in NMDA receptor-indepdendent synaptic plasticity and spatial memory. J Neurosci 25: 9883β9892.1625143510.1523/JNEUROSCI.1531-05.2005PMC6725564 | β | β | β |
| MowryBJGrattenJ (2013) The emerging spectrum of allelic variation in schizophrenia: Current evidence and strategies for the identification and functional characterization of common and rare variants. Mol Psychiatry 18: 38β52.2254711410.1038/mp.2012.34 | β | β | β |
| MugliaP (2012) From genes to therapeutic targets for psychiatric disorders β what to expect? Curr Opin Pharmacol 11: 563β571.2189343010.1016/j.coph.2011.08.003 | β | β | β |
| NeedACGoldsteinDB (2014) Schizophrenia genetics comes of age. Neuron 83: 760β762.2514487310.1016/j.neuron.2014.08.015 | β | β | β |
| NicodemusKKLawAJRadulescuE (2010) Biological validation of increased schizophrenia risk with NRG1, ERBB4, and AKT1 epistasis via functional neuroimaging in healthy controls. Arch Gen Psychiatry 67: 991β1001.2092111510.1001/archgenpsychiatry.2010.117PMC4291187 | β | β | β |
| NicodemusKKMarencoSBattenAJ (2008) Serious obstetric complications interact with hypoxia-regulated/vascular-expression genes to influence schizophrenia risk. Mol Psychiatry 13: 873β877.1819571310.1038/sj.mp.4002153 | β | β | β |
| NortonNMoskvinaVMorrisDW (2006) Evidence that interaction between neuregulin 1 and its receptor erbB4 increases susceptibility to schizophrenia. Am J Med Genet B Neuropsychiatr Genet 141B: 96β101.1624999410.1002/ajmg.b.30236 | β | β | β |
| OkadaYWuDTrynkaG (2014). Genetics of rheumatoid arthritis contributes to biology and drug discovery. Nature 506: 376β381.2439034210.1038/nature12873PMC3944098 | β | β | β |
| OlneyJWFarberNB (1995) Glutamate receptor dysfunction and schizophrenia. Arch Gen Psychiatry 52: 998β1007.749226010.1001/archpsyc.1995.03950240016004 | β | β | β |
| OwenMJOβDonovanMCHarrisonPJ (2005) Schizophrenia: A genetic disorder of the synapse? BMJ 330: 158β159.1566176210.1136/bmj.330.7484.158PMC544978 | β | β | β |
| OβConnellGLawrieSMMcIntoshAM (2011) Schizophrenia risk genes: Implications for future drug development and discovery. Biochem Pharmacol 81: 1367β1373.2109341710.1016/j.bcp.2010.11.009 | β | β | β |
| OβDonoghueTMorrisDWFaheyC (2014) Effects of ZNF804A on auditory P300 response in schizophrenia. Transl Psychiatry 4: e345.2442439110.1038/tp.2013.115PMC3905225 | β | β | β |
| OβDonovanMCCraddockNNortonN (2008) Identification of loci associated with schizophrenia by genome-wide association and follow-up. Nature Genet 40: 1053β1055.1867731110.1038/ng.201 | β | β | β |
| PaolettiPBelloneCZhouQ (2013) NMDA receptor subunit diversity: Impact on receptor properties, synaptic plasticity and disease. Nat Rev Neurosci 14: 383β400.2368617110.1038/nrn3504 | β | β | β |
| PapaleoFBurdickMCCallicottJH (2014) Epistatic interaction between COMT and DTNBP1 modulates prefrontal function in mice and in humans. Mol Psychiatry 19: 311β316.2414537610.1038/mp.2013.133PMC4845721 | β | β | β |
| PasquinelliAE (2012) MicroRNAs and their targets: Recognition, regulation and an emerging reciprocal relationship. Nat Rev Genet 13: 271β282.2241146610.1038/nrg3162 | β | β | β |
| PatersonCWangYKleinmanJE (2014) Effects of schizophrenia risk variation in the NRG1 gene on NRG1-IV splicing during fetal and early postnatal human neocortical development. Am J Psychiatry 171: 979β989.2493540610.1176/appi.ajp.2014.13111518PMC4330971 | β | β | β |
| PattersonPH (2009) Immune involvement in schizophrenia: Etiology, pathology and animal models. Behav Brain Res 204: 313β321.1913603110.1016/j.bbr.2008.12.016 | β | β | β |
| PhillipsPC (2008) Epistasis-the essential role of gene interactions in the structure and evolution of genetic systems. Nat Rev Genet 9: 855β867.1885269710.1038/nrg2452PMC2689140 | β | β | β |
| PlengeRMScolnickEMAltshulerD (2013) Validating therapeutic targets through human genetics. Nat Rev Drug Discov 12: 581β594.2386811310.1038/nrd4051 | β | β | β |
| PocklingtonAJOβDonovanMOwenMJ (2014) The synapse in schizophrenia. Eur J Neurosci 39: 1059β1067.2471298610.1111/ejn.12489 | β | β | β |
| PorteousDJThomsonPAMillarJK (2014) DISC1 as a genetic risk factor for schizophrenia and related major mental illness: Response to Sullivan. Mol Psychiatry 19: 141β143.2445752210.1038/mp.2013.160PMC4238281 | β | β | β |
| PrattJWinchesterCDawsonN (2012) Advancing schizophrenia drug discovery: Optimizing rodent models to bridge the translational gap. Nat Rev Drug Discov 11: 560β579.2272253210.1038/nrd3649 | β | β | β |
| PurcellSMMoranJLFromerM (2014) A polygenic burden of rare disruptive mutations in schizophrenia. Nature 506:185β190.2446350810.1038/nature12975PMC4136494 | β | β | β |
| PurcellSMWrayNMStoneJL (2009) Common polygenic variation contributes to risk of schizophrenia and bipolar disorder. Nature 460: 748β752.1957181110.1038/nature08185PMC3912837 | β | β | β |
| RasettiRSambataroFChenQ (2011) Altered cortical network dynamics: A potential intermediate phenotype for schizophrenia and association with ZNF804A. Arch Gen Psychiatry 68: 1207β1217.2181062810.1001/archgenpsychiatry.2011.103 | β | β | β |
| RazinSVBorunovaVVMaksimenkoOG (2012) Cys2His2 zinc finger protein family: Classification, functions, and major members. Biochemistry (Moscow) 77: 217β226.2280394010.1134/S0006297912030017 | β | β | β |
| ReesEWaltersJTRGeorgievaL (2014) Analysis of copy number variations at 15 schizophrenia-associated loci. Br J Psychiatry 204: 108β114.2431155210.1192/bjp.bp.113.131052PMC3909838 | β | β | β |
| RipkeSOβDushlaineCChambertK (2013) Genome-wide association analysis identifies 13 new risk loci for schizophrenia. Nat Genet 45: 1150β1159.2397487210.1038/ng.2742PMC3827979 | β | β | β |
| RossCATabriziSJ (2011) Huntingtonβs disease: From molecular pathogenesis to clinical treatment. Lancet Neurol 10: 83β98.2116344610.1016/S1474-4422(10)70245-3 | β | β | β |
| SanseauPAgarwalPBarnesMR (2012) Use of genome-wide association studies for drug repositioning. Nat Biotechnol 30: 317β320.2249127710.1038/nbt.2151 | β | β | β |
| SartoriusLJWeinbergerDRHydeTM (2008) Expression of a GRM3 splice variant is increased in the dorsolateral prefrontal cortex of individuals carrying a schizophrenia risk SNP. Neuropsychopharmacology 33: 2626β2634.1825659510.1038/sj.npp.1301669 | β | β | β |
| SchaubMABoyleAPKundajeA (2012) Linking disease associations with regulatory information in the human genome. Genome Res 22: 1748β1759.2295598610.1101/gr.136127.111PMC3431491 | β | β | β |
| Schizophrenia Working Group of the Psychiatric Genomics Consortium (2014) Biological insights from 108 schizophrenia-associated genomic loci. Nature 511: 421β427.2505606110.1038/nature13595PMC4112379 | β | β | β |
| SchneiderMDebbaneMBassettAS (2014) Psychiatric disorders from childhood to adulthood in 22q11.2 deletion syndrome: Results from the International Consortium on Brain and Behavior in 22q11.2 Deletion Syndrome. Am J Psychiatry 171: 627β639.2457724510.1176/appi.ajp.2013.13070864PMC4285461 | β | β | β |
| SolovieffNCotsapasCLeePH (2013) Pleiotropy in complex traits: Challenges and strategies. Nat Rev Genet 14: 483β495.2375279710.1038/nrg3461PMC4104202 | β | β | β |
| SullivanPF (2013) Questions about DISC1 as a genetic risk factor for schizophrenia. Mol Psychiatry 18: 1050β1052.2405690910.1038/mp.2012.182PMC3967792 | β | β | β |
| SullivanPFDalyMJOβDonovanM (2012) Genetic architectures of psychiatric disorders: The emerging picture and its implications. Nat Rev Genet 13: 537β551.2277712710.1038/nrg3240PMC4110909 | β | β | β |
| SullivanPFKendlerKSNealeMC (2003) Schizophrenia as a complex trait β Evidence from a meta-analysis of twin studies. Arch Gen Psychiatry 60: 1187β1192.1466255010.1001/archpsyc.60.12.1187 | β | β | β |
| TanWWangYGoldB (2007) Molecular cloning of a brain-specific, developmentally regulated neuregulin 1 (NRG1) isoform and identification of a functional promoter variant associated with schizophrenia. J Biol Chem 282: 24343β24351.1756598510.1074/jbc.M702953200 | β | β | β |
| TaoRCousijnHJaffeAE (2014) Expression of ZNF804A expression in human brain and alterations in schizophrenia, bipolar disorder and major depression: A novel transcript fetally regulated by the psychosis risk single nucleotide polymorphism rs1344706. JAMA Psychiatry 71: 1112β1120.2516254010.1001/jamapsychiatry.2014.1079PMC5894803 | β | β | β |
| TimmsAEDorschnerMOWechslerJ (2013) Support for the N-Methyl-D-Aspartate receptor hypofunction hypothesis of schizophrenia from exome sequencing in multiplex families. JAMA Psychiatry 70: 582β590.2355320310.1001/jamapsychiatry.2013.1195 | β | β | β |
| VanhaesebroeckBGuillermet-GuibertJGrauperaM (2010) The emerging mechanisms of isoform-specific PI3K signalling. Nat Rev Mol Cell Biol 11: 329β341.2037920710.1038/nrm2882 | β | β | β |
| VerrallLBurnetPWJBettsJF (2010) The neurobiology of D-amino acid oxidase and its involvement in schizophrenia. Mol Psychiatry 15: 122β137.1978696310.1038/mp.2009.99PMC2811712 | β | β | β |
| VisscherPMGoddardMEDerksEM (2012) Evidence-based psychiatric genetics, AKA the false dichotomy between common and rare variant hypotheses. Mol Psychiatry 17: 474β485.2167073010.1038/mp.2011.65 | β | β | β |
| WaltersJTRCorvinAOwenMJ (2010) Psychosis susceptibility gene ZNF804A and cognitive performance in schizophrenia. Arch Gen Psychiatry 67: 692β700.2060345010.1001/archgenpsychiatry.2010.81 | β | β | β |
| WangKSLiuXZhangQ (2011) Genome-wide association analysis of age at onset in schizophrenia in a European-American sample. Am J Med Genet B Neuropsychiatr Genet 156B: 671β680.2168838410.1002/ajmg.b.31209 | β | β | β |
| WhiteJAMcKinneyBCJohnMC (2008) Conditional forebrain deletion of the L-type calcium channel Cav1.2 disrupts remote spatial memories in mice. Learn Memory 15: 1β5.10.1101/lm.77320818174367 | β | β | β |
| WilliamsHJNortonNDwyerS (2011) Fine mapping of ZNF804A and genome-wide significant evidence for its involvement in schizophrenia and bipolar disorder. Mol Psychiatry 16: 429β441.2036870410.1038/mp.2010.36PMC3918934 | β | β | β |
| WinchesterCLPrattJAMorrisBJ (2014) Risk genes for schizophrenia: Translational opportunities for drug discovery. Pharmacol Therap 143: 34β50.2456113210.1016/j.pharmthera.2014.02.003 | β | β | β |
| WrightCTurnerJACalhounVD (2013) Potential impact of miR-137 and its targets in schizophrenia. Front Genet 4: 58.2363770410.3389/fgene.2013.00058PMC3636510 | β | β | β |
| XuBIonita-LazaIRoosJL (2012) De novo gene mutations highlight patterns of genetic and neural complexity in schizophrenia. Nat Genet 44: 1365β1369.2304211510.1038/ng.2446PMC3556813 | β | β | β |
| XuBRoosJLDexheimerP (2011) Exome sequencing supports a de novo mutational paradigm for schizophrenia. Nat Genet 43:864β868.2182226610.1038/ng.902PMC3196550 | β | β | β |
| ZhangJPMalhotraAK (2013) Pharmacogenetics of antipsychotics: Recent progress and methodological issues. Exp Rev Drug Metab Toxicol 9: 183β191.10.1517/17425255.2013.736964PMC354714623199282 | β | β | β |
| ZhengWHWangHTZengZW (2012) The possible role of the Akt signaling pathway in schizophrenia. Brain Res 1470: 145β168.2277171110.1016/j.brainres.2012.06.032 | β | β | β |
| ZuccottiAClementiSReinbotheT (2011) Structural and functional differences between L-type calcium channels: Crucial issues for future selective targeting. Trends Pharmacol Sci 32: 366β375.2145035210.1016/j.tips.2011.02.012 | β | β | β |
In this knowledge base
| Title | Year | PMID |
|---|---|---|
| Genetic correlates of the development of theta event related oscillationsΒ in adolescents and young adults. | 2017 | 27847216 |
External
| Title | Authors | Journal | Year | Link |
|---|---|---|---|---|
| Lactate restores PGC1Ξ± and BDNF expression rescuing cognitive impairments in a mouse model for schizophrenia. | Kambali M et al. | β | 2026 | β |
| SNP-based prediction of schizophrenia using machine learning. | Ramazanova Z et al. | β | 2026 | β |
| A Genome-Wide Association Study of First-Episode Psychosis: A Genetic Exploration in an Italian Cohort. | Treccani M et al. | β | 2025 | β |
| Maximising translational value of the Iowa gambling task in preclinical studies through the use of the rodent touchscreen. | Pratt JA et al. | β | 2025 | β |
| A comprehensive update on genetic inheritance, epigenetic factors, associated pathology, and recent therapeutic intervention by gene therapy in schizophrenia. | R R et al. | β | 2024 | β |
| Advances in the understanding of the pathophysiology of schizophrenia and bipolar disorder through induced pluripotent stem cell models. | Perrottelli A et al. | β | 2024 | β |
| Genetic mechanisms for impaired synaptic plasticity in schizophrenia revealed by computational modeling. | MΓ€ki-Marttunen T et al. | β | 2024 | β |
| MicroRNA dysregulation in glutamate and dopamine pathways of schizophrenia: From molecular pathways to diagnostic and therapeutic approaches. | Khosroshahi PA et al. | β | 2024 | β |
| The Underlying Neurobiological Mechanisms of Psychosis: Focus on Neurotransmission Dysregulation, Neuroinflammation, Oxidative Stress, and Mitochondrial Dysfunction. | Rawani NS et al. | β | 2024 | β |
| Biological hypotheses, risk factors, and biomarkers of schizophrenia. | FiΕ‘ar Z | β | 2023 | β |
| Brain transcriptome-wide association study implicates novel risk genes underlying schizophrenia risk. | Zhang C et al. | β | 2023 | β |
| Glutamatergic dysfunction leads to a hyper-dopaminergic phenotype through deficits in short-term habituation: a mechanism for aberrant salience. | Panayi MC et al. | β | 2023 | β |
| Prospects and Pitfalls of Plasma Complement C4 in Schizophrenia: Building a Better Biomarker. | Severance EG et al. | β | 2023 | β |
| Understanding neural development and diseases using CRISPR screens in human pluripotent stem cell-derived cultures. | Ahmed M et al. | β | 2023 | β |
| CACNA1C (Ca<sub>V</sub>1.2) and other L-type calcium channels in the pathophysiology and treatment of psychiatric disorders: Advances from functional genomics and pharmacoepidemiology. | Harrison PJ et al. | β | 2022 | β |
| Disease Modeling of Neurodegenerative Disorders Using Direct Neural Reprogramming. | Legault EM et al. | β | 2022 | β |
| Distinct contributions of GluA1-containing AMPA receptors of different hippocampal subfields to salience processing, memory and impulse control. | Kilonzo K et al. | β | 2022 | β |
| Exposure to Circadian Disruption During Adolescence Interacts With a Genetic Risk Factor to Modify Schizophrenia-relevant Behaviors in a Sex-dependent Manner. | Cloutier MΓ et al. | β | 2022 | β |
| GABRB2, a key player in neuropsychiatric disorders and beyond. | Barki M et al. | β | 2022 | β |
| Genes of the Glutamatergic System and Tardive Dyskinesia in Patients with Schizophrenia. | Fedorenko OY et al. | β | 2022 | β |
| Investigation of accelerated epigenetic aging in individuals suffering from schizophrenia in the context of lifetime suicide attempt. | Jeremian R et al. | β | 2022 | β |
| New drug targets in psychiatry: Neurobiological considerations in the genomics era. | Harrison PJ et al. | β | 2022 | β |
| Prioritization of risk genes in multiple sclerosis by a refined Bayesian framework followed by tissue-specificity and cell type feature assessment. | Liu A et al. | β | 2022 | β |
| Schizophrenia: a Narrative Review of Etiological and Diagnostic Issues. | Oskolkova S | β | 2022 | β |
| The druggable schizophrenia genome: from repurposing opportunities to unexplored drug targets. | Lago SG et al. | β | 2022 | β |
| Visual masking deficits in schizophrenia: a view into the genetics of the disease through an endophenotype. | Shaqiri A et al. | β | 2022 | β |
| Complement C4 associations with altered microbial biomarkers exemplify gene-by-environment interactions in schizophrenia. | Severance EG et al. | β | 2021 | β |
| Discrimination between 34 of 36 Possible Combinations of Three C>T SNP Genotypes in the <i>MGMT</i> Promoter by High Resolution Melting Analysis Coupled with Pyrosequencing Using A Single Primer Set. | Zappe K et al. | β | 2021 | β |
| Disorganization of Oscillatory Activity in Animal Models of Schizophrenia. | Speers LJ et al. | β | 2021 | β |
| Dysmaturation Observed as Altered Hippocampal Functional Connectivity at Rest Is Associated With the Emergence of Positive Psychotic Symptoms in Patients With 22q11 Deletion Syndrome. | Delavari F et al. | β | 2021 | β |
| Genetic contributors to risk of schizophrenia in the presence of a 22q11.2 deletion. | Cleynen I et al. | β | 2021 | β |
| In-vitro tumor microenvironment models containing physical and biological barriers for modelling multidrug resistance mechanisms and multidrug delivery strategies. | Rahmanian M et al. | β | 2021 | β |
| Relationship between <i>P2XR4</i> Gene Variants and the Risk of Schizophrenia in South-East of Iran: A Preliminary Case-Control Study and in Silico Analysis. | Nia MH et al. | β | 2021 | β |
| Sex-specific sensitivity to methamphetamine-induced schizophrenia-relevant behaviours in <i>neuregulin 1 type III</i> overexpressing mice. | Chesworth R et al. | β | 2021 | β |
| The Drosophila ortholog of the schizophrenia-associated CACNA1A and CACNA1B voltage-gated calcium channels regulate memory, sleep and circadian rhythms. | Hidalgo S et al. | β | 2021 | β |
| The implications of hypothalamic abnormalities for schizophrenia. | Bernstein HG et al. | β | 2021 | β |
| Towards in vivo imaging of functionally active 5-HT<sub>1A</sub> receptors in schizophrenia: concepts and challenges. | Razakarivony O et al. | β | 2021 | β |
| Understanding the excess psychosis risk in ethnic minorities: the impact of structure and identity. | Jongsma HE et al. | β | 2021 | β |
| Zebrafish Larvae Carrying a Splice Variant Mutation in cacna1d: A New Model for Schizophrenia-Like Behaviours? | Banono NS et al. | β | 2021 | β |
| Cell-Type-Specific Proteogenomic Signal Diffusion for Integrating Multi-Omics Data Predicts Novel Schizophrenia Risk Genes. | Torshizi AD et al. | β | 2020 | β |
| Critical review of the evidence base regarding theories conceptualising the aetiology of psychosis. | Riley M | β | 2020 | β |
| Dissecting the Epigenetic Changes Induced by Non-Antipsychotic Mood Stabilizers on Schizophrenia and Affective Disorders: A Systematic Review. | Gardea-Resendez M et al. | β | 2020 | β |
| Genetic polymorphisms of PIP5K2A and course of schizophrenia. | Poltavskaya EG et al. | β | 2020 | β |
| Human gene and disease associations for clinical-genomics and precision medicine research. | Ahmed Z et al. | β | 2020 | β |
| Impaired Potentiation of Theta Oscillations During a Visual Cortical Plasticity Paradigm in Individuals With Schizophrenia. | Hamilton HK et al. | β | 2020 | β |
| In Vitro and In Vivo Models for the Investigation of Potential Drugs Against Schizophrenia. | KoszΕa O et al. | β | 2020 | β |
| Rare copy number variants in individuals at clinical high risk for psychosis: Enrichment of synaptic/brain-related functional pathways. | Jagannath V et al. | β | 2020 | β |
| The behavioral and neurochemical characterization of a Drosophila dysbindin mutant supports the contribution of serotonin to schizophrenia negative symptoms. | Hidalgo S et al. | β | 2020 | β |
| The Gene Polymorphism of VMAT2 Is Associated with Risk of Schizophrenia in Male Han Chinese. | Han H et al. | β | 2020 | β |
| The origin of NMDA receptor hypofunction in schizophrenia. | Nakazawa K et al. | β | 2020 | β |
| Voltage-gated calcium channel blockers for psychiatric disorders: genomic reappraisal. | Harrison PJ et al. | β | 2020 | β |
| A Bayesian framework that integrates multi-omics data and gene networks predicts risk genes from schizophrenia GWAS data. | Wang Q et al. | β | 2019 | β |
| Association of rs4680 <i>COMT</i>, rs6280 <i>DRD3</i>, and rs7322347 <i>5HT2A</i> With Clinical Features of Youth-Onset Schizophrenia. | Morozova A et al. | β | 2019 | β |
| Case Report of Childhood-Onset Psychosis in a Patient with a Known WNT10A Mutation. | Kobza AO et al. | β | 2019 | β |
| Genotype Variations of rs13381800 in TCF4 Gene and rs17039988 in NRXN1 Gene among a Sample of Iranian Patients with Schizophrenia. | Agahi M et al. | β | 2019 | β |
| Integrative Transcriptomics Reveals Sexually Dimorphic Control of the Cholinergic/Neurokine Interface in Schizophrenia and Bipolar Disorder. | Lobentanzer S et al. | β | 2019 | β |
| Machine learning in schizophrenia genomics, a case-control study using 5,090 exomes. | Trakadis YJ et al. | β | 2019 | β |
| Multi-scale analysis of schizophrenia risk genes, brain structure, and clinical symptoms reveals integrative clues for subtyping schizophrenia patients. | Ma L et al. | β | 2019 | β |
| NMDAR Hypofunction Animal Models of Schizophrenia. | Lee G et al. | β | 2019 | β |
| Prenatal Maternal Stress and the Cascade of Risk to Schizophrenia Spectrum Disorders in Offspring. | Lipner E et al. | β | 2019 | β |
| Targeted Treatment of Individuals With Psychosis Carrying a Copy Number Variant Containing a Genomic Triplication of the Glycine Decarboxylase Gene. | Bodkin JA et al. | β | 2019 | β |
| The current status of the magnocellular theory of developmental dyslexia. | Stein J | β | 2019 | β |
| The Emerging Neurobiology of Bipolar Disorder. | Harrison PJ et al. | β | 2019 | β |
| Therapeutic potential and underlying mechanism of sarcosine (N-methylglycine) in N-methyl-D-aspartate (NMDA) receptor hypofunction models of schizophrenia. | Pei JC et al. | β | 2019 | β |
| The role of polygenic risk score gene-set analysis in the context of the omnigenic model of schizophrenia. | Rammos A et al. | β | 2019 | β |
| The Stanley Neuropathology Consortium Integrative Database (SNCID) for Psychiatric Disorders. | Kim S et al. | β | 2019 | β |
| Acquisition of nicotine self-administration in amphetamine and phencyclidine models of schizophrenia: A role for stress? | Fletcher PJ et al. | β | 2018 | β |
| A polygenic risk score analysis of psychosis endophenotypes across brain functional, structural, and cognitive domains. | Ranlund S et al. | β | 2018 | β |
| Association between B vitamins and schizophrenia: A population-based case-control study. | Cao B et al. | β | 2018 | β |
| Associations between polygenic risk scores for four psychiatric illnesses and brain structure using multivariate pattern recognition. | Ranlund S et al. | β | 2018 | β |
| Associations between psychosis endophenotypes across brain functional, structural, and cognitive domains. | Blakey R et al. | β | 2018 | β |
| Axon guidance pathway genes are associated with schizophrenia risk. | Wang Z et al. | β | 2018 | β |
| Discovery of Novel Aminotetralines and Aminochromanes as Selective and Competitive Glycine Transporter 1 (GlyT1) Inhibitors. | Amberg W et al. | β | 2018 | β |
| DNA Methylation as a Biomarker of Treatment Response Variability in Serious Mental Illnesses: A Systematic Review Focused on Bipolar Disorder, Schizophrenia, and Major Depressive Disorder. | Goud Alladi C et al. | β | 2018 | β |
| Gabrb2-knockout mice displayed schizophrenia-like and comorbid phenotypes with interneuron-astrocyte-microglia dysregulation. | Yeung RK et al. | β | 2018 | β |
| Genetic variability in scaffolding proteins and risk for schizophrenia and autism-spectrum disorders: a systematic review. | Soler J et al. | β | 2018 | β |
| Hippocampal dysfunction in the pathophysiology of schizophrenia: a selective review and hypothesis for early detection and intervention. | Lieberman JA et al. | β | 2018 | β |
| Imaging genetics of schizophrenia in the post-GWAS era. | Arslan A | β | 2018 | β |
| Mapping the Schizophrenia Genes by Neuroimaging: The Opportunities and the Challenges. | Arslan A | β | 2018 | β |
| Mini-review: Update on the genetics of schizophrenia. | Coelewij L et al. | β | 2018 | β |
| Patient Similarity Networks for Precision Medicine. | Pai S et al. | β | 2018 | β |
| Potential and Challenges for the Clinical Use of d-Serine As a Cognitive Enhancer. | Guercio GD et al. | β | 2018 | β |
| Pre- and Perinatal Risk Factors for Serious Mental Disorders: Ethical Considerations in Prevention and Prediction Efforts. | Ellman LM et al. | β | 2018 | β |
| SULFATION PATHWAYS: The steroid sulfate axis and its relationship to maternal behaviour and mental health. | Davies W | β | 2018 | β |
| The effect of the DISC1 Ser704Cys polymorphism on striatal dopamine synthesis capacity: an [18F]-DOPA PET study. | Dahoun T et al. | β | 2018 | β |
| The Emerging Neurobiology of Bipolar Disorder. | Harrison PJ et al. | β | 2018 | β |
| The interaction between cannabis use and the Val158Met polymorphism of the COMT gene in psychosis: A transdiagnostic meta - analysis. | Vaessen TSJ et al. | β | 2018 | β |
| Use of schizophrenia and bipolar disorder polygenic risk scores to identify psychotic disorders. | Calafato MS et al. | β | 2018 | β |
| A group II metabotropic glutamate receptor 3 (mGlu3, GRM3) isoform implicated in schizophrenia interacts with canonical mGlu3 and reduces ligand binding. | GarcΓa-Bea A et al. | β | 2017 | β |
| Altered cytokine profile, pain sensitivity, and stress responsivity in mice with co-disruption of the developmental genes Neuregulin-1ΓDISC1. | Desbonnet L et al. | β | 2017 | β |
| Animal models for neuropsychiatric disorders: prospects for circuit intervention. | Kaiser T et al. | β | 2017 | β |
| Applications of CRISPR/Cas9 in the Mammalian Central Nervous System. | Savell KE et al. | β | 2017 | β |
| Association Between NOS1 Gene Polymorphisms and Schizophrenia in Asian and Caucasian Populations: A Meta-Analysis. | Ahmed SSSJ et al. | β | 2017 | β |
| Associations between SNPs and immune-related circulating proteins in schizophrenia. | Chan MK et al. | β | 2017 | β |
| Effects of Immune Activation during Early or Late Gestation on <i>N</i>-Methyl-d-Aspartate Receptor Measures in Adult Rat Offspring. | Rahman T et al. | β | 2017 | β |
| Epistatic and Independent Effects on Schizophrenia-Related Phenotypes Following Co-disruption of the Risk Factors Neuregulin-1 Γ DISC1. | O'Tuathaigh CM et al. | β | 2017 | β |
| Exome sequences of multiplex, multigenerational families reveal schizophrenia risk loci with potential implications for neurocognitive performance. | Kos MZ et al. | β | 2017 | β |
| Genetic correlates of the development of theta event related oscillationsΒ in adolescents and young adults. | Chorlian DB et al. | β | 2017 | β |
| Prevalence and clinical characteristics of serum neuronal cell surface antibodies in first-episode psychosis: a case-control study. | Lennox BR et al. | β | 2017 | β |
| Rare Genome-Wide Copy Number Variation and Expression of Schizophrenia in 22q11.2 Deletion Syndrome. | Bassett AS et al. | β | 2017 | β |
| Structural Analysis of G1691S Variant in the Human Filamin B Gene Responsible for Larsen Syndrome: A Comparative Computational Approach. | P S et al. | β | 2017 | β |
| The DAOA gene is associated with schizophrenia in the Taiwanese population. | Chu CS et al. | β | 2017 | β |
| The impact of genetics on future drug discovery in schizophrenia. | Matsumoto M et al. | β | 2017 | β |
| Translating advances in the molecular basis of schizophrenia into novel cognitive treatment strategies. | O'Tuathaigh CMP et al. | β | 2017 | β |
| ZNF804A: Insights From the First Genome-wide Significant Schizophrenia Gene. | Harrison PJ | β | 2017 | β |
| Animal models of gene-environment interaction in schizophrenia: A dimensional perspective. | Ayhan Y et al. | β | 2016 | β |
| Common variants on 17q25 and gene-gene interactions conferring risk of schizophrenia in Han Chinese population and regulating gene expressions in human brain. | Guan L et al. | β | 2016 | β |
| DNA methylation in a Scottish family multiply affected by bipolar disorder and major depressive disorder. | Walker RM et al. | β | 2016 | β |
| Down-Regulation of Hippocampal Genes Regulating Dopaminergic, GABAergic, and Glutamatergic Function Following Combined Neonatal Phencyclidine and Post-Weaning Social Isolation of Rats as a Neurodevelopmental Model for Schizophrenia. | Gaskin PL et al. | β | 2016 | β |
| Epigenetic Treatment of Neuropsychiatric Disorders: Autism and Schizophrenia. | Moos WH et al. | β | 2016 | β |
| Gene Γ Environment Interactions in Schizophrenia: Evidence from Genetic Mouse Models. | Moran P et al. | β | 2016 | β |
| Gene-set analysis based on the pharmacological profiles of drugs to identify repurposing opportunities in schizophrenia. | de Jong S et al. | β | 2016 | β |
| High-resolution DNA accessibility profiles increase the discovery and interpretability of genetic associations | Madar A et al. | β | 2016 | β |
| Innovative approaches to bipolar disorder and its treatment. | Harrison PJ et al. | β | 2016 | β |
| Metabotropic glutamate receptor 3 (mGlu3; mGluR3; GRM3) in schizophrenia: Antibody characterisation and a semi-quantitative western blot study. | GarcΓa-Bea A et al. | β | 2016 | β |
| Molecular neurobiological clues to the pathogenesis of bipolar disorder. | Harrison PJ | β | 2016 | β |
| omicsNPC: Applying the Non-Parametric Combination Methodology to the Integrative Analysis of Heterogeneous Omics Data. | Karathanasis N et al. | β | 2016 | β |
| Systems psychopharmacology: A network approach to developing novel therapies. | Gebicke-Haerter PJ | β | 2016 | β |
| Therapeutic improvements expected in the near future for schizophrenia and schizoaffective disorder: an appraisal of phase III clinical trials of schizophrenia-targeted therapies as found in US and EU clinical trial registries. | Garay RP et al. | β | 2016 | β |
| Hippocampal-Prefrontal Interactions in Cognition, Behavior and Psychiatric Disease. | Sigurdsson T et al. | β | 2015 | β |
| Ketamine and phencyclidine: the good, the bad and the unexpected. | Lodge D et al. | β | 2015 | β |
| Translational psychiatry--light at the end of the tunnel. | Jones KA et al. | β | 2015 | β |
| Understanding the genetic architectonics of complex CNS traits: Lost by the association, but found in the interaction? | Stewart AM et al. | β | 2015 | β |