Involvement of the endocannabinoid system in drug addiction.
paper
Cited
Public
Unavailable
- Authors
- Maldonado, Rafael; Valverde, Olga; Berrendero, Fernando
- Year
- 2006
- Journal
- Trends in neurosciences
- PMID
- 16483675
- DOI
- 10.1016/j.tins.2006.01.008
Recent studies have shown that the endocannabinoid system is involved in the common neurobiological mechanism underlying drug addiction. This system participates in the primary rewarding effects of cannabinoids, nicotine, alcohol and opioids, through the release of endocannabinoids in the ventral tegmental area. Endocannabinoids are also involved in the motivation to seek drugs by a dopamine-independent mechanism, demonstrated for psychostimulants and opioids. The endocannabinoid system also participates in the common mechanisms underlying relapse to drug-seeking behaviour by mediating the motivational effects of drug-related environmental stimuli and drug re-exposure. In agreement, clinical trials have suggested that the CB(1) cannabinoid antagonist rimonabant can cause smoking cessation. Thus, CB(1) cannabinoid antagonists could represent a new generation of compounds to treat drug addiction.
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|---|---|---|---|---|
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| The effect of methamphetamine and 3,4-methylenedioxymethamphetamine on peripheral endocannabinoid concentrations: a study in healthy adults. | Deutsch A et al. | β | 2026 | β |
| Changes in peripheral endocannabinoid levels in substance use disorders: a review of clinical evidence. | Elliott GO et al. | β | 2025 | β |
| Effect of cannabinol, tetrahydrocannabivarin and cannabidiol on voluntary alcohol consumption | Poceviciute I et al. | β | 2025 | β |
| High-intensity interval training exercise decreases brain CB1 receptor levels in male and female adult rats. | Tyler J et al. | β | 2025 | β |
| Role of interplay between endocannabinoids and neuropeptides in pathogenesis and therapy of depressive and anxiety disorders. | GoΕyszny M et al. | β | 2025 | β |
| Therapeutic potential of minor cannabinoids in psychiatric disorders: A systematic review. | CammΓ G et al. | β | 2025 | β |
| Cannabidiol Protects against the Reinstatement of Oxycodone-Induced Conditioned Place Preference in Adolescent Male but Not Female Rats: The Role of MOR and CB1R. | Socha J et al. | β | 2024 | β |
| G protein-coupled receptor (GPCR) pharmacogenomics. | Thompson MD et al. | β | 2024 | β |
| Negative allosteric modulation of CB1 cannabinoid receptor signalling decreases intravenous morphine self-administration and relapse in mice. | Oliva I et al. | β | 2024 | β |
| Neurobiology of Stress-Induced Nicotine Relapse. | Wang X et al. | β | 2024 | β |
| Context-dependent effects of the CB1 receptor antagonist rimonabant on morphine-induced behavioral sensitization in female mice. | Marinho EAV et al. | β | 2023 | β |
| Cross-talk between neurosteroid and endocannabinoid systems in cannabis addiction. | Raux PL et al. | β | 2023 | β |
| Crosstalk between the endocannabinoid and mid-brain dopaminergic systems: Implication in dopamine dysregulation. | Kibret BG et al. | β | 2023 | β |
| Endocannabinoids at the synapse and beyond: implications for neuropsychiatric disease pathophysiology and treatment. | Scheyer A et al. | β | 2023 | β |
| Endocannabinoid system as a therapeutic target for psychostimulants relapse: A systematic review of preclinical studies. | Karimi-Haghighi S et al. | β | 2023 | β |
| Exploring the influence of circulating endocannabinoids and nucleus accumbens functional connectivity on anorexia nervosa severity. | Miranda-Olivos R et al. | β | 2023 | β |
| Oleoylethanolamide attenuates cocaine-primed reinstatement and alters dopaminergic gene expression in the striatum. | GonzΓ‘lez-Portilla M et al. | β | 2023 | β |
| Oral Cannabidiol does not alter Alcohol SeekingΒ and Self-Administration in Baboons. | Moore CF et al. | β | 2023 | β |
| Biomarkers of the Endocannabinoid System in Substance Use Disorders. | Navarrete F et al. | β | 2022 | β |
| Cellular and behavioral basis of cannabinioid and opioid interactions: Implications for opioid dependence and withdrawal. | Mohammadkhani A et al. | β | 2022 | β |
| Co-exposure of cannabinoids with amphetamines and biological, behavioural and health outcomes: a scoping review of animal and human studies. | Daldegan-Bueno D et al. | β | 2022 | β |
| Considerations for Cannabinoids in Perioperative Care by Anesthesiologists. | Laudanski K et al. | β | 2022 | β |
| Differential Effects of the Lateral Hypothalamus Lesion as an Origin of Orexin and Blockade of Orexin-1 Receptor in the Orbitofrontal Cortex and Anterior Cingulate Cortex on Their Neuronal Activity. | Karimi S et al. | β | 2022 | β |
| Hippocampal Cannabinoid 1 Receptors Are Modulated Following Cocaine Self-administration in Male Rats. | De Sa Nogueira D et al. | β | 2022 | β |
| Mepirapim, a Novel Synthetic Cannabinoid, Induces Addiction-Related Behaviors through Neurochemical Maladaptation in the Brain of Rodents. | Hur KH et al. | β | 2022 | β |
| Natural Products for the Treatment of Drug Addiction: Narrative Review. | Raslan MA | β | 2022 | β |
| Negative allosteric modulation of CB<sub>1</sub> cannabinoid receptor signaling suppresses opioid-mediated reward. | Iyer V et al. | β | 2022 | β |
| Neutral CB1 Receptor Antagonists as Pharmacotherapies for Substance Use Disorders: Rationale, Evidence, and Challenge. | Soler-Cedeno O et al. | β | 2022 | β |
| Proteomic profiling of postmortem prefrontal cortex tissue of suicide completers. | Kim MJ et al. | β | 2022 | β |
| Repeated cocaine administration upregulates CB<sub>2</sub> receptor expression in striatal medium-spiny neurons that express dopamine D<sub>1</sub> receptors in mice. | Zhang HY et al. | β | 2022 | β |
| The Role of Ghrelin/GHS-R1A Signaling in Nonalcohol Drug Addictions. | Sustkova-Fiserova M et al. | β | 2022 | β |
| Binge sucrose-induced neuroadaptations: A focus on the endocannabinoid system. | de Sa Nogueira D et al. | β | 2021 | β |
| Cannabinoid-Induced Conditioned Place Preference, Intravenous Self-Administration, and Behavioral Stimulation Influenced by Ghrelin Receptor Antagonism in Rats. | Charalambous C et al. | β | 2021 | β |
| Cocaine-induced increases in motivation require 2-arachidonoylglycerol mobilization and CB1 receptor activation in the ventral tegmental area. | Engi SA et al. | β | 2021 | β |
| Dependence-like behaviour in patients treated for medication overuse headache: A prospective open-label randomized controlled trial. | Rouw C et al. | β | 2021 | β |
| Early-life stress exacerbates the effects of WIN55,212-2 and modulates the cannabinoid receptor type 1 expression. | MartΓn-SΓ‘nchez A et al. | β | 2021 | β |
| Effects of High-Fat Diet and Maternal Binge-Like Alcohol Consumption and Their Influence on Cocaine Response in Female Mice Offspring. | Duart-Castells L et al. | β | 2021 | β |
| New Disulfiram Derivatives as MAGL-Selective Inhibitors. | Omran Z | β | 2021 | β |
| Optogenetic brain-stimulation reward: A new procedure to re-evaluate the rewarding versus aversive effects of cannabinoids in dopamine transporter-Cre mice. | Humburg BA et al. | β | 2021 | β |
| Pharmacology and adverse effects of new psychoactive substances: synthetic cannabinoid receptor agonists. | Chung EY et al. | β | 2021 | β |
| Region-specific dysregulation of endocannabinoid system in learned helplessness model of depression. | Huang W et al. | β | 2021 | β |
| Role of Cannabidiol in the Therapeutic Intervention for Substance Use Disorders. | Navarrete F et al. | β | 2021 | β |
| Suppressing effect of the novel positive allosteric modulator of the GABA<sub>B</sub> receptor, COR659, on locomotor hyperactivity induced by different drugs of abuse. | Lobina C et al. | β | 2021 | β |
| Alterations in Rat Accumbens Dopamine, Endocannabinoids and GABA Content During WIN55,212-2 Treatment: The Role of Ghrelin. | Charalambous C et al. | β | 2020 | β |
| Assessing physiological dependence and withdrawal potential of mitragynine using schedule-controlled behaviour in rats. | Harun N et al. | β | 2020 | β |
| Cannabinoid receptor modulation changes the accumbal neuronal responses to morphine in the reinstatement of morphine-induced conditioned place preference. | Khaleghzadeh-Ahangar H et al. | β | 2020 | β |
| Crosstalk between Opioid and Anti-Opioid Systems: An Overview and Its Possible Therapeutic Significance. | Gibula-Tarlowska E et al. | β | 2020 | β |
| Ghrelin receptor antagonism of fentanyl-induced conditioned place preference, intravenous self-administration, and dopamine release in the nucleus accumbens in rats. | Sustkova-Fiserova M et al. | β | 2020 | β |
| Interaction of Cannabis Use and Aging: From Molecule to Mind. | Yoo HB et al. | β | 2020 | β |
| Monoacylglycerol lipase inhibitors: modulators for lipid metabolism in cancer malignancy, neurological and metabolic disorders. | Deng H et al. | β | 2020 | β |
| Neurochemical Evidence of Preclinical and Clinical Reports on Target-Based Therapy in Alcohol Used Disorder. | Prajapati SK et al. | β | 2020 | β |
| New Insights Into Peptide Cannabinoids: Structure, Biosynthesis and Signaling. | Riquelme-Sandoval A et al. | β | 2020 | β |
| Targeting the endocannabinoid system: a predictive, preventive, and personalized medicine-directed approach to the management of brain pathologies. | Reddy V et al. | β | 2020 | β |
| The therapeutic potential of exercise for neuropsychiatric diseases: A review. | Swenson S et al. | β | 2020 | β |
| Understanding the neurobiological effects of drug abuse: Lessons from zebrafish models. | MΓΌller TE et al. | β | 2020 | β |
| Alcohol, tobacco, and marijuana consumption is associated with increased odds of same-day substance co- and tri-use. | Roche DJO et al. | β | 2019 | β |
| Behavioral effects of psychostimulants in mutant mice with cell-type specific deletion of CB2 cannabinoid receptors in dopamine neurons. | Canseco-Alba A et al. | β | 2019 | β |
| Brain activity of anandamide: a rewarding bliss? | Scherma M et al. | β | 2019 | β |
| Cannabinoid CB<sub>1</sub> and CB<sub>2</sub> receptor mechanisms underlie cannabis reward and aversion in rats. | Spiller KJ et al. | β | 2019 | β |
| CB1R mediates oleamide's reward while 5HT2cR mediates aversion in the nucleus accumbens shell of rats. | MΓ©ndez-DΓaz M et al. | β | 2019 | β |
| Diarylureas Containing 5-Membered Heterocycles as CB<sub>1</sub> Receptor Allosteric Modulators: Design, Synthesis, and Pharmacological Evaluation. | Nguyen T et al. | β | 2019 | β |
| Ketamine induces central antinociception mediated by endogenous cannabinoids and activation of CB<sub>1</sub> receptors. | Pacheco DDF et al. | β | 2019 | β |
| Opposing roles of CB<sub>1</sub> and CB<sub>2</sub> cannabinoid receptors in the stimulant and rewarding effects of cocaine. | Gobira PH et al. | β | 2019 | β |
| Orexin 1 receptors in the anterior cingulate and orbitofrontal cortex regulate cost and benefit decision-making. | Karimi S et al. | β | 2019 | β |
| Potential of Cannabinoid Receptor Ligands as Treatment for Substance Use Disorders. | Galaj E et al. | β | 2019 | β |
| Progress in brain cannabinoid CB<sub>2</sub> receptor research: From genes to behavior. | Jordan CJ et al. | β | 2019 | β |
| Review: brain neurobiology of gambling disorder based on rodent models. | Quintero Garzola GC | β | 2019 | β |
| Reward, Control & Decision-Making in Cannabis Use Disorder: Insights from Functional MRI. | Fatima H et al. | β | 2019 | β |
| Surrogate analyte-based quantification of main endocannabinoids in whole blood using liquid chromatography-tandem mass spectrometry. | Dong X et al. | β | 2019 | β |
| The Endocannabinoid System and Cannabidiol's Promise for the Treatment of Substance Use Disorder. | Chye Y et al. | β | 2019 | β |
| The impact of sugar consumption on stress driven, emotional and addictive behaviors. | Jacques A et al. | β | 2019 | β |
| The modulatory role of nicotine on cognitive and non-cognitive functions. | Zarrindast MR et al. | β | 2019 | β |
| The Potential of Cannabidiol as a Treatment for Psychosis and Addiction: Who Benefits Most? A Systematic Review. | Batalla A et al. | β | 2019 | β |
| Ξ<sup>8</sup> -Tetrahydrocannabivarin has potent anti-nicotine effects in several rodent models of nicotine dependence. | Xi ZX et al. | β | 2019 | β |
| 2-Arachidonoylglycerol: A signaling lipid with manifold actions in the brain. | Baggelaar MP et al. | β | 2018 | β |
| Adolescent cannabinoid exposure effects on natural reward seeking and learning in rats. | Schoch H et al. | β | 2018 | β |
| Allosteric modulators of cannabinoid receptor 1: developing compounds for improved specificity. | Dopart R et al. | β | 2018 | β |
| Cannabidiol as a Therapeutic Alternative for Post-traumatic Stress Disorder: From Bench Research to Confirmation in Human Trials. | Bitencourt RM et al. | β | 2018 | β |
| Development of novel oxazolo[5,4-d]pyrimidines as competitive CB<sub>2</sub> neutral antagonists based on scaffold hopping. | Tuo W et al. | β | 2018 | β |
| Dose-Response Effect of Antibodies to S100 Protein and Cannabinoid Receptor Type 1 in Released-Active Form in the Light-Dark Test in Mice. | Kardash EV et al. | β | 2018 | β |
| Effects of Cannabinoid Drugs on Aversive or Rewarding Drug-Associated Memory Extinction and Reconsolidation. | Stern CAJ et al. | β | 2018 | β |
| Hedonic Eating and the "Delicious Circle": From Lipid-Derived Mediators to Brain Dopamine and Back. | Coccurello R et al. | β | 2018 | β |
| Highway to hell or magic smoke? The dose-dependence of Ξ<sup>9</sup>-THC in place conditioning paradigms. | Kubilius RA et al. | β | 2018 | β |
| Marijuana use among US tobacco users: Findings from wave 1 of the population assessment of tobacco health (PATH) study. | Strong DR et al. | β | 2018 | β |
| Modulatory role of the intra-accumbal CB1 receptor in protein level of the c-fos and pCREB/CREB ratio in the nucleus accumbens and ventral tegmental area in extinction and morphine seeking in the rats. | Khaleghzadeh-Ahangar H et al. | β | 2018 | β |
| Pediatric obesity: Current concepts. | Greydanus DE et al. | β | 2018 | β |
| Pharmacology for obesity: perspectives of history. | Greydanus DE et al. | β | 2018 | β |
| Role of the endocannabinoid system in drug addiction. | Manzanares J et al. | β | 2018 | β |
| The Modulating Role of Sex and Anabolic-Androgenic Steroid Hormones in Cannabinoid Sensitivity. | Struik D et al. | β | 2018 | β |
| Alterations in Rat Accumbens Endocannabinoid and GABA Content during Fentanyl Treatment: The Role of Ghrelin. | Sustkova-Fiserova M et al. | β | 2017 | β |
| Cannabinoid 1 receptor blockade in the dorsal hippocampus prevents the reinstatement but not acquisition of morphine-induced conditioned place preference in rats. | Zhao X et al. | β | 2017 | β |
| CB1 Receptor Activation on VgluT2-Expressing Glutamatergic Neurons Underlies Ξ<sup>9</sup>-Tetrahydrocannabinol (Ξ<sup>9</sup>-THC)-Induced Aversive Effects in Mice. | Han X et al. | β | 2017 | β |
| CB<sub>1</sub> Cannabinoid Receptors Mediate Cognitive Deficits and Structural Plasticity Changes During Nicotine Withdrawal. | Saravia R et al. | β | 2017 | β |
| Differential expression of endocannabinoid system-related genes in the dorsal hippocampus following expression and reinstatement of morphine conditioned place preference in mice. | Li W et al. | β | 2017 | β |
| Effects of nicotine on homeostatic and hedonic components of food intake. | Stojakovic A et al. | β | 2017 | β |
| Endocannabinoid and Mood Responses to Exercise in Adults with Varying Activity Levels. | Brellenthin AG et al. | β | 2017 | β |
| Genetic or pharmacological depletion of cannabinoid CB1 receptor protects against dopaminergic neurotoxicity induced by methamphetamine in mice. | Dang DK et al. | β | 2017 | β |
| Intra-accumbal Cannabinoid Agonist Attenuated Reinstatement but not Extinction Period of Morphine-Induced Conditioned Place Preference; Evidence for Different Characteristics of Extinction Period and Reinstatement. | Khaleghzadeh-Ahangar H et al. | β | 2017 | β |
| MECHANISMS IN ENDOCRINOLOGY: Endocannabinoids and metabolism: past, present and future. | Simon V et al. | β | 2017 | β |
| Neuromodulatory effects of the dorsal hippocampal endocannabinoid system in dextromethorphan/morphine-induced amnesia. | Ghasemzadeh Z et al. | β | 2017 | β |
| Obesity: Current and potential pharmacotherapeutics and targets. | Narayanaswami V et al. | β | 2017 | β |
| The CB1 Receptor as the Cornerstone of Exostasis. | Piazza PV et al. | β | 2017 | β |
| Acute and chronic effects of cannabinoids on effort-related decision-making and reward learning: an evaluation of the cannabis 'amotivational' hypotheses. | Lawn W et al. | β | 2016 | β |
| A role for the endocannabinoid 2-arachidonoyl-sn-glycerol for social and high-fat food reward in male mice. | Wei D et al. | β | 2016 | β |
| Behavioral sensitization to ethanol: Neural basis and factors that influence its acquisition and expression. | Camarini R et al. | β | 2016 | β |
| Cannabinoid Receptors in the Central Nervous System: Their Signaling and Roles in Disease. | Kendall DA et al. | β | 2016 | β |
| CB1 Cannabinoid Agonist (WIN55,212-2) Within the Basolateral Amygdala Induced Sensitization to Morphine and Increased the Level of ΞΌ-Opioid Receptor and c-fos in the Nucleus Accumbens. | Molaei M et al. | β | 2016 | β |
| Chronic ethanol exposure decreases CB1 receptor function at GABAergic synapses in the rat central amygdala. | Varodayan FP et al. | β | 2016 | β |
| Comorbid Cannabis and Tobacco Use in Adolescents and Adults. | Subramaniam P et al. | β | 2016 | β |
| Differential Control of Cocaine Self-Administration by GABAergic and Glutamatergic CB1 Cannabinoid Receptors. | MartΓn-GarcΓa E et al. | β | 2016 | β |
| Does marijuana "blunt" smoking contribute to nicotine exposure?: Preliminary product testing of nicotine content in wrappers of cigars commonly used for blunt smoking. | Peters EN et al. | β | 2016 | β |
| Effects of cannabinoids and their receptors on viral infections. | Tahamtan A et al. | β | 2016 | β |
| Effects of various cannabinoid ligands on choice behaviour in a rat model of gambling. | Gueye AB et al. | β | 2016 | β |
| Endocannabinoid system: Role in depression, reward and pain control (Review). | Huang WJ et al. | β | 2016 | β |
| Examination of the Addictive and Behavioral Properties of Fatty Acid-Binding Protein Inhibitor SBFI26. | Thanos PK et al. | β | 2016 | β |
| From Phytocannabinoids to Cannabinoid Receptors and Endocannabinoids: Pleiotropic Physiological and Pathological Roles Through Complex Pharmacology. | Ligresti A et al. | β | 2016 | β |
| Inhibition of monoacylglycerol lipase (MAGL) enhances cue-induced reinstatement of nicotine-seeking behavior in mice. | Trigo JM et al. | β | 2016 | β |
| Marijuana Use Is Associated with Behavioral Approach and Depressive Symptoms in Adolescents and Emerging Adults. | Wright NE et al. | β | 2016 | β |
| Morphine-induced locomotor sensitization produces structural plasticity in the mesocorticolimbic system dependent on CB1-R activity. | Guegan T et al. | β | 2016 | β |
| New insights on the role of the endocannabinoid system in the regulation of energy balance. | Gatta-Cherifi B et al. | β | 2016 | β |
| Opposite regulation of cannabinoid CB1 and CB2 receptors in the prefrontal cortex of rats treated with cocaine during adolescence. | GarcΓa-Cabrerizo R et al. | β | 2016 | β |
| Putative Epigenetic Involvement of the Endocannabinoid System in Anxiety- and Depression-Related Behaviors Caused by Nicotine as a Stressor. | Hayase T | β | 2016 | β |
| Sex differences in drug addiction and response to exercise intervention: From human to animal studies. | Zhou Y et al. | β | 2016 | β |
| The CB1 Neutral Antagonist AM4113 Retains the Therapeutic Efficacy of the Inverse Agonist Rimonabant for Nicotine Dependence and Weight Loss with Better Psychiatric Tolerability. | Gueye AB et al. | β | 2016 | β |
| Triglyceride sensing in the reward circuitry: A new insight in feeding behaviour regulation. | Cansell C et al. | β | 2016 | β |
| Alterations of monetary reward and punishment processing in chronic cannabis users: an FMRI study. | Enzi B et al. | β | 2015 | β |
| Altered CB1 receptor coupling to G-proteins in the post-mortem caudate nucleus and cerebellum of alcoholic subjects. | Erdozain AM et al. | β | 2015 | β |
| Blocking of fatty acid amide hydrolase activity with PF-04457845 in human brain: a positron emission tomography study with the novel radioligand [(11)C]CURB. | Boileau I et al. | β | 2015 | β |
| Cannabis and Exercise Science: A Commentary on Existing Studies and Suggestions for Future Directions. | Gillman AS et al. | β | 2015 | β |
| Common single nucleotide variants underlying drug addiction: more than a decade of research. | BΓΌhler KM et al. | β | 2015 | β |
| Distribution of the Endocannabinoid System in the Central Nervous System. | Hu SS et al. | β | 2015 | β |
| Effects of rimonabant on the development of single dose-induced behavioral sensitization to ethanol, morphine and cocaine in mice. | Marinho EA et al. | β | 2015 | β |
| Elucidating cannabinoid biology in zebrafish (Danio rerio). | Krug RG et al. | β | 2015 | β |
| Endocannabinoids and Metabolic Disorders. | Gatta-Cherifi B et al. | β | 2015 | β |
| Endocannabinoid Signaling in Motivation, Reward, and Addiction: Influences on Mesocorticolimbic Dopamine Function. | Sagheddu C et al. | β | 2015 | β |
| Endocannabinoids Induce Lateral Long-Term Potentiation of Transmitter Release by Stimulation of Gliotransmission. | GΓ³mez-Gonzalo M et al. | β | 2015 | β |
| Genetic Versus Pharmacological Assessment of the Role of Cannabinoid Type 2 Receptors in Alcohol Reward-Related Behaviors. | Powers MS et al. | β | 2015 | β |
| Inhibition of monoacylglycerol lipase reduces nicotine withdrawal. | Muldoon PP et al. | β | 2015 | β |
| Interactions of the opioid and cannabinoid systems in reward: Insights from knockout studies. | Befort K | β | 2015 | β |
| Intra-accumbal CB1 receptor blockade reduced extinction and reinstatement of morphine. | Khaleghzadeh-Ahangar H et al. | β | 2015 | β |
| Medial prefrontal cannabinoid CB1 receptors modulate consolidation and extinction of cocaine-associated memory in mice. | Hu SS et al. | β | 2015 | β |
| Role of the endogenous cannabinoid system in nicotine addiction: novel insights. | Gamaleddin IH et al. | β | 2015 | β |
| The effect of medical marijuana laws on adolescent and adult use of marijuana, alcohol, and other substances. | Wen H et al. | β | 2015 | β |
| The endocannabinoid system is altered in the post-mortem prefrontal cortex of alcoholic subjects. | Erdozain AM et al. | β | 2015 | β |
| The Endocannabinoid System: Pivotal Orchestrator of Obesity and Metabolic Disease. | Mazier W et al. | β | 2015 | β |
| The hippocampal NMDA receptors may be involved in acquisition, but not expression of ACPA-induced place preference. | Nasehi M et al. | β | 2015 | β |
| The spectroscopic (FT-IR, FT-Raman, (l3)C, (1)H NMR and UV) and NBO analyses of 4-bromo-1-(ethoxycarbonyl)piperidine-4-carboxylic acid. | Vitnik VD et al. | β | 2015 | β |
| To Act or Not to Act: Endocannabinoid/Dopamine Interactions in Decision-Making. | Hernandez G et al. | β | 2015 | β |
| Behavioral and electrophysiological effects of endocannabinoid and dopaminergic systems on salient stimuli. | Laricchiuta D et al. | β | 2014 | β |
| Cannabinoid receptor-dependent metabolism of 2-arachidonoylglycerol during aging. | Pascual AC et al. | β | 2014 | β |
| CB1 antagonism: interference with affective properties of acute naloxone-precipitated morphine withdrawal in rats. | Wills KL et al. | β | 2014 | β |
| Cocaine-induced behavioral sensitization is associated with changes in the expression of endocannabinoid and glutamatergic signaling systems in the mouse prefrontal cortex. | Blanco E et al. | β | 2014 | β |
| Convergent pharmacological mechanisms in impulsivity and addiction: insights from rodent models. | Jupp B et al. | β | 2014 | β |
| Effects of acute versus repeated cocaine exposure on the expression of endocannabinoid signaling-related proteins in the mouse cerebellum. | Palomino A et al. | β | 2014 | β |
| Endocannabinoid-dependent modulation of phasic dopamine signaling encodes external and internal reward-predictive cues. | Wenzel JM et al. | β | 2014 | β |
| Endocannabinoid signaling and food addiction. | D'Addario C et al. | β | 2014 | β |
| Endocannabinoids promote cocaine-induced impulsivity and its rapid dopaminergic correlates. | Hernandez G et al. | β | 2014 | β |
| Endocannabinoids underlie reconsolidation of hedonic memories in Wistar rats. | De Carvalho CR et al. | β | 2014 | β |
| Individual differences in response to positive and negative stimuli: endocannabinoid-based insight on approach and avoidance behaviors. | Laricchiuta D et al. | β | 2014 | β |
| Individual differences underlying susceptibility to addiction: Role for the endogenous oxytocin system. | Buisman-Pijlman FT et al. | β | 2014 | β |
| Interrelationship of CB1R and OBR pathways in regulation of metabolic, neuroendocrine, and behavioral responses to food restriction and voluntary wheel running. | Diane A et al. | β | 2014 | β |
| Neuroinflammation as a possible link between cannabinoids and addiction. | Rodrigues LC et al. | β | 2014 | β |
| Nicotine self-administration induces CB1-dependent LTP in the bed nucleus of the stria terminalis. | Reisiger AR et al. | β | 2014 | β |
| Pharmacogenetics of the G protein-coupled receptors. | Thompson MD et al. | β | 2014 | β |
| Pregnenolone can protect the brain from cannabis intoxication. | VallΓ©e M et al. | β | 2014 | β |
| Psychiatric, psychosocial, and physical health correlates of co-occurring cannabis use disorders and nicotine dependence. | Peters EN et al. | β | 2014 | β |
| Relationships between serotonergic and cannabinoid system in depressive-like behavior: a PET study with [11C]-DASB. | Burokas A et al. | β | 2014 | β |
| The cannabinoid receptor 2 agonist, Ξ²-caryophyllene, reduced voluntary alcohol intake and attenuated ethanol-induced place preference and sensitivity in mice. | Al Mansouri S et al. | β | 2014 | β |
| The endocannabinoid system controls food intake via olfactory processes. | Soria-GΓ³mez E et al. | β | 2014 | β |
| The hypocretin/orexin receptor-1 as a novel target to modulate cannabinoid reward. | Flores Γ et al. | β | 2014 | β |
| Animal models as tools to study the pathophysiology of depression. | Abelaira HM et al. | β | 2013 | β |
| Brain regional differences in CB1 receptor adaptation and regulation of transcription. | Lazenka MF et al. | β | 2013 | β |
| Cannabinoid-hypocretin cross-talk in the central nervous system: what we know so far. | Flores A et al. | β | 2013 | β |
| Cannabinoid receptors and cholecystokinin in feeding inhibition. | AlΓ©n F et al. | β | 2013 | β |
| Central manipulation of dopamine receptors attenuates the orexigenic action of ghrelin. | Romero-PicΓ³ A et al. | β | 2013 | β |
| Default mode network in the effects of Ξ9-Tetrahydrocannabinol (THC) on human executive function. | Bossong MG et al. | β | 2013 | β |
| Dissociable effects of CB1 receptor blockade on anxiety-like and consummatory behaviors in the novelty-induced hypophagia test in mice. | Gamble-George JC et al. | β | 2013 | β |
| Dysregulation of cannabinoid CB1 receptor and associated signaling networks in brains of cocaine addicts and cocaine-treated rodents. | Γlvaro-BartolomΓ© M et al. | β | 2013 | β |
| Endocannabinoid system and drug addiction: new insights from mutant mice approaches. | Maldonado R et al. | β | 2013 | β |
| G-protein-coupled heteromers: regulation in disease. | Gomes I et al. | β | 2013 | β |
| Inhibition of FAAH and activation of PPAR: new approaches to the treatment of cognitive dysfunction and drug addiction. | Panlilio LV et al. | β | 2013 | β |
| Oleoylethanolamide dose-dependently attenuates cocaine-induced behaviours through a PPARΞ± receptor-independent mechanism. | Bilbao A et al. | β | 2013 | β |
| Operant behavior to obtain palatable food modifies neuronal plasticity in the brain reward circuit. | Guegan T et al. | β | 2013 | β |
| Opioid receptor types involved in the development of nicotine physical dependence in an invertebrate (Planaria) model. | Raffa RB et al. | β | 2013 | β |
| Paradoxical Decrease in Striatal Activation on an fMRI Reward Task Following Treatment in Youth with Co-morbid Cannabis Dependence/Major Depression. | Cornelius JR et al. | β | 2013 | β |
| Prefrontal synaptic markers of cocaine addiction-like behavior in rats. | Kasanetz F et al. | β | 2013 | β |
| Recent molecular approaches to understanding astrocyte function in vivo. | Davila D et al. | β | 2013 | β |
| Temporal and behavioral variability in cannabinoid receptor expression in outbred mice submitted to ethanol-induced locomotor sensitization paradigm. | Coelhoso CC et al. | β | 2013 | β |
| THC reduces the anticipatory nucleus accumbens response to reward in subjects with a nicotine addiction. | Jansma JM et al. | β | 2013 | β |
| The cannabinoid CB2 receptor is necessary for nicotine-conditioned place preference, but not other behavioral effects of nicotine in mice. | Ignatowska-Jankowska BM et al. | β | 2013 | β |
| The endocannabinoid system and the brain. | Mechoulam R et al. | β | 2013 | β |
| The FAAH inhibitor URB597 efficiently reduces tyrosine hydroxylase expression through CBβ- and FAAH-independent mechanisms. | Bosier B et al. | β | 2013 | β |
| Transient changes in the endocannabinoid system after acute and chronic ethanol exposure and abstinence in the rat: a combined PET and microdialysis study. | Ceccarini J et al. | β | 2013 | β |
| Ventral tegmental area cannabinoid type-1 receptors control voluntary exercise performance. | Dubreucq S et al. | β | 2013 | β |
| Acute reduction of anandamide-hydrolase (FAAH) activity is coupled with a reduction of nociceptive pathways facilitation in medication-overuse headache subjects after withdrawal treatment. | Perrotta A et al. | β | 2012 | β |
| Cannabinoid receptor 1-expressing neurons in the nucleus accumbens. | Winters BD et al. | β | 2012 | β |
| Cannabinoid receptors CB1 and CB2 form functional heteromers in brain. | CallΓ©n L et al. | β | 2012 | β |
| CB1 receptor autoradiographic characterization of the individual differences in approach and avoidance motivation. | Laricchiuta D et al. | β | 2012 | β |
| CB1 receptor-deficient mice as a model for depression. | Valverde O et al. | β | 2012 | β |
| Cellular signal mechanisms of reward-related plasticity in the hippocampus. | Isokawa M | β | 2012 | β |
| Clinical correlates of co-occurring cannabis and tobacco use: a systematic review. | Peters EN et al. | β | 2012 | β |
| Contributions of endocannabinoid signaling to psychiatric disorders in humans: genetic and biochemical evidence. | Hillard CJ et al. | β | 2012 | β |
| Decreased cocaine motor sensitization and self-administration in mice overexpressing cannabinoid CBβ receptors. | Aracil-FernΓ‘ndez A et al. | β | 2012 | β |
| Decreased reward sensitivity in rats from the Fischer344 strain compared to Wistar rats is paralleled by differences in endocannabinoid signaling. | Brand T et al. | β | 2012 | β |
| Differences in spontaneously avoiding or approaching mice reflect differences in CB1-mediated signaling of dorsal striatal transmission. | Laricchiuta D et al. | β | 2012 | β |
| Differential modulations of striatal tyrosine hydroxylase and dopamine metabolism by cannabinoid agonists as evidence for functional selectivity in vivo. | Bosier B et al. | β | 2012 | β |
| Effects induced by cannabinoids on monoaminergic systems in the brain and their implications for psychiatric disorders. | Esteban S et al. | β | 2012 | β |
| Electroacupuncture inhibits CB1 upregulation induced by ethanol withdrawal in mice. | Escosteguy-Neto JC et al. | β | 2012 | β |
| Genetic dissection of the role of cannabinoid type-1 receptors in the emotional consequences of repeated social stress in mice. | Dubreucq S et al. | β | 2012 | β |
| Innate difference in the endocannabinoid signaling and its modulation by alcohol consumption in alcohol-preferring sP rats. | Vinod KY et al. | β | 2012 | β |
| Intense exercise increases circulating endocannabinoid and BDNF levels in humans--possible implications for reward and depression. | Heyman E et al. | β | 2012 | β |
| Interactions between the cannabinoid and dopaminergic systems: evidence from animal studies. | El Khoury MA et al. | β | 2012 | β |
| Involvement of the endocannabinoid system in ethanol-induced corticostriatal synaptic depression. | Cho HS et al. | β | 2012 | β |
| Involvement of the endocannabinoid system in reward processing in the human brain. | van Hell HH et al. | β | 2012 | β |
| Long-term effects of juvenile nicotine exposure on abstinence-related social anxiety-like behavior and amygdalar cannabinoid receptor 1 (CB1R) mRNA expression in the novelty-seeking phenotype. | Aydin C et al. | β | 2012 | β |
| Protracted abstinence from distinct drugs of abuse shows regulation of a common gene network. | Le Merrer J et al. | β | 2012 | β |
| Sex differences in cannabinoid receptor-1 (CB1) pharmacology in mice selectively bred for high voluntary wheel-running behavior. | Keeney BK et al. | β | 2012 | β |
| The genetic basis of the endocannabinoid system and drug addiction in humans. | LΓ³pez-Moreno JA et al. | β | 2012 | β |
| The genetics of substance dependence. | Wang JC et al. | β | 2012 | β |
| The role of the endocannabinoid system in skeletal muscle and metabolic adaptations to exercise: potential implications for the treatment of obesity. | Heyman E et al. | β | 2012 | β |
| The role of the endocannabinoid system in the neuroendocrine regulation of energy balance. | Bermudez-Silva FJ et al. | β | 2012 | β |
| Toward a mechanistic understanding of how variability in neurobiology shapes individual differences in behavior. | Bogdan R et al. | β | 2012 | β |
| ACSL6 is associated with the number of cigarettes smoked and its expression is altered by chronic nicotine exposure. | Chen J et al. | β | 2011 | β |
| Acute blockade of CB1 receptor leads to reinstatement of MDMA-induced conditioned place preference. | Daza-Losada M et al. | β | 2011 | β |
| [Addictive behaviour in medication overuse headache: A review of recent data]. | Radat F et al. | β | 2011 | β |
| Altered expression of neuronal tryptophan hydroxylase-2 mRNA in the dorsal and median raphe nuclei of three genetically modified mouse models relevant to depression and anxiety. | Jahanshahi A et al. | β | 2011 | β |
| Association Study of Two Cannabinoid Receptor Genes, CNR1 and CNR2, with Methamphetamine Dependence. | Okahisa Y et al. | β | 2011 | β |
| Determination of endocannabinoids in nematodes and human brain tissue by liquid chromatography electrospray ionization tandem mass spectrometry. | Lehtonen M et al. | β | 2011 | β |
| Dissociable roles of mGlu5 and dopamine receptors in the rewarding and sensitizing properties of morphine and cocaine. | Veeneman MM et al. | β | 2011 | β |
| Effect of ΞFosB overexpression on opioid and cannabinoid receptor-mediated signaling in the nucleus accumbens. | Sim-Selley LJ et al. | β | 2011 | β |
| Effects of cannabinoid CBβ receptor antagonist rimonabant on acquisition and reinstatement of psychostimulant reward memory in mice. | Yu LL et al. | β | 2011 | β |
| Endocannabinoids and motor behavior: CB1 receptors also control running activity. | Chaouloff F et al. | β | 2011 | β |
| Endocannabinoid system and psychiatry: in search of a neurobiological basis for detrimental and potential therapeutic effects. | Marco EM et al. | β | 2011 | β |
| Expression of the mRNA coding the cannabinoid receptor 2 in the pallidal complex of Macaca fascicularis. | Lanciego JL et al. | β | 2011 | β |
| Genes differentially expressed in CB1 knockout mice: involvement in the depressive-like phenotype. | Aso E et al. | β | 2011 | β |
| Influence of three-day morphine-treatment upon impairment of memory consolidation induced by cannabinoid infused into the dorsal hippocampus in rats. | Zarrindast MR et al. | β | 2011 | β |
| Involvement of the endocannabinoid system in alcohol dependence: the biochemical, behavioral and genetic evidence. | Erdozain AM et al. | β | 2011 | β |
| Local pretreatment with the cannabinoid CB1 receptor antagonist AM251 attenuates methamphetamine intra-accumbens self-administration. | Rodriguez JS et al. | β | 2011 | β |
| Loss of striatal cannabinoid CB1 receptor function in attention-deficitβ/βhyperactivity disorder mice with point-mutation of the dopamine transporter. | Castelli M et al. | β | 2011 | β |
| Methods of the pharmacological imaging of the cannabinoid system (PhICS) study: towards understanding the role of the brain endocannabinoid system in human cognition. | van Hell HH et al. | β | 2011 | β |
| Neurochemical basis of cannabis addiction. | Maldonado R et al. | β | 2011 | β |
| Previous exposure to delta9-tetrahydrocannibinol enhances locomotor responding to but not self-administration of amphetamine. | Cortright JJ et al. | β | 2011 | β |
| Strain differences in the dose-response relationship for morphine self-administration and impulsive choice between Lewis and Fischer 344 rats. | GarcΓa-Lecumberri C et al. | β | 2011 | β |
| The biological control of voluntary exercise, spontaneous physical activity and daily energy expenditure in relation to obesity: human and rodent perspectives. | Garland T et al. | β | 2011 | β |
| The Endocannabinoid System as Pharmacological Target Derived from Its CNS Role in Energy Homeostasis and Reward. Applications in Eating Disorders and Addiction. | Viveros MP et al. | β | 2011 | β |
| Amygdala reactivity is inversely related to level of cannabis use in individuals with comorbid cannabis dependence and major depression. | Cornelius JR et al. | β | 2010 | β |
| Animal models of cannabinoid reward. | Panlilio LV et al. | β | 2010 | β |
| A second-order schedule of food reinforcement in rats to examine the role of CB1 receptors in the reinforcement-enhancing effects of nicotine. | Wing VC et al. | β | 2010 | β |
| Cannabinoid CB1 receptor-interacting proteins: novel targets for central nervous system drug discovery? | Smith TH et al. | β | 2010 | β |
| Cannabinoid conditioned reward and aversion: behavioral and neural processes. | Murray JE et al. | β | 2010 | β |
| Cannabinoid-dopamine interaction in the pathophysiology and treatment of CNS disorders. | FernΓ‘ndez-Ruiz J et al. | β | 2010 | β |
| Cannabinoid-hormone interactions in the regulation of motivational processes. | LΓ³pez HH | β | 2010 | β |
| Cannabinoid modulation of limbic forebrain noradrenergic circuitry. | Carvalho AF et al. | β | 2010 | β |
| CB(1) cannabinoid receptors and their associated proteins. | Howlett AC et al. | β | 2010 | β |
| CB1 receptor deficiency decreases wheel-running activity: consequences on emotional behaviours and hippocampal neurogenesis. | Dubreucq S et al. | β | 2010 | β |
| CB1 receptors modulate the intake of a sweetened-fat diet in response to ΞΌ-opioid receptor stimulation of the nucleus accumbens. | Skelly MJ et al. | β | 2010 | β |
| Converging action of alcohol consumption and cannabinoid receptor activation on adult hippocampal neurogenesis. | AlΓ©n F et al. | β | 2010 | β |
| Deficits in sensory-specific devaluation task performance following genetic deletions of cannabinoid (CB1) receptor. | Crombag HS et al. | β | 2010 | β |
| Does dopamine mediate the psychosis-inducing effects of cannabis? A review and integration of findings across disciplines. | Kuepper R et al. | β | 2010 | β |
| Effect of adolescent exposure to WIN 55212-2 on the acquisition and reinstatement of MDMA-induced conditioned place preference. | RodrΓguez-Arias M et al. | β | 2010 | β |
| Effect of the CB1 cannabinoid agonist WIN 55212-2 on the acquisition and reinstatement of MDMA-induced conditioned place preference in mice. | Manzanedo C et al. | β | 2010 | β |
| Effects of fatty acid amide hydrolase inhibition on neuronal responses to nicotine, cocaine and morphine in the nucleus accumbens shell and ventral tegmental area: involvement of PPAR-alpha nuclear receptors. | Luchicchi A et al. | β | 2010 | β |
| Endocannabinoids and voluntary activity in mice: runner's high and long-term consequences in emotional behaviors. | Fuss J et al. | β | 2010 | β |
| Endocannabinoids potentiate synaptic transmission through stimulation of astrocytes. | Navarrete M et al. | β | 2010 | β |
| Endogenous cannabinoids in post-mortem brains of Cloninger type 1 and 2 alcoholics. | Lehtonen M et al. | β | 2010 | β |
| Influence of chronic nicotine administration on cerebral type 1 cannabinoid receptor binding: an in vivo micro-PET study in the rat using [18F]MK-9470. | GΓ©rard N et al. | β | 2010 | β |
| Medication overuse headache: neurobiological, behavioural and therapeutic aspects. | Cupini LM et al. | β | 2010 | β |
| More aroused, less fatigued: fatty acid amide hydrolase gene polymorphisms influence acute response to amphetamine. | Dlugos AM et al. | β | 2010 | β |
| Neurobiological mechanisms involved in nicotine dependence and reward: participation of the endogenous opioid system. | Berrendero F et al. | β | 2010 | β |
| Periadolescent exposure to cannabinoids alters the striatal and hippocampal dopaminergic system in the adult rat brain. | Higuera-Matas A et al. | β | 2010 | β |
| Pharmacological approaches to methamphetamine dependence: a focused review. | Karila L et al. | β | 2010 | β |
| Reduced expression of glutamate receptors and phosphorylation of CREB are responsible for in vivo Delta9-THC exposure-impaired hippocampal synaptic plasticity. | Fan N et al. | β | 2010 | β |
| Regulation of plasticity of glutamate synapses by endocannabinoids and the cyclic-AMP/protein kinase A pathway in midbrain dopamine neurons. | Haj-Dahmane S et al. | β | 2010 | β |
| Rimonabant attenuates sensitization, cross-sensitization and cross-reinstatement of place preference induced by nicotine and ethanol. | BiaΕa G et al. | β | 2010 | β |
| Second-order schedules of nicotine reinforcement in rats: effect of AM251. | Wing VC et al. | β | 2010 | β |
| Shared brain vulnerabilities open the way for nonsubstance addictions: carving addiction at a new joint? | Frascella J et al. | β | 2010 | β |
| The endocannabinoid system tonically regulates inhibitory transmission and depresses the effect of ethanol in central amygdala. | Roberto M et al. | β | 2010 | β |
| The endogenous opioid system: a common substrate in drug addiction. | Trigo JM et al. | β | 2010 | β |
| [The endogenous opioid system and drug addiction]. | Maldonado R | β | 2010 | β |
| What is the role of dependence-related behavior in medication-overuse headache? | Radat F et al. | β | 2010 | β |
| Alcoholism: a systems approach from molecular physiology to addictive behavior. | Spanagel R | β | 2009 | β |
| Attenuation of basal and cocaine-enhanced locomotion and nucleus accumbens dopamine in cannabinoid CB1-receptor-knockout mice. | Li X et al. | β | 2009 | β |
| Caffeine drinking potentiates cannabinoid transmission in the striatum: interaction with stress effects. | Rossi S et al. | β | 2009 | β |
| Cannabinoid-induced conditioned place preference in the spontaneously hypertensive rat-an animal model of attention deficit hyperactivity disorder. | Pandolfo P et al. | β | 2009 | β |
| Cannabinoid type 1 receptors in human skeletal muscle cells participate in the negative crosstalk between fat and muscle. | Eckardt K et al. | β | 2009 | β |
| CB1 receptor knockout mice are hyporesponsive to the behavior-stimulating actions of d-amphetamine: role of mGlu5 receptors. | Tzavara ET et al. | β | 2009 | β |
| Chronic treatment and withdrawal of the cannabinoid agonist WIN 55,212-2 modulate the sensitivity of presynaptic receptors involved in the regulation of monoamine syntheses in rat brain. | Moranta D et al. | β | 2009 | β |
| Deletion of vanilloid receptor (TRPV1) in mice alters behavioral effects of ethanol. | Blednov YA et al. | β | 2009 | β |
| Divergent effects of genetic variation in endocannabinoid signaling on human threat- and reward-related brain function. | Hariri AR et al. | β | 2009 | β |
| Drug addiction. | Justinova Z et al. | β | 2009 | β |
| Effects of a cannabinoid receptor (CB) 1 antagonist AM251 on behavioral sensitization to nicotine in a rat model of novelty-seeking behavior: correlation with hippocampal 5HT. | Bhatti AS et al. | β | 2009 | β |
| Endocannabinoid-mediated control of synaptic transmission. | Kano M et al. | β | 2009 | β |
| Lack of CB1 receptor activity impairs serotonergic negative feedback. | Aso E et al. | β | 2009 | β |
| Modulation of brain endocannabinoid levels by voluntary alcohol consumption in alcohol-preferring AA rats. | Malinen H et al. | β | 2009 | β |
| Neurochemical evidence that stimulation of CB1 cannabinoid receptors on GABAergic nerve terminals activates the dopaminergic reward system by increasing dopamine release in the rat nucleus accumbens. | SperlΓ‘gh B et al. | β | 2009 | β |
| Prosocial effects of nicotine and ethanol in adolescent rats through partially dissociable neurobehavioral mechanisms. | Trezza V et al. | β | 2009 | β |
| Quantitative and qualitative profiling of endocannabinoids in human plasma using a triple quadrupole linear ion trap mass spectrometer with liquid chromatography. | Thomas A et al. | β | 2009 | β |
| Sub-chronic administration of AM251, CB1 receptor antagonist, within the nucleus accumbens induced sensitization to morphine in the rat. | Haghparast A et al. | β | 2009 | β |
| Synthesis and pharmacological evaluation of coumarin derivatives as cannabinoid receptor antagonists and inverse agonists. | Behrenswerth A et al. | β | 2009 | β |
| The endocannabinoid system as a link between homoeostatic and hedonic pathways involved in energy balance regulation. | Di Marzo V et al. | β | 2009 | β |
| The endocannabinoid system as a target for modelling psychosis. | Koethe D et al. | β | 2009 | β |
| The neurobiology of individual differences in complex behavioral traits. | Hariri AR | β | 2009 | β |
| The neuronal pathways mediating the behavioral and addictive properties of nicotine. | Balfour DJ | β | 2009 | β |
| Variations in the cannabinoid receptor 1 gene predispose to migraine. | Juhasz G et al. | β | 2009 | β |
| Advances in the field of cannabinoid--opioid cross-talk. | Robledo P et al. | β | 2008 | β |
| Aminopyrazine CB1 receptor inverse agonists. | Wustrow DJ et al. | β | 2008 | β |
| An endocannabinoid hypothesis of drug reward and drug addiction. | Onaivi ES | β | 2008 | β |
| Bidirectional cannabinoid modulation of social behavior in adolescent rats. | Trezza V et al. | β | 2008 | β |
| Blockade of THC-seeking behavior and relapse in monkeys by the cannabinoid CB(1)-receptor antagonist rimonabant. | Justinova Z et al. | β | 2008 | β |
| Calcium-dependent mechanisms of the reinstatement of nicotine-conditioned place preference by drug priming in rats. | Biala G et al. | β | 2008 | β |
| Cannabinoid and opioid modulation of social play behavior in adolescent rats: differential behavioral mechanisms. | Trezza V et al. | β | 2008 | β |
| Cannabinoid CB1 receptor antagonists in therapeutic and structural perspectives. | Lange JH et al. | β | 2008 | β |
| Cannabinoid CB1 receptors of the rat central amygdala mediate anxiety-like behavior: interaction with the opioid system. | Zarrindast MR et al. | β | 2008 | β |
| Cannabinoid receptor 1 blocker rimonabant (SR 141716) for treatment of alcohol dependence: results from a placebo-controlled, double-blind trial. | Soyka M et al. | β | 2008 | β |
| Cannabinoid receptor 1 gene association with nicotine dependence. | Chen X et al. | β | 2008 | β |
| Cannabinoid receptors in the bed nucleus of the stria terminalis control cortical excitation of midbrain dopamine cells in vivo. | Massi L et al. | β | 2008 | β |
| CB1 cannabinoid receptor modulates 3,4-methylenedioxymethamphetamine acute responses and reinforcement. | TouriΓ±o C et al. | β | 2008 | β |
| CB1 receptor blockade reduces the anxiogenic-like response and ameliorates the neurochemical imbalances associated with alcohol withdrawal in rats. | Rubio M et al. | β | 2008 | β |
| Communication networks in the brain: neurons, receptors, neurotransmitters, and alcohol. | Lovinger DM | β | 2008 | β |
| Context-specific reversal of cocaine sensitization by the CB1 cannabinoid receptor antagonist rimonabant. | Gerdeman GL et al. | β | 2008 | β |
| Cross-sensitization and cross-tolerance between exogenous cannabinoid antinociception and endocannabinoid-mediated stress-induced analgesia. | Suplita RL et al. | β | 2008 | β |
| Degradation of endocannabinoids in chronic migraine and medication overuse headache. | Cupini LM et al. | β | 2008 | β |
| Endocannabinoids enhance lipid synthesis and apoptosis of human sebocytes via cannabinoid receptor-2-mediated signaling. | Dobrosi N et al. | β | 2008 | β |
| Endocannabinoid signaling as a synaptic circuit breaker in neurological disease. | Katona I et al. | β | 2008 | β |
| Endocannabinoid signaling mediates cocaine-induced inhibitory synaptic plasticity in midbrain dopamine neurons. | Pan B et al. | β | 2008 | β |
| Endocannabinoids in platelets of chronic migraine patients and medication-overuse headache patients: relation with serotonin levels. | Rossi C et al. | β | 2008 | β |
| Endocannabinoids mediate neuron-astrocyte communication. | Navarrete M et al. | β | 2008 | β |
| Glutamatergic substrates of drug addiction and alcoholism. | Gass JT et al. | β | 2008 | β |
| Hypothesis-driven medication discovery for the treatment of psychostimulant addiction. | Xi ZX et al. | β | 2008 | β |
| Identification of the sites of 2-arachidonoylglycerol synthesis and action imply retrograde endocannabinoid signaling at both GABAergic and glutamatergic synapses in the ventral tegmental area. | MΓ‘tyΓ‘s F et al. | β | 2008 | β |
| Influence of neuronal nicotinic receptors over nicotine addiction and withdrawal. | De Biasi M et al. | β | 2008 | β |
| Inhibitory control and emotional stress regulation: neuroimaging evidence for frontal-limbic dysfunction in psycho-stimulant addiction. | Li CS et al. | β | 2008 | β |
| Involvement of kappa-opioid and endocannabinoid system on Salvinorin A-induced reward. | Braida D et al. | β | 2008 | β |
| Locomotor effects of morphine or alcohol in mice after a repeated treatment with the cannabinoid agonist HU 210. | Hagues G et al. | β | 2008 | β |
| New treatments for cocaine dependence: a focused review. | Karila L et al. | β | 2008 | β |
| Rimonabant blocks the expression but not the development of locomotor sensitization to nicotine in rats. | Kelsey JE et al. | β | 2008 | β |
| Sex-dependent effects of periadolescent exposure to the cannabinoid agonist CP-55,940 on morphine self-administration behaviour and the endogenous opioid system. | Biscaia M et al. | β | 2008 | β |
| Suppression by the cannabinoid CB1 receptor antagonist, rimonabant, of the reinforcing and motivational properties of a chocolate-flavoured beverage in rats. | Maccioni P et al. | β | 2008 | β |
| The diverse CB1 and CB2 receptor pharmacology of three plant cannabinoids: delta9-tetrahydrocannabinol, cannabidiol and delta9-tetrahydrocannabivarin. | Pertwee RG | β | 2008 | β |
| The endocannabinoid system: a new molecular target for the treatment of tobacco addiction. | Scherma M et al. | β | 2008 | β |
| The endocannabinoid system: emotion, learning and addiction. | Moreira FA et al. | β | 2008 | β |
| The endocannabinoid system in brain reward processes. | Solinas M et al. | β | 2008 | β |
| The incentive salience of alcohol: translating the effects of genetic variant in CNR1. | Hutchison KE et al. | β | 2008 | β |
| The pharmacology of the endocannabinoid system: functional and structural interactions with other neurotransmitter systems and their repercussions in behavioral addiction. | LΓ³pez-Moreno JA et al. | β | 2008 | β |
| The role of CB1 receptors in psychostimulant addiction. | Wiskerke J et al. | β | 2008 | β |
| [18F]MK-9470, a positron emission tomography (PET) tracer for in vivo human PET brain imaging of the cannabinoid-1 receptor. | Burns HD et al. | β | 2007 | β |
| Acute and non-acute effects of cannabis on brain functioning and neuropsychological performance. | Gonzalez R | β | 2007 | β |
| Acute, chronic and withdrawal effects of the cannabinoid receptor agonist WIN55212-2 on the sequential activation of MAPK/Raf-MEK-ERK signaling in the rat cerebral frontal cortex: short-term regulation by intrinsic and extrinsic pathways. | Moranta D et al. | β | 2007 | β |
| A possible role for the endocannabinoid system in the neurobiology of depression. | Serra G et al. | β | 2007 | β |
| Blocking the cannabinoid receptors: drug candidates and therapeutic promises. | Muccioli GG | β | 2007 | β |
| Cannabinoid CB1 receptors of the dorsal hippocampus are important for induction of conditioned place preference (CPP) but do not change morphine CPP. | Zarrindast MR et al. | β | 2007 | β |
| Chronic cocaine treatment alters dendritic arborization in the adult motor cortex through a CB1 cannabinoid receptor-dependent mechanism. | Ballesteros-YÑñez I et al. | β | 2007 | β |
| Effects of the cannabinoid antagonist SR141716 (rimonabant) and d-amphetamine on palatable food and food pellet intake in non-human primates. | Foltin RW et al. | β | 2007 | β |
| Endocannabinoid signaling in midbrain dopamine neurons: more than physiology? | Melis M et al. | β | 2007 | β |
| Endocannabinoid system involvement in brain reward processes related to drug abuse. | Solinas M et al. | β | 2007 | β |
| Enhancement of endocannabinoid signaling and the pharmacotherapy of depression. | Mangieri RA et al. | β | 2007 | β |
| Genetic dissection of behavioural and autonomic effects of Delta(9)-tetrahydrocannabinol in mice. | Monory K et al. | β | 2007 | β |
| Is dopamine a physiologically relevant mediator of feeding behavior? | Palmiter RD | β | 2007 | β |
| Medial forebrain bundle stimulation evokes endocannabinoid-mediated modulation of ventral tegmental area dopamine neuron firing in vivo. | Pillolla G et al. | β | 2007 | β |
| Medications Development for the Treatment of Nicotine Dependence in Individuals with Schizophrenia. | Montoya ID et al. | β | 2007 | β |
| Pharmacotherapy of dual substance abuse and dependence. | Kenna GA et al. | β | 2007 | β |
| Polymorphisms of the dopamine D4 receptor gene (DRD4 VNTR) and cannabinoid CB1 receptor gene (CNR1) are not strongly related to cue-reactivity after alcohol exposure. | van den Wildenberg E et al. | β | 2007 | β |
| Rimonabant: just an antiobesity drug? Current evidence on its pleiotropic effects. | Bifulco M et al. | β | 2007 | β |
| Role of cannabinoid type 1 receptors in locomotor activity and striatal signaling in response to psychostimulants. | CorbillΓ© AG et al. | β | 2007 | β |
| Role of endocannabinoids in alcohol consumption and intoxication: studies of mice lacking fatty acid amide hydrolase. | Blednov YA et al. | β | 2007 | β |
| Role of endocannabinoids in regulating drug dependence. | Parolaro D et al. | β | 2007 | β |
| Short- and long-term plasticity of the endocannabinoid system in neuropsychiatric and neurological disorders. | Bisogno T et al. | β | 2007 | β |
| Short-term exposure to alcohol in rats affects brain levels of anandamide, other N-acylethanolamines and 2-arachidonoyl-glycerol. | Rubio M et al. | β | 2007 | β |
| Subchronic cannabinoid agonist (WIN 55,212-2) treatment during cocaine abstinence alters subsequent cocaine seeking behavior. | GonzΓ‘lez-Cuevas G et al. | β | 2007 | β |
| Subchronic nicotine exposure in adolescence induces long-term effects on hippocampal and striatal cannabinoid-CB1 and mu-opioid receptors in rats. | Marco EM et al. | β | 2007 | β |
| Targeted modulators of the endogenous cannabinoid system: future medications to treat addiction disorders and obesity. | Janero DR et al. | β | 2007 | β |
| The cannabinoid CB1 receptor antagonist AM251 does not modify methamphetamine reinstatement of responding. | Boctor SY et al. | β | 2007 | β |
| The cannabinoid CB1 receptor antagonist, rimonabant, as a promising pharmacotherapy for alcohol dependence: preclinical evidence. | Colombo G et al. | β | 2007 | β |
| The endocannabinoid system and rimonabant: a new drug with a novel mechanism of action involving cannabinoid CB1 receptor antagonism--or inverse agonism--as potential obesity treatment and other therapeutic use. | Xie S et al. | β | 2007 | β |
| The lack of CB1 receptors prevents neuroadapatations of both NMDA and GABA(A) receptors after chronic ethanol exposure. | Warnault V et al. | β | 2007 | β |
| The role of the cannabinoid type 1 receptor and down-stream cAMP/DARPP-32 signal in the nucleus accumbens of methamphetamine-sensitized rats. | Chiang YC et al. | β | 2007 | β |
| Rimonabant: endocannabinoid inhibition for the metabolic syndrome. | Wierzbicki AS | β | 2006 | β |
| The endocannabinoid system as an emerging target of pharmacotherapy. | Pacher P et al. | β | 2006 | β |