Regulation of ryanodine receptors by dopamine D1 receptors during methamphetamine-induced place conditioning.
- Authors
- Kurokawa, Kazuhiro; Mizuno, Koji; Shibasaki, Masahiro; Ohkuma, Seitaro
- Year
- 2010
- Journal
- Journal of neurochemistry
- PMID
- 20854431
- DOI
- 10.1111/j.1471-4159.2010.07010.x
Little is known about ryanodine receptors (RyRs) related to the methamphetamine (METH)-induced place preference. The present study was designed to ascertain whether RyRs could play a role in the development of METH-induced place preference in the mouse. The METH-induced place preference was dose-dependently suppressed by dantrolene, a RyRs receptor antagonist. The levels of RyRs 1 and 2 in the frontal cortex and RyRs 1 in the limbic forebrain were significantly increased in METH-conditioned mice. This up-regulation of RyRs were not inhibited by nifedipine. Both the dopamine D(1) receptor antagonist SCH23390 and the dopamine D(2) receptor antagonist sulpiride inhibited the development of METH-induced place conditioning. In contrast, the increases of RyRs 1 and 2 in the frontal cortex and of RyRs 1 in the limbic forebrain were completely abolished by SCH23390, whereas sulpiride had no effect. These findings indicate that up-regulation of RyRs is regulated through the activation of dopamine D(1) receptors in the METH-conditioning.
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