Prospective association of dopamine-related polymorphisms with smoking cessation in general care.
- Authors
- Breitling, Lutz P; Twardella, Dorothee; Hoffmann, Michael M; Witt, Stephanie H; Treutlein, Jens; Brenner, Hermann
- Year
- 2010
- Journal
- Pharmacogenomics
- PMID
- 20350135
- DOI
- 10.2217/pgs.10.1
AIMS: Genetic contributions to nicotine dependence have been demonstrated repeatedly, but the relevance of individual polymorphisms for smoking cessation remains controversial. MATERIALS & METHODS: We examined genotypes at two dopamine-related loci, DRD2/ANKK1 (rs1800497) and DBH (rs77905), in 577 heavy smokers participating in a prospective study of smoking cessation in general care in Germany. RESULTS: Smoking status after 1 year was significantly associated with DRD2/ANKK1, odds of abstinence being 4.4-fold (95% CI: 1.5-12.9) increased in TT- versus CC-homozygous subjects (p = 0.008). No effect was observed for the DBH genotype. The smoking cessation drug bupropion appeared to be particularly effective in CC-homozygotes (among CC subjects there was a 28% higher cessation probability among those taking buproprion; among T carrier subjects there was an increase only by 12%). CONCLUSION: The large effects observed for DRD2/ANKK1 might be related to our study design, in which individual therapy was decided by the physician. Further studies are needed to clarify the genetic effects of DRD2/ANKK1 especially in 'real-life' settings outside clinical trials.
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In this knowledge base
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|---|---|---|
| Interplay of genetic risk factors (CHRNA5-CHRNA3-CHRNB4) and cessation treatments in smoking cessation success. | 2012 | 22648373 |
External
| Title | Authors | Journal | Year | Link |
|---|---|---|---|---|
| Single Nucleotide Polymorphisms Within <i>DRD2, COMT, and DBH</i> and Smoking Cessation: A Systematic Review Considering Genetic Differences by Ancestry and Biological Sex. | Jones SK et al. | — | 2024 | → |
| A scoping review of smoking cessation pharmacogenetic studies to advance future research across racial, ethnic, and ancestral populations. | Prom-Wormley EC et al. | — | 2023 | → |
| Smoking Genes: A Case-Control Study of Dopamine Transporter Gene (<i>SLC6A3</i>) and Dopamine Receptor Genes (<i>DRD1</i>, <i>DRD2</i> and <i>DRD3</i>) Polymorphisms and Smoking Behaviour in a Malay Male Cohort. | Ruzilawati AB et al. | — | 2020 | → |
| From genes to treatments: a systematic review of the pharmacogenetics in smoking cessation. | Salloum NC et al. | — | 2018 | → |
| Pathways to precision medicine in smoking cessation treatments. | Chen LS et al. | — | 2018 | → |
| Association of the DBH Polymorphism rs3025343 With Smoking Cessation in a Large Population-Based Sample. | Hirvonen K et al. | — | 2017 | → |
| Associations between smoking behavior-related alleles and the risk of melanoma. | Wu W et al. | — | 2016 | → |
| Contribution of Variants in CHRNA5/A3/B4 Gene Cluster on Chromosome 15 to Tobacco Smoking: From Genetic Association to Mechanism. | Wen L et al. | — | 2016 | → |
| A review of pharmacogenetic studies of substance-related disorders. | Jones JD et al. | — | 2015 | → |
| CHRNA5 risk variant predicts delayed smoking cessation and earlier lung cancer diagnosis--a meta-analysis. | Chen LS et al. | — | 2015 | → |
| Lack of Associations of CHRNA5-A3-B4 Genetic Variants with Smoking Cessation Treatment Outcomes in Caucasian Smokers despite Associations with Baseline Smoking. | Tyndale RF et al. | — | 2015 | → |
| The significant association of Taq1A genotypes in DRD2/ANKK1 with smoking cessation in a large-scale meta-analysis of Caucasian populations. | Ma Y et al. | — | 2015 | → |
| The value of control conditions for evaluating pharmacogenetic effects. | Chen LS et al. | — | 2015 | → |
| CHRNA5 variant predicts smoking cessation in patients with acute myocardial infarction. | Chen LS et al. | — | 2014 | → |
| Interplay of genetic risk (CHRNA5) and environmental risk (partner smoking) on cigarette smoking reduction. | Chen LS et al. | — | 2014 | → |
| Genomics and personalized medicine: <i>CHRNA5-CHRNA3-CHRNB4</i> and smoking cessation treatment. | Chen LS et al. | — | 2013 | → |
| Physician advice for smoking cessation. | Stead LF et al. | — | 2013 | → |
| Association between dopamine beta hydroxylase rs5320 polymorphism and smoking behaviour in elderly Japanese. | Ella E et al. | — | 2012 | → |
| Genetics of dopamine receptors and drug addiction. | Gorwood P et al. | — | 2012 | → |
| Interplay of genetic risk factors (CHRNA5-CHRNA3-CHRNB4) and cessation treatments in smoking cessation success. | Chen LS et al. | — | 2012 | → |
| ANKK1/DRD2 locus variants are associated with rimonabant efficacy in aiding smoking cessation: pilot data. | Wilcox CS et al. | — | 2011 | → |
| Dopamine-related genes and spontaneous smoking cessation in ever-heavy smokers. | Breitling LP et al. | — | 2011 | → |