Enhanced and delayed stress-induced alcohol drinking in mice lacking functional CRH1 receptors.
paper
Cited
Public
Unavailable
- Authors
- Sillaber, Inge; Rammes, Gerhard; Zimmermann, Stephan; Mahal, Beatrice; ZieglgΓ€nsberger, Walter; Wurst, Wolfgang; Holsboer, Florian; Spanagel, Rainer
- Year
- 2002
- Journal
- Science (New York, N.Y.)
- PMID
- 11988580
- DOI
- 10.1126/science.1069836
There is a relation between stress and alcohol drinking. We show that the corticotropin-releasing hormone (CRH) system that mediates endocrine and behavioral responses to stress plays a role in the control of long-term alcohol drinking. In mice lacking a functional CRH1 receptor, stress leads to enhanced and progressively increasing alcohol intake. The effect of repeated stress on alcohol drinking behavior appeared with a delay and persisted throughout life. It was associated with an up-regulation of the N-methyl-d-aspartate receptor subunit NR2B. Alterations in the CRH1 receptor gene and adaptional changes in NR2B subunits may constitute a genetic risk factor for stress-induced alcohol drinking and alcoholism.
No figures extracted from this document.
No chunks β full text not yet ingested.
No entities extracted from this document yet.
No uploaded files.
Not in any collection.
No citations found.
In this knowledge base
External
| Title | Authors | Journal | Year | Link |
|---|---|---|---|---|
| Behavioral Neurobiology of Alcohol Addiction: A Decade of Great Challenges, New Hopes, and Hypes. | Sommer WH et al. | β | 2025 | β |
| Good Practice Guideline for Preclinical Alcohol Research: The STRINGENCY Framework. | Meinhardt MW et al. | β | 2025 | β |
| Reducing stress and alcohol-related behaviors by targeting D1-CRHR1 receptor interactions in the amygdala. | Broccoli L et al. | β | 2025 | β |
| Synaptic Effects Induced by Alcohol. | Lovinger DM et al. | β | 2025 | β |
| Neurokinin-1 receptors in the nucleus accumbens shell influence sensitivity to social defeat stress and stress-induced alcohol consumption in male mice. | Solomon MG et al. | β | 2024 | β |
| Age, Ξ²-endorphin, and sex dependent effects of maternal separation on locomotor activity, anxiety-like behavior, and alcohol reward. | Scopano MR et al. | β | 2023 | β |
| Corticotropin releasing factor and drug seeking in substance use disorders: Preclinical evidence and translational limitations. | Mantsch JR | β | 2022 | β |
| Excessive alcohol consumption after exposure to two types of chronic social stress: intermittent episodes vs. continuous exposure in C57BL/6J mice with a history of drinking. | Miczek KA et al. | β | 2022 | β |
| Neurobiological Bases of Alcohol Consumption After Social Stress. | Miczek KA et al. | β | 2022 | β |
| Sex differences in stress-induced alcohol intake: a review of preclinical studies focused on amygdala and inflammatory pathways. | Mineur YS et al. | β | 2022 | β |
| Ten Points to Improve Reproducibility and Translation of Animal Research. | Spanagel R | β | 2022 | β |
| Alcohol narrows physical distance between strangers. | Gurrieri L et al. | β | 2021 | β |
| Early life sleep disruption is a risk factor for increased ethanol drinking after acute footshock stress in prairie voles. | Jones CE et al. | β | 2020 | β |
| GPCR and Alcohol-Related Behaviors in Genetically Modified Mice. | Neasta J et al. | β | 2020 | β |
| Role of corticotropin-releasing factor in alcohol and nicotine addiction. | Simpson S et al. | β | 2020 | β |
| Environmental stressors and alcoholism development: Focus on molecular targets and their epigenetic regulation. | Pucci M et al. | β | 2019 | β |
| Bidirectional relationship between alcohol intake and sensitivity to social defeat: association with Tacr1 and Avp expression. | Nelson BS et al. | β | 2018 | β |
| Common Biological Mechanisms of Alcohol Use Disorder and Post-Traumatic Stress Disorder. | Suh J et al. | β | 2018 | β |
| Persistent escalation of alcohol consumption by mice exposed to brief episodes of social defeat stress: suppression by CRF-R1 antagonism. | Newman EL et al. | β | 2018 | β |
| Social defeat stress and escalation of cocaine and alcohol consumption: Focus on CRF. | Newman EL et al. | β | 2018 | β |
| Targeted overexpression of CRH receptor subtype 1 in central amygdala neurons: effect on alcohol-seeking behavior. | Broccoli L et al. | β | 2018 | β |
| Characterization of CRF<sub>1</sub> receptor antagonists with differential peripheral vs central actions in CRF challenge in rats. | Tanaka M et al. | β | 2017 | β |
| Corticotropin Releasing Factor in the Bed Nucleus of the Stria Terminalis in Socially Defeated and Non-stressed Mice with a History of Chronic Alcohol Intake. | Albrechet-Souza L et al. | β | 2017 | β |
| Depression and substance use comorbidity: What we have learned from animal studies. | Ng E et al. | β | 2017 | β |
| Neurobiology of comorbid post-traumatic stress disorder and alcohol-use disorder. | Gilpin NW et al. | β | 2017 | β |
| Pathophysiology of the Effects of Alcohol Abuse on the Endocrine System. | Rachdaoui N et al. | β | 2017 | β |
| Synergistic blockade of alcohol escalation drinking in mice by a combination of novel kappa opioid receptor agonist Mesyl Salvinorin B and naltrexone. | Zhou Y et al. | β | 2017 | β |
| The Corticotropin Releasing Factor Receptor 1 in Alcohol Use Disorder: Still a Valid Drug Target? | Pomrenze MB et al. | β | 2017 | β |
| Chronic distress and the vulnerable host: a new target for HIV treatment and prevention? | Contoreggi C et al. | β | 2016 | β |
| Effect of different stressors on voluntary ethanol intake in ethanol-dependent and nondependent C57BL/6J mice. | Lopez MF et al. | β | 2016 | β |
| Genes and Alcohol Consumption: Studies with Mutant Mice. | Mayfield J et al. | β | 2016 | β |
| Increased alcohol consumption in relaxin-3 deficient male mice. | Shirahase T et al. | β | 2016 | β |
| Social stress-escalated intermittent alcohol drinking: modulation by CRF-R1 in the ventral tegmental area and accumbal dopamine in mice. | Hwa LS et al. | β | 2016 | β |
| Stress-Induced Enhancement of Ethanol Intake in C57BL/6J Mice with a History of Chronic Ethanol Exposure: Involvement of Kappa Opioid Receptors. | Anderson RI et al. | β | 2016 | β |
| The CRF1 and the CRF2 receptor mediate recognition memory deficits and vulnerability induced by opiate withdrawal. | Morisot N et al. | β | 2016 | β |
| The Need for Treatment Responsive Translational Biomarkers in Alcoholism Research. | Heilig M et al. | β | 2016 | β |
| Acetaldehyde self-administration by a two-bottle choice paradigm: consequences on emotional reactivity, spatial learning, and memory. | Plescia F et al. | β | 2015 | β |
| Alcohol and violence: neuropeptidergic modulation of monoamine systems. | Miczek KA et al. | β | 2015 | β |
| An ultrastructural analysis of the effects of ethanol self-administration on the hypothalamic paraventricular nucleus in rhesus macaques. | Jimenez VA et al. | β | 2015 | β |
| Preclinical evidence implicating corticotropin-releasing factor signaling in ethanol consumption and neuroadaptation. | Phillips TJ et al. | β | 2015 | β |
| Reduction of ethanol intake by corticotropin-releasing factor receptor-1 antagonist in "heavy-drinking" mice in a free-choice paradigm. | Correia D et al. | β | 2015 | β |
| Relaxin-3 receptor (RXFP3) signalling mediates stress-related alcohol preference in mice. | Walker AW et al. | β | 2015 | β |
| Social stress and escalated drug self-administration in mice I. Alcohol and corticosterone. | Norman KJ et al. | β | 2015 | β |
| Brain-derived neurotrophic factor mediates the suppression of alcohol self-administration by memantine. | Jeanblanc J et al. | β | 2014 | β |
| CRF1 receptor-deficiency induces anxiety-like vulnerability to cocaine. | Morisot N et al. | β | 2014 | β |
| Deciphering the relationship between vulnerability to ethanol-induced behavioral sensitization and ethanol consumption in outbred mice. | Legastelois R et al. | β | 2014 | β |
| Making organisms model human behavior: situated models in North-American alcohol research, since 1950. | Ankeny RA et al. | β | 2014 | β |
| Stress and alcohol interactions: animal studies and clinical significance. | Spanagel R et al. | β | 2014 | β |
| Activation of CRH receptor type 1 expressed on glutamatergic neurons increases excitability of CA1 pyramidal neurons by the modulation of voltage-gated ion channels. | Kratzer S et al. | β | 2013 | β |
| Advanced transgenic approaches to understand alcohol-related phenotypes in animals. | Bilbao A | β | 2013 | β |
| CRF1 receptor signaling regulates food and fluid intake in the drinking-in-the-dark model of binge alcohol consumption. | Giardino WJ et al. | β | 2013 | β |
| Effects of alcohol on the endocrine system. | Rachdaoui N et al. | β | 2013 | β |
| Individual differences and social influences on the neurobehavioral pharmacology of abused drugs. | Bardo MT et al. | β | 2013 | β |
| New insights on neurobiological mechanisms underlying alcohol addiction. | Cui C et al. | β | 2013 | β |
| Synaptic effects induced by alcohol. | Lovinger DM et al. | β | 2013 | β |
| Work hours and cortisol variation from non-working to working days. | Marchand A et al. | β | 2013 | β |
| Affect-related behaviors in mice selectively bred for high and low voluntary alcohol consumption. | Can A et al. | β | 2012 | β |
| Brain-specific inactivation of the Crhr1 gene inhibits post-dependent and stress-induced alcohol intake, but does not affect relapse-like drinking. | Molander A et al. | β | 2012 | β |
| Corticotropin-releasing factor acting on corticotropin-releasing factor receptor type 1 is critical for binge alcohol drinking in mice. | Kaur S et al. | β | 2012 | β |
| Emotional valence and context of social influences on drug abuse-related behavior in animal models of social stress and prosocial interaction. | Neisewander JL et al. | β | 2012 | β |
| Genetic deficiency in neprilysin or its pharmacological inhibition initiate excessive stress-induced alcohol consumption in mice. | Maul B et al. | β | 2012 | β |
| Putative genes mediating the effects of orexins in the posterior paraventricular thalamus on neuroendocrine and behavioral adaptations to repeated stress. | Heydendael W et al. | β | 2012 | β |
| Social rank, chronic ethanol self-administration, and diurnal pituitary-adrenal activity in cynomolgus monkeys. | Helms CM et al. | β | 2012 | β |
| The interaction of chronic restraint stress and voluntary alcohol intake: effects on spatial memory in male rats. | Gomez JL et al. | β | 2012 | β |
| Urocortins: CRF's siblings and their potential role in anxiety, depression and alcohol drinking behavior. | Ryabinin AE et al. | β | 2012 | β |
| Cannabinoid exposure in pubertal rats increases spontaneous ethanol consumption and NMDA receptor associated protein levels. | Klugmann M et al. | β | 2011 | β |
| Chronic alcohol neuroadaptation and stress contribute to susceptibility for alcohol craving and relapse. | Breese GR et al. | β | 2011 | β |
| Circulating leptin levels are associated with increased craving to smoke in abstinent smokers. | al'Absi M et al. | β | 2011 | β |
| Effects of corticotropin-releasing hormone receptor antagonists on the ethanol-induced increase of dynorphin A1-8 release in the rat central amygdala. | Lam MP et al. | β | 2011 | β |
| Effects of stress on alcohol drinking: a review of animal studies. | Becker HC et al. | β | 2011 | β |
| Effects of the circadian rhythm gene period 1 (per1) on psychosocial stress-induced alcohol drinking. | Dong L et al. | β | 2011 | β |
| ERK activation in the amygdala and hippocampus induced by fear conditioning in ethanol withdrawn rats: modulation by MK-801. | Bertotto ME et al. | β | 2011 | β |
| Ethanol concentration-dependent effects and the role of stress on ethanol drinking in corticotropin-releasing factor type 1 and double type 1 and 2 receptor knockout mice. | Pastor R et al. | β | 2011 | β |
| Glutamatergic and dopaminergic neurons mediate anxiogenic and anxiolytic effects of CRHR1. | Refojo D et al. | β | 2011 | β |
| mGluR7 genetics and alcohol: intersection yields clues for addiction. | Gyetvai B et al. | β | 2011 | β |
| Alcohol response and consumption in adolescent rhesus macaques: life history and genetic influences. | Schwandt ML et al. | β | 2010 | β |
| Alcohol self-administration in rats: Modulation by temporal parameters related to repeated mild social defeat stress. | Caldwell EE et al. | β | 2010 | β |
| An integrated genome research network for studying the genetics of alcohol addiction. | Spanagel R et al. | β | 2010 | β |
| Genetic and environmental influences on ethanol consumption: perspectives from preclinical research. | Pautassi RM et al. | β | 2010 | β |
| Genetic variation and brain gene expression in rodent models of alcoholism implications for medication development. | BjΓΆrk K et al. | β | 2010 | β |
| Interacting effects of CRHR1 gene and stressful life events on drinking initiation and progression among 19-year-olds. | Schmid B et al. | β | 2010 | β |
| Quantitative trait loci contributing to physiological and behavioural ethanol responses after acute and chronic treatment. | Drews E et al. | β | 2010 | β |
| Single-nucleotide polymorphisms in corticotropin releasing hormone receptor 1 gene (CRHR1) are associated with quantitative trait of event-related potential and alcohol dependence. | Chen AC et al. | β | 2010 | β |
| Stress hormone regulation: biological role and translation into therapy. | Holsboer F et al. | β | 2010 | β |
| Alcoholism: a systems approach from molecular physiology to addictive behavior. | Spanagel R | β | 2009 | β |
| Differential effects of free versus imposed motor activity on alcohol consumption in C57BL/6J versus DBA/2J mice. | Pichard C et al. | β | 2009 | β |
| Presynaptic CRF1 receptors mediate the ethanol enhancement of GABAergic transmission in the mouse central amygdala. | Nie Z et al. | β | 2009 | β |
| Alcohol preference in mice lacking the Avpr1a vasopressin receptor. | Sanbe A et al. | β | 2008 | β |
| Conditional mouse mutants highlight mechanisms of corticotropin-releasing hormone effects on stress-coping behavior. | Lu A et al. | β | 2008 | β |
| Differences in ethanol drinking between mice selected for high and low swim stress-induced analgesia. | Sacharczuk M et al. | β | 2008 | β |
| Effects of chronic swim stress on EtOH-related behaviors in C57BL/6J, DBA/2J and BALB/cByJ mice. | Boyce-Rustay JM et al. | β | 2008 | β |
| Effects of naltrexone, duloxetine, and a corticotropin-releasing factor type 1 receptor antagonist on binge-like alcohol drinking in rats. | Ji D et al. | β | 2008 | β |
| HPA-axis activity in alcoholism: examples for a gene-environment interaction. | Clarke TK et al. | β | 2008 | β |
| Neurobiology of addiction. An integrative review. | Goodman A | β | 2008 | β |
| Neuronal actions of glucocorticoids: focus on depression. | Yu S et al. | β | 2008 | β |
| Restraint stress and ethanol consumption in two mouse strains. | Yang X et al. | β | 2008 | β |
| Review. Neurogenetic studies of alcohol addiction. | Crabbe JC | β | 2008 | β |
| Social stress, therapeutics and drug abuse: preclinical models of escalated and depressed intake. | Miczek KA et al. | β | 2008 | β |
| The CRF-1 receptor antagonist, CP-154,526, attenuates stress-induced increases in ethanol consumption by BALB/cJ mice. | Lowery EG et al. | β | 2008 | β |
| A key role for corticotropin-releasing factor in alcohol dependence. | Heilig M et al. | β | 2007 | β |
| Chronic swim stress alters sensitivity to acute behavioral effects of ethanol in mice. | Boyce-Rustay JM et al. | β | 2007 | β |
| Corticotropin-releasing factor (CRF) receptor type 1-dependent modulation of synaptic plasticity. | Schierloh A et al. | β | 2007 | β |
| Dependence-induced increases in ethanol self-administration in mice are blocked by the CRF1 receptor antagonist antalarmin and by CRF1 receptor knockout. | Chu K et al. | β | 2007 | β |
| Evidence of an association of leptin serum levels and craving in alcohol dependence. | Hillemacher T et al. | β | 2007 | β |
| Glutamate receptor metabotropic 7 is cis-regulated in the mouse brain and modulates alcohol drinking. | Vadasz C et al. | β | 2007 | β |
| Alcohol-related genes: contributions from studies with genetically engineered mice. | Crabbe JC et al. | β | 2006 | β |
| Different effects of stress on alcohol drinking behaviour in male and female mice selectively bred for high alcohol preference. | Chester JA et al. | β | 2006 | β |
| Genetic association of the human corticotropin releasing hormone receptor 1 (CRHR1) with binge drinking and alcohol intake patterns in two independent samples. | Treutlein J et al. | β | 2006 | β |
| Hypothalamic-pituitary-adrenal axis and substance use: so many questions--and we can answer them. | Schumann G | β | 2006 | β |
| Hypothalamic-pituitary-adrenocortical axis activity: a target of pharmacological anticraving treatment? | Kiefer F et al. | β | 2006 | β |
| Lack of angiotensin II conversion to angiotensin III increases water but not alcohol consumption in aminopeptidase A-deficient mice. | Faber F et al. | β | 2006 | β |
| Loss of flexibility in alcohol-taking rats: promoting factors. | Turyabahika-Thyen K et al. | β | 2006 | β |
| Multidisciplinary perspectives on impaired control over substance use. | Martin CS et al. | β | 2006 | β |
| The acute intoxicating effects of ethanol are not dependent on the vasopressin 1a or 1b receptors. | Caldwell HK et al. | β | 2006 | β |
| Variation at the rat Crhr1 locus and sensitivity to relapse into alcohol seeking induced by environmental stress. | Hansson AC et al. | β | 2006 | β |
| Addiction and its brain science. | Spanagel R et al. | β | 2005 | β |
| Advances in alcoholism research in Germany. | Schmidt LG et al. | β | 2005 | β |
| Combining research approaches to advance our understanding of drug addiction. | van den Bree MB | β | 2005 | β |
| Conceptual framework for the etiology of alcoholism: a "kindling"/stress hypothesis. | Breese GR et al. | β | 2005 | β |
| Decreased oral self-administration of alcohol in kappa-opioid receptor knock-out mice. | Kovacs KM et al. | β | 2005 | β |
| Dissecting the genetic effect of the CRH system on anxiety and stress-related behaviour. | Deussing JM et al. | β | 2005 | β |
| Excitatory amino acid neurotransmission. | Parsons CG et al. | β | 2005 | β |
| Influence of age at drinking onset on long-term ethanol self-administration with deprivation and stress phases. | Siegmund S et al. | β | 2005 | β |
| Mice deficient in corticotropin-releasing factor receptor type 2 exhibit normal ethanol-associated behaviors. | Sharpe AL et al. | β | 2005 | β |
| Polymorphisms in the NMDA subunit 2B are not associated with alcohol dependence and alcohol withdrawal-induced seizures and delirium tremens. | Tadic A et al. | β | 2005 | β |
| CRF and CRF receptors: role in stress responsivity and other behaviors. | Bale TL et al. | β | 2004 | β |
| CRH, stress, and major depression: a psychobiological interplay. | Claes SJ | β | 2004 | β |
| Ethanol augments GABAergic transmission in the central amygdala via CRF1 receptors. | Nie Z et al. | β | 2004 | β |
| Genomic regions controlling corticosterone levels in rats. | Potenza MN et al. | β | 2004 | β |
| Getting closer to affective disorders: the role of CRH receptor systems. | MΓΌller MB et al. | β | 2004 | β |
| Hypothalamic-pituitary-adrenocortical system and mood disorders: highlights from mutant mice. | MΓΌller MB et al. | β | 2004 | β |
| Mouse mutants for the study of corticotropin-releasing hormone receptor function: development of novel treatment strategies for mood disorders. | Keck ME et al. | β | 2004 | β |
| Mutant G-protein-coupled receptors as a cause of human diseases. | SchΓΆneberg T et al. | β | 2004 | β |
| Neuropeptides: implications for alcoholism. | Cowen MS et al. | β | 2004 | β |
| Pharmacogenetic studies of alcohol self-administration and withdrawal. | Crabbe JC et al. | β | 2004 | β |
| Rats on the grog: novel pharmacotherapies for alcohol craving. | McGregor IS et al. | β | 2004 | β |
| Strain-specific responses of inbred mice to ethanol following food shortage. | Schroff KC et al. | β | 2004 | β |
| Tau haplotypes regulate transcription and are associated with Parkinson's disease. | Kwok JB et al. | β | 2004 | β |
| A comparative study on alcohol-preferring rat lines: effects of deprivation and stress phases on voluntary alcohol intake. | Vengeliene V et al. | β | 2003 | β |
| A critical role for the cannabinoid CB1 receptors in alcohol dependence and stress-stimulated ethanol drinking. | Racz I et al. | β | 2003 | β |
| A family history of smoking predicts heightened levels of stress-induced cigarette craving. | Erblich J et al. | β | 2003 | β |
| Alcohol addiction research: from animal models to clinics. | Spanagel R | β | 2003 | β |
| Alcoholism and obesity: overlapping neuropeptide pathways? | Thiele TE et al. | β | 2003 | β |
| Animal models in the investigation of anorexia. | Siegfried Z et al. | β | 2003 | β |
| Candidate genes for alcohol dependence: animal studies. | Schumann G et al. | β | 2003 | β |
| Corticotropin-releasing factor requires CRF binding protein to potentiate NMDA receptors via CRF receptor 2 in dopamine neurons. | Ungless MA et al. | β | 2003 | β |
| Functional genomics of neural and behavioral plasticity. | Hofmann HA | β | 2003 | β |
| High-quality antidepressant discovery by understanding stress hormone physiology. | Holsboer F | β | 2003 | β |
| Limbic corticotropin-releasing hormone receptor 1 mediates anxiety-related behavior and hormonal adaptation to stress. | MΓΌller MB et al. | β | 2003 | β |
| Long-term voluntary ethanol drinking increases expression of NMDA receptor 2B subunits in rat frontal cortex. | Henniger MS et al. | β | 2003 | β |
| Neurobehavioral effects of alcohol in AMPA receptor subunit (GluR1) deficient mice. | Cowen MS et al. | β | 2003 | β |
| Neuropeptides: opportunities for drug discovery. | HΓΆkfelt T et al. | β | 2003 | β |
| Pharmacological mechanisms of naltrexone and acamprosate in the prevention of relapse in alcohol dependence. | Littleton J et al. | β | 2003 | β |
| Role of Fyn tyrosine kinase in ethanol consumption by mice. | Cowen MS et al. | β | 2003 | β |
| The CRF1 receptor antagonist antalarmin reduces volitional ethanol consumption in isolation-reared fawn-hooded rats. | Lodge DJ et al. | β | 2003 | β |
| Pharmacotherapy of addictions. | Kreek MJ et al. | β | 2002 | β |
| Restoring the addicted brain. | Goldman D et al. | β | 2002 | β |